Details of the Drug Combinations

General Information of This Drug (ID: DM82Z30)

Drug Name

Topiramate DM82Z30

Synonyms

Epitoma; Epitomax; TOR; Tipiramate; Tipiramato; Topamac; Topamax; Topimax; Topina; Topiramato; Topiramatum; Topomax; Cilag brandof topiramate; Janssen brand of topiramate; Ortho brand of topiramate; Tipiramate [French]; Tipiramato [Spanish]; Topamax Sprinkle; Topiramate tablet; Topiramatum [Latin]; Topiramic acid; McN 4853; RWJ 17021; KS-1122; KW-6485; McN-4853; RWJ-17021; Topamax (TN); Topamax, Topiramate; Topiramate (TPM); Topiramate / Placebo; Topiramato [INN-Spanish]; Topiramatum [INN-Latin]; USL-255; RWJ-17021-000; Topiramate [USAN:BAN:INN]; Topiramate (JAN/USAN/INN); Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate; Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI);Beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate; [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate; 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-(beta)-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate; 5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, beta

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Approved	[1]
Epilepsy	8A60-8A68	Approved	[1]
Epilepsy with generalized tonic-clonic seizures	N.A.	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[2]
Hypertriglyceridemia	5C80.1	Approved	[2]
Obesity	5B81	Approved	[2]
Metabolic syndrome x	5C50-5D2Z	Investigative	[2]
Seizure disorder	8A6Z	Investigative	[3]
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Therapeutic Class

Anticonvulsants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Topiramate + Lumefantrine	DCNJZE3	Lumefantrine	DD2 (Cell Line: DD2)	[4]
Topiramate + Piperaquine	DCTEVAT	Piperaquine	DD2 (Cell Line: DD2)	[4]
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6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Topiramate + Phentermine	DCB35O4	Phentermine	Obesity	[5]
Topiramate + Amantadine	DCBAE1L	Amantadine	Idiopathic Parkinson's Disease	[6]
Topiramate + Amantadine	DCH1826	Amantadine	Parkinson's Disease	[7]
Topiramate + Nicotine	DCI1OB2	Nicotine	Tobacco Dependence	[8]
Topiramate + Phentermine	DCRUCQY	Phentermine	Obesity	[9]
Topiramate + Lorazepam	DC2NI8D	Lorazepam	Cognitive Deficits	[10]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6849).
2	Topiramate FDA Label
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT00518466) Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
6	ClinicalTrials.gov (NCT01789047) Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
7	ClinicalTrials.gov (NCT00794313) Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease
8	ClinicalTrials.gov (NCT00755716) Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study
9	Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy. J Clin Pharm Ther. 2008 Oct;33(5):513-9.
10	ClinicalTrials.gov (NCT01889602) Characterizing and Predicting Drug Effects on Cognition