Details of the Drug Combination

General Information of Drug Combination (ID: DC1OVG9)

Drug Combination Name
Cyclobenzaprine Ibuprofen
Indication
Disease Entry Status REF
Temporomandibular Disorder Phase 1 [1]
Component Drugs Cyclobenzaprine   DM1YBRM Ibuprofen   DM8VCBE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cyclobenzaprine
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [2]
Pain MG30-MG3Z Approved [3]
Sleep disorder, initiating and maintaining sleep N.A. Investigative [3]
Cyclobenzaprine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
5-HT 2 receptor (5HT2R) TTYSN63 NOUNIPROTAC Antagonist [6]
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Cyclobenzaprine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [7]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [7]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [7]
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Indication(s) of Ibuprofen
Disease Entry ICD 11 Status REF
Dysmenorrhea GA34.3 Approved [4]
Fever MG26 Approved [4]
Headache 8A80-8A84 Approved [4]
Osteoarthritis FA00-FA05 Approved [4]
Pain MG30-MG3Z Approved [5]
Patent ductus arteriosus N.A. Approved [4]
Ibuprofen Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [13]
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Inhibitor [14]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [13]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [15]
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Ibuprofen Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [16]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [17]
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Ibuprofen Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [18]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [19]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [20]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [20]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [21]
Alpha-methylacyl-CoA racemase (AMACR) DEGKWJB AMACR_HUMAN Metabolism [22]
Acyl-CoA thioesterase 2 (ACOT2) DEMEPVJ ACOT2_HUMAN Metabolism [23]
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⏷ Show the Full List of 9 DME(s)
Ibuprofen Interacts with 185 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases ADR [24]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [25]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [25]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [25]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [25]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [25]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [26]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Activity [27]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [28]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Affects Expression [29]
Ephrin type-B receptor 6 (EPHB6) OTKNN6GC EPHB6_HUMAN Affects Expression [29]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) OTQ0BYK6 LX12B_HUMAN Affects Expression [29]
Annexin A9 (ANXA9) OTKNYMU2 ANXA9_HUMAN Decreases Expression [29]
Metastasis-associated protein MTA2 (MTA2) OTCCYIQJ MTA2_HUMAN Increases Expression [29]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Affects Expression [29]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Affects Expression [29]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [29]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Affects Expression [29]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [29]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [29]
Peptide YY (PYY) OTXX6AF5 PYY_HUMAN Decreases Expression [29]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Expression [29]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Affects Expression [29]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Affects Expression [29]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [29]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) OTPWI88U CEAM1_HUMAN Affects Expression [29]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [29]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Affects Expression [29]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Decreases Expression [29]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Affects Expression [29]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [29]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Affects Expression [29]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Increases Expression [29]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Affects Expression [29]
Protein PML (PML) OT6SM2GD PML_HUMAN Affects Expression [29]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Decreases Expression [29]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Affects Expression [29]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [29]
Fractalkine (CX3CL1) OTPLGI0E X3CL1_HUMAN Affects Expression [29]
Insulinoma-associated protein 1 (INSM1) OTG8RV8E INSM1_HUMAN Decreases Expression [29]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [29]
Desmocollin-1 (DSC1) OTNII6GZ DSC1_HUMAN Affects Expression [29]
Corneodesmosin (CDSN) OTQW4HV6 CDSN_HUMAN Affects Expression [29]
Microtubule-associated protein RP/EB family member 2 (MAPRE2) OTAE3MX4 MARE2_HUMAN Affects Expression [29]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) OTEH9HGE CA2D3_HUMAN Affects Expression [29]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [29]
Hydroperoxide isomerase ALOXE3 (ALOXE3) OT76J52A LOXE3_HUMAN Affects Expression [29]
T-lymphocyte surface antigen Ly-9 (LY9) OT1PKGDI LY9_HUMAN Decreases Expression [29]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [29]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8) OT2KFY1S ATS8_HUMAN Increases Expression [29]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [30]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [31]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [31]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [31]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Decreases Expression [11]
Excitatory amino acid transporter 5 (SLC1A7) OTVN5C6W EAA5_HUMAN Increases Expression [11]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Increases Expression [11]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [11]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [11]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [11]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Decreases Expression [11]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [11]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [11]
Ribosomal L1 domain-containing protein 1 (RSL1D1) OT3CL4R3 RL1D1_HUMAN Increases Expression [11]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [11]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [11]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [11]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [11]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Decreases Expression [11]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Increases Expression [11]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [11]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Decreases Expression [11]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [11]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Increases Expression [11]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [11]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [11]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Expression [11]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [11]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [11]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Affects Activity [11]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [11]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Decreases Expression [11]
Iduronate 2-sulfatase (IDS) OTZO94EO IDS_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [11]
DnaJ homolog subfamily B member 2 (DNAJB2) OTZHPV5M DNJB2_HUMAN Increases Expression [11]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Decreases Expression [11]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Increases Expression [11]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [11]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [11]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [11]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Affects Activity [11]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [11]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [11]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Increases Expression [11]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Increases Expression [11]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Increases Expression [11]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Decreases Expression [11]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Expression [11]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [11]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [11]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [11]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [11]
Adenylate cyclase type 1 (ADCY1) OTSLLFZO ADCY1_HUMAN Decreases Expression [11]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [11]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [11]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [11]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [11]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [11]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [11]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [11]
RRP12-like protein (RRP12) OTQQAEH4 RRP12_HUMAN Increases Expression [11]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [11]
Dipeptidyl peptidase 9 (DPP9) OTBMZW2O DPP9_HUMAN Increases Expression [11]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Decreases Expression [11]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Increases Expression [11]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [11]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [11]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [11]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [11]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Decreases Expression [11]
Carboxymethylenebutenolidase homolog (CMBL) OT8H3S3G CMBL_HUMAN Decreases Expression [11]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [11]
Protein FAM210B, mitochondrial (FAM210B) OT2QHEQ6 F210B_HUMAN Decreases Expression [11]
Spermatid perinuclear RNA-binding protein (STRBP) OTU7XLZL STRBP_HUMAN Increases Expression [11]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [11]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Increases Expression [11]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [11]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [11]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [11]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [11]
Dual specificity protein phosphatase 22 (DUSP22) OTEZ3U85 DUS22_HUMAN Increases Expression [11]
Phospholipase A and acyltransferase 2 (PLAAT2) OTI5RMWB PLAT2_HUMAN Increases Expression [11]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Increases Expression [11]
Mitochondrial fission process protein 1 (MTFP1) OT3L6F7U MTFP1_HUMAN Increases Expression [11]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [11]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) OTM3CQZT BIG2_HUMAN Increases Expression [11]
Protein piccolo (PCLO) OTXJZZ98 PCLO_HUMAN Increases Expression [11]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Affects Activity [32]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Activity [33]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Decreases Expression [34]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [35]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [36]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [37]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [38]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Phosphorylation [39]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Expression [40]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Affects Expression [40]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [41]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [42]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [36]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Affects Expression [40]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [43]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Localization [44]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [45]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [46]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Secretion [47]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Increases Expression [40]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Affects Expression [40]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Increases Expression [40]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Affects Binding [48]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [49]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [49]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Expression [40]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Decreases Expression [50]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [40]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Affects Expression [40]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Affects Expression [40]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [51]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [52]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Decreases Activity [53]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Expression [40]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Affects Cleavage [54]
ELAV-like protein 1 (ELAVL1) OTY55PLY ELAV1_HUMAN Increases Expression [39]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [12]
Sodium-coupled monocarboxylate transporter 1 (SLC5A8) OTA0WELF SC5A8_HUMAN Decreases Activity [55]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Increases Expression [52]
ATP-dependent RNA helicase DDX1 (DDX1) OT3U8FD0 DDX1_HUMAN Affects Expression [40]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [12]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [52]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Response To Substance [56]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Increases ADR [24]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Affects Response To Substance [57]
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⏷ Show the Full List of 185 DOT(s)

References

1 ClinicalTrials.gov (NCT02974166) Analysis of the Effects of the Osteopathic Manipulative Treatment in Carriers of Temporomandibular Disorders
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7152).
3 Cyclobenzaprine FDA Label
4 Ibuprofen FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2713).
6 Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92.
7 Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
8 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
9 Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther. 1993 Jan;264(1):475-9.
10 Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem. 2004 Jul 2;279(27):28320-9. doi: 10.1074/jbc.M401396200. Epub 2004 Apr 26.
11 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
12 Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003 Aug 1;9(8):3150-7.
13 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
14 Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
15 Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
16 Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB.
17 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
18 PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb;25(2):96-106.
19 Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87.
20 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
21 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
22 Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 2009 Dec;17(6):275-342.
23 A study on the chiral inversion of mandelic acid in humans. Org Biomol Chem. 2014 Sep 14;12(34):6737-44.
24 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
25 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
26 Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J Steroid Biochem Mol Biol. 2005 May;95(1-5):129-36.
27 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305.
28 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
29 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
30 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
31 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
32 Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chem Biol Interact. 2015 Jun 5;234:105-13.
33 Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
34 Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene. 2001 Nov 29;20(55):7965-75. doi: 10.1038/sj.onc.1204985.
35 Effects of ibuprofen and hypoxia on neutrophil apoptosis in neonates. Biol Neonate. 2004;86(4):235-9. doi: 10.1159/000079831. Epub 2004 Jul 15.
36 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
37 Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain. 2005 Jun;128(Pt 6):1442-53. doi: 10.1093/brain/awh452. Epub 2005 Apr 7.
38 Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis. Respir Med. 2008 Feb;102(2):287-98. doi: 10.1016/j.rmed.2007.08.013. Epub 2007 Oct 10.
39 The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
40 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
41 Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life Sci. 2008 Mar 12;82(11-12):591-9. doi: 10.1016/j.lfs.2007.11.030. Epub 2007 Dec 23.
42 A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol. 2008 Feb;61(2):203-14. doi: 10.1007/s00280-007-0462-3. Epub 2007 Apr 20.
43 Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells. Hum Mol Genet. 2005 Dec 1;14(23):3673-84. doi: 10.1093/hmg/ddi395. Epub 2005 Oct 20.
44 Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun. 2004 Jan 23;313(4):863-70. doi: 10.1016/j.bbrc.2003.12.018.
45 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
46 Regulation of CD36 expression in human melanoma cells. Adv Exp Med Biol. 2002;507:337-42. doi: 10.1007/978-1-4615-0193-0_52.
47 Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. Biol Neonate. 2002 Aug;82(2):73-7. doi: 10.1159/000063090.
48 Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13.
49 Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic Biol Med. 2002 Apr 1;32(7):650-62. doi: 10.1016/s0891-5849(02)00755-4.
50 Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci. 2003 Oct 29;23(30):9796-804. doi: 10.1523/JNEUROSCI.23-30-09796.2003.
51 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
52 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
53 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
54 Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31.
55 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol. 2004 Jun 15;557(Pt 3):719-31. doi: 10.1113/jphysiol.2004.063859. Epub 2004 Apr 16.
56 Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. Clin Pharmacol Ther. 2006 May;79(5):407-18.
57 Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha. Am J Epidemiol. 2006 Nov 15;164(10):984-9. doi: 10.1093/aje/kwj294. Epub 2006 Aug 24.