Details of the Drug Combinations

General Information of This Drug (ID: DM2POTE)

Drug Name

Colchicine DM2POTE

Synonyms

Colchicin; Colchicina; Colchicinum; Colchineos; Colchisol; Colchysat; Colcin; Colcrys; Colsaloid; Colstat; Condylon; Goutnil; Kolkicin; LOC; Binds to tubulin; Colchicin [German]; Colchicina [Italian]; Colchicine [JAN]; Inhibits microtubular assembly; Spindle poison; C 9754; Colchicine (TN); Colchicine, Colchicum autumnale; MPC-004; N-Acetyl trimethylcolchicinic acid methylether; Colchicine (JP15/USP); Colchicine, (R)-Isomer; Benzo(a)heptalen-9(5H)-one; Colchicine, (+-)-Isomer; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 7-alpha-H-Colchicine; 7.alpha.H-Colchicine; 7alphaH-Colchicine

Indication

Disease Entry	ICD 11	Status	REF
Acute gout flare	FA25.0	Approved	[1]
Acute gouty arthritis	FA25.0	Approved	[2]
Gout	FA25	Approved	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Familial Mediterranean fever	N.A.	Investigative	[3]
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Therapeutic Class

Gout Suppressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Colchicine + DZNep	DCTXM9H	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Panobinostat	DC52YHU	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[5]
Colchicine + WAY-100635	DCXM98I	WAY-100635	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Piperacetazine	DCKCRDV	Piperacetazine	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + RG6046	DCHGP32	RG6046	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Apilimod	DCKH9XN	Apilimod	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Sunitinib malate	DC66TWZ	Sunitinib malate	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Mizoribine	DCI01E1	Mizoribine	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + PM1183	DC1MNSA	PM1183	Lymphoid neoplasm (Cell Line: Mak)	[5]
Colchicine + Ruxolitinib	DC3CHE1	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[6]
DZNep + Colchicine	DCU492I	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[5]
Ospemifene + Colchicine	DCNWNE2	Ospemifene	Lymphoid neoplasm (Cell Line: Mak)	[5]
Piperacetazine + Colchicine	DCI3M2W	Piperacetazine	Lymphoid neoplasm (Cell Line: Mak)	[5]
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⏷ Show the Full List of 13 DrugCom(s)

22 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Allopurinol + Colchicine	DCW593F	Allopurinol	Intercritical Gout	[7]
Azithromycin + Colchicine	DCN9B8N	Azithromycin	Pharmacokinetics	[8]
Clarithromycin + Colchicine	DC7AJLZ	Clarithromycin	Pharmacokinetics	[9]
Cyclosporin A + Colchicine	DCHKNIH	Cyclosporin A	Pharmacokinetics	[10]
Febuxostat + Colchicine	DCIG6OC	Febuxostat	Gout	[11]
Ketoconazole + Colchicine	DC0AXQ7	Ketoconazole	Pharmacokinetics	[12]
M102 + Colchicine	DCB91BI	M102	Hyperuricemia	[13]
Theophylline + Colchicine	DCIQ6O7	Theophylline	Pharmacokinetics	[14]
Allopurinol + Colchicine	DCVDTLX	Allopurinol	Gout	[15]
Atorvastatin + Colchicine	DC5ROEX	Atorvastatin	Non ST Segment Elevation Acute Coronary Syndrome	[16]
Methotrexate + Colchicine	DCG5MN4	Methotrexate	Coronary Artery Disease	[17]
Naltrexone + Colchicine	DCIFQFH	Naltrexone	Covid19	[18]
Pentoxifylline + Colchicine	DCJE5ZE	Pentoxifylline	Behçet Disease Affecting Oral Mucosa	[19]
Aspirin + Colchicine	DC62SDX	Aspirin	Stroke	[20]
Brilinta + Colchicine	DC55FQF	Brilinta	Stroke	[20]
DU-176B + Colchicine	DCOVCXI	DU-176B	SARS-CoV Infection	[21]
Lenalidomide + Colchicine	DC02ZGK	Lenalidomide	Multiple Myeloma	[22]
Spironolactone + Colchicine	DC6JEVX	Spironolactone	ST Elevation Myocardial Infarction	[23]
Allopurinol + Colchicine	DCKTT31	Allopurinol	Gout	[24]
Aspirin + Colchicine	DC87OZE	Aspirin	Acute Coronary Syndrome	[25]
Febuxostat + Colchicine	DC6R8CU	Febuxostat	Primary Gout	[26]
Rosuvastatin + Colchicine	DCY13M2	Rosuvastatin	Coronary Artery Disease	[27]
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⏷ Show the Full List of 22 DrugCom(s)

References

1	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (NDA) 022351
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7526).
3	Colchicine FDA Label
4	ClinicalTrials.gov (NCT04322565) Colchicine Counteracting Inflammation in COVID-19 Pneumonia. U.S. National Institutes of Health.
5	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
7	ClinicalTrials.gov (NCT01451645) Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol
8	ClinicalTrials.gov (NCT00983294) Drug-Drug Interaction Study of Colchicine and Azithromycin
9	ClinicalTrials.gov (NCT00984061) Drug-Drug Interaction Study of Colchicine and Clarithromycin
10	ClinicalTrials.gov (NCT00983931) Drug-Drug Interaction Study Between Colchicine and Cyclosporine
11	ClinicalTrials.gov (NCT01112982) An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels.
12	ClinicalTrials.gov (NCT00983216) Drug-Drug Interaction Study Between Colchicine and Ketoconazole
13	ClinicalTrials.gov (NCT01336686) Safety and Efficacy Study of MBX-102 in Treatment of Hyperuricemia in Patients With Gout
14	ClinicalTrials.gov (NCT00983905) Drug-Drug Interaction Study of Colchicine and Theophylline
15	ClinicalTrials.gov (NCT02063997) Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
16	ClinicalTrials.gov (NCT05250596) COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
17	ClinicalTrials.gov (NCT02366091) Inflammation and Coronary Endothelial Function
18	ClinicalTrials.gov (NCT04756128) Impact of Colchicine and Low-dose Naltrexone on COVID-19
19	ClinicalTrials.gov (NCT03888846) Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
20	ClinicalTrials.gov (NCT05476991) Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis
21	ClinicalTrials.gov (NCT04516941) CorONa Virus edoxabaN ColchicinE (CONVINCE) COVID-19
22	ClinicalTrials.gov (NCT05802992) The Efficacy and Safety of Colchicine Combined With Conventional Therapy in Multiple Myeloma Patients
23	ClinicalTrials.gov (NCT03048825) Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry
24	ClinicalTrials.gov (NCT04875702) Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
25	ClinicalTrials.gov (NCT04949516) Mono Antiplatelet and Colchicine Therapy
26	ClinicalTrials.gov (NCT02060552) Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels
27	ClinicalTrials.gov (NCT05850091) Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine