Details of the Drug Combinations

General Information of This Drug (ID: DMA8FS5)

• Drug Name: Dronedarone (DMA8FS5)
• Synonyms: Multaq; Dronedarone [INN]; SR 33589; SR 33589B; Dronedarone (INN); Sanofi-Aventis brand of dronedarone; N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide; N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide; N-[2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide; N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide

Indication

Angina pectoris; ICD 11: BA40; Status: Approved [1]; Atrial fibrillation; ICD 11: BC81.3; Status: Withdrawn from market [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Dronedarone	DCZPC9Y	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Acitretin + Dronedarone	DCZNXD6	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cerivastatin + Dronedarone	DCYFZFV	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dantrolene + Dronedarone	DCFX2FV	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diazoxide + Dronedarone	DCEOT0X	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Docetaxel + Dronedarone	DCQSFAL	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxapram + Dronedarone	DCP58LT	Doxapram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxorubicin + Dronedarone	DC5F51D	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Ribavirin-TP	DCLSEBE	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Sertraline	DCF9T2P	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Mebutamate	DCHC1UV	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Picoplatin	DCFDBBU	Picoplatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Gefitinib	DCQ54DJ	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Diethylcarbamazine	DCRMA3S	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Terazosin	DC8W3XT	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + PMID28460551-Compound-2	DC02LZR	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Trioxsalen	DC3G1R2	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Fomepizole	DCTBYTV	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Triapine	DCL55HR	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Pepstatin	DCS81Z2	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Metyrosine	DCZPZIB	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Emetine	DCXJ8VV	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Chlorzoxazone	DCYSGYF	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Metformin	DC3E7EZ	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Fluspirilene	DCXPJM3	Fluspirilene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Clopidogrel	DC84O6C	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + PFK-158	DCFKIWS	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Triflupromazine	DCXB723	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Tiagabine	DCU4NAU	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Fenoprofen	DCQIMV3	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Bortezomib	DCXT6AL	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Methylene blue	DC2CUCT	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Artemisinin	DC6YXZV	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Trimethobenzamide	DCU7BCP	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Leflunomide	DCAGXNR	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Brincidofovir	DCZ14D3	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Hyodeoxycholic acid	DCKI5LI	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Loperamide	DCJUUCK	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Pomalidomide	DCB5XIH	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Mycophenolic acid	DCTTQQL	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Hydralazine	DCIUEUI	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Cerivastatin	DCHUDK0	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dronedarone + Cytarabine	DCW98IG	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Enalaprilat + Dronedarone	DCHKAI2	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Epinephrine + Dronedarone	DCLALVW	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Imatinib + Dronedarone	DC4GYC9	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Levamisole + Dronedarone	DC4REMZ	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Maprotiline + Dronedarone	DCPKERF	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Meclofenamic acid + Dronedarone	DCRE4SQ	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Nabilone + Dronedarone	DC352Z0	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Nizatidine + Dronedarone	DCVM2O5	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pramipexole + Dronedarone	DCB6JGH	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
SCH 727965 + Dronedarone	DCIQCPL	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Trihexyphenidyl + Dronedarone	DC9D5SW	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Vinblastine + Dronedarone	DC3XTYE	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ranolazine + Dronedarone	DCH3PCS	Ranolazine	Atrial Fibrillation	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7465).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT01522651) Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation