General Information of This Drug (ID: DM5XPIJ)

Drug Name
Leuprolide   DM5XPIJ
Synonyms Enantone; Eligard (TN); Leuprorelin (INN); Viadur (TN); 5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
Indication
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [1]
Prostate cancer 2C82.0 Approved [2]
Endometriosis GA10 Investigative [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

47 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Degarelix + Leuprolide DCCTGA6 Degarelix Metastatic Castration Sensitive Prostate Cancer (mCSPC) [3]
Leuprolide + Pyrotinib DCMOQG0 Pyrotinib Acute HIV Infection [4]
Leuprolide + Goserelin DCHVXZQ Goserelin Prostate Cancer [5]
Leuprolide + Testosterone DCR3QLK Testosterone Hypertension [6]
Leuprolide + Medroxyprogesterone DC3ZHAA Medroxyprogesterone Cognitive Impairment [7]
Leuprolide + Progesterone DC87F2J Progesterone Coronary Heart Disease [8]
Leuprolide + Docetaxel DCBLK3Y Docetaxel Prostatic Neoplasms [9]
Leuprolide + Dasatinib DC2YU6A Dasatinib Prostate Cancer [10]
Leuprolide + Docetaxel DC3W6F5 Docetaxel Prostate Cancer [11]
Leuprolide + Goserelin DC6Z3D7 Goserelin Recurrent Prostate Cancer [12]
Leuprolide + Estradiol DC944EK Estradiol Obesity [13]
Leuprolide + Zoledronate DCF8M22 Zoledronate Prostate Cancer [14]
Leuprolide + Docetaxel DCHCJ2P Docetaxel Prostatic Neoplasms [15]
Leuprolide + Testosterone DCNRTBR Testosterone Obesity [16]
Leuprolide + Flutamide DCPXP5D Flutamide Prostatic Neoplasms [17]
Leuprolide + Goserelin DCTGJYL Goserelin Prostate Cancer [18]
Leuprolide + Bicalutamide DCWYSTW Bicalutamide Prostatic Neoplasms [9]
Leuprolide + Flutamide DCYQ0KN Flutamide Prostate Cancer [19]
Leuprolide + Anastrozole DCZVOGR Anastrozole Hypertension [20]
Leuprolide + Docetaxel DCB97BQ Docetaxel Prostate Cancer [21]
Leuprolide + ABIRATERONE DCC5P8T ABIRATERONE Prostate Cancer [22]
Leuprolide + Goserelin DCD7XMI Goserelin Adenocarcinoma of the Prostate [23]
Leuprolide + Everolimus DCJ7016 Everolimus Prostate Cancer [24]
Leuprolide + Bicalutamide DC6UM7H Bicalutamide Adenocarcinoma of the Prostate [25]
Leuprolide + ABIRATERONE DCLJJZL ABIRATERONE Prostate Cancer [26]
Leuprolide + Goserelin DCY45M7 Goserelin Breast Cancer [27]
Leuprolide + Everolimus DC4262U Everolimus Metastatic Breast Cancer [28]
Leuprolide + Goserelin DC43XRL Goserelin Adenocarcinoma of the Prostate [29]
Leuprolide + Testosterone DC4L1H1 Testosterone Contraception [30]
Leuprolide + Letrozole DCB32SG Letrozole Breast Cancer [31]
Leuprolide + ABIRATERONE DCHM8XH ABIRATERONE Prostate Cancer [32]
Leuprolide + Goserelin DCLI0V7 Goserelin Recurrent Prostate Cancer [33]
Leuprolide + Docetaxel DCUVPRW Docetaxel Prostate Cancer [34]
Leuprolide + Goserelin DCVMLM2 Goserelin Prostate Cancer [35]
Leuprolide + ABIRATERONE DCWFB6E ABIRATERONE Newly Diagnosed Oligometastatic Prostate Cancer [36]
Leuprolide + Enzalutamide DCZAT12 Enzalutamide Prostate Cancer [37]
Leuprolide + Letrozole DC4JITU Letrozole Endometrial Neoplasms [38]
Leuprolide + Letrozole DC4WU4F Letrozole Metastatic Breast Cancer [28]
Leuprolide + Letrozole DCJE91Y Letrozole Breast Cancer [39]
Leuprolide + Arn-509 DCJYGIX Arn-509 Prostate Cancer [40]
Leuprolide + Enzalutamide DCNIJI0 Enzalutamide Prostate Cancer [41]
Leuprolide + Goserelin DC763GJ Goserelin Prostate Cancer [42]
Leuprolide + Goserelin DCZXJZA Goserelin Breast Cancer [43]
Leuprolide + Goserelin DC9C9SC Goserelin Prostate Cancer [44]
Leuprolide + Goserelin DCW1ETX Goserelin Gastrointestinal Complications [45]
Leuprolide + Enzalutamide DCPV5K3 Enzalutamide Hormone Sensitive Prostate Cancer [46]
Leuprolide + Cetrorelix DCV70LW Cetrorelix Polycystic Ovary Syndrome [47]
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⏷ Show the Full List of 47 DrugCom(s)

References

1 Leuprolide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1175).
3 ClinicalTrials.gov (NCT05701007) Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland
4 ClinicalTrials.gov (NCT05087706) Exploratory Study of Molecular Profile-Associated Evidence Guided Precision Therapy for Salivary Gland CancerMAPS?Unknown status
5 ClinicalTrials.gov (NCT02366494) Micro RNAs to Predict Response to Androgen Deprivation Therapy
6 ClinicalTrials.gov (NCT02269072) Testosterone Regulation of the Natriuretic Peptide System
7 ClinicalTrials.gov (NCT02122198) Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
8 ClinicalTrials.gov (NCT01546454) Relationship Between the Menstrual Cycle and Heart Disease in Women
9 ClinicalTrials.gov (NCT00514917) A Study of Androgen Deprivation With Leuprolide, +/- Docetaxel for Clinically Asymptomatic Prostate Cancer Participants With a Rising Prostate Specific Antigen (PSA)
10 ClinicalTrials.gov (NCT00860158) Neoadjuvant Dasatinib Plus LHRH Analogue Therapy in High-Risk Localized Prostate Cancer
11 ClinicalTrials.gov (NCT00225420) Docetaxel, Androgen Ablation, and External-Beam Radiation Therapy in Patients With High-Risk Localized Prostate Cancer
12 ClinicalTrials.gov (NCT00454571) Pazopanib Hydrochloride After Leuprolide Acetate or Goserelin Acetate in Treating Patients With Relapsed Prostate Cancer
13 ClinicalTrials.gov (NCT00687739) Prevention of Obesity in Women Via Estradiol Regulation
14 ClinicalTrials.gov (NCT00193856) RADAR Trial - Randomised Androgen Deprivation and Radiotherapy
15 ClinicalTrials.gov (NCT00452556) The ELDORADO (Eligard, Docetaxel and Radiotherapy) Study
16 ClinicalTrials.gov (NCT01160328) Influence of Male Hormones on Regional Fat Metabolism
17 ClinicalTrials.gov (NCT00817739) Intermittent Hormonal Therapy With Leuprorelin and Flutamide in the Treatment of Stage D2 or TxNxM1b,c
18 ClinicalTrials.gov (NCT00004635) Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer
19 ClinicalTrials.gov (NCT00003645) Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer Patients at High Risk for Recurrence
20 ClinicalTrials.gov (NCT01763541) Study of the Effect of Testosterone and Estradiol on NP Responses to Acute and Chronic Salt Loading
21 ClinicalTrials.gov (NCT00099086) Docetaxel, Radiation Therapy, and Hormone Therapy in Treating Patients With Locally Advanced Prostate Cancer
22 ClinicalTrials.gov (NCT04194554) A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer
23 ClinicalTrials.gov (NCT02023463) Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer
24 ClinicalTrials.gov (NCT00943956) Everolimus, Bicalutamide, and Leuprolide Acetate in Treating Patients Undergoing Radiation Therapy For High-Risk Locally Advanced Prostate Cancer
25 ClinicalTrials.gov (NCT02064036) Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate
26 ClinicalTrials.gov (NCT03043807) A Study of Definitive Therapy to Treat Prostate Cancer After Prostatectomy
27 ClinicalTrials.gov (NCT03056755) Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments
28 ClinicalTrials.gov (NCT02344550) Study of GnRH-A [Leuprorelin(Lorelin Depot] Plus Leterozole +/- Everolimus for Premenopausal Women With Metastatic Breast Cancer
29 ClinicalTrials.gov (NCT02058706) LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Hormone Sensitive Prostate Cancer
30 ClinicalTrials.gov (NCT00161421) Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone
31 ClinicalTrials.gov (NCT00903162) Extended Endocrine Therapy for Premenopausal Women With Breast Cancer
32 ClinicalTrials.gov (NCT02772588) AASUR in High Risk Prostate Cancer
33 ClinicalTrials.gov (NCT01750398) Bipolar Androgen-based Therapy for Prostate Cancer (BAT)
34 ClinicalTrials.gov (NCT02716974) A Study of Definitive Therapy to Treat Prostate Cancer
35 ClinicalTrials.gov (NCT02059213) A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer
36 ClinicalTrials.gov (NCT03298087) Systemic and Tumor-Directed Therapy for Oligometastatic Prostate Cancer
37 ClinicalTrials.gov (NCT01547299) Study of Enzalutamide (Formerly MDV3100) as a Neoadjuvant Therapy for Patients Undergoing Prostatectomy for Localized Prostate Cancer
38 ClinicalTrials.gov (NCT05316935) GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients
39 ClinicalTrials.gov (NCT03900637) PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate
40 ClinicalTrials.gov (NCT02770391) Apalutamide and Leuprolide in Intermediate and High-risk Prostate Cancer
41 ClinicalTrials.gov (NCT02064582) Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer
42 ClinicalTrials.gov (NCT00388804) External Beam Radiation Therapy (EBRT) With or Without Hormonal Therapy in Prostate Cancer
43 ClinicalTrials.gov (NCT02941926) Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC
44 ClinicalTrials.gov (NCT00002597) Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
45 ClinicalTrials.gov (NCT00541047) RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
46 ClinicalTrials.gov (NCT02319837) Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
47 ClinicalTrials.gov (NCT04094467) Comparison Between Two Different Protocols in Polycystic Ovary Symdrome Women Undergoing Intra-cytoplasmic Injection