Details of the Drug Combinations

General Information of This Drug (ID: DMA7PEW)

Drug Name

Verapamil DMA7PEW

Synonyms

Arpamyl; Calan; Calcan; Cordilox; Dexverapamil; Dilacoran; Drosteakard; Iproveratril; Isoptimo; Isoptin; Isotopin; Vasolan; Veracim; Verapamilo; Verapamilum; Veraptin; Verexamil; Bosoptin (TN); Calan (TN); D-365; Isoptin (TN); Verapamilo [INN-Spanish]; Verapamilum [INN-Latin]; Verelan (TN); CP-16533-1; Covera-HS (TN); Verapamil (USAN/INN); Verapamil [USAN:BAN:INN]; Verapamil [USAN:INN:BAN]; Alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile; (+-)-Verapamil; (+/-)-VERAPAMIL; (1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile; 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile; 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; Verapamil (Na-Ca chanel blocker)

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Approved	[1]
Atrial fibrillation	BC81.3	Approved	[1]
Classic phenylketonuria	N.A.	Approved	[1]
Hypertension	BA00-BA04	Approved	[2]
Malignant essential hypertension	BA00	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[3]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

20 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dihydroergotamine + Verapamil	DC3LFRE	Dihydroergotamine	DD2 (Cell Line: DD2)	[4]
JTC-801 + Verapamil	DCX89UH	JTC-801	DD2 (Cell Line: DD2)	[4]
NITD609 + Verapamil	DC8T65B	NITD609	DD2 (Cell Line: DD2)	[4]
NITD609 + Verapamil	DCVVKDA	NITD609	Hepatoblastoma (Cell Line: HB3)	[5]
Omacetaxine mepesuccinate + Verapamil	DCUTDR3	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[5]
Proguanil + Verapamil	DCFVO5D	Proguanil	DD2 (Cell Line: DD2)	[4]
SB 228357 + Verapamil	DCRIXDN	SB 228357	DD2 (Cell Line: DD2)	[4]
Sorafenib + Verapamil	DCQJL04	Sorafenib	DD2 (Cell Line: DD2)	[4]
Verapamil + OZ277	DC134AR	OZ277	DD2 (Cell Line: DD2)	[5]
Verapamil + Lumefantrine	DC8O7LO	Lumefantrine	DD2 (Cell Line: DD2)	[5]
Verapamil + Diltiazem	DCJI66A	Diltiazem	DD2 (Cell Line: DD2)	[5]
Verapamil + SB 228357	DCA3C5U	SB 228357	DD2 (Cell Line: DD2)	[5]
Verapamil + SB 228357	DC53SQ6	SB 228357	Hepatoblastoma (Cell Line: HB3)	[5]
Verapamil + Epothilone B	DCC92QV	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[5]
Verapamil + Artemisinin	DCUQIHX	Artemisinin	DD2 (Cell Line: DD2)	[5]
Verapamil + MK-4815	DCERZAA	MK-4815	DD2 (Cell Line: DD2)	[5]
Verapamil + Mefloquine	DCVIJ4O	Mefloquine	DD2 (Cell Line: DD2)	[5]
Verapamil + Nitisinone	DC2PNGZ	Nitisinone	DD2 (Cell Line: DD2)	[5]
Verapamil + Vorinostat	DCCE0KZ	Vorinostat	DD2 (Cell Line: DD2)	[5]
Verapamil + Atovaquone	DCK9CIM	Atovaquone	DD2 (Cell Line: DD2)	[5]
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4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Fostamatinib + Verapamil	DCVQ9JN	Fostamatinib	Drug Drug Interactions	[6]
Verapamil + Hydroxyurea	DCK37TP	Hydroxyurea	Cancer	[7]
Verapamil + Canagliflozin	DCTQSQP	Canagliflozin	Type 2 Diabetes Mellitus	[8]
Verapamil + Quinidine	DCW8L6S	Quinidine	Short-coupled Idiopathic Ventricular Fibrillation	[9]
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References

1	Verapamil FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2406).
3	ClinicalTrials.gov (NCT04351763) Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms. U.S. National Institutes of Health.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6	ClinicalTrials.gov (NCT01197781) Evaluation of the Drug-drug Interaction Between FosD and Verapamil When Taken Together in Healthy Volunteers
7	ClinicalTrials.gov (NCT00706810) Combination of Hydroxyurea and Verapamil for Refractory Meningiomas
8	ClinicalTrials.gov (NCT03296800) Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects
9	ClinicalTrials.gov (NCT05593757) Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation