Details of the Drug Combinations

General Information of This Drug (ID: DMAI95U)

Drug Name
PMID25656651-Compound-5   DMAI95U
Indication
Disease Entry ICD 11 Status REF
Chronic myeloid leukaemia 2A20 Patented [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

34 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Belinostat + PMID25656651-Compound-5 DCZ7KXY Belinostat Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
BMS-754807 + PMID25656651-Compound-5 DCQ8MEU BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
BMS-754807 + PMID25656651-Compound-5 DC3BX78 BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
BMS-754807 + PMID25656651-Compound-5 DC50YSE BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
Ceritinib + PMID25656651-Compound-5 DCMUK17 Ceritinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
Everolimus + PMID25656651-Compound-5 DCBTVJN Everolimus Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
GDC-0084 + PMID25656651-Compound-5 DCFLGGM GDC-0084 Ewing sarcoma (Cell Line: TC-71) [3]
GSK2126458 + PMID25656651-Compound-5 DCIH7OL GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
GSK2126458 + PMID25656651-Compound-5 DCSWZ68 GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
GSK2126458 + PMID25656651-Compound-5 DCWBAGS GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
MK-2206 + PMID25656651-Compound-5 DCXCC6U MK-2206 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-906 + PMID25656651-Compound-5 DC4C2I5 OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
PMID25656651-Compound-5 + PF-3758309 DC710ZN PF-3758309 Ewing sarcoma (Cell Line: TC-71) [3]
PMID25656651-Compound-5 + Panobinostat DC2TELB Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
PMID25656651-Compound-5 + THAPSIGARGIN DC8VOMV THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
PMID25656651-Compound-5 + Mitomycin DCQMM2V Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
PMID25656651-Compound-5 + Trametinib DC3409A Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PMID25656651-Compound-5 + Trametinib DCS5BNF Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PMID25656651-Compound-5 + Trametinib DCVTL4W Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PMID25656651-Compound-5 + JQ1 DC8FSNM JQ1 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PMID25656651-Compound-5 + JQ1 DCZQUSS JQ1 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PMID25656651-Compound-5 + JQ1 DCBWZAT JQ1 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PMID25656651-Compound-5 + GDC-0084 DC4WVNG GDC-0084 Hodgkin lymphoma (Cell Line: L-1236) [2]
PMID25656651-Compound-5 + PMID25656651-Compound-5 DCMVINI PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PMID25656651-Compound-5 + PMID25656651-Compound-5 DCUZZEQ PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PMID25656651-Compound-5 + PMID25656651-Compound-5 DC5Y3GW PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PMID25656651-Compound-5 + Azathioprine DC3GT63 Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [2]
PMID25656651-Compound-5 + Azathioprine DCSISMF Azathioprine Hodgkin lymphoma (Cell Line: HDLM-2) [2]
PMID25656651-Compound-5 + Azathioprine DCE5S7Q Azathioprine Hodgkin lymphoma (Cell Line: L-428) [2]
PMID25656651-Compound-5 + MK-2206 DCUYW1J MK-2206 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PMID25656651-Compound-5 + CP-673451 DCE5NQG CP-673451 Hodgkin lymphoma (Cell Line: L-1236) [2]
SCH772984 + PMID25656651-Compound-5 DCAFRKO SCH772984 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + PMID25656651-Compound-5 DCQP06W SCH772984 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + PMID25656651-Compound-5 DCMF3GZ SCH772984 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
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References

1 Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.