Details of the Drug Combination

General Information of Drug Combination (ID: DCZ7KXY)

Drug Combination Name
PDX-101 PMID25656651-Compound-5
Indication
Disease Entry Status REF
Embryonal rhabdomyosarcoma Investigative [1]
Component Drugs PDX-101   DM6OC53 PMID25656651-Compound-5   DMAI95U
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: Rh36
Zero Interaction Potency (ZIP) Score: 10.144
Bliss Independence Score: 12.529
Loewe Additivity Score: 0.884
LHighest Single Agent (HSA) Score: 2.118

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of PDX-101
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Haematological malignancy 2B33.Y Phase 1 [4]
Peripheral T-cell lymphoma 2A90.C Phase 1 [4]
PDX-101 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Histone deacetylase (HDAC) TTBH0VX NOUNIPROTAC Modulator [11]
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PDX-101 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [12]
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PDX-101 Interacts with 566 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [7]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [7]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Expression [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [7]
Histone H1.0 (H1-0) OTRLJK4Z H10_HUMAN Increases Expression [7]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [7]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [7]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [7]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [7]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [7]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [7]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [7]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [7]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [7]
Multifunctional protein CAD (CAD) OTNCUYYE PYR1_HUMAN Decreases Expression [7]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [7]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [7]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Decreases Expression [7]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) OTEO98CR IF4G2_HUMAN Decreases Expression [7]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) OTFHWIY8 DHRS2_HUMAN Increases Expression [7]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [7]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Decreases Expression [7]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Increases Expression [7]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Increases Expression [7]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [7]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [7]
Inner centromere protein (INCENP) OT9HFRYK INCE_HUMAN Decreases Expression [7]
Nucleolar RNA helicase 2 (DDX21) OTV73GMZ DDX21_HUMAN Decreases Expression [7]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Decreases Expression [7]
Protein RCC2 (RCC2) OTUJVTLS RCC2_HUMAN Decreases Expression [7]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [7]
Proliferation-associated protein 2G4 (PA2G4) OT7IG7HT PA2G4_HUMAN Decreases Expression [7]
Rho guanine nucleotide exchange factor 37 (ARHGEF37) OTXQSCDO ARH37_HUMAN Decreases Expression [8]
Homeobox protein HMX2 (HMX2) OTBRXY6D HMX2_HUMAN Increases Expression [8]
Developmental pluripotency-associated 5 protein (DPPA5) OTLZC371 DPPA5_HUMAN Increases Expression [8]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Decreases Expression [8]
Transmembrane protein 221 (TMEM221) OTNSYQ3L TM221_HUMAN Decreases Expression [8]
Coiled-coil domain-containing protein 69 (CCDC69) OT43MI0R CCD69_HUMAN Increases Expression [8]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Increases Expression [8]
Suppressyn (ERVH48-1) OT303JGE SUPYN_HUMAN Increases Expression [8]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [8]
Bone morphogenetic protein receptor type-1B (BMPR1B) OTGFN0OD BMR1B_HUMAN Decreases Expression [8]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [8]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Increases Expression [8]
Astrotactin-1 (ASTN1) OT23FQIB ASTN1_HUMAN Decreases Expression [8]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Decreases Expression [8]
Neurocan core protein (NCAN) OT8OO6ZE NCAN_HUMAN Decreases Expression [8]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [8]
Semaphorin-3E (SEMA3E) OTD4S36H SEM3E_HUMAN Increases Expression [8]
Synaptojanin-2 (SYNJ2) OTLRHXP1 SYNJ2_HUMAN Decreases Expression [8]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Expression [8]
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Increases Expression [8]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) OTZKOTDB ADA12_HUMAN Decreases Expression [8]
Phospholipid-transporting ATPase IC (ATP8B1) OTALGS63 AT8B1_HUMAN Increases Expression [8]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [8]
Integral membrane protein 2A (ITM2A) OT590V63 ITM2A_HUMAN Increases Expression [8]
Plexin-C1 (PLXNC1) OTJ5XKYY PLXC1_HUMAN Decreases Expression [8]
Gremlin-1 (GREM1) OTCK4IGV GREM1_HUMAN Increases Expression [8]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [8]
Protein diaphanous homolog 2 (DIAPH2) OTBEYFEZ DIAP2_HUMAN Increases Expression [8]
Inward rectifier potassium channel 13 (KCNJ13) OTG1CNND KCJ13_HUMAN Decreases Expression [8]
Frizzled-7 (FZD7) OTTK3F6E FZD7_HUMAN Increases Expression [8]
Slit homolog 1 protein (SLIT1) OT35RBNT SLIT1_HUMAN Increases Expression [8]
Core histone macro-H2A.1 (MACROH2A1) OTV2DQDD H2AY_HUMAN Decreases Expression [8]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [8]
Forkhead box protein H1 (FOXH1) OTEXJ9SL FOXH1_HUMAN Increases Expression [8]
Leukocyte cell-derived chemotaxin 1 (CNMD) OTHND8EL CNMD_HUMAN Increases Expression [8]
Lysozyme-like protein 6 (LYZL6) OT6XS67M LYZL6_HUMAN Increases Expression [8]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Increases Expression [8]
Nucleolar protein 4 (NOL4) OTWI587R NOL4_HUMAN Decreases Expression [8]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Increases Expression [8]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [8]
Neurexophilin-2 (NXPH2) OTHD8HPU NXPH2_HUMAN Decreases Expression [8]
Protocadherin-8 (PCDH8) OTDDOQM2 PCDH8_HUMAN Increases Expression [8]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Decreases Expression [8]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Increases Expression [8]
C-X-C motif chemokine 14 (CXCL14) OTM189TA CXL14_HUMAN Increases Expression [8]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Increases Expression [8]
Leucine-rich glioma-inactivated protein 1 (LGI1) OTPS77HO LGI1_HUMAN Increases Expression [8]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [8]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Decreases Expression [8]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Increases Expression [8]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Decreases Expression [8]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [8]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [8]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [8]
Calbindin (CALB1) OTM7IXDG CALB1_HUMAN Increases Expression [8]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [8]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Increases Expression [8]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Increases Expression [8]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [8]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases Expression [8]
Tumor-associated calcium signal transducer 2 (TACSTD2) OTLSZR00 TACD2_HUMAN Increases Expression [8]
Apelin receptor early endogenous ligand (APELA) OTYY0P69 ELA_HUMAN Increases Expression [8]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [8]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Increases Expression [8]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Increases Expression [8]
Thyroid hormone receptor beta (THRB) OTBBIRHZ THB_HUMAN Increases Expression [8]
Hyaluronan and proteoglycan link protein 1 (HAPLN1) OTXWR9TJ HPLN1_HUMAN Increases Expression [8]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [8]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [8]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [8]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [8]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [8]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [8]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [8]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Increases Expression [8]
Atrial natriuretic peptide receptor 3 (NPR3) OT6MQP3A ANPRC_HUMAN Increases Expression [8]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) OTAKDCMR KAPCA_HUMAN Increases Expression [8]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Increases Expression [8]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Increases Expression [8]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Decreases Expression [8]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Increases Expression [8]
Alpha-1-acid glycoprotein 2 (ORM2) OTRJGZP8 A1AG2_HUMAN Decreases Expression [8]
Serine protease inhibitor Kazal-type 2 (SPINK2) OTSFBT0G ISK2_HUMAN Increases Expression [8]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Increases Expression [8]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [8]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Increases Expression [8]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [8]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Increases Expression [8]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [8]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [8]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Increases Expression [8]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Increases Expression [8]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Increases Expression [8]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [8]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Decreases Expression [8]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [8]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Increases Expression [8]
Rhombotin-2 (LMO2) OTCC370G RBTN2_HUMAN Decreases Expression [8]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [8]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [8]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Increases Expression [8]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) OT80C3D4 GBRB3_HUMAN Increases Expression [8]
Ephrin type-A receptor 3 (EPHA3) OTZJF3ML EPHA3_HUMAN Increases Expression [8]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [8]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [8]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [8]
Gastrin/cholecystokinin type B receptor (CCKBR) OTQSNXOI GASR_HUMAN Decreases Expression [8]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) OTCZQY1U ACHA3_HUMAN Increases Expression [8]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Increases Expression [8]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Decreases Expression [8]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Increases Expression [8]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Increases Expression [8]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [8]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Increases Expression [8]
Peptidyl-prolyl cis-trans isomerase C (PPIC) OTY5Q42N PPIC_HUMAN Increases Expression [8]
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) OTDO6HBG ACDSB_HUMAN Increases Expression [8]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Increases Expression [8]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Increases Expression [8]
Protein ERGIC-53 (LMAN1) OTYHKDEO LMAN1_HUMAN Decreases Expression [8]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Increases Expression [8]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Increases Expression [8]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [8]
Cysteine-rich protein 1 (CRIP1) OT0EICG3 CRIP1_HUMAN Increases Expression [8]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [8]
LIM/homeobox protein Lhx2 (LHX2) OTK61NP8 LHX2_HUMAN Decreases Expression [8]
Probable global transcription activator SNF2L2 (SMARCA2) OTSGJ8SV SMCA2_HUMAN Increases Expression [8]
Beta-crystallin A4 (CRYBA4) OTQJ5XGE CRBA4_HUMAN Decreases Expression [8]
GDNF family receptor alpha-1 (GFRA1) OT3WBVYB GFRA1_HUMAN Decreases Expression [8]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Expression [8]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [8]
Neurexin-2-beta (NRXN2) OTB04QSU NRX2B_HUMAN Decreases Expression [8]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Decreases Expression [8]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Increases Expression [8]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [8]
Somatostatin (SST) OTY75GQH SMS_HUMAN Increases Expression [8]
Neurocalcin-delta (NCALD) OTJZ8UEL NCALD_HUMAN Decreases Expression [8]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) OTHIXBGW GBG11_HUMAN Increases Expression [8]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [8]
Iroquois-class homeodomain protein IRX-1 (IRX1) OT0ZN9EJ IRX1_HUMAN Increases Expression [8]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Expression [8]
Nucleobindin-2 (NUCB2) OTHO6JWN NUCB2_HUMAN Decreases Expression [8]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB) OTRWGNBF LACTB_HUMAN Increases Expression [8]
Norrin (NDP) OTGDJ4US NDP_HUMAN Decreases Expression [8]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [8]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Increases Expression [8]
Putative POU domain, class 5, transcription factor 1B (POU5F1B) OT0FKQ51 P5F1B_HUMAN Increases Expression [8]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Increases Expression [8]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Increases Expression [8]
Contactin-1 (CNTN1) OT7RNPEY CNTN1_HUMAN Increases Expression [8]
Noggin (NOG) OTGRHHPG NOGG_HUMAN Increases Expression [8]
N-myc-interactor (NMI) OTYVG3NM NMI_HUMAN Increases Expression [8]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Decreases Expression [8]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Increases Expression [8]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [8]
Septin-6 (SEPTIN6) OTIV9RTK SEPT6_HUMAN Increases Expression [8]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [8]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Increases Expression [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [8]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [8]
Ephrin type-A receptor 7 (EPHA7) OT3VC211 EPHA7_HUMAN Increases Expression [8]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [8]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Decreases Expression [8]
Metallophosphoesterase MPPED2 (MPPED2) OT7XLMJ6 MPPD2_HUMAN Decreases Expression [8]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [8]
Gamma-interferon-inducible protein 16 (IFI16) OT4SPU0U IF16_HUMAN Increases Expression [8]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [8]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Decreases Expression [8]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [8]
Complement component receptor 1-like protein (CR1L) OTX3KR7U CR1L_HUMAN Increases Expression [8]
Cell cycle control protein 50B (TMEM30B) OTNSBH84 CC50B_HUMAN Increases Expression [8]
Protein shisa-like-1 (SHISAL1) OTOIUVC4 SHSL1_HUMAN Decreases Expression [8]
Protein PTHB1 (BBS9) OT23V9YF PTHB1_HUMAN Increases Expression [8]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases Expression [8]
F-box only protein 43 (FBXO43) OT6ST2A4 FBX43_HUMAN Decreases Expression [8]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Increases Expression [8]
Seizure protein 6 homolog (SEZ6) OTCD8K5D SEZ6_HUMAN Increases Expression [8]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [8]
Fibulin-7 (FBLN7) OT1XRDP6 FBLN7_HUMAN Decreases Expression [8]
Protein BEX5 (BEX5) OTZ2RB6L BEX5_HUMAN Increases Expression [8]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [8]
Solute carrier family 35 member D3 (SLC35D3) OTHKRBGM S35D3_HUMAN Increases Expression [8]
Centrosomal protein of 85 kDa-like (CEP85L) OTSHJFOT CE85L_HUMAN Increases Expression [8]
Protein FAM162B (FAM162B) OTZ31RP5 F162B_HUMAN Increases Expression [8]
Transcription factor HES-5 (HES5) OTW7JEHV HES5_HUMAN Decreases Expression [8]
Protein FAM222A (FAM222A) OTRD9AUH F222A_HUMAN Decreases Expression [8]
Scm-like with four MBT domains protein 2 (SFMBT2) OTZQT61Q SMBT2_HUMAN Increases Expression [8]
LIM/homeobox protein Lhx8 (LHX8) OT0DFL7C LHX8_HUMAN Increases Expression [8]
TMF-regulated nuclear protein 1 (TRNP1) OTYYV8LN TRNP1_HUMAN Increases Expression [8]
Lactase-like protein (LCTL) OTN36T21 LCTL_HUMAN Decreases Expression [8]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [8]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Increases Expression [8]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Increases Expression [8]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Increases Expression [8]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Increases Expression [8]
Leucine-rich repeat-containing protein 55 (LRRC55) OT8LQI1W LRC55_HUMAN Decreases Expression [8]
UPF0606 protein KIAA1549L (KIAA1549L) OT80HUVY K154L_HUMAN Decreases Expression [8]
Monocarboxylate transporter 14 (SLC16A14) OTUGDEUV MOT14_HUMAN Decreases Expression [8]
E3 ubiquitin-protein ligase RNF144B (RNF144B) OTN7FCDE R144B_HUMAN Increases Expression [8]
Developmental pluripotency-associated protein 2 (DPPA2) OT8Y55RY DPPA2_HUMAN Increases Expression [8]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [8]
Sodium/hydrogen exchanger 9B2 (SLC9B2) OTZVOY8T SL9B2_HUMAN Decreases Expression [8]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) OTKI3IU9 LRRT1_HUMAN Increases Expression [8]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2) OTXDDKZS MAGI2_HUMAN Increases Expression [8]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5) OTP46PZM ITIH5_HUMAN Increases Expression [8]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1) OTLQJTBI CMTD1_HUMAN Increases Expression [8]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) OTVCRXEZ PPR3B_HUMAN Increases Expression [8]
Podoplanin (PDPN) OTBUV19I PDPN_HUMAN Increases Expression [8]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) OTN6FKCB PRGC2_HUMAN Increases Expression [8]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Increases Expression [8]
Procollagen galactosyltransferase 2 (COLGALT2) OTV9EDZB GT252_HUMAN Decreases Expression [8]
Ras and EF-hand domain-containing protein (RASEF) OTGSAM2E RASEF_HUMAN Increases Expression [8]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [8]
Protein SIX6OS1 (C14ORF39) OTFKQ6HO S6OS1_HUMAN Decreases Expression [8]
Rho GTPase-activating protein 24 (ARHGAP24) OTCQCEZS RHG24_HUMAN Increases Expression [8]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [8]
ELMO domain-containing protein 1 (ELMOD1) OT0WRVJC ELMD1_HUMAN Increases Expression [8]
Mucin-15 (MUC15) OT3PQT6L MUC15_HUMAN Increases Expression [8]
Chemokine-like protein TAFA-2 (TAFA2) OTU6WP6J TAFA2_HUMAN Increases Expression [8]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K) OTNZ4N4E PPM1K_HUMAN Increases Expression [8]
Thioredoxin domain-containing protein 3 (NME8) OT4RULP5 TXND3_HUMAN Increases Expression [8]
Leucine-rich repeat-containing protein 17 (LRRC17) OT3NZSX3 LRC17_HUMAN Increases Expression [8]
Inactive phospholipase D5 (PLD5) OTEVPYNY PLD5_HUMAN Decreases Expression [8]
BMP-binding endothelial regulator protein (BMPER) OTBYON4H BMPER_HUMAN Increases Expression [8]
Tandem C2 domains nuclear protein (TC2N) OT6482WN TAC2N_HUMAN Increases Expression [8]
Tetratricopeptide repeat protein 29 (TTC29) OT37KCUL TTC29_HUMAN Increases Expression [8]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [8]
Beta-galactosidase-1-like protein 3 (GLB1L3) OTWAWGX4 GLBL3_HUMAN Increases Expression [8]
Zinc finger protein GLIS3 (GLIS3) OTBC960E GLIS3_HUMAN Decreases Expression [8]
Interleukin-17 receptor D (IL17RD) OTKD9XST I17RD_HUMAN Decreases Expression [8]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [8]
Semaphorin-6D (SEMA6D) OTU0UAZS SEM6D_HUMAN Decreases Expression [8]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [8]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase RNF217 (RNF217) OTAX91ES RN217_HUMAN Increases Expression [8]
Ciliary microtubule-associated protein 3 (CIMAP3) OT8RL1WO CMAP3_HUMAN Increases Expression [8]
Mucolipin-3 (MCOLN3) OTCRPRVS MCLN3_HUMAN Increases Expression [8]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Increases Expression [8]
DENN domain-containing protein 1A (DENND1A) OTONDAA0 DEN1A_HUMAN Decreases Expression [8]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [8]
Secretogranin-3 (SCG3) OTUYSV2S SCG3_HUMAN Increases Expression [8]
Myosin-IIIb (MYO3B) OTVD4TNG MYO3B_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Increases Expression [8]
Transcription factor AP-2-beta (TFAP2B) OTR1T8E9 AP2B_HUMAN Increases Expression [8]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1) OTBG1FU4 PIEZ1_HUMAN Decreases Expression [8]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Increases Expression [8]
Deleted in azoospermia-like (DAZL) OTZMTD4R DAZL_HUMAN Decreases Expression [8]
Stathmin-2 (STMN2) OT0FUHLH STMN2_HUMAN Increases Expression [8]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) OTV5OHBT S38A4_HUMAN Increases Expression [8]
Copine-4 (CPNE4) OTTAGM5L CPNE4_HUMAN Increases Expression [8]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Increases Expression [8]
Collagen triple helix repeat-containing protein 1 (CTHRC1) OTV88X2G CTHR1_HUMAN Increases Expression [8]
Ras-related protein Rab-3C (RAB3C) OTFTJNGA RAB3C_HUMAN Increases Expression [8]
BLOC-1-related complex subunit 8 (BORCS8) OTVRSVCB BORC8_HUMAN Increases Expression [8]
Serine dehydratase-like (SDSL) OTGZEAGJ SDSL_HUMAN Decreases Expression [8]
Calmodulin-like protein 4 (CALML4) OT6DD5EW CALL4_HUMAN Decreases Expression [8]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) OTW7D1SV HPDL_HUMAN Increases Expression [8]
Microtubule-associated protein 6 (MAP6) OTPUI00F MAP6_HUMAN Decreases Expression [8]
TOX high mobility group box family member 2 (TOX2) OT7RZRVK TOX2_HUMAN Decreases Expression [8]
Collagen alpha-1(XXI) chain (COL21A1) OT7GS82E COLA1_HUMAN Increases Expression [8]
Noelin-3 (OLFM3) OTBHPDTL NOE3_HUMAN Increases Expression [8]
Secretoglobin family 3A member 2 (SCGB3A2) OTB63PHR SG3A2_HUMAN Increases Expression [8]
DEP domain-containing protein 7 (DEPDC7) OT62C942 DEPD7_HUMAN Increases Expression [8]
MAP7 domain-containing protein 2 (MAP7D2) OTN85925 MA7D2_HUMAN Decreases Expression [8]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Increases Expression [8]
Protein kinase C-binding protein NELL2 (NELL2) OTS4MJZ7 NELL2_HUMAN Decreases Expression [8]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Decreases Expression [8]
Neuroserpin (SERPINI1) OTUJHIJW NEUS_HUMAN Increases Expression [8]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Increases Expression [8]
Forkhead box protein C2 (FOXC2) OT83P1E0 FOXC2_HUMAN Increases Expression [8]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [8]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [8]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) OTM4ECDK MLP3C_HUMAN Increases Expression [8]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) OTA0DE43 B3GN5_HUMAN Decreases Expression [8]
Anoctamin-3 (ANO3) OTM34U6Q ANO3_HUMAN Increases Expression [8]
Iroquois-class homeodomain protein IRX-2 (IRX2) OTBHXXQ2 IRX2_HUMAN Increases Expression [8]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Increases Expression [8]
AP-5 complex subunit mu-1 (AP5M1) OTDLWEBL AP5M1_HUMAN Increases Expression [8]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Increases Expression [8]
Serine/threonine-protein kinase TAO3 (TAOK3) OTYBATSH TAOK3_HUMAN Increases Expression [8]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [8]
SPARC-related modular calcium-binding protein 1 (SMOC1) OTJG2JQY SMOC1_HUMAN Decreases Expression [8]
Nuclear body protein SP140-like protein (SP140L) OTL30JKT SP14L_HUMAN Increases Expression [8]
Chondrolectin (CHODL) OTVCNOUQ CHODL_HUMAN Increases Expression [8]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [8]
Adhesion G protein-coupled receptor L3 (ADGRL3) OT81Q8LY AGRL3_HUMAN Decreases Expression [8]
Roundabout homolog 2 (ROBO2) OTFJ9FQW ROBO2_HUMAN Decreases Expression [8]
Band 4.1-like protein 5 (EPB41L5) OTPPQPLU E41L5_HUMAN Increases Expression [8]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [8]
Homer protein homolog 2 (HOMER2) OT4JGKJF HOME2_HUMAN Decreases Expression [8]
Muscleblind-like protein 3 (MBNL3) OT2T2YOK MBNL3_HUMAN Increases Expression [8]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Decreases Expression [8]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [8]
Neuroligin-3 (NLGN3) OTKDEC1Q NLGN3_HUMAN Decreases Expression [8]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Increases Expression [8]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [8]
Docking protein 5 (DOK5) OT2XWUPN DOK5_HUMAN Increases Expression [8]
Contactin-3 (CNTN3) OTC1274J CNTN3_HUMAN Decreases Expression [8]
Protocadherin-10 (PCDH10) OT2GIT0E PCD10_HUMAN Increases Expression [8]
Centrosomal protein of 126 kDa (CEP126) OTUMFEME CE126_HUMAN Increases Expression [8]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Increases Expression [8]
Homeobox expressed in ES cells 1 (HESX1) OT5E2Z4G HESX1_HUMAN Decreases Expression [8]
Forkhead box protein D3 (FOXD3) OTXYV6GO FOXD3_HUMAN Increases Expression [8]
TRAF2 and NCK-interacting protein kinase (TNIK) OTDZBJ4K TNIK_HUMAN Increases Expression [8]
POU domain, class 2, transcription factor 3 (POU2F3) OTIOOJWD PO2F3_HUMAN Increases Expression [8]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Decreases Expression [8]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Decreases Expression [8]
RING finger protein 150 (RNF150) OTAMSBK5 RN150_HUMAN Increases Expression [8]
Sex comb on midleg-like protein 1 (SCML1) OT7V5DAR SCML1_HUMAN Increases Expression [8]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Decreases Expression [8]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) OT74EK7Z PDE10_HUMAN Decreases Expression [8]
C-C motif chemokine 26 (CCL26) OT2B7HR9 CCL26_HUMAN Increases Expression [8]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [8]
Retinal homeobox protein Rx (RAX) OTJ3YCE7 RX_HUMAN Decreases Expression [8]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Increases Expression [8]
Neuropeptide FF receptor 2 (NPFFR2) OTVI4Q85 NPFF2_HUMAN Increases Expression [8]
Glypican-6 (GPC6) OTNJBESF GPC6_HUMAN Decreases Expression [8]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [8]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Expression [8]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Increases Expression [8]
KAT8 regulatory NSL complex subunit 1-like protein (KANSL1L) OTOAH2RR KAL1L_HUMAN Decreases Expression [9]
Cilia- and flagella-associated protein 119 (CFAP119) OT7PL1Q6 CF119_HUMAN Increases Expression [9]
Leucine-rich repeat-containing protein 10B (LRRC10B) OT9NKWFW LR10B_HUMAN Decreases Expression [9]
Collagen alpha-6(VI) chain (COL6A6) OT4MVGRW CO6A6_HUMAN Decreases Expression [9]
Sulfotransferase 1C2 (SULT1C2) OT07MMZS ST1C2_HUMAN Decreases Expression [9]
Acetyl-CoA carboxylase 2 (ACACB) OT96UIP1 ACACB_HUMAN Decreases Expression [9]
Homeobox protein CDX-4 (CDX4) OTD1SQKM CDX4_HUMAN Decreases Expression [9]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [9]
Ras-related protein Rab-7L1 (RAB29) OTDZT6LP RAB7L_HUMAN Increases Expression [9]
Synemin (SYNM) OTOI8TRJ SYNEM_HUMAN Decreases Expression [9]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3) OT2U6VF5 ATS3_HUMAN Decreases Expression [9]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Decreases Expression [9]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [9]
Maltase-glucoamylase (MGAM) OTVLMDUE MGA_HUMAN Decreases Expression [9]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Decreases Expression [9]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [9]
Src kinase-associated phosphoprotein 2 (SKAP2) OTSF44KP SKAP2_HUMAN Increases Expression [9]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) OT6WZPWV KBL_HUMAN Decreases Expression [9]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1) OT8GFSQL B3GL1_HUMAN Decreases Expression [9]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Decreases Expression [9]
Kelch-like protein 18 (KLHL18) OTX7NOSM KLH18_HUMAN Increases Expression [9]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Decreases Expression [9]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Decreases Expression [9]
Coagulation factor XIII A chain (F13A1) OTO8O184 F13A_HUMAN Increases Expression [9]
Coagulation factor X (F10) OT2BLK17 FA10_HUMAN Decreases Expression [9]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Decreases Expression [9]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Decreases Expression [9]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Increases Expression [9]
Hemoglobin subunit epsilon (HBE1) OTJPKMX4 HBE_HUMAN Decreases Expression [9]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [9]
Hemopexin (HPX) OT14T7Q1 HEMO_HUMAN Decreases Expression [9]
Platelet-derived growth factor subunit A (PDGFA) OTCMZ0W8 PDGFA_HUMAN Decreases Expression [9]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Decreases Expression [9]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [9]
Thyroxine-binding globulin (SERPINA7) OTUYVTSU THBG_HUMAN Decreases Expression [9]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Decreases Expression [9]
Asialoglycoprotein receptor 1 (ASGR1) OTS99MJO ASGR1_HUMAN Decreases Expression [9]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [9]
Homeobox protein Hox-D4 (HOXD4) OTQR4WCG HXD4_HUMAN Increases Expression [9]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Decreases Expression [9]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Decreases Expression [9]
Tartrate-resistant acid phosphatase type 5 (ACP5) OTBV4498 PPA5_HUMAN Decreases Expression [9]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [9]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [9]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Decreases Expression [9]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Decreases Expression [9]
Carbonic anhydrase 4 (CA4) OT3K93LZ CAH4_HUMAN Decreases Expression [9]
Sodium-dependent noradrenaline transporter (SLC6A2) OTMHQJMP SC6A2_HUMAN Increases Expression [9]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [9]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [9]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Decreases Expression [9]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Decreases Expression [9]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [9]
Homeobox protein Hox-D3 (HOXD3) OTBUZ35T HXD3_HUMAN Increases Expression [9]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [9]
Glutamate receptor ionotropic, kainate 1 (GRIK1) OTO19X5C GRIK1_HUMAN Increases Expression [9]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [9]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Decreases Expression [9]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) OTOZTA1F M3K8_HUMAN Increases Expression [9]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases Expression [9]
Cathepsin O (CTSO) OTFL6VRO CATO_HUMAN Decreases Expression [9]
Cathepsin K (CTSK) OTT3YX5O CATK_HUMAN Decreases Expression [9]
G protein-coupled receptor kinase 6 (GRK6) OT4LZTP9 GRK6_HUMAN Decreases Expression [9]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [9]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [9]
Inositol polyphosphate 1-phosphatase (INPP1) OTHSJCRQ INPP_HUMAN Decreases Expression [9]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Decreases Expression [9]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Decreases Expression [9]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Decreases Expression [9]
Arylsulfatase D (ARSD) OTAHW9M8 ARSD_HUMAN Decreases Expression [9]
G-protein coupled receptor 143 (GPR143) OTWUA2AV GP143_HUMAN Decreases Expression [9]
Pancreatic lipase-related protein 2 (PNLIPRP2) OTJG6BA7 LIPR2_HUMAN Decreases Expression [9]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) OT2H1KDK PTN5_HUMAN Decreases Expression [9]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [9]
Hormonally up-regulated neu tumor-associated kinase (HUNK) OTZR4GBH HUNK_HUMAN Decreases Expression [9]
F-box/WD repeat-containing protein 4 (FBXW4) OTEGSZOX FBXW4_HUMAN Decreases Expression [9]
Clarin-1 (CLRN1) OT1ADI7Q CLRN1_HUMAN Increases Expression [9]
Beta-defensin 1 (DEFB1) OT5SV0E4 DEFB1_HUMAN Decreases Expression [9]
DDB1- and CUL4-associated factor 7 (DCAF7) OT3W5DYL DCAF7_HUMAN Increases Expression [9]
Inward rectifier potassium channel 2 (KCNJ2) OT2OQEZS KCNJ2_HUMAN Decreases Expression [9]
POU domain, class 6, transcription factor 2 (POU6F2) OTNSW95F PO6F2_HUMAN Increases Expression [9]
Protein crumbs homolog 1 (CRB1) OTXYUNG0 CRUM1_HUMAN Increases Expression [9]
Fibulin-2 (FBLN2) OTEHR7N7 FBLN2_HUMAN Decreases Expression [9]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Decreases Expression [9]
AMP deaminase 3 (AMPD3) OT5SP1KJ AMPD3_HUMAN Decreases Expression [9]
Trefoil factor 2 (TFF2) OTRXB19X TFF2_HUMAN Decreases Expression [9]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Decreases Expression [9]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Decreases Expression [9]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Decreases Expression [9]
Filensin (BFSP1) OTXZ3YIU BFSP1_HUMAN Decreases Expression [9]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Decreases Expression [9]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Decreases Expression [9]
Caprin-1 (CAPRIN1) OTEJAMS3 CAPR1_HUMAN Decreases Expression [9]
Sarcospan (SSPN) OTYG2SL7 SSPN_HUMAN Decreases Expression [9]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Decreases Expression [9]
NT-3 growth factor receptor (NTRK3) OTII30MY NTRK3_HUMAN Increases Expression [9]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Decreases Expression [9]
Interphotoreceptor matrix proteoglycan 1 (IMPG1) OT12HBL0 IMPG1_HUMAN Increases Expression [9]
Protein Shroom1 (SHROOM1) OTUP99ZD SHRM1_HUMAN Decreases Expression [9]
Transmembrane protein 44 (TMEM44) OTRUF467 TMM44_HUMAN Decreases Expression [9]
Hexokinase HKDC1 (HKDC1) OTTHDMBM HKDC1_HUMAN Decreases Expression [9]
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2) OTSSP13W IPIL2_HUMAN Decreases Expression [9]
Membrane protein FAM174B (FAM174B) OT1SCOTY F174B_HUMAN Decreases Expression [9]
OCIA domain-containing protein 2 (OCIAD2) OTSWB4SZ OCAD2_HUMAN Decreases Expression [9]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [9]
FRAS1-related extracellular matrix protein 1 (FREM1) OTMHRV87 FREM1_HUMAN Decreases Expression [9]
Calcium homeostasis modulator protein 6 (CALHM6) OTLX9B4Y CAHM6_HUMAN Decreases Expression [9]
Putative hydroxypyruvate isomerase (HYI) OTFPNOTN HYI_HUMAN Decreases Expression [9]
Probable gluconokinase (IDNK) OT5ZC54L GNTK_HUMAN Decreases Expression [9]
Dynein regulatory complex protein 8 (EFCAB2) OTXEFI4O DRC8_HUMAN Decreases Expression [9]
Little elongation complex subunit 2 (ICE2) OTJ3BXND ICE2_HUMAN Increases Expression [9]
Polypeptide N-acetylgalactosaminyltransferase 17 (GALNT17) OTMF0W2U GLT17_HUMAN Decreases Expression [9]
Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4) OTKZDDIF PP4R4_HUMAN Increases Expression [9]
Transmembrane protein 220 (TMEM220) OTGTRDNX TM220_HUMAN Decreases Expression [9]
Sushi domain-containing protein 1 (SUSD1) OTR3UGLY SUSD1_HUMAN Decreases Expression [9]
Thiol S-methyltransferase TMT1B (TMT1B) OTP0QOAL TMT1B_HUMAN Decreases Expression [9]
Gliomedin (GLDN) OTA8TQU9 GLDN_HUMAN Increases Expression [9]
Refilin-A (RFLNA) OT6GS3XQ RFLA_HUMAN Decreases Expression [9]
Protein CFAP20DC (CFAP20DC) OTVOREMP CF20D_HUMAN Increases Expression [9]
Fibrillin-3 (FBN3) OTEWLXTH FBN3_HUMAN Decreases Expression [9]
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) OTOBEH24 CYFP1_HUMAN Decreases Expression [9]
Carbohydrate sulfotransferase 15 (CHST15) OTNTM2SP CHSTF_HUMAN Increases Expression [9]
Neuronal growth regulator 1 (NEGR1) OT57ECW9 NEGR1_HUMAN Increases Expression [9]
Microtubule organization protein AKNA (AKNA) OTQ6E2C8 AKNA_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RNF180 (RNF180) OT2GKIKE RN180_HUMAN Decreases Expression [9]
Hyaluronan and proteoglycan link protein 4 (HAPLN4) OTZQOG9A HPLN4_HUMAN Decreases Expression [9]
Proline-rich membrane anchor 1 (PRIMA1) OT9ITT3P PRIMA_HUMAN Decreases Expression [9]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2) OTL0DWCO ECHD2_HUMAN Decreases Expression [9]
L-seryl-tRNA(Sec) kinase (PSTK) OTA5UXAX PSTK_HUMAN Decreases Expression [9]
Protein mono-ADP-ribosyltransferase PARP9 (PARP9) OT7K4494 PARP9_HUMAN Decreases Expression [9]
Solute carrier family 35 member F3 (SLC35F3) OTAOBKBG S35F3_HUMAN Decreases Expression [9]
Ribonuclease SLFN12 (SLFN12) OTTBXM25 SLN12_HUMAN Increases Expression [9]
UPF0462 protein C4orf33 (C4ORF33) OT3O3FC3 CD033_HUMAN Increases Expression [9]
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) OTJIX22S PYRD2_HUMAN Decreases Expression [9]
T-cell activation inhibitor, mitochondrial (TCAIM) OTOBD7YO TCAIM_HUMAN Decreases Expression [9]
Choline transporter-like protein 3 (SLC44A3) OTL0FT8L CTL3_HUMAN Decreases Expression [9]
Dynein light chain Tctex-type 5 (DYNLT5) OTDM1DWJ DYLT5_HUMAN Increases Expression [9]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Decreases Expression [9]
Clarin-3 (CLRN3) OTZDNL65 CLRN3_HUMAN Decreases Expression [9]
Putative methyltransferase NSUN7 (NSUN7) OTDTL9UE NSUN7_HUMAN Decreases Expression [9]
Phospholipid phosphatase 5 (PLPP5) OTHT51D6 PLPP5_HUMAN Decreases Expression [9]
Interleukin-17D (IL17D) OTMBLLRF IL17D_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase DTX3L (DTX3L) OTCCO2QZ DTX3L_HUMAN Decreases Expression [9]
CDK5 and ABL1 enzyme substrate 1 (CABLES1) OTMN4XSX CABL1_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase 32A (STK32A) OTONYLYO ST32A_HUMAN Decreases Expression [9]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3) OTUWZTH7 ARAP3_HUMAN Decreases Expression [9]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Decreases Expression [9]
Lysophosphatidic acid receptor 1 (LPAR1) OTJNJQPF LPAR1_HUMAN Decreases Expression [9]
Histone-lysine N-methyltransferase EZH1 (EZH1) OTFLUU94 EZH1_HUMAN Increases Expression [9]
Peroxisomal membrane protein PEX13 (PEX13) OTXUAYEW PEX13_HUMAN Increases Expression [9]
Homogentisate 1,2-dioxygenase (HGD) OTTKLQOO HGD_HUMAN Decreases Expression [9]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Decreases Expression [9]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Decreases Expression [9]
Copine-2 (CPNE2) OTPESEM5 CPNE2_HUMAN Decreases Expression [9]
Coiled-coil domain-containing protein 34 (CCDC34) OTZ3AGSQ CCD34_HUMAN Increases Expression [9]
Fatty acyl-CoA reductase 2 (FAR2) OTRYY709 FACR2_HUMAN Decreases Expression [9]
Adenylate kinase 7 (AK7) OTASZDJN KAD7_HUMAN Increases Expression [9]
Sodium channel and clathrin linker 1 (SCLT1) OT2ZSSP4 SCLT1_HUMAN Increases Expression [9]
Erythroid membrane-associated protein (ERMAP) OTKXBB52 ERMAP_HUMAN Decreases Expression [9]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [9]
Glutathione peroxidase 7 (GPX7) OTINT9Z4 GPX7_HUMAN Decreases Expression [9]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [9]
Melanin-concentrating hormone receptor 1 (MCHR1) OTT57EOE MCHR1_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Decreases Expression [9]
NAD-capped RNA hydrolase NUDT12 (NUDT12) OTBUY58C NUD12_HUMAN Increases Expression [9]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Decreases Expression [9]
MARVEL domain-containing protein 1 (MARVELD1) OT5CPOJE MALD1_HUMAN Decreases Expression [9]
Spexin (SPX) OTY3G4AR SPXN_HUMAN Decreases Expression [9]
Acireductone dioxygenase (ADI1) OT8IOD03 MTND_HUMAN Decreases Expression [9]
Caspase recruitment domain-containing protein 10 (CARD10) OT2RPM4I CAR10_HUMAN Decreases Expression [9]
Contactin-associated protein-like 4 (CNTNAP4) OTKXR9AW CNTP4_HUMAN Decreases Expression [9]
Glycosyltransferase 8 domain-containing protein 2 (GLT8D2) OT4VS9YY GL8D2_HUMAN Decreases Expression [9]
Cytosolic beta-glucosidase (GBA3) OT86XWU2 GBA3_HUMAN Decreases Expression [9]
Lysine-specific demethylase 4C (KDM4C) OT2RHV9S KDM4C_HUMAN Increases Expression [9]
NIPA-like protein 2 (NIPAL2) OTX9UREP NPAL2_HUMAN Decreases Expression [9]
Sialate O-acetylesterase (SIAE) OTDQUESH SIAE_HUMAN Increases Expression [9]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Decreases Expression [9]
Beta-parvin (PARVB) OT9OGVWX PARVB_HUMAN Decreases Expression [9]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B) OTK3SHT2 PDE7B_HUMAN Increases Expression [9]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Decreases Expression [9]
Rho guanine nucleotide exchange factor 4 (ARHGEF4) OTR2VG0W ARHG4_HUMAN Decreases Expression [9]
Interleukin-17 receptor B (IL17RB) OT0KDNSF I17RB_HUMAN Decreases Expression [9]
Probable G-protein coupled receptor 27 (GPR27) OTH4KQPI GPR27_HUMAN Decreases Expression [9]
Transmembrane protein 51 (TMEM51) OTZCW8XJ TMM51_HUMAN Decreases Expression [9]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Expression [9]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) OTJISZOX PLCE1_HUMAN Decreases Expression [9]
Doublecortin domain-containing protein 2 (DCDC2) OTSUFH1H DCDC2_HUMAN Decreases Expression [9]
Cadherin-9 (CDH9) OTV9N5XK CADH9_HUMAN Decreases Expression [9]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Decreases Expression [9]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [9]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [9]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9) OTLIJBQY FUT9_HUMAN Increases Expression [9]
Sorting nexin-10 (SNX10) OT05B7BT SNX10_HUMAN Decreases Expression [9]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [10]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [13]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases Expression [10]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [10]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [13]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [10]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [13]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [13]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [13]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [10]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [14]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [13]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [10]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Acetylation [13]
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⏷ Show the Full List of 566 DOT(s)
Indication(s) of PMID25656651-Compound-5
Disease Entry ICD 11 Status REF
Chronic myeloid leukaemia 2A20 Patented [5]
PMID25656651-Compound-5 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [5]
------------------------------------------------------------------------------------
PMID25656651-Compound-5 Interacts with 68 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Activity [16]
Macrophage colony-stimulating factor 1 receptor (CSF1R) OTDYTB9C CSF1R_HUMAN Decreases Activity [16]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Activity [16]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Decreases Activity [16]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Decreases Activity [16]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Activity [16]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Activity [16]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Activity [16]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Decreases Activity [16]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Activity [16]
Fibroblast growth factor receptor 4 (FGFR4) OTRQERG2 FGFR4_HUMAN Decreases Activity [16]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Activity [16]
Ephrin type-A receptor 2 (EPHA2) OTI6QNX2 EPHA2_HUMAN Decreases Activity [16]
Ephrin type-A receptor 3 (EPHA3) OTZJF3ML EPHA3_HUMAN Decreases Activity [16]
Vascular endothelial growth factor receptor 3 (FLT4) OTRAA26B VGFR3_HUMAN Decreases Activity [16]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Decreases Activity [16]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Activity [16]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Decreases Activity [16]
Ephrin type-A receptor 7 (EPHA7) OT3VC211 EPHA7_HUMAN Decreases Activity [16]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [17]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Activity [15]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Activity [15]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [17]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [18]
High affinity nerve growth factor receptor (NTRK1) OTJORQAU NTRK1_HUMAN Decreases Activity [15]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Activity [15]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Activity [15]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Activity [15]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Activity [15]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Decreases Activity [15]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [19]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [17]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Activity [15]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Phosphorylation [15]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [17]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Secretion [20]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Decreases Activity [15]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Decreases Activity [15]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [21]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [22]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [22]
Ephrin type-A receptor 8 (EPHA8) OTHOESG6 EPHA8_HUMAN Decreases Activity [15]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Activity [15]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [17]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [17]
Tyrosine-protein kinase CSK (CSK) OTP03OD0 CSK_HUMAN Decreases Activity [15]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Decreases Phosphorylation [18]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [23]
Tyrosine-protein kinase ABL2 (ABL2) OTS8F4GD ABL2_HUMAN Decreases Activity [15]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Decreases Activity [15]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [20]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Activity [15]
Cytoplasmic tyrosine-protein kinase BMX (BMX) OTJUE0ZD BMX_HUMAN Decreases Activity [15]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Decreases Activity [15]
Ephrin type-B receptor 3 (EPHB3) OT4XD8O3 EPHB3_HUMAN Decreases Activity [15]
Ephrin type-A receptor 5 (EPHA5) OTAM0CVX EPHA5_HUMAN Decreases Activity [15]
Ephrin type-B receptor 4 (EPHB4) OTKLPVXJ EPHB4_HUMAN Decreases Activity [15]
Ephrin type-B receptor 1 (EPHB1) OTPG2DRZ EPHB1_HUMAN Decreases Activity [15]
Ephrin type-A receptor 4 (EPHA4) OT3AMK0C EPHA4_HUMAN Decreases Activity [15]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [17]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [22]
Protein-tyrosine kinase 6 (PTK6) OT7NWIQ0 PTK6_HUMAN Decreases Activity [15]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Decreases Activity [15]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Decreases Activity [15]
NT-3 growth factor receptor (NTRK3) OTII30MY NTRK3_HUMAN Decreases Activity [15]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Activity [15]
Discoidin domain-containing receptor 2 (DDR2) OT9IHOGZ DDR2_HUMAN Decreases Activity [15]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) OTPMGIU4 MLP3A_HUMAN Increases Lipidation [23]
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⏷ Show the Full List of 68 DOT(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Belinostat FDA Label
3 A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar;168(6):811-9.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
6 Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
7 Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs. 2009 Sep;20(8):682-92.
8 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
9 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
10 Histone acetylation-mediated regulation of the Hippo pathway. PLoS One. 2013 May 6;8(5):e62478. doi: 10.1371/journal.pone.0062478. Print 2013.
11 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
12 Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73.
13 Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res. 2008 Jan 15;14(2):549-58. doi: 10.1158/1078-0432.CCR-07-1934.
14 Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase. Mol Cells. 2015;38(2):138-44. doi: 10.14348/molcells.2015.2193. Epub 2014 Dec 24.
15 AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
16 Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8.
17 BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. Mol Cancer Ther. 2014 Oct;13(10):2315-27. doi: 10.1158/1535-7163.MCT-14-0258. Epub 2014 Jul 22.
18 Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome. Haematologica. 2013 Jan;98(1):103-6. doi: 10.3324/haematol.2012.066407. Epub 2012 Aug 8.
19 Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther. 2011 Jun;10(6):1028-35. doi: 10.1158/1535-7163.MCT-10-1044. Epub 2011 Apr 11.
20 A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity. Toxicol Sci. 2015 Jan;143(1):147-55. doi: 10.1093/toxsci/kfu215. Epub 2014 Oct 10.
21 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
22 Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation. Br J Haematol. 2012 May;157(4):483-92. doi: 10.1111/j.1365-2141.2012.09085.x. Epub 2012 Mar 13.
23 Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology. 2018 Feb 15;395:34-44. doi: 10.1016/j.tox.2018.01.005. Epub 2018 Jan 16.