Details of the Drug Combinations

General Information of This Drug (ID: DM7VTQO)

Drug Name

Entecavir DM7VTQO

Synonyms

Baraclude; ETV; Entecavir hydrate; Entecavir monohydrate; BMS-200475; Baraclude (TN); Entecavir (INN); Entecavir (USAN); Entecavir hydrate (JAN); SQ-34676; 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one-water (1/1); 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one; 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]; 9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B virus infection	1E51.0	Approved	[1]
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Therapeutic Class

Antiviral Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Entecavir + Panobinostat	DCKMLXP	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Entecavir + Lamivudine	DCQ001S	Lamivudine	Hepatitis B virus infection (Cell Line: .)	[3]
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10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Entecavir + Adefovir	DC5MTN9	Adefovir	Hepatitis B, Chronic	[4]
Entecavir + Lamivudine	DCNLS75	Lamivudine	Hepatitis B Virus	[5]
Simvastatin + Entecavir	DCOTVPH	Simvastatin	Hepatitis B	[6]
Tenofovir + Entecavir	DCXIXJ5	Tenofovir	Hepatitis B, Chronic	[4]
Tenofovir + Entecavir	DCYL3PT	Tenofovir	Chronic Viral Hepatitis B Without Delta-agent	[7]
Entecavir + F-351	DCAAH7O	F-351	Hepatitis B, Chronic	[8]
Entecavir + Lamivudine	DCBH8D1	Lamivudine	Non-Hodgkin Lymphoma	[9]
Entecavir + Adefovir	DCE88RB	Adefovir	Hepatitis B, Chronic	[10]
Entecavir + Interferon alfa-2B	DCMIFY5	Interferon alfa-2B	Hepatitis B, Chronic	[11]
Tenofovir disoproxil + Entecavir	DCEY6WC	Tenofovir disoproxil	Chronic Hepatitis B	[12]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4	ClinicalTrials.gov (NCT00410202) Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus
5	ClinicalTrials.gov (NCT01438424) Safety and Antiviral Activity of Entecavir in Participants With Chronic Hepatitis B Following Monotherapy in Other Entecavir Trials
6	ClinicalTrials.gov (NCT00994773) Simvastatin for the Treatment of Chronic Hepatitis B
7	ClinicalTrials.gov (NCT01639066) Tenofovir Plus Entecavir vs. Tenofovir in Adefovir-Resistant Chronic Hepatitis B
8	ClinicalTrials.gov (NCT02499562) A Phase II Clinical Trial of Hydronidone Capsules(F351) in Patients With Liver Fibrosis Induced by HBV Chronic Hepatitis
9	ClinicalTrials.gov (NCT01914744) Entecavir Versus Lamivudine for Preventing the Risk of Hepatitis B Reactivation in NHL
10	ClinicalTrials.gov (NCT02482272) Compare Continuing Lamivudine Plus Adefovir or Adefovir Versus Switching to Entecavir Plus Adefovir in Patients With LAM-resistant Chronic Hepatitis B
11	ClinicalTrials.gov (NCT02360592) Combination Therapy With Interferon Plus Interleukin 2 and Hepatitis B Vaccine in Chronic Hepatitis B Patients
12	ClinicalTrials.gov (NCT03357822) A Real-World Study of Pegylated Interferon In Nucleoside-treated Patients With Chronic Hepatitis B