General Information of This Drug (ID: DM9HPW3)

Drug Name
Exemestane   DM9HPW3
Synonyms
Aromasil; Aromasin; Aromasine; EXE; Exemestance; Exemestano; Exemestanum; Nikidess; Pfizer brand of exemestane; Curator_000009; Fce 24304; Aromasin (TN); Aromasin, Exemestane; Exemestano [INN-Spanish]; Exemestanum [INN-Latin]; FCE-24304; PNU-155971; Exemestane [USAN:INN:BAN]; Exemestane (JAN/USP/INN); (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione; 6-Methylenandrosta-1,4-diene-3,17-dione; 6-Methyleneandrosta-1,4-diene-3,17-dione; 6-methylideneandrosta-1,4-diene-3,17-dione
Indication
Disease Entry ICD 11 Status REF
Hormonally-responsive breast cancer 2C60-2C65 Approved [1]
Male breast carcinoma N.A. Investigative [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Exemestane + Panobinostat DCJNUV9 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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30 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Celecoxib + Exemestane DC1HUX2 Celecoxib Breast Cancer [4]
Celecoxib + Exemestane DC2KT08 Celecoxib Metastatic Breast Cancer [5]
Everolimus + Exemestane DC4MTXP Everolimus Breast Cancer [6]
Everolimus + Exemestane DCL5AZI Everolimus Metastatic Breast Cancer [7]
Everolimus + Exemestane DCHZ936 Everolimus Neoplasms [8]
Everolimus + Exemestane DCKTQTO Everolimus Breast Cancer [9]
Exemestane + Letrozole DC565RC Letrozole Male Breast Cancer [10]
Exemestane + Letrozole DCL9I4L Letrozole Breast Cancer [11]
Exemestane + Bosutinib DC1KDX3 Bosutinib Advanced Breast Cancer [12]
Exemestane + Enzalutamide DC6X13Z Enzalutamide Breast Cancer [13]
Exemestane + Aspirin DCN5C10 Aspirin Breast Neoplasms [14]
Exemestane + BIIB-021 DCPE3U2 BIIB-021 Breast Cancer [15]
Exemestane + Ridaforolimus DCRJMFI Ridaforolimus Breast Neoplasms [16]
Exemestane + SNDX-275 DCW9KXF SNDX-275 Breast Cancer [17]
Exemestane + Goserelin DCWJATP Goserelin Breast Cancer [18]
Exemestane + Carboplatin DCF7E5Y Carboplatin Stage IV Non-small Cell Lung Cancer [19]
Exemestane + LEE011 DC33SHL LEE011 Breast Cancer [20]
Exemestane + Alpelisib DCDZQPO Alpelisib Neoplasms [8]
Exemestane + Alpelisib DCKL9HQ Alpelisib Metastatic or Locally-advanced Unresectable Breast Cancer [21]
Fulvestrant + Exemestane DC5HU7A Fulvestrant Breast Cancer [22]
Lapatinib + Exemestane DCZA7XF Lapatinib Breast Cancer [23]
LY2835219 + Exemestane DCUZLDF LY2835219 Breast Neoplasms [24]
Ruxolitinib + Exemestane DC267XW Ruxolitinib Estrogen-receptor Positive Invasive Metastatic Breast Cancer [25]
Cyclophosphamide + Exemestane DCZABKE Cyclophosphamide Metastatic Beast Cancer [26]
Exemestane + Letrozole DCUQK86 Letrozole Estrogen Receptor Negative [27]
Exemestane + Letrozole DCZHHUA Letrozole Breast Cancer [28]
Exemestane + Sapanisertib DC097MH Sapanisertib Breast Cancer [29]
Exemestane + Letrozole DCSL7NG Letrozole Breast Cancer [30]
Exemestane + Letrozole DC93Z3D Letrozole Breast Cancer [31]
Fulvestrant + Exemestane DCRTS97 Fulvestrant Breast Cancer [32]
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⏷ Show the Full List of 30 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7073).
2 Exemestane FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT00201773) Exemestane With Celecoxib as Neoadjuvant Treatment in Postmenopausal Women With Stage II, III, and IV Breast Cancer
5 ClinicalTrials.gov (NCT00525096) Exemestane + Celecoxib vs Exemestane + Placebo in Metastatic Breast Cancer
6 ClinicalTrials.gov (NCT00863655) Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole
7 ClinicalTrials.gov (NCT01626222) 4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer
8 ClinicalTrials.gov (NCT02077933) Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors
9 ClinicalTrials.gov (NCT02732119) Study of Ribociclib With Everolimus + Exemestane in HR+ HER2- Locally Advanced/Metastatic Breast Cancer Post Progression on CDK 4/6 Inhibitor.
10 ClinicalTrials.gov (NCT01153672) Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor Therapy
11 ClinicalTrials.gov (NCT00719966) Effect of Aromatase Inhibitor Therapy on Blood Vessel Function in Postmenopausal Women With Breast Cancer
12 ClinicalTrials.gov (NCT00793546) Study Evaluating Bosutinib-Exemestane Combination Vs Exemestane Alone in Post Menopausal Women With Breast Cancer
13 ClinicalTrials.gov (NCT01597193) Safety Study of Enzalutamide (MDV3100) in Patients With Incurable Breast Cancer
14 ClinicalTrials.gov (NCT01431053) Study of Aspirin and Exemestane as Adjuvant Treatment in Breast Cancer
15 ClinicalTrials.gov (NCT01004081) Hormone Receptor Positive Metastatic Breast Cancer (HR+ mBC) BIIB021 Plus Aromasin Schedule Finding
16 ClinicalTrials.gov (NCT01605396) A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064). U.S. National Institutes of Health.
17 ClinicalTrials.gov (NCT00676663) Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer
18 ClinicalTrials.gov (NCT00432172) Selective Neoadjuvant Treatment According to Immunohistochemical Subtype for HER2 Negative Breast Cancer Patients
19 ClinicalTrials.gov (NCT01664754) Exemestane, Pemetrexed Disodium, and Carboplatin in Treating Post-Menopausal Women With Stage IV Non-Small Cell Lung Cancer
20 ClinicalTrials.gov (NCT01857193) Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer
21 ClinicalTrials.gov (NCT01870505) BYL719 Plus Letrozole or Exemestane for Patients With Hormone-Receptor Positive Locally-Advanced Unresectable or Metastatic Breast Cancer
22 ClinicalTrials.gov (NCT00201864) Exemestane in Combination With Fulvestrant in Postmenopausal Women With Hormone Sensitive Advanced Breast Cancer
23 ClinicalTrials.gov (NCT01005641) ELBA: Exemestane and Lapatinib in Advanced Breast Cancer
24 ClinicalTrials.gov (NCT02057133) A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
25 ClinicalTrials.gov (NCT01594216) Ruxolitinib in Estrogen Receptor Positive Breast Cancer
26 ClinicalTrials.gov (NCT01963481) Exemestane and Cyclophosphamide for Metastatic Breast Cancer
27 ClinicalTrials.gov (NCT02648477) Pembrolizumab and Doxorubicin Hydrochloride or Anti-Estrogen Therapy in Treating Patients With Triple-Negative or Hormone Receptor-Positive Metastatic Breast Cancer
28 ClinicalTrials.gov (NCT00573755) Sorafenib and Letrozole, Anastrozole, or Exemestane in Treating Postmenopausal Women With Estrogen Receptor-Positive and/or Progesterone Receptor-Positive Metastatic Breast Cancer
29 ClinicalTrials.gov (NCT02049957) Safety and Efficacy Study of Sapanisertib in Combination With Exemestane or Fulvestrant in Postmenopausal Women With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Metastatic Breast Cancer. U.S. National Institutes of Health.
30 ClinicalTrials.gov (NCT02995772) Neoadjuvant Hormonal Therapy Compared to Neoadjuvant Chemotherapy in Stage IIIB/C and IV Breast Cancer Patients
31 ClinicalTrials.gov (NCT00893061) Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast Cancer
32 ClinicalTrials.gov (NCT06016738) OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer