Details of the Drug Combinations

General Information of This Drug (ID: DM3XQDH)

Drug Name
JQ1   DM3XQDH
Synonyms JQ1 compound; JQ-1; UNII-1MRH0IMX0W; (S)-JQ1; Bromodomain Inhibitor, (+)-JQ1; 1MRH0IMX0W
Indication
Disease Entry ICD 11 Status REF
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
Therapeutic Class
Antiviral Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

99 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + JQ1 DC8RL9H (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-199 + JQ1 DC65KCR ABT-199 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ABT-263 + JQ1 DCSNW9A ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Afatinib + JQ1 DCSP0SS Afatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AT7519 + JQ1 DC4MCSR AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
ATI-17000 + JQ1 DCAV5CD ATI-17000 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AZD8055 + JQ1 DC0I3UN AZD8055 Ewing sarcoma (Cell Line: TC-71) [2]
AZD8330 + JQ1 DCR4TIG AZD8330 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + JQ1 DCYTHU4 Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bardoxolone methyl + JQ1 DC6Q2IK Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
Belinostat + JQ1 DCLHWO2 Belinostat Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
Belinostat + JQ1 DCI7TZR Belinostat Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
Belinostat + JQ1 DC4YRLQ Belinostat Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
BGJ398 + JQ1 DCJIVPA BGJ398 Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
BGJ398 + JQ1 DCUFEZC BGJ398 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
BMS-754807 + JQ1 DCUXPF0 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BMS-754807 + JQ1 DCYUI3F BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + JQ1 DCTS3NH BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
BMS-754807 + JQ1 DCWXF5Y BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
Buparlisib + JQ1 DC12CEJ Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CA4P + JQ1 DCO26JX CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + JQ1 DCU06XJ CA4P Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Carfilzomib + JQ1 DC9BWGL Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Carfilzomib + JQ1 DCZ39N1 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Ceritinib + JQ1 DC1GI3P Ceritinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
Ceritinib + JQ1 DCR4V0P Ceritinib Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
CF102 + JQ1 DCVCNOI CF102 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Dasatinib + JQ1 DCQBYOJ Dasatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Erlotinib + JQ1 DCNG14S Erlotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Evacetrapib + JQ1 DC1K5OB Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Everolimus + JQ1 DC9SOGG Everolimus Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
Everolimus + JQ1 DC6SJF4 Everolimus Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
Everolimus + JQ1 DC5D4JM Everolimus Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
Everolimus + JQ1 DC7O1KK Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Flavopiridol + JQ1 DC0KNR8 Flavopiridol Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Fostamatinib + JQ1 DC83XBH Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
GSK2126458 + JQ1 DCBPIX1 GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
GSK2126458 + JQ1 DCA1K6M GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
IMD-0354 + JQ1 DCXA4PR IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
JQ1 + Epothilone D DCIIJA2 Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Ombrabulin DCXI9F0 Ombrabulin Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + AT13387 DCWP5X7 AT13387 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JQ1 + AT13387 DCXJIS9 AT13387 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Trametinib DCQON09 Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
JQ1 + Trametinib DC3OV52 Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
JQ1 + Trametinib DCGUSF6 Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
JQ1 + JQ1 DCML9LO JQ1 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
JQ1 + JQ1 DC2HU66 JQ1 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
JQ1 + Carfilzomib DC5FTDR Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JQ1 + Panobinostat DC7XMB9 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JQ1 + Ixazomib DCOBPZE Ixazomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JQ1 + Eltanexor oral DCKOQVR Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Everolimus DCHT1GS Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + GDC-0084 DCYS331 GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Cantharidin DCL3Y4P Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Exherin DC3Y0UZ Exherin Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + THAPSIGARGIN DC9J1WC THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
JQ1 + THAPSIGARGIN DCG95YV THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Etoposide DCO2KAV Etoposide Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + PHA-739358 DCDNYYN PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Mitomycin DC6SOCF Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
JQ1 + SNX-5422 DC7BWUL SNX-5422 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + AS602868 DCXEB2O AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
JQ1 + Tamoxifen DCYQ995 Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
JQ1 + Nintedanib DCPPAQK Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Tivantinib DCORMXU Tivantinib Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + (-)-englerin A DCB5F80 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + MK-2206 DC2BNQF MK-2206 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
JQ1 + MK-2206 DC6Y2ID MK-2206 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
JQ1 + MK-2206 DC4856K MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + CHS-828 DC8EPRF CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + LY2874455 DCK29BS LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Cytarabine DC6SD56 Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
Larotrectinib + JQ1 DCJT9I6 Larotrectinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
LY2874455 + JQ1 DCYKKPZ LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Mebendazole + JQ1 DCB3U1E Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mitomycin + JQ1 DCVU9CT Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + JQ1 DCBW51D MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-2206 + JQ1 DC7FY3J MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
MLN8237 + JQ1 DCSXFFT MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
ONC201 + JQ1 DCU7KJB ONC201 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Palbociclib + JQ1 DCI500M Palbociclib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PD-0325901 + JQ1 DCQSVFV PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PHA848125 + JQ1 DCXU8V3 PHA848125 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PMID25656651-Compound-5 + JQ1 DC8FSNM PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
PMID25656651-Compound-5 + JQ1 DCZQUSS PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
PMID25656651-Compound-5 + JQ1 DCBWZAT PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
Prochlorperazine + JQ1 DC4LO0V Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
RTB101 + JQ1 DC46MY2 RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
RTB101 + JQ1 DCG35RB RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
SCH772984 + JQ1 DCRE1S2 SCH772984 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
SCH772984 + JQ1 DCBTTPJ SCH772984 Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
SCH772984 + JQ1 DC3TIFI SCH772984 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
Selumetinib + JQ1 DC37SQX Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + JQ1 DC4E95Q THZ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Tosyl-l-arginine methyl ester + JQ1 DCNF6GW Tosyl-l-arginine methyl ester Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Trametinib + JQ1 DC5SX13 Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Trametinib + JQ1 DC0F9K2 Trametinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Venglustat + JQ1 DCMZKTD Venglustat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 99 DrugCom(s)

References

1 Uncovering the Role of BRD2 in COVID-19. 2020-03-19
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.