Details of the Drug Combination

General Information of Drug Combination (ID: DCSISMF)

Drug Combination Name

PMID25656651-Compound-5 Azathioprine

Indication

Disease Entry	Status	REF
Hodgkin lymphoma	Investigative	[1]

Component Drugs

PMID25656651-Compound-5 DMAI95U

Azathioprine DMMZSXQ

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: HDLM-2

Zero Interaction Potency (ZIP) Score: 7.545

Bliss Independence Score: 6.869

Loewe Additivity Score: 2.856

LHighest Single Agent (HSA) Score: 7.286

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of PMID25656651-Compound-5

Disease Entry	ICD 11	Status	REF
Chronic myeloid leukaemia	2A20	Patented	[2]

PMID25656651-Compound-5 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[2]
------------------------------------------------------------------------------------

PMID25656651-Compound-5 Interacts with 68 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Activity	[6]
Macrophage colony-stimulating factor 1 receptor (CSF1R)	OTDYTB9C	CSF1R_HUMAN	Decreases Activity	[6]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Decreases Activity	[6]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Decreases Activity	[6]
Fibroblast growth factor receptor 1 (FGFR1)	OT4GLCXW	FGFR1_HUMAN	Decreases Activity	[6]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Activity	[6]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Activity	[6]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Activity	[6]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Decreases Activity	[6]
Fibroblast growth factor receptor 2 (FGFR2)	OTLOPACK	FGFR2_HUMAN	Decreases Activity	[6]
Fibroblast growth factor receptor 4 (FGFR4)	OTRQERG2	FGFR4_HUMAN	Decreases Activity	[6]
Fibroblast growth factor receptor 3 (FGFR3)	OTSAXDIL	FGFR3_HUMAN	Decreases Activity	[6]
Ephrin type-A receptor 2 (EPHA2)	OTI6QNX2	EPHA2_HUMAN	Decreases Activity	[6]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Decreases Activity	[6]
Vascular endothelial growth factor receptor 3 (FLT4)	OTRAA26B	VGFR3_HUMAN	Decreases Activity	[6]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Decreases Activity	[6]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Activity	[6]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Decreases Activity	[6]
Ephrin type-A receptor 7 (EPHA7)	OT3VC211	EPHA7_HUMAN	Decreases Activity	[6]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[7]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Decreases Activity	[5]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Activity	[5]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[7]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[8]
High affinity nerve growth factor receptor (NTRK1)	OTJORQAU	NTRK1_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase Lck (LCK)	OT883FG9	LCK_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase Fgr (FGR)	OTCUYU9F	FGR_HUMAN	Decreases Activity	[5]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[7]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Activity	[5]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Phosphorylation	[5]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[7]
Troponin I, cardiac muscle (TNNI3)	OT65E12V	TNNI3_HUMAN	Increases Secretion	[10]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Decreases Activity	[5]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Increases Secretion	[11]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[12]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[12]
Ephrin type-A receptor 8 (EPHA8)	OTHOESG6	EPHA8_HUMAN	Decreases Activity	[5]
Ephrin type-B receptor 2 (EPHB2)	OT8VZ6C5	EPHB2_HUMAN	Decreases Activity	[5]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[7]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Decreases Activity	[5]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Decreases Phosphorylation	[8]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[13]
Tyrosine-protein kinase ABL2 (ABL2)	OTS8F4GD	ABL2_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase FRK (FRK)	OTEKV1SC	FRK_HUMAN	Decreases Activity	[5]
Crk-like protein (CRKL)	OTOYSD1R	CRKL_HUMAN	Decreases Phosphorylation	[10]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Activity	[5]
Cytoplasmic tyrosine-protein kinase BMX (BMX)	OTJUE0ZD	BMX_HUMAN	Decreases Activity	[5]
Tyrosine-protein kinase JAK3 (JAK3)	OTQ8QW2L	JAK3_HUMAN	Decreases Activity	[5]
Ephrin type-B receptor 3 (EPHB3)	OT4XD8O3	EPHB3_HUMAN	Decreases Activity	[5]
Ephrin type-A receptor 5 (EPHA5)	OTAM0CVX	EPHA5_HUMAN	Decreases Activity	[5]
Ephrin type-B receptor 4 (EPHB4)	OTKLPVXJ	EPHB4_HUMAN	Decreases Activity	[5]
Ephrin type-B receptor 1 (EPHB1)	OTPG2DRZ	EPHB1_HUMAN	Decreases Activity	[5]
Ephrin type-A receptor 4 (EPHA4)	OT3AMK0C	EPHA4_HUMAN	Decreases Activity	[5]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Decreases Expression	[7]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[12]
Protein-tyrosine kinase 6 (PTK6)	OT7NWIQ0	PTK6_HUMAN	Decreases Activity	[5]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Decreases Activity	[5]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Decreases Activity	[5]
NT-3 growth factor receptor (NTRK3)	OTII30MY	NTRK3_HUMAN	Decreases Activity	[5]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Decreases Activity	[5]
Discoidin domain-containing receptor 2 (DDR2)	OT9IHOGZ	DDR2_HUMAN	Decreases Activity	[5]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)	OTPMGIU4	MLP3A_HUMAN	Increases Lipidation	[13]
------------------------------------------------------------------------------------


⏷ Show the Full List of 68 DOT(s)

Indication(s) of Azathioprine

Disease Entry	ICD 11	Status	REF
Lupus nephritis	4A40.0Y	Approved	[3]
Organ transplant rejection	NE84	Approved	[4]

Azathioprine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Amidophosphoribosyltransferase (PPAT)	TTZFTY4	PUR1_HUMAN	Inhibitor	[17]
------------------------------------------------------------------------------------

Azathioprine Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[18]
------------------------------------------------------------------------------------

Azathioprine Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[19]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Metabolism	[20]
Glutathione S-transferase alpha-2 (GSTA2)	DEH49YS	GSTA2_HUMAN	Metabolism	[21]
Glutathione S-transferase mu-1 (GSTM1)	DEYZEJA	GSTM1_HUMAN	Metabolism	[21]
------------------------------------------------------------------------------------

Azathioprine Interacts with 574 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Increases ADR	[22]
Glutathione S-transferase A2 (GSTA2)	OTW7UB1H	GSTA2_HUMAN	Affects Response To Substance	[23]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Affects Response To Substance	[24]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Affects Response To Substance	[25]
Inosine triphosphate pyrophosphatase (ITPA)	OTQ47WVR	ITPA_HUMAN	Affects Response To Substance	[26]
Dipeptidyl peptidase 4 (DPP4)	OT16MVL9	DPP4_HUMAN	Decreases Expression	[27]
Solute carrier family 15 member 1 (SLC15A1)	OT1P16B5	S15A1_HUMAN	Decreases Expression	[27]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Increases Expression	[28]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Increases Expression	[28]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[28]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Increases Expression	[28]
Glutathione synthetase (GSS)	OTVSBEIW	GSHB_HUMAN	Increases Expression	[28]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[14]
Phospholipid phosphatase 3 (PLPP3)	OTSSF7BK	PLPP3_HUMAN	Decreases Expression	[14]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Decreases Expression	[14]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Decreases Expression	[14]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Decreases Expression	[14]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Decreases Expression	[14]
Gasdermin-E (GSDME)	OT1ZWY32	GSDME_HUMAN	Decreases Expression	[14]
Toll-like receptor 2 (TLR2)	OTGO5P4R	TLR2_HUMAN	Decreases Expression	[14]
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3)	OTDA431Y	ENTP3_HUMAN	Increases Expression	[14]
Antiviral innate immune response receptor RIG-I (RIGI)	OTFIIC43	RIGI_HUMAN	Decreases Expression	[14]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Decreases Expression	[14]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases Expression	[14]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Expression	[14]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Decreases Expression	[14]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[14]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[14]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Expression	[14]
Steryl-sulfatase (STS)	OTXTJQPC	STS_HUMAN	Increases Expression	[14]
Neuromedin-B (NMB)	OT4NLN6H	NMB_HUMAN	Decreases Expression	[14]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Decreases Expression	[14]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[14]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Decreases Expression	[14]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Decreases Expression	[14]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[14]
Interleukin-1 receptor antagonist protein (IL1RN)	OT308CBE	IL1RA_HUMAN	Decreases Expression	[14]
Interferon-induced GTP-binding protein Mx1 (MX1)	OT6X8G5T	MX1_HUMAN	Decreases Expression	[14]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Increases Expression	[14]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[14]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Expression	[14]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Decreases Expression	[14]
Adenosine receptor A2a (ADORA2A)	OTVRBZ0I	AA2AR_HUMAN	Decreases Expression	[14]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[14]
Guanylate-binding protein 1 (GBP1)	OTUM7RPJ	GBP1_HUMAN	Decreases Expression	[14]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[14]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Increases Expression	[14]
Macrophage metalloelastase (MMP12)	OT9Z7LHM	MMP12_HUMAN	Decreases Expression	[14]
Interferon alpha-inducible protein 27, mitochondrial (IFI27)	OTI2XGIT	IFI27_HUMAN	Decreases Expression	[14]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Decreases Expression	[14]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Increases Expression	[14]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[14]
Spermine synthase (SMS)	OT8JYKNH	SPSY_HUMAN	Decreases Expression	[14]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Expression	[14]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Decreases Expression	[14]
Interferon-induced 35 kDa protein (IFI35)	OTV9RZ53	IN35_HUMAN	Decreases Expression	[14]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[14]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)	OTRZH80H	TNAP2_HUMAN	Decreases Expression	[14]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Increases Expression	[14]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Decreases Expression	[14]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[14]
Probable ATP-dependent RNA helicase DDX10 (DDX10)	OTH48438	DDX10_HUMAN	Increases Expression	[14]
Neuronal membrane glycoprotein M6-b (GPM6B)	OT8Q1582	GPM6B_HUMAN	Increases Expression	[14]
Laminin subunit beta-3 (LAMB3)	OTFPU6W8	LAMB3_HUMAN	Decreases Expression	[14]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)	OTTUU92F	ENPP2_HUMAN	Increases Expression	[14]
Nidogen-2 (NID2)	OTHC33FF	NID2_HUMAN	Increases Expression	[14]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Decreases Expression	[14]
Lymphocyte antigen 6E (LY6E)	OTMG16BZ	LY6E_HUMAN	Decreases Expression	[14]
Interferon-induced protein 44-like (IFI44L)	OTXKORJP	IF44L_HUMAN	Decreases Expression	[14]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Increases Expression	[14]
Olfactomedin-like protein 2B (OLFML2B)	OTDNJFR4	OLM2B_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase RNF19B (RNF19B)	OTYCWKBP	RN19B_HUMAN	Decreases Expression	[14]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Decreases Expression	[14]
Probable E3 ubiquitin-protein ligase HERC6 (HERC6)	OT7G9PQE	HERC6_HUMAN	Decreases Expression	[14]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Decreases Expression	[14]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)	OTCA9WCM	RSAD2_HUMAN	Decreases Expression	[14]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Decreases Expression	[14]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Decreases Expression	[14]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Decreases Expression	[14]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Increases Expression	[14]
Interferon-induced helicase C domain-containing protein 1 (IFIH1)	OTZA2AHA	IFIH1_HUMAN	Decreases Expression	[14]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Increases Expression	[14]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Increases Expression	[14]
Interleukin-23 subunit alpha (IL23A)	OTYO99HC	IL23A_HUMAN	Decreases Expression	[14]
Matrix-remodeling-associated protein 5 (MXRA5)	OTXZBWCU	MXRA5_HUMAN	Increases Expression	[14]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)	OTK0PG7R	NUA4L_HUMAN	Decreases Expression	[14]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)	OT7FCZRM	PP4R2_HUMAN	Increases Expression	[14]
E3 ISG15--protein ligase HERC5 (HERC5)	OTZ5PR39	HERC5_HUMAN	Decreases Expression	[14]
Paired immunoglobulin-like type 2 receptor alpha (PILRA)	OTBE0PLF	PILRA_HUMAN	Decreases Expression	[14]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[14]
Hypoxia-inducible lipid droplet-associated protein (HILPDA)	OTEID3ZM	HLPDA_HUMAN	Decreases Expression	[14]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Decreases Expression	[14]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Decreases Expression	[15]
Odontogenic ameloblast-associated protein (ODAM)	OTT666SJ	ODAM_HUMAN	Decreases Expression	[15]
UPF0524 protein C3orf70 (C3ORF70)	OTDWU4AC	CC070_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Decreases Expression	[15]
Cell division cycle 7-related protein kinase (CDC7)	OT5133XY	CDC7_HUMAN	Decreases Expression	[15]
Citron Rho-interacting kinase (CIT)	OTOZDKPG	CTRO_HUMAN	Decreases Expression	[15]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)	OTB6YLFT	ENPP3_HUMAN	Decreases Expression	[15]
Inositol monophosphatase 2 (IMPA2)	OTNFB9YN	IMPA2_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Decreases Expression	[15]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[15]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[15]
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B)	OT8JQ1F7	PI51B_HUMAN	Decreases Expression	[15]
Matrilin-3 (MATN3)	OTH9H74J	MATN3_HUMAN	Decreases Expression	[15]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Increases Expression	[15]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[15]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Increases Expression	[15]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)	OTIK337D	TGFI1_HUMAN	Increases Expression	[15]
Protein Mis18-beta (OIP5)	OTI5C2DE	MS18B_HUMAN	Decreases Expression	[15]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Expression	[15]
Band 4.1-like protein 2 (EPB41L2)	OT6UABPM	E41L2_HUMAN	Decreases Expression	[15]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[15]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[15]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[15]
Periplakin (PPL)	OTTM4WDO	PEPL_HUMAN	Increases Expression	[15]
Integral membrane protein GPR137B (GPR137B)	OT1CINQQ	G137B_HUMAN	Increases Expression	[15]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[15]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[15]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[15]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[15]
Geminin (GMNN)	OTDYKNIY	GEMI_HUMAN	Decreases Expression	[15]
Transcription elongation factor A protein 3 (TCEA3)	OTLTRSK4	TCEA3_HUMAN	Decreases Expression	[15]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[15]
Isocitrate dehydrogenase cytoplasmic (IDH1)	OT4DLHC8	IDHC_HUMAN	Decreases Expression	[15]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)	OT15HOJX	AL1L1_HUMAN	Increases Expression	[15]
Rho-related BTB domain-containing protein 1 (RHOBTB1)	OTGE8K45	RHBT1_HUMAN	Decreases Expression	[15]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Decreases Expression	[15]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[15]
Centrosomal protein of 152 kDa (CEP152)	OTOKZR9B	CE152_HUMAN	Decreases Expression	[15]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Decreases Expression	[15]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Decreases Expression	[15]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)	OTQ9ALTR	GCNT3_HUMAN	Increases Expression	[15]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10)	OTL32QH7	GTR10_HUMAN	Decreases Expression	[15]
Caveolae-associated protein 2 (CAVIN2)	OTFHHDRU	CAVN2_HUMAN	Decreases Expression	[15]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Decreases Expression	[15]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[15]
Glutamate dehydrogenase 1, mitochondrial (GLUD1)	OTXKOCUH	DHE3_HUMAN	Decreases Expression	[15]
Phenylalanine-4-hydroxylase (PAH)	OT6GT2K8	PH4H_HUMAN	Decreases Expression	[15]
Haptoglobin-related protein (HPR)	OTXSC9UB	HPTR_HUMAN	Decreases Expression	[15]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[15]
Cystatin-A (CSTA)	OT1K68KE	CYTA_HUMAN	Increases Expression	[15]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[15]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[15]
Apolipoprotein C-III (APOC3)	OTW3520C	APOC3_HUMAN	Decreases Expression	[15]
Fibrinogen alpha chain (FGA)	OTMIHY80	FIBA_HUMAN	Decreases Expression	[15]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Decreases Expression	[15]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Decreases Expression	[15]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Increases Expression	[15]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[15]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[15]
Complement factor I (CFI)	OTQYYX0P	CFAI_HUMAN	Decreases Expression	[15]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[15]
Thyroxine-binding globulin (SERPINA7)	OTUYVTSU	THBG_HUMAN	Decreases Expression	[15]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[15]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Increases Expression	[15]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[15]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Decreases Expression	[15]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Increases Expression	[15]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Increases Expression	[15]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Increases Expression	[15]
Rho-related GTP-binding protein RhoC (RHOC)	OTOLE1FT	RHOC_HUMAN	Increases Expression	[15]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[15]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Increases Expression	[15]
Monocyte differentiation antigen CD14 (CD14)	OT83GJ47	CD14_HUMAN	Increases Expression	[15]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[15]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Increases Expression	[15]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[15]
Histone H2A.Z (H2AZ1)	OT3KJJNQ	H2AZ_HUMAN	Decreases Expression	[15]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Decreases Expression	[15]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Increases Expression	[15]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)	OTBL2W7R	GTR2_HUMAN	Decreases Expression	[15]
Mannose-binding protein C (MBL2)	OTS63HG5	MBL2_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[15]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[15]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[15]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Decreases Expression	[15]
Interleukin-7 (IL7)	OTT6YSKM	IL7_HUMAN	Decreases Expression	[15]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[15]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Increases Expression	[15]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Increases Expression	[15]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Decreases Expression	[15]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[15]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Expression	[15]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[15]
Hexokinase-1 (HK1)	OTMPHE8O	HXK1_HUMAN	Increases Expression	[15]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[15]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[15]
Neutrophil cytosol factor 2 (NCF2)	OTAUW7L2	NCF2_HUMAN	Increases Expression	[15]
Follistatin (FST)	OTRIVK9Y	FST_HUMAN	Increases Expression	[15]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[15]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[15]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Decreases Expression	[15]
Interleukin-11 (IL11)	OTXHN86R	IL11_HUMAN	Increases Expression	[15]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Decreases Expression	[15]
COUP transcription factor 2 (NR2F2)	OTJFS67N	COT2_HUMAN	Decreases Expression	[15]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[15]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Decreases Expression	[15]
Deoxycytidine kinase (DCK)	OTW8HLZC	DCK_HUMAN	Decreases Expression	[15]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Decreases Expression	[15]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[15]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Decreases Expression	[15]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[15]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[15]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[15]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Increases Expression	[15]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[15]
Protein S100-A11 (S100A11)	OTI57KDN	S10AB_HUMAN	Increases Expression	[15]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[15]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Decreases Expression	[15]
DNA replication licensing factor MCM5 (MCM5)	OTAHLB62	MCM5_HUMAN	Decreases Expression	[15]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Decreases Expression	[15]
Serine hydroxymethyltransferase, cytosolic (SHMT1)	OTIINA3J	GLYC_HUMAN	Decreases Expression	[15]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Increases Expression	[15]
Sodium channel protein type 1 subunit alpha (SCN1A)	OTJ9ZTYI	SCN1A_HUMAN	Decreases Expression	[15]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Decreases Expression	[15]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[15]
Glutaredoxin-1 (GLRX)	OT0QHTAR	GLRX1_HUMAN	Increases Expression	[15]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[15]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[15]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Decreases Expression	[15]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[15]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[15]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[15]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Increases Expression	[15]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[15]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Decreases Expression	[15]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[15]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[15]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Increases Expression	[15]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[15]
Nuclear autoantigenic sperm protein (NASP)	OTNE4THC	NASP_HUMAN	Decreases Expression	[15]
Flavin-containing monooxygenase 5 (FMO5)	OTTILF8T	FMO5_HUMAN	Decreases Expression	[15]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)	OTV57BZD	AL7A1_HUMAN	Decreases Expression	[15]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[15]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[15]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[15]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Decreases Expression	[15]
Type I iodothyronine deiodinase (DIO1)	OTFYLYJ0	IOD1_HUMAN	Decreases Expression	[15]
Kinetochore-associated protein 1 (KNTC1)	OTI2OOFN	KNTC1_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase RNF144A (RNF144A)	OTCG27CT	R144A_HUMAN	Decreases Expression	[15]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[15]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[15]
Aldo-keto reductase family 1 member D1 (AKR1D1)	OTBDJ6RL	AK1D1_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[15]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[15]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF11 (KIF11)	OTHRGLCQ	KIF11_HUMAN	Decreases Expression	[15]
2-iminobutanoate/2-iminopropanoate deaminase (RIDA)	OTW4098I	RIDA_HUMAN	Decreases Expression	[15]
Hexokinase-2 (HK2)	OTC0GCQO	HXK2_HUMAN	Decreases Expression	[15]
Thimet oligopeptidase (THOP1)	OT9E148D	THOP1_HUMAN	Increases Expression	[15]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Increases Expression	[15]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[15]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)	OT6W40XU	P5CS_HUMAN	Decreases Expression	[15]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Decreases Expression	[15]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Decreases Expression	[15]
Breast cancer anti-estrogen resistance protein 1 (BCAR1)	OTKT2C2N	BCAR1_HUMAN	Increases Expression	[15]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[15]
Anthrax toxin receptor 2 (ANTXR2)	OTOGFGOJ	ANTR2_HUMAN	Increases Expression	[15]
Protein FAM3B (FAM3B)	OTC2S91N	FAM3B_HUMAN	Decreases Expression	[15]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Increases Expression	[15]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Decreases Expression	[15]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Increases Expression	[15]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE)	OTXF5ICU	GBRE_HUMAN	Increases Expression	[15]
Iroquois-class homeodomain protein IRX-3 (IRX3)	OTLJ48FG	IRX3_HUMAN	Decreases Expression	[15]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[15]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Decreases Expression	[15]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Decreases Expression	[15]
Cyclic AMP-responsive element-binding protein 5 (CREB5)	OTJDUJPI	CREB5_HUMAN	Increases Expression	[15]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Decreases Expression	[15]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Decreases Expression	[15]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[15]
Max dimerization protein 1 (MXD1)	OTS5CTHX	MAD1_HUMAN	Increases Expression	[15]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[15]
Peroxisomal bifunctional enzyme (EHHADH)	OTBAAHL5	ECHP_HUMAN	Decreases Expression	[15]
Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11)	OTFXRU35	S38AB_HUMAN	Decreases Expression	[15]
TBC1 domain family member 8B (TBC1D8B)	OTSYGOXH	TBC8B_HUMAN	Decreases Expression	[15]
Coiled-coil domain-containing protein 15 (CCDC15)	OT1NZX84	CCD15_HUMAN	Decreases Expression	[15]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[15]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Expression	[15]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[15]
Syntaxin-3 (STX3)	OT4CIWLJ	STX3_HUMAN	Increases Expression	[15]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Decreases Expression	[15]
Growth factor receptor-bound protein 10 (GRB10)	OTCKXGRC	GRB10_HUMAN	Increases Expression	[15]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[15]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Increases Expression	[15]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Decreases Expression	[15]
Four and a half LIM domains protein 3 (FHL3)	OTMPRLZ5	FHL3_HUMAN	Increases Expression	[15]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[15]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Decreases Expression	[15]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[15]
Glucokinase regulatory protein (GCKR)	OTSIWXGG	GCKR_HUMAN	Increases Expression	[15]
Growth factor receptor-bound protein 14 (GRB14)	OTFET2YM	GRB14_HUMAN	Decreases Expression	[15]
Histone RNA hairpin-binding protein (SLBP)	OTVYYQRT	SLBP_HUMAN	Decreases Expression	[15]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Decreases Expression	[15]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[15]
Separin (ESPL1)	OTMGEVOK	ESPL1_HUMAN	Decreases Expression	[15]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Decreases Expression	[15]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Decreases Expression	[15]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Increases Expression	[15]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[15]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[15]
DNA polymerase delta subunit 3 (POLD3)	OTEQEFQ2	DPOD3_HUMAN	Decreases Expression	[15]
Transcription elongation factor A protein-like 1 (TCEAL1)	OTAPG2L5	TCAL1_HUMAN	Decreases Expression	[15]
Transcription factor E2F5 (E2F5)	OT1XWING	E2F5_HUMAN	Decreases Expression	[15]
Disks large-associated protein 5 (DLGAP5)	OTWCN39U	DLGP5_HUMAN	Decreases Expression	[15]
SH2 domain-containing adapter protein B (SHB)	OTF2HSC0	SHB_HUMAN	Increases Expression	[15]
SCL-interrupting locus protein (STIL)	OT9799VN	STIL_HUMAN	Decreases Expression	[15]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Decreases Expression	[15]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Decreases Expression	[15]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Decreases Expression	[15]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Decreases Expression	[15]
C-C motif chemokine 15 (CCL15)	OTOGZ85M	CCL15_HUMAN	Increases Expression	[15]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[15]
Dual specificity protein phosphatase 5 (DUSP5)	OTH96RA7	DUS5_HUMAN	Increases Expression	[15]
Kynureninase (KYNU)	OTINL2RE	KYNU_HUMAN	Increases Expression	[15]
Histone H2B type 2-E (H2BC21)	OT0FDCUC	H2B2E_HUMAN	Increases Expression	[15]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Decreases Expression	[15]
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)	OTW1SCZW	CPEB4_HUMAN	Increases Expression	[15]
Sodium/glucose cotransporter 4 (SLC5A9)	OTWQBZ5Q	SC5A9_HUMAN	Decreases Expression	[15]
Autophagy-related protein 2 homolog A (ATG2A)	OTGYDDSV	ATG2A_HUMAN	Increases Expression	[15]
Protein FAM161A (FAM161A)	OTF5ZRYJ	F161A_HUMAN	Decreases Expression	[15]
Renal cancer differentiation gene 1 protein (C4ORF46)	OTXL7SLI	CD046_HUMAN	Decreases Expression	[15]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[15]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[15]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[15]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[15]
Spindlin-4 (SPIN4)	OT09ZWHM	SPIN4_HUMAN	Decreases Expression	[15]
N-acetyltransferase ESCO2 (ESCO2)	OTJEMAQU	ESCO2_HUMAN	Decreases Expression	[15]
Transmembrane protein 170B (TMEM170B)	OT4AS8RJ	T170B_HUMAN	Decreases Expression	[15]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4)	OT5WC0Q8	KANK4_HUMAN	Decreases Expression	[15]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Increases Expression	[15]
Coiled-coil domain-containing protein 18 (CCDC18)	OT0S9DA2	CCD18_HUMAN	Decreases Expression	[15]
DEP domain-containing protein 1A (DEPDC1)	OT0JWE1B	DEP1A_HUMAN	Decreases Expression	[15]
PX domain-containing protein 1 (PXDC1)	OTQUA3TG	PXDC1_HUMAN	Increases Expression	[15]
Mitochondrial amidoxime-reducing component 1 (MTARC1)	OTNBE033	MARC1_HUMAN	Decreases Expression	[15]
Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1)	OTRSC1CD	IKBP1_HUMAN	Decreases Expression	[15]
Immediate early response gene 5 protein (IER5)	OTJPTXMD	IER5_HUMAN	Increases Expression	[15]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Increases Expression	[15]
Protein sel-1 homolog 3 (SEL1L3)	OT10N6Z2	SE1L3_HUMAN	Increases Expression	[15]
Cell division cycle-associated protein 2 (CDCA2)	OTX8UF9J	CDCA2_HUMAN	Decreases Expression	[15]
Transcription factor Sp5 (SP5)	OT4HUP9B	SP5_HUMAN	Decreases Expression	[15]
Phostensin (PPP1R18)	OT0JVGOZ	PPR18_HUMAN	Increases Expression	[15]
Mis18-binding protein 1 (MIS18BP1)	OT41T0FB	M18BP_HUMAN	Decreases Expression	[15]
Mitochondrial fission regulator 2 (MTFR2)	OTLOR68D	MTFR2_HUMAN	Decreases Expression	[15]
Rho GTPase-activating protein 11A (ARHGAP11A)	OTVQCFVP	RHGBA_HUMAN	Decreases Expression	[15]
Proline/serine-rich coiled-coil protein 1 (PSRC1)	OT7MDJMN	PSRC1_HUMAN	Decreases Expression	[15]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[15]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Decreases Expression	[15]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[15]
HHIP-like protein 2 (HHIPL2)	OTB7P4GV	HIPL2_HUMAN	Increases Expression	[15]
Nephronectin (NPNT)	OTFZAO1G	NPNT_HUMAN	Decreases Expression	[15]
Calcium/manganese antiporter SLC30A10 (SLC30A10)	OTXM5JW4	ZNT10_HUMAN	Decreases Expression	[15]
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2)	OT4IN0MV	HSDL2_HUMAN	Decreases Expression	[15]
Lysosomal amino acid transporter 1 homolog (SLC66A1)	OTUM63MK	LAAT1_HUMAN	Increases Expression	[15]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1)	OTVILUUN	SO4C1_HUMAN	Decreases Expression	[15]
RNA-binding protein with multiple splicing 2 (RBPMS2)	OTY24L1F	RBPS2_HUMAN	Increases Expression	[15]
Rho GTPase-activating protein 27 (ARHGAP27)	OT8BSRPC	RHG27_HUMAN	Increases Expression	[15]
SH2 domain-containing protein 5 (SH2D5)	OTJDS1NN	SH2D5_HUMAN	Increases Expression	[15]
Vesicle transport protein GOT1A (GOLT1A)	OTY8H2OF	GOT1A_HUMAN	Increases Expression	[15]
Membrane progestin receptor epsilon (PAQR9)	OTLY2CZM	PAQR9_HUMAN	Decreases Expression	[15]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[15]
Histone H2A.V (H2AZ2)	OT0I5H2P	H2AV_HUMAN	Decreases Expression	[15]
Carbohydrate sulfotransferase 9 (CHST9)	OT1DEZRM	CHST9_HUMAN	Decreases Expression	[15]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[15]
Transmembrane channel-like protein 7 (TMC7)	OT9RUFN8	TMC7_HUMAN	Increases Expression	[15]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Increases Expression	[15]
Low-density lipoprotein receptor-related protein 10 (LRP10)	OT8490HT	LRP10_HUMAN	Increases Expression	[15]
HAUS augmin-like complex subunit 6 (HAUS6)	OT7ZVR57	HAUS6_HUMAN	Decreases Expression	[15]
Protein O-glucosyltransferase 3 (POGLUT3)	OTBTJI73	PLGT3_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase SH3RF1 (SH3RF1)	OT7MYGYO	SH3R1_HUMAN	Increases Expression	[15]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Expression	[15]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Decreases Expression	[15]
Suppressor APC domain-containing protein 2 (SAPCD2)	OTXS0EXM	SAPC2_HUMAN	Decreases Expression	[15]
Condensin-2 complex subunit G2 (NCAPG2)	OTZYENKO	CNDG2_HUMAN	Decreases Expression	[15]
GAS2-like protein 3 (GAS2L3)	OTWPVI29	GA2L3_HUMAN	Decreases Expression	[15]
Cilium assembly protein DZIP1 (DZIP1)	OTBVPO66	DZIP1_HUMAN	Decreases Expression	[15]
Rab11 family-interacting protein 4 (RAB11FIP4)	OTIGHER7	RFIP4_HUMAN	Decreases Expression	[15]
Inactive tyrosine-protein kinase PRAG1 (PRAG1)	OTV83SGI	PRAG1_HUMAN	Increases Expression	[15]
Transmembrane channel-like protein 8 (TMC8)	OTUAD95X	TMC8_HUMAN	Increases Expression	[15]
Leucine rich adaptor protein 1-like (LURAP1L)	OTSJ29M5	LUR1L_HUMAN	Increases Expression	[15]
Immunoglobulin superfamily DCC subclass member 3 (IGDCC3)	OTGR1KA4	IGDC3_HUMAN	Decreases Expression	[15]
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP)	OT9YEJXS	IPRI_HUMAN	Increases Expression	[15]
Volume-regulated anion channel subunit LRRC8A (LRRC8A)	OT23OE7H	LRC8A_HUMAN	Increases Expression	[15]
Protein FAM200C (FAM200C)	OTZOXUEK	F200C_HUMAN	Decreases Expression	[15]
Solute carrier family 22 member 15 (SLC22A15)	OT60WAAI	S22AF_HUMAN	Increases Expression	[15]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Decreases Expression	[15]
EP300-interacting inhibitor of differentiation 3 (EID3)	OTAND0C7	EID3_HUMAN	Increases Expression	[15]
N-acetylglutamate synthase, mitochondrial (NAGS)	OTITB7DO	NAGS_HUMAN	Increases Expression	[15]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[15]
Mucin-20 (MUC20)	OTYYE1GK	MUC20_HUMAN	Increases Expression	[15]
Choline transporter-like protein 3 (SLC44A3)	OTL0FT8L	CTL3_HUMAN	Decreases Expression	[15]
Testis-expressed protein 9 (TEX9)	OTMYCDCW	TEX9_HUMAN	Decreases Expression	[15]
Mixed lineage kinase domain-like protein (MLKL)	OTDSLC81	MLKL_HUMAN	Decreases Expression	[15]
Golgi membrane protein 1 (GOLM1)	OTOZSV6O	GOLM1_HUMAN	Increases Expression	[15]
Aquaporin-11 (AQP11)	OT1IQMHV	AQP11_HUMAN	Decreases Expression	[15]
Uncharacterized protein C1orf131 (C1ORF131)	OTTFSELE	CA131_HUMAN	Decreases Expression	[15]
Meiosis-specific nuclear structural protein 1 (MNS1)	OT67F3JQ	MNS1_HUMAN	Decreases Expression	[15]
SHC SH2 domain-binding protein 1 (SHCBP1)	OT3A21CM	SHCBP_HUMAN	Decreases Expression	[15]
Methylcytosine dioxygenase TET1 (TET1)	OTZDHT1D	TET1_HUMAN	Decreases Expression	[15]
V-type proton ATPase subunit e 2 (ATP6V0E2)	OTFU678I	VA0E2_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF18A (KIF18A)	OTSMBJ24	KI18A_HUMAN	Decreases Expression	[15]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Increases Expression	[15]
Arrestin domain-containing protein 2 (ARRDC2)	OTVEOXAG	ARRD2_HUMAN	Increases Expression	[15]
Nuclear protein MDM1 (MDM1)	OTI9JUWA	MDM1_HUMAN	Decreases Expression	[15]
Pantothenate kinase 1 (PANK1)	OT2CZVRT	PANK1_HUMAN	Decreases Expression	[15]
2-phosphoxylose phosphatase 1 (PXYLP1)	OTX8T7F6	PXYP1_HUMAN	Decreases Expression	[15]
Rhomboid-related protein 4 (RHBDD1)	OTL5J132	RHBL4_HUMAN	Increases Expression	[15]
Centrosomal protein of 192 kDa (CEP192)	OTBLFV7T	CE192_HUMAN	Decreases Expression	[15]
PDZ domain-containing protein GIPC2 (GIPC2)	OT68YFO1	GIPC2_HUMAN	Decreases Expression	[15]
Monocarboxylate transporter 10 (SLC16A10)	OTH70529	MOT10_HUMAN	Decreases Expression	[15]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5)	OTUM65JL	GDPD5_HUMAN	Decreases Expression	[15]
Sodium-dependent phosphate transporter 1 (SLC20A1)	OTC3D894	S20A1_HUMAN	Increases Expression	[15]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[15]
Kelch repeat and BTB domain-containing protein 7 (KBTBD7)	OT1NIRLK	KBTB7_HUMAN	Decreases Expression	[15]
Cytoskeleton-associated protein 2 (CKAP2)	OTCLTC0J	CKAP2_HUMAN	Decreases Expression	[15]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Increases Expression	[15]
Ras and Rab interactor 2 (RIN2)	OTCY73U9	RIN2_HUMAN	Increases Expression	[15]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)	OTBXYFRH	ARAP2_HUMAN	Increases Expression	[15]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Increases Expression	[15]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[15]
Gamma-glutamyl hydrolase (GGH)	OTL71J7T	GGH_HUMAN	Decreases Expression	[15]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[15]
GTP-binding protein Rit1 (RIT1)	OTVNOGOH	RIT1_HUMAN	Increases Expression	[15]
Liver-expressed antimicrobial peptide 2 (LEAP2)	OTUOPIS5	LEAP2_HUMAN	Decreases Expression	[15]
Protein MAL2 (MAL2)	OTVPEI80	MAL2_HUMAN	Decreases Expression	[15]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[15]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Decreases Expression	[15]
RAD51-associated protein 1 (RAD51AP1)	OTXM7UTD	R51A1_HUMAN	Decreases Expression	[15]
SPRY domain-containing SOCS box protein 1 (SPSB1)	OTGY26U4	SPSB1_HUMAN	Increases Expression	[15]
Spindle and kinetochore-associated protein 1 (SKA1)	OTDYJ12A	SKA1_HUMAN	Decreases Expression	[15]
Solute carrier family 22 member 18 (SLC22A18)	OT9C3KR4	S22AI_HUMAN	Increases Expression	[15]
Endoplasmic reticulum resident protein 27 (ERP27)	OTVMGE2H	ERP27_HUMAN	Decreases Expression	[15]
Ankyrin repeat and SOCS box protein 9 (ASB9)	OT3AA61T	ASB9_HUMAN	Decreases Expression	[15]
RecQ-mediated genome instability protein 2 (RMI2)	OTA0HP4S	RMI2_HUMAN	Decreases Expression	[15]
Protein Spindly (SPDL1)	OTI0JNTM	SPDLY_HUMAN	Decreases Expression	[15]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[15]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[15]
Cell division cycle-associated 7-like protein (CDCA7L)	OT1FFWKC	CDA7L_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase greatwall (MASTL)	OTQ7YKK5	GWL_HUMAN	Decreases Expression	[15]
Coiled-coil domain-containing protein 34 (CCDC34)	OTZ3AGSQ	CCD34_HUMAN	Decreases Expression	[15]
Carboxypeptidase B2 (CPB2)	OTPIL8IE	CBPB2_HUMAN	Decreases Expression	[15]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[15]
Leucine-rich repeat protein 1 (LRR1)	OTSWDXVY	LLR1_HUMAN	Decreases Expression	[15]
Coiled-coil domain-containing protein 138 (CCDC138)	OTT1TXO8	CC138_HUMAN	Decreases Expression	[15]
Uncharacterized protein C5orf34 (C5ORF34)	OTT2ESR4	CE034_HUMAN	Decreases Expression	[15]
Transmembrane protein 237 (TMEM237)	OTQEVL7L	TM237_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF20B (KIF20B)	OTS68AHH	KI20B_HUMAN	Decreases Expression	[15]
Sperm-associated antigen 5 (SPAG5)	OTCLJ56M	SPAG5_HUMAN	Decreases Expression	[15]
PAS domain-containing serine/threonine-protein kinase (PASK)	OT4MOQZ8	PASK_HUMAN	Decreases Expression	[15]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[15]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Increases Expression	[15]
Serine incorporator 2 (SERINC2)	OTZ039U0	SERC2_HUMAN	Increases Expression	[15]
Cytochrome P450 2S1 (CYP2S1)	OTKHX4RF	CP2S1_HUMAN	Increases Expression	[15]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[15]
Cell division cycle-associated protein 3 (CDCA3)	OTUI8QK3	CDCA3_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Decreases Expression	[15]
BRCA1-associated RING domain protein 1 (BARD1)	OTTC0Z9Y	BARD1_HUMAN	Decreases Expression	[15]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[15]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[15]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Decreases Expression	[15]
SMC5-SMC6 complex localization factor protein 1 (SLF1)	OT6ZA2K9	SLF1_HUMAN	Decreases Expression	[15]
Coiled-coil domain-containing protein 77 (CCDC77)	OTQQT2IC	CCD77_HUMAN	Decreases Expression	[15]
DNA replication complex GINS protein PSF3 (GINS3)	OT8NVXTD	PSF3_HUMAN	Decreases Expression	[15]
Centromere protein K (CENPK)	OTKPUF8K	CENPK_HUMAN	Decreases Expression	[15]
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1)	OTYKRRGE	RHNO1_HUMAN	Decreases Expression	[15]
Protein PIMREG (PIMREG)	OTKC8T3E	PIMRE_HUMAN	Decreases Expression	[15]
Immediate early response gene 2 protein (IER2)	OT5OY8BO	IER2_HUMAN	Increases Expression	[15]
EF-hand calcium-binding domain-containing protein 11 (EFCAB11)	OTXDJ9R8	EFC11_HUMAN	Decreases Expression	[15]
Sister chromatid cohesion protein DCC1 (DSCC1)	OTPUVLZT	DCC1_HUMAN	Decreases Expression	[15]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Decreases Expression	[15]
Cell division cycle-associated protein 7 (CDCA7)	OT12HDZY	CDCA7_HUMAN	Decreases Expression	[15]
Meiotic nuclear division protein 1 homolog (MND1)	OTS87F3H	MND1_HUMAN	Decreases Expression	[15]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Increases Expression	[15]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[15]
Cell adhesion molecule 1 (CADM1)	OTRWG9QS	CADM1_HUMAN	Decreases Expression	[15]
Sulfiredoxin-1 (SRXN1)	OTYDBO4L	SRXN1_HUMAN	Increases Expression	[15]
Kinetochore protein Nuf2 (NUF2)	OTOOQL35	NUF2_HUMAN	Decreases Expression	[15]
Protein sprouty homolog 4 (SPRY4)	OT2VK9N0	SPY4_HUMAN	Increases Expression	[15]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Decreases Expression	[15]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[15]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Decreases Expression	[15]
Homeobox protein MIXL1 (MIXL1)	OT584VOQ	MIXL1_HUMAN	Decreases Expression	[15]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[15]
Kinetochore-associated protein DSN1 homolog (DSN1)	OTHROI0H	DSN1_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[15]
Protein FAM83D (FAM83D)	OTQWZ1UO	FA83D_HUMAN	Decreases Expression	[15]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Increases Expression	[15]
ATP-dependent DNA helicase PIF1 (PIF1)	OTUHKKVP	PIF1_HUMAN	Decreases Expression	[15]
Syncoilin (SYNC)	OTEFLG59	SYNCI_HUMAN	Decreases Expression	[15]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Decreases Expression	[15]
Cytochrome P450 4F11 (CYP4F11)	OTHZ2GG2	CP4FB_HUMAN	Increases Expression	[15]
Kinetochore protein Spc25 (SPC25)	OTCAS0OH	SPC25_HUMAN	Decreases Expression	[15]
DNA polymerase delta subunit 4 (POLD4)	OTG578YH	DPOD4_HUMAN	Increases Expression	[15]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[15]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Increases Expression	[15]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[15]
Unconventional myosin-Vc (MYO5C)	OTKLOCWZ	MYO5C_HUMAN	Decreases Expression	[15]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[15]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF15 (KIF15)	OTJRJEXL	KIF15_HUMAN	Decreases Expression	[15]
Sal-like protein 1 (SALL1)	OTYYZGLH	SALL1_HUMAN	Decreases Expression	[15]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM)	OTALLHT1	FIRRM_HUMAN	Decreases Expression	[15]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)	OTR4990X	PLPL3_HUMAN	Decreases Expression	[15]
Protein diaphanous homolog 3 (DIAPH3)	OTPOT23F	DIAP3_HUMAN	Decreases Expression	[15]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[15]
Serine palmitoyltransferase 3 (SPTLC3)	OTZDX6PT	SPTC3_HUMAN	Decreases Expression	[15]
Transmembrane protein 140 (TMEM140)	OTQCEGEO	TM140_HUMAN	Increases Expression	[15]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Decreases Expression	[15]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Increases Expression	[15]
PCNA-interacting partner (PARPBP)	OTPZDGW7	PARI_HUMAN	Decreases Expression	[15]
Membrane progestin receptor gamma (PAQR5)	OTGGWXQE	PAQR5_HUMAN	Increases Expression	[15]
Protein Mis18-alpha (MIS18A)	OTD80K5X	MS18A_HUMAN	Decreases Expression	[15]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Decreases Expression	[15]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[15]
Kelch-like protein 14 (KLHL14)	OTYOS55H	KLH14_HUMAN	Decreases Expression	[15]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Decreases Expression	[15]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Increases Expression	[15]
CAP-Gly domain-containing linker protein 2 (CLIP2)	OTSCIQIY	CLIP2_HUMAN	Increases Expression	[15]
Doublecortin domain-containing protein 2 (DCDC2)	OTSUFH1H	DCDC2_HUMAN	Decreases Expression	[15]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)	OTZ71SK9	BI2L1_HUMAN	Increases Expression	[15]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Increases Expression	[15]
Oxidative stress-induced growth inhibitor 1 (OSGIN1)	OT9KIVZW	OSGI1_HUMAN	Increases Expression	[15]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[15]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Increases Expression	[15]
Protein phosphatase 1H (PPM1H)	OTKSVU7S	PPM1H_HUMAN	Decreases Expression	[15]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[15]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Increases Expression	[15]
Sex comb on midleg-like protein 1 (SCML1)	OT7V5DAR	SCML1_HUMAN	Decreases Expression	[15]
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14)	OTN51IPT	S6A14_HUMAN	Decreases Expression	[15]
Exonuclease 1 (EXO1)	OTI87RS5	EXO1_HUMAN	Decreases Expression	[15]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Decreases Expression	[15]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[15]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[15]
Dexamethasone-induced Ras-related protein 1 (RASD1)	OT2BAJHK	RASD1_HUMAN	Increases Expression	[15]
E3 ubiquitin-protein ligase DTX4 (DTX4)	OTGX30AO	DTX4_HUMAN	Decreases Expression	[15]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Decreases Expression	[15]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Decreases Expression	[15]
BTB/POZ domain-containing protein KCTD3 (KCTD3)	OT6EGR42	KCTD3_HUMAN	Decreases Expression	[15]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)	OTJQL0I3	HEY1_HUMAN	Increases Expression	[15]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Decreases Expression	[15]
Mitochondrial pyruvate carrier 1 (MPC1)	OT6DYFUO	MPC1_HUMAN	Decreases Expression	[15]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Decreases Expression	[15]
Lymphocyte antigen 96 (LY96)	OTN4HXA2	LY96_HUMAN	Increases Expression	[15]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[29]
Rap1 GTPase-activating protein 1 (RAP1GAP)	OTC31ONQ	RPGP1_HUMAN	Increases Expression	[29]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Increases Expression	[29]
Glycerol-3-phosphate acyltransferase 3 (GPAT3)	OTJUGPK0	GPAT3_HUMAN	Increases Expression	[29]
F-box only protein 30 (FBXO30)	OTD1P6LA	FBX30_HUMAN	Increases Expression	[29]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[30]
Serine protease inhibitor Kazal-type 1 (SPINK1)	OTSUVAL2	ISK1_HUMAN	Increases Expression	[31]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[32]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[33]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Mutagenesis	[34]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[32]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[35]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Increases Phosphorylation	[35]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[35]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[35]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Phosphorylation	[35]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Decreases Activity	[16]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[36]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Phosphorylation	[16]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[16]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Affects Mutagenesis	[37]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Increases Expression	[30]
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	OT6QGM5Y	IMDH1_HUMAN	Affects Response To Substance	[38]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Affects Metabolism	[39]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)	OTC6GISG	DQA1_HUMAN	Affects Response To Substance	[40]
Purine nucleoside phosphorylase (PNP)	OTO5NIJ2	PNPH_HUMAN	Increases ADR	[41]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Affects Response To Substance	[40]
Cytosolic 5'-nucleotidase 1A (NT5C1A)	OTS7UF36	5NT1A_HUMAN	Increases ADR	[41]
------------------------------------------------------------------------------------


⏷ Show the Full List of 574 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Hodgkin lymphoma	DC3GT63	L-1236	Investigative	[1]
Hodgkin lymphoma	DCE5S7Q	L-428	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2	Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
3	Azathioprine FDA Label
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7120).
5	AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
6	Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8.
7	BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. Mol Cancer Ther. 2014 Oct;13(10):2315-27. doi: 10.1158/1535-7163.MCT-14-0258. Epub 2014 Jul 22.
8	Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome. Haematologica. 2013 Jan;98(1):103-6. doi: 10.3324/haematol.2012.066407. Epub 2012 Aug 8.
9	Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther. 2011 Jun;10(6):1028-35. doi: 10.1158/1535-7163.MCT-10-1044. Epub 2011 Apr 11.
10	A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity. Toxicol Sci. 2015 Jan;143(1):147-55. doi: 10.1093/toxsci/kfu215. Epub 2014 Oct 10.
11	Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
12	Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation. Br J Haematol. 2012 May;157(4):483-92. doi: 10.1111/j.1365-2141.2012.09085.x. Epub 2012 Mar 13.
13	Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology. 2018 Feb 15;395:34-44. doi: 10.1016/j.tox.2018.01.005. Epub 2018 Jan 16.
14	Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
15	A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
16	CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003 Apr;111(8):1133-45. doi: 10.1172/JCI16432.
17	IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.
18	Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
19	Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000 Jun;21(6):1157-62.
20	Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease. Immunopharmacol Immunotoxicol. 2011 Jun;33(2):398-402.
21	PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
22	PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Hum Mol Genet. 2012 Nov 1;21(21):4793-804.
23	Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine. Chem Biol Interact. 2010 Jul 30;186(2):110-7. doi: 10.1016/j.cbi.2010.04.028. Epub 2010 Apr 29.
24	Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jan;13(1):57-64. doi: 10.1002/ibd.20004.
25	MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease. Inflamm Bowel Dis. 2007 May;13(5):585-90. doi: 10.1002/ibd.20044.
26	Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics. 2004 Mar;14(3):181-7. doi: 10.1097/00008571-200403000-00006.
27	Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology. 2003 Jun;124(7):1950-7.
28	Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol In Vitro. 2008;22(3):632-642. [PMID: 18222062]
29	Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
30	Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
31	Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
32	Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
33	Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
34	More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine. Exp Dermatol. 2008 Apr;17(4):349-55. doi: 10.1111/j.1600-0625.2007.00651.x. Epub 2007 Nov 2.
35	Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78. doi: 10.1016/j.taap.2013.07.024. Epub 2013 Aug 16.
36	A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
37	PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.
38	IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance. Pharmacogenomics J. 2007 Oct;7(5):312-7. doi: 10.1038/sj.tpj.6500421. Epub 2006 Oct 17.
39	Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members. J Mol Biol. 2008 Feb 1;375(5):1365-79. doi: 10.1016/j.jmb.2007.11.034. Epub 2007 Nov 19.
40	HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet. 2014 Oct;46(10):1131-4. doi: 10.1038/ng.3093. Epub 2014 Sep 14.
41	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.