General Information of This Drug (ID: DM48QOT)

Drug Name
Artemether   DM48QOT
Synonyms
Artemetero; Artemether[inn]; Artemetheri; Artemetherum; Artemos; Artenam; Artesaph; Artesian; Artimist; Artmether; Falcidol; Gvither; Malartem; Paluther; Rither; Arteannuin ether; Artemether [INN]; Artemisininelactol methyl ether; Dihydroartemisinin methyl ether; Dihydroquinghaosu methyl ether; SM 224; SM 229; Alpha-Artemether; Alpha-Dihydroartemisinin methyl ether; Artemetero [INN-Spanish]; Artemether (INN); Artemetherum [INN-Latin]; Beta-Artemether; Beta-Dihydroartemisinin methyl ether; Methyl-dihydroartemisinine; O-Methyldihydroartemisinine; SM-224; Beta-Methylether of 11-epi-dihydroartemisinin; Artemether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin; (3alpha,5abeta,6beta,8abeta,9alpha,10beta,12beta,12aR*)-isomer of artemether; (3r,5as,6r,8as,9r,10r,12r,12ar)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene; (5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene; 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-tri
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

65 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Artemether DCQSS5B (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + Artemether DC1FBFL ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Alvespimycin hydrochloride + Artemether DCKKQ3Y Alvespimycin hydrochloride DD2 (Cell Line: DD2) [2]
Artemether + Lumefantrine DCR20DL Lumefantrine DD2 (Cell Line: DD2) [2]
Artemether + Lumefantrine DC7EE3K Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Artemether + BIX-01294 DC7USAS BIX-01294 DD2 (Cell Line: DD2) [2]
Artemether + Diltiazem DCZO91N Diltiazem Hepatoblastoma (Cell Line: HB3) [2]
Artemether + Pralatrexate DCSWTQ0 Pralatrexate Ewing sarcoma (Cell Line: TC-71) [2]
Artemether + AEE-788 DCIFAXR AEE-788 Ewing sarcoma (Cell Line: TC-71) [2]
Artemether + PHA-739358 DC6GP68 PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
Artemether + Perhexiline DCYSTON Perhexiline DD2 (Cell Line: DD2) [2]
Artemether + Perhexiline DCIEO6L Perhexiline Hepatoblastoma (Cell Line: HB3) [2]
Artemether + KN-62 DCH046X KN-62 DD2 (Cell Line: DD2) [2]
Artemether + Artemisinin DC7WTX0 Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
Artemether + Ispinesib DCEFUN6 Ispinesib Ewing sarcoma (Cell Line: TC-71) [2]
Artemether + Omacetaxine mepesuccinate DCTHZI4 Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [2]
Artemether + Romidepsin DC1RAB1 Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
Artemether + Mefloquine DC7A9R2 Mefloquine DD2 (Cell Line: DD2) [2]
Artemether + Mefloquine DCQXXBU Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Artemisinin + Artemether DCTW8IV Artemisinin DD2 (Cell Line: DD2) [2]
Artemisinin + Artemether DC1HZUT Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
AT13387 + Artemether DCUXBVL AT13387 Ewing sarcoma (Cell Line: TC-71) [2]
Atovaquone + Artemether DCTVOX9 Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
AXL-1717 + Artemether DC7PM0M AXL-1717 Ewing sarcoma (Cell Line: TC-71) [2]
Carfilzomib + Artemether DCA29IU Carfilzomib Hepatoblastoma (Cell Line: HB3) [2]
Chloroquine + Artemether DC9GF3T Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Dihydroergotamine + Artemether DCX4ZWB Dihydroergotamine DD2 (Cell Line: DD2) [2]
Docetaxel + Artemether DC5RWNG Docetaxel Ewing sarcoma (Cell Line: TC-71) [2]
Doxepin + Artemether DC3UFMS Doxepin DD2 (Cell Line: DD2) [2]
Eltanexor oral + Artemether DCYHXLX Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + Artemether DCT44MN Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Ivermectin + Artemether DCQ2I9U Ivermectin DD2 (Cell Line: DD2) [2]
KN-62 + Artemether DCOHYY3 KN-62 Hepatoblastoma (Cell Line: HB3) [3]
Lumefantrine + Artemether DCFJJBJ Lumefantrine DD2 (Cell Line: DD2) [2]
Lumefantrine + Artemether DC4D1NQ Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
LY2874455 + Artemether DCELQYC LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Mefloquine + Artemether DC6FDKN Mefloquine DD2 (Cell Line: DD2) [2]
Mefloquine + Artemether DCRPIPK Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Methylene blue + Artemether DC60NAY Methylene blue DD2 (Cell Line: DD2) [2]
Methylene blue + Artemether DCC948Y Methylene blue Hepatoblastoma (Cell Line: HB3) [3]
Miconazole + Artemether DCLT5QF Miconazole Hepatoblastoma (Cell Line: HB3) [3]
Midostaurin + Artemether DCI262X Midostaurin DD2 (Cell Line: DD2) [2]
MK-1775 + Artemether DCS6Z5Q MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
MK-4815 + Artemether DC4G84F MK-4815 DD2 (Cell Line: DD2) [2]
MK-4815 + Artemether DC64Y1B MK-4815 Hepatoblastoma (Cell Line: HB3) [3]
Naltrexone + Artemether DC24T9N Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
Nintedanib + Artemether DCC0YLW Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
NITD609 + Artemether DCFPKEE NITD609 DD2 (Cell Line: DD2) [2]
NITD609 + Artemether DCTBVSF NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Nitisinone + Artemether DCAI961 Nitisinone DD2 (Cell Line: DD2) [2]
Otilonium bromide + Artemether DC46EBV Otilonium bromide Hepatoblastoma (Cell Line: HB3) [2]
Panobinostat + Artemether DCHVV5H Panobinostat DD2 (Cell Line: DD2) [2]
Panobinostat + Artemether DC9BBE0 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Panobinostat + Artemether DC7ZTQ5 Panobinostat Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Artemether DC05DK4 Piperaquine DD2 (Cell Line: DD2) [2]
Piperaquine + Artemether DC7TA72 Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
Pyronaridine + Artemether DC7U9JD Pyronaridine DD2 (Cell Line: DD2) [2]
Quinine + Artemether DC3OBBQ Quinine Hepatoblastoma (Cell Line: HB3) [2]
SB 228357 + Artemether DCHVQG4 SB 228357 Hepatoblastoma (Cell Line: HB3) [3]
SCH 727965 + Artemether DCCQ10Q SCH 727965 Ewing sarcoma (Cell Line: TC-71) [2]
SCH-900776 + Artemether DC2BQFO SCH-900776 Ewing sarcoma (Cell Line: TC-71) [2]
Tetrandrine + Artemether DCENTZJ Tetrandrine Hepatoblastoma (Cell Line: HB3) [2]
THAPSIGARGIN + Artemether DCQUIUI THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
Thiolactomycin + Artemether DCB4P02 Thiolactomycin DD2 (Cell Line: DD2) [2]
Verteporfin + Artemether DCDNUTT Verteporfin Ewing sarcoma (Cell Line: TC-71) [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 65 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Tafenoquine + Artemether DC12ZVN Tafenoquine Plasmodium Vivax Malaria [4]
------------------------------------------------------------------------------------

References

1 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT04704999) Southeast Asia Dose Optimization of Tafenoquine