Details of the Drug Combinations

General Information of This Drug (ID: DM8VCBE)

• Drug Name: Ibuprofen (DM8VCBE)
• Synonyms: ibuprofen; 15687-27-1; 2-(4-Isobutylphenyl)propanoic acid; Motrin; Brufen; Advil; Nurofen; Dolgit; Nuprin; Liptan; Ibuprocin; Buburone; Medipren; Butylenin; Ibumetin; Anflagen; Lamidon; Ebufac; Mynosedin; Trendar; Roidenin; Apsifen; Haltran; Epobron; Nobgen; Adran; Nobfen; Rufen; PediaProfen; Andran; Bluton; Nobfelon; Pantrop; Brufort; Suspren; Rebugen; Tabalon; Inabrin; (RS)-Ibuprofen; Urem; Anco; 2-[4-(2-methylpropyl)phenyl]propanoic acid; Ibu-slo; Napacetin; Brufanic; Ibuprohm; Ibufen; Ibren; 4-Isobutylhydratropic acid; p-Isobutylhydratropic acid; Actiprofen; Alaxan; Algofen; Amelior; Amersol; Amibufen; Anafen; Antagil; Antalfene; Antarene; Antiflam; Artofen; Artril; Balkaprofen; Betaprofen; Bloom; Brofen; Bruflam; Bufeno; Bufigen; Bukrefen; Bupron; Buracaps; Burana; Carol;Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; Daiprophen; Dalsy; Dansida; Dentigoa; Dibufen; Dignoflex; Dolgirid; Dolibu; Dolmaral; Dolocyl; Dolofen; Dolofin; Dolofort; Dologel; Dolomax; Doloren; Dolormin; Doltibil; Dolven; Dorival; Drin; Duafen; Duobrus; Dysdolen; Easifon; Emflam; Eputex; Ergix; Esprenit; Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid;Fendol; Fenspan; Fibraflex; Gelufene; Gofen; Grefen; Gynofug; Ibol; Ibu; Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibuflamar; Ibufug; Ibugel; Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibulgan; Ibumed; Ibumerck; Ibupirac; Ibuprin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprophen; Ibusal; Ibutid; Ifen; Inflam; Inoven; Ipren; Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Lebrufen; Librofem; Lidifen; Lopane; Malafene; Manypren; Melfen; Mensoton; Midol; Moment; Narfen; Neobrufen; Nerofen; Noalgil; Nobafon; Noritis; Norton; Novadol; Novogent; Novoprofen; Nuprilan; Optifen; Opturem; Oralfene; Ostarin; Ostofen; Ozonol; Paduden; Panafen; Paxofen; Perofen; Proartinal; Profen; Proflex; Provon; Quadrax; Rafen; Ranofen; Relcofen; Rhinadvil; Rofen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solufen; Stelar; Sugafen; Suprafen; Syntofene; Tatanal; Tempil; Tofen; Tonal; Unipron; Upfen; Uprofen; Zafen; Zofen; DOLO PUREN; Deep Relief; Donjust B; Motrin IB; Novogent N; Togal N; Adex 200; Artril 300; Brufen 400; I 4883; IP 82; IP82; Midol 200; RD 13621; Tabalon 400; U 18573; UCB 79171; VUFB 9649; Act-3; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan (TN); Algoflex (TN); Alivium (TN); Am-Fam 400; Apsifen-F; Arthrofen (TN); Bonifen (TN); Brufen (TN); Bugesic (TN); Burana (TN); Caldolor (TN); Calprofen (TN); Cap-Profen; Dalsy (TN); Dismenol (TN); Diverin (TN); Dolgit (TN); Dolo-Dolgit; Dolofen-F; Dolofort (TN); Doloraz (TN); Dolormin (TN); Dorival (TN); Dura-Ibu; Ebufac (TN); Emflam-200; EmuProfen (TN); Espidifen (TN); Eve (TN); Fenbid (TN); Fenpaed (TN); Finalflex (TN); Galprofen (TN); Hedex (TN); Herron Blue (TN); IB-100; IBUFEN (TN); IP-82; Ibalgin (TN); Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-slow; IbuHEXAL (TN); Ibugel (TN); Ibuleve (TN); Ibum (TN); Ibumax (TN); Ibumetin (TN); Ibuprom (TN); Ibuprosyn (TN); Ibux (TN); Ibuxin (TN); Ipren (TN); Kratalgin (TN); Medicol (TN); Moment (TN); Motrin (TN); Nagifen-D; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen (TN); Neofen (TN); Norvectan (TN); Novo-Profen; Nuprin (TN); Nureflex (TN); Nurofen (TN); Orbifen (TN); Panafen (TN); Pedia-Profen; Perifar (TN); Profin (TN); Ratiodolor (TN); Retard (TN); Rimafen (TN); Salvarina (TN); Solpaflex (TN); Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Tab-Profen; U-18573; Upfen (TN); ACHES-N-PAIN; Act-3 (TN); Dolo-Spedifen (TN); I-profen (TN); IBU-Ratiopharm (TN); Ibu-Vivimed (TN); U-18,573; IBUPROPHEN

Indication

Dysmenorrhea; ICD 11: GA34.3; Status: Approved [1]; Fever; ICD 11: MG26; Status: Approved [1]; Headache; ICD 11: 8A80-8A84; Status: Approved [1]; Osteoarthritis; ICD 11: FA00-FA05; Status: Approved [1]; Pain; ICD 11: MG30-MG3Z; Status: Approved [2]; Patent ductus arteriosus; ICD 11: N.A.; Status: Approved [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

42 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cyclobenzaprine + Ibuprofen	DC1OVG9	Cyclobenzaprine	Temporomandibular Disorder	[3]
Ibuprofen + Morphine	DCP2633	Morphine	Postoperative Pain	[4]
Ibuprofen + Acetaminophen	DC2VCAA	Acetaminophen	Soft Tissue Injuries	[5]
Ibuprofen + Drotaverine	DCA83J3	Drotaverine	Dysmenorrhea	[6]
Ibuprofen + Ketorolac	DCCOSP4	Ketorolac	Chronic Pelvic Pain	[7]
Ibuprofen + Capsaicin	DCL3SV1	Capsaicin	Osteoarthritis, Knee	[8]
Ibuprofen + Hydromorphone	DCMLN5A	Hydromorphone	Breast Cancer	[9]
Ibuprofen + Telcagepant	DCOMG2L	Telcagepant	Migraine	[10]
Ibuprofen + Remifentanil	DCP2ON0	Remifentanil	Ibuprofen	[11]
Ibuprofen + Indomethacin	DCSCRMD	Indomethacin	Patent Ductus Arteriosus	[12]
Ibuprofen + Pilocarpine	DCSPB51	Pilocarpine	Stability & Variability of Lipid-derived Molecules in Sweat	[13]
Ibuprofen + Acetaminophen	DCTB4YH	Acetaminophen	Fever	[14]
Ibuprofen + Oxycodone	DCYW9RB	Oxycodone	Opioid Use, Unspecified	[15]
Ibuprofen + Morphine	DC26UBS	Morphine	Trauma	[16]
Ibuprofen + Ibuprofen	DC686G0	Ibuprofen	Moderate Pain	[17]
Ibuprofen + Atorvastatin	DC0U7CU	Atorvastatin	Osteoarthritis	[18]
Ibuprofen + Acetaminophen	DC3MGX3	Acetaminophen	Adenotonsillectomy	[19]
Lorazepam + Ibuprofen	DCTEYR2	Lorazepam	Subfertility	[20]
Ibuprofen + Ketorolac	DCCWSQE	Ketorolac	Preeclampsia Severe	[21]
Ibuprofen + Acetaminophen	DCUYRGY	Acetaminophen	Surgery	[22]
Ibuprofen + Sucralfate	DCXO3AB	Sucralfate	Herpangina	[23]
Ibuprofen + Acetaminophen	DCYH03A	Acetaminophen	Chronic Rhinosinusitis (Diagnosis)	[24]
Cromoglicate + Ibuprofen	DCIQXXP	Cromoglicate	Alzheimer's Disease	[25]
Dexamethasone + Ibuprofen	DCD4OPJ	Dexamethasone	Adenotonsillectomy	[26]
Ibuprofen + Ibuprofen	DC3IHWC	Ibuprofen	Fever	[27]
Ibuprofen + Lacosamide	DCBRHFG	Lacosamide	Effect of Drug	[28]
Ibuprofen + Caffeine	DCDY58I	Caffeine	Back Pain	[29]
Ibuprofen + Caffeine	DCHMOCH	Caffeine	Pain, Postoperative	[30]
Ibuprofen + Etonogestrel	DCPJ4JG	Etonogestrel	Moderate to Severe Primary Dysmenorrhea	[31]
Baclofen + Ibuprofen	DCRC7BJ	Baclofen	Low Back Pain	[32]
Dexamethasone + Ibuprofen	DCAIVP1	Dexamethasone	Pain, Acute	[33]
Dexamethasone + Ibuprofen	DCO1A3U	Dexamethasone	Radiculopathy, Lumbosacral Region	[34]
Gabapentin + Ibuprofen	DCFX6J6	Gabapentin	Pain	[35]
Ibuprofen + Acetaminophen	DC9FS1F	Acetaminophen	Sinusitis	[36]
Ibuprofen + Hydrocodone	DCFTU1T	Hydrocodone	Nail Diseases	[37]
Ibuprofen + Piroxicam	DCGUXXA	Piroxicam	Hypertension	[38]
Ibuprofen + Fentanyl	DC3YPH0	Fentanyl	Congenital Muscular Torticollis	[39]
Ibuprofen + Oxycodone	DCAPBZY	Oxycodone	Abortion Second Trimester	[40]
Ibuprofen + Metaxalone	DCTWLPP	Metaxalone	Low Back Pain	[32]
Ibuprofen + Diclofenac	DCWJXT4	Diclofenac	Low Back Pain	[41]
Ibuprofen + Tizanidine	DCZ2VS8	Tizanidine	Low Back Pain	[32]
Lorazepam + Ibuprofen	DC25V5X	Lorazepam	Pain	[42]

References

• [1] Ibuprofen FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2713).
• [3] ClinicalTrials.gov (NCT02974166) Analysis of the Effects of the Osteopathic Manipulative Treatment in Carriers of Temporomandibular Disorders
• [4] ClinicalTrials.gov (NCT02605187) Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management
• [5] ClinicalTrials.gov (NCT00528658) Cost-effectiveness of Two Painkillers for Treating Pain After Limb Injuries
• [6] ClinicalTrials.gov (NCT00292747) Drotaverine in Dysmenorrhoea Treatment
• [7] ClinicalTrials.gov (NCT01514175) A Pilot Study Comparing the Analgesic Efficacy of IV Ibuprofen and IV Ketorolac
• [8] ClinicalTrials.gov (NCT03146689) Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?
• [9] ClinicalTrials.gov (NCT02461056) Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
• [10] ClinicalTrials.gov (NCT00758836) A Study to Test the Safety and Effectiveness of MK-0974 (Telcagepant) Co-administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura (MK-0974-046)
• [11] ClinicalTrials.gov (NCT02243254) Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
• [12] ClinicalTrials.gov (NCT02884219) Early Treatment Versus Expectative Management of PDA in Preterm Infants
• [13] ClinicalTrials.gov (NCT02935894) Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat
• [14] ClinicalTrials.gov (NCT00267293) Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever
• [15] ClinicalTrials.gov (NCT03959969) Educational Video on Pain Management and Subsequent Opioid Use After Cesarean Delivery
• [16] ClinicalTrials.gov (NCT05355441) Pain Multidisciplinar Intervention in Major Trauma Patients
• [17] ClinicalTrials.gov (NCT03225352) A Study to Assess Disintegration of the New Aspirin Disintegrating Tablets
• [18] ClinicalTrials.gov (NCT00411190) Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
• [19] ClinicalTrials.gov (NCT04791761) Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy
• [20] ClinicalTrials.gov (NCT02863614) Analgesia for Endometrial Scratching
• [21] ClinicalTrials.gov (NCT03978767) Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
• [22] ClinicalTrials.gov (NCT03588910) Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
• [23] ClinicalTrials.gov (NCT03241030) Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial
• [24] ClinicalTrials.gov (NCT03055507) Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
• [25] ClinicalTrials.gov (NCT02547818) Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease
• [26] ClinicalTrials.gov (NCT04879823) Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
• [27] ClinicalTrials.gov (NCT01131000) Efficacy, Safety, and Pharmacokinetics of Intravenous Ibuprofen in Adult Febrile Patients
• [28] ClinicalTrials.gov (NCT05632133) The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients
• [29] ClinicalTrials.gov (NCT03003000) Ibuprofen/Caffeine Lower Back or Neck Pain Study
• [30] ClinicalTrials.gov (NCT01929031) Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
• [31] ClinicalTrials.gov (NCT02668783) Efficacy and Safety of Etonogestrel + 17-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059)
• [32] ClinicalTrials.gov (NCT03068897) Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
• [33] ClinicalTrials.gov (NCT04123873) Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty
• [34] ClinicalTrials.gov (NCT05721027) Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
• [35] ClinicalTrials.gov (NCT02076893) Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen
• [36] ClinicalTrials.gov (NCT03783702) Pain Control Following Sinus Surgery
• [37] ClinicalTrials.gov (NCT05544734) Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia
• [38] ClinicalTrials.gov (NCT00631514) Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
• [39] ClinicalTrials.gov (NCT02651311) Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular Torticollis
• [40] ClinicalTrials.gov (NCT03545893) Overnight Pain Treatment Investigating Opioids vs. Nonopioids
• [41] ClinicalTrials.gov (NCT04611529) Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
• [42] ClinicalTrials.gov (NCT01330459) Hydrocodone For Pain Control in First Trimester Surgical Abortion