Details of the Drug Combinations

General Information of This Drug (ID: DMAQ469)

• Drug Name: Gonadorelin (DMAQ469)
• Synonyms: Dirigestran; Factrel; Fertagyl; Gonadorelina; Gonadorelinum; Hypocrine; Kryptocur; LFRH; LHFSHRH; Luforan; Luliberin; Lutal; Lutamin; Lutrefact; Relefact; Relisorm; Dirigestran Spofa; Gonadoliberin I; Gonadotropin releasing hormone; LHFSH Releasing Hormone; LUTEINIZING HORMONE; Lutrepulse KIT; MammalianGnRH; Relisorm l; Synthetic LRF; Synthetic gonadoliberin; HOE 471; AY-24031; FSH-Releasing Hormone; Fertagyl (TN); GnRH-I; Gonadorelin (INN); Gonadorelin [INN:BAN]; Gonadorelina [INN-Spanish]; Gonadorelinum [INN-Latin]; Gonadotropin-releasing factor; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone I; Human LH-RH; LH-FSH Releasing Hormone; LH-Releasing hormone; Luteinizing hormone-releasing hormone; Mammalian LH-RH; Mammalian gonadotropin-releasing hormone; Ovine LH-RH; Ovine gonadotropin-releasing hormone; Porchine LH-RH; Porcine LH-releasing factor; Synthetic Gn-RH; Synthetic LH-FSH releasing hormone; Synthetic LH-RF; Synthetic LH-RH; Synthetic LH-releasing factor; Synthetic LH-releasing hormone; Synthetic gonadotropic hormone-releasing hormone; Synthetic gonadotropin-releasing hormone; LH-RH (swine); LH-Releasing factor (pig); LH-Releasing hormone (porcine); Luteinizing hormone-releasing factor (human); Luteinizing hormone-releasing factor (pig); Luteinizing hormone-releasing factor (rat); Luteinizing hormone-releasing factor (sheep); Luteinizing hormone-releasing factor (swine); Luteinizing hormone-releasing hormone (swin); Synthetic LH-FSH-RH; Synthetic decapeptide FSH/LH-RH; Follicle-stimulating hormone-releasing factor (pig); Gonadotropin, luteinizing hormone-releasing hormone, synthetic; Synthetic LH-RH/FSH-RH; Synthetic LH-releasing hormone/FSH-releasing hormone; PyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Indication

Amenorrhea; ICD 11: GA20.0; Status: Approved [1]; Hypothalamic hypogonadism; ICD 11: 5A61.2; Status: Approved [2]

• Therapeutic Class: Fertility Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Gonadorelin + Docetaxel	DCVR00C	Docetaxel	Prostate Cancer	[3]
Gonadorelin + EXISULIND	DCUFLUR	EXISULIND	Prostate Cancer	[4]
Gonadorelin + Bicalutamide	DCBGLV0	Bicalutamide	Prostate Cancer	[5]
LY2835219 + Gonadorelin	DC5BMCN	LY2835219	Early Breast Cancer	[6]
Gonadorelin + Arn-509	DCMQMZU	Arn-509	Prostate Cancer	[7]
Gonadorelin + Enzalutamide	DCXMZ7S	Enzalutamide	Prostatic Neoplasms	[8]

References

• [1] Gonadorelin FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4391).
• [3] ClinicalTrials.gov (NCT01603420) External Beam Radiation With or Without Chemotherapy to Treat High Risk Prostate Cancer
• [4] ClinicalTrials.gov (NCT00283803) Exisulind and Intermittent Androgen Suppression (ADT) in Biochemical Relapsed Prostate Cancer
• [5] ClinicalTrials.gov (NCT03141671) Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone and Apalutamide for Rising PSA After RP (FORMULA-509)
• [6] ClinicalTrials.gov (NCT04293393) Neoadjuvant Study Chemotherapy vs Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk Breast Cancer Patients
• [7] ClinicalTrials.gov (NCT03009981) A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer
• [8] ClinicalTrials.gov (NCT02446444) Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer