Details of the Drug Combinations

General Information of This Drug (ID: DM3906J)

Drug Name
Bedaquiline   DM3906J
Synonyms SIRTURO (TN)
Indication
Disease Entry ICD 11 Status REF
Drug-resistant tuberculosis N.A. Approved [1]
Multi-drug resistant tuberculosis MG52.00 Approved [2]
Pulmonary tuberculosis 1B10.Z Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

31 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Bedaquiline + Pretomanid DC08DD6 Pretomanid Pulmonary Tuberculosis [3]
Bedaquiline + Efavirenz DCBVRU8 Efavirenz Tuberculosis [4]
Bedaquiline + Rifampicin DCY5P0R Rifampicin Tuberculosis [5]
Bedaquiline + Pyrazinamide DCZDPWB Pyrazinamide Pulmonary Tuberculosis [3]
Bedaquiline + Rifapentine DCE5ENS Rifapentine Tuberculosis [6]
Rifabutin + Bedaquiline DCQ2NGW Rifabutin Tuberculosis [5]
Bedaquiline + Pyrazinamide DC04ZDQ Pyrazinamide Tuberculosis, Pulmonary [7]
Bedaquiline + Pyrazinamide DCDLBJZ Pyrazinamide Pulmonary Tuberculosis [8]
Bedaquiline + Pyrazinamide DCFX2VP Pyrazinamide Tuberculosis, Pulmonary [9]
Bedaquiline + Pyrazinamide DCLYUYV Pyrazinamide Tuberculosis, Pulmonary [10]
Bedaquiline + Pyrazinamide DCV7C4N Pyrazinamide Tuberculosis [11]
Bedaquiline + Clarithromycin DC066AG Clarithromycin Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD) [12]
Bedaquiline + Pyrazinamide DCCKTXG Pyrazinamide Pulmonary Tuberculosis [8]
Bedaquiline + Pyrazinamide DCDBKWI Pyrazinamide Tuberculosis [11]
Bedaquiline + Moxifloxacin DCDV78F Moxifloxacin Tuberculosis, Pulmonary [13]
Bedaquiline + Pyrazinamide DCQR6Q4 Pyrazinamide Pulmonary Tuberculosis [8]
Bedaquiline + Pretomanid DCTEABV Pretomanid Pulmonary Tuberculosis [8]
Bedaquiline + Moxifloxacin DCVMZGP Moxifloxacin Pulmonary Tuberculosis [14]
Bedaquiline + Delamanid DCTDKUM Delamanid Tuberculosis [15]
Linezolid + Bedaquiline DCDV0TP Linezolid Multi-drug Resistant Tuberculosis [16]
Linezolid + Bedaquiline DCLF1FC Linezolid Multi-drug Resistant Tuberculosis [16]
Linezolid + Bedaquiline DCX979N Linezolid Tuberculosis, Multidrug-Resistant [17]
Linezolid + Bedaquiline DCYP39B Linezolid Tuberculosis, Multidrug-Resistant [17]
Linezolid + Bedaquiline DC7VMU1 Linezolid Tuberculosis, Multidrug-Resistant [17]
Linezolid + Bedaquiline DCMV1JA Linezolid Multi-drug Resistant Tuberculosis [16]
Rifabutin + Bedaquiline DCC63N1 Rifabutin Tuberculosis, Pulmonary [10]
Sutezolid + Bedaquiline DCZ3OD9 Sutezolid Tuberculosis [18]
Sutezolid + Bedaquiline DCZSUT4 Sutezolid Pulmonary Tuberculosis [19]
Sutezolid + Bedaquiline DC5SDH7 Sutezolid Tuberculosis [18]
Linezolid + Bedaquiline DCCPSGD Linezolid Tuberculosis, Multidrug-Resistant [20]
Linezolid + Bedaquiline DCSYM2Q Linezolid Pulmonary Tuberculosis [21]
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⏷ Show the Full List of 31 DrugCom(s)

References

1 Bedaquiline FDA Label
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3 ClinicalTrials.gov (NCT01215851) Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)
4 ClinicalTrials.gov (NCT00992069) Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers
5 ClinicalTrials.gov (NCT01341184) TMC207 +/- Rifabutin/Rifampin
6 ClinicalTrials.gov (NCT02216331) PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)
7 ClinicalTrials.gov (NCT05556746) Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB
8 ClinicalTrials.gov (NCT01691534) Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z). U.S. National Institutes of Health.
9 ClinicalTrials.gov (NCT03338621) Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients
10 ClinicalTrials.gov (NCT05766267) Short-course Regimens for the Treatment of Pulmonary Tuberculosis
11 ClinicalTrials.gov (NCT02193776) A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.
12 ClinicalTrials.gov (NCT04630145) A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
13 ClinicalTrials.gov (NCT05926466) BTZ-043 Dose Evaluation in Combination and Selection
14 ClinicalTrials.gov (NCT06114628) Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
15 ClinicalTrials.gov (NCT05382312) Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary Tuberculosis
16 ClinicalTrials.gov (NCT04207112) Economic Evaluation of New MDR TB Regimens
17 ClinicalTrials.gov (NCT02589782) Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)
18 ClinicalTrials.gov (NCT05686356) A Pan-TB Regimen Targeting Host and Microbe
19 ClinicalTrials.gov (NCT05807399) PanACEA - STEP2C -01
20 ClinicalTrials.gov (NCT02754765) Evaluating Newly Approved Drugs for Multidrug-resistant TB
21 ClinicalTrials.gov (NCT02333799) A Phase 3 Study Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis