Details of the Drug Combinations

General Information of This Drug (ID: DM7IW9J)

Drug Name
Ramelteon   DM7IW9J
Synonyms
Rozerem; Ramelteon [USAN]; Rozerem (TN); TAK-375; Ramelteon (JAN/USAN/INN); Rozerem, TAK-375, Ramelteon; N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide; N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]fur-8-yl]ethyl}propanamid; (-)-N-(2-(((8S)-1,6,7,8-Tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)propanamide; (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide
Indication
Disease Entry ICD 11 Status REF
Insomnia 7A00-7A0Z Approved [1]
Circadian rhythm sleep disorder 7A60-7A65 Terminated [1]
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Ramelteon DCVDLX4 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acetazolamide + Ramelteon DCJR6B9 Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Albendazole + Ramelteon DCVVC9Y Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + Ramelteon DCT1TDB Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Ramelteon DCUOWI2 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Ramelteon DCKX5BJ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Ramelteon DCFATE5 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dactinomycin + Ramelteon DCX30XK Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Ramelteon DC42NRW Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Ramelteon DCLKG48 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + Ramelteon DCIQWDU Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + Ramelteon DCPSZPS Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Ramelteon DCJBNK2 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Ramelteon DCRMDYH Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Ramelteon DCYVV1C Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nizatidine + Ramelteon DCVZLX5 Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Ramelteon DC3J0SN Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Ramelteon DCI8OQR PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Triiodothyronine DCUJSHG Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Gefitinib DCUGSWQ Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Kanamycin DCM6HMX Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Epinephrine DCPW3LF Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Tindamax DCSZD31 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + PMID28460551-Compound-2 DC4S14E PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Methotrexate DCZ34P8 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Vinblastine DCQ42Z7 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Triapine DCZEG0I Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + IT-141 DCR3LX9 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Metyrosine DCX07IF Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Pazopanib DCFXEIG Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Phensuximide DCQDZCI Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Fibrates DC0YNLN Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Triflupromazine DCRQVWZ Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + BIO-300 DCG93FO BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Lubiprostone DC1UMF4 Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Isoproterenol DCH3RPB Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Tiagabine DCBCRAG Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Benserazide DCAFAV7 Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Idarubicin DC8S43D Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Ramelteon + Atenolol DCTICVI Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Pramipexole DCQVEPH Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Maprotiline DC16S4D Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Valproic Acid DCPOHEN Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Hyodeoxycholic acid DCTE0WY Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Mycophenolic acid DCKYCYU Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Mefloquine DCNBQXV Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + PMID28870136-Compound-43 DCJNX7I PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Vorinostat DCQ5MLJ Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Aciclovir DCM9CHA Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Enoxacin DCEYDUA Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Acetohydroxamic Acid DCTSHKT Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rufinamide + Ramelteon DC0T47X Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Ramelteon DC0U5FT Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Ramelteon DCG1LVW Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
WAY-100635 + Ramelteon DCGHWIF WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 55 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Ramelteon + Escitalopram DCJYIJZ Escitalopram Major Depressive Disorder [4]
Ramelteon + Eszopiclone DC7LCRZ Eszopiclone Marijuana Dependence [5]
Ramelteon + Citicoline DC8RFZ6 Citicoline Delirium [6]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1356).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00642694) Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
5 ClinicalTrials.gov (NCT00893269) The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
6 ClinicalTrials.gov (NCT02840591) Ramelteon and Citicoline for Delirium