Details of the Drug Combinations

General Information of This Drug (ID: DMC0GSJ)

Drug Name
Efavirenz   DMC0GSJ
Synonyms
EFV; EFZ; Eravirenz; Stocrin; Sustiva; DMP 266; L 743726; DMP-266; L-741211; L-743725; L-743726; Stocrin (TN); Strocin (TM); Sustiva (TM); Sustiva (TN); Efavirenz (JAN/INN); L-743,726; Zoxazin-2-one; Efavirenz, (S)-isomer; Met-SDF-1.beta. & Efavirenz; Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz; (-)-Efavirenz; (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; (4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one; (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one; (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben; (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; (S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-(9; 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Arfolitixorin + Efavirenz DCEAQNF Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Efavirenz DCWZKT9 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Efavirenz DCPBPWX Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Efavirenz DCC5CGX Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Efavirenz DCH6F46 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Efavirenz DC3P5Y8 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Efavirenz DC06889 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Efavirenz DCMMEJP Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Efavirenz DCE6VMN Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + Efavirenz DCI7RWC Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Efavirenz DCZJ21Y Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Terazosin DCDGRZL Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Panobinostat DCH2OU4 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Efavirenz + Methotrexate DCZH4FN Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Acitretin DCBCNJH Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + IT-141 DCS2U8V IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Terameprocol DCPTDQ0 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Emetine DC991TM Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Phenprocoumon DCO9M6I Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Galantamine DCONP5F Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Bosentan DCBQAEL Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + PF-02545920 DCQKZ7T PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Bortezomib DCUYRU3 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Methylene blue DCQJ0I5 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Trimethobenzamide DCZSVMT Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Maprotiline DCFLRS1 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Eptifibatide DC11EA6 Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Sorafenib DCWMCX5 Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Chlormezanone DC0OW8R Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Doxorubicin DC31M2X Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Albendazole DC1D2OR Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Efavirenz DC42M8R Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Efavirenz DCVC6O9 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Efavirenz DCR037R Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Efavirenz DCTHAAJ JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Efavirenz DC1BK5E Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + Efavirenz DCTV9HY Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mecamylamine + Efavirenz DCOKFB5 Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Memantine + Efavirenz DCSFPPV Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Efavirenz DC1NJCI Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miglustat + Efavirenz DCC2ADD Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Efavirenz DC8OXH9 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Efavirenz DCWE9DF Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Olanzapine + Efavirenz DCZPS4W Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pamidronate + Efavirenz DCH4V9A Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pargyline + Efavirenz DCFFEMD Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Efavirenz DCLCKLS Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rufinamide + Efavirenz DC94CZ8 Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfapyridine + Efavirenz DC9UO1G Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Efavirenz DC2H6PR Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tindamax + Efavirenz DC9IFMG Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Efavirenz DCFU6CZ Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trifluoperazine + Efavirenz DC7WL3L Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Efavirenz DCOX1YK Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triiodothyronine + Efavirenz DCCGGIF Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Efavirenz DCS18SG Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Efavirenz DC0V6ID Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Zileuton + Efavirenz DCQ749A Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 58 DrugCom(s)
22 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Bedaquiline + Efavirenz DCBVRU8 Bedaquiline Tuberculosis [4]
Efavirenz + Pretomanid DC9WMNX Pretomanid Tuberculosis [5]
Efavirenz + Pitavastatin DCD1FIL Pitavastatin Hyperlipidemia [6]
Efavirenz + Rilpivirine DCQI5VE Rilpivirine HIV [7]
Efavirenz + KAF156 DC4K36Z KAF156 Malaria [8]
Levonorgestrel + Efavirenz DCEU4AK Levonorgestrel HIV [9]
Nevirapine + Efavirenz DCSMO90 Nevirapine HCV Infection. [10]
Rifampicin + Efavirenz DC1VXQW Rifampicin Tuberculosis [11]
Rifampicin + Efavirenz DCJUT3M Rifampicin HIV Infections [12]
Tenofovir disoproxil + Efavirenz DC5OIQZ Tenofovir disoproxil HIV [13]
Tenofovir disoproxil + Efavirenz DC4AW4F Tenofovir disoproxil HIV Infections [14]
Tenofovir disoproxil + Efavirenz DCA8U4I Tenofovir disoproxil HIV Infections [14]
Voriconazole + Efavirenz DCWQS8Z Voriconazole Efavirenz, Metabolism and Pharmacokinetics Changes [15]
Tenofovir + Efavirenz DC3BWC7 Tenofovir HIV Infections [16]
Tenofovir + Efavirenz DCK1LPD Tenofovir HIV-1 Infection [17]
Tenofovir + Efavirenz DCLY8CK Tenofovir HIV Infections [16]
Zidovudine + Efavirenz DCISV1I Zidovudine HIV-1 Infection [18]
Zidovudine + Efavirenz DCWUOC4 Zidovudine Malaria [19]
Stavudine + Efavirenz DCZFBRA Stavudine HIV [20]
Tenofovir + Efavirenz DCC72B6 Tenofovir HIV Infections [21]
Tenofovir disoproxil + Efavirenz DCZLM62 Tenofovir disoproxil HIV Infections [22]
Zidovudine + Efavirenz DC4FYY3 Zidovudine HIV [20]
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⏷ Show the Full List of 22 DrugCom(s)

References

1 Approved antiretroviral drugs. Antiretroviral Drugs. Company report of AVERT. 2009.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00992069) Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers
5 ClinicalTrials.gov (NCT01571414) Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin
6 ClinicalTrials.gov (NCT01695954) Pharmacokinetic Study of Pitavastatin and Ritonavir-Boosted Darunavir or Efavirenz
7 ClinicalTrials.gov (NCT01268839) A Phase I, Open-label Trial to Explore the Pharmacokinetics, Safety and Tolerability of TMC278 (Rilpivirine) 25 mg Once Daily Following a 2-week Period Receiving Efavirenz, in Healthy Male and Female Volunteers
8 ClinicalTrials.gov (NCT05330273) Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Efavirenz
9 ClinicalTrials.gov (NCT01789879) A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy
10 ClinicalTrials.gov (NCT01277627) Influence of Nevirapine on HCV Viral Load
11 ClinicalTrials.gov (NCT00495326) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)
12 ClinicalTrials.gov (NCT00802802) Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
13 ClinicalTrials.gov (NCT02404259) PK TDF in Thai HIV-infected Children
14 ClinicalTrials.gov (NCT00260078) Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
15 ClinicalTrials.gov (NCT01104376) Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers
16 ClinicalTrials.gov (NCT00350272) Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-naive Participants
17 ClinicalTrials.gov (NCT01489046) Safety, Efficacy and Dose-response Study of BMS-986001 in Subjects With HIV-1 Infection Who Are Treatment-naive
18 ClinicalTrials.gov (NCT01714414) A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen
19 ClinicalTrials.gov (NCT00993031) Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women
20 ClinicalTrials.gov (NCT00342355) Antiretroviral Therapy for Advanced HIV Disease in South Africa
21 ClinicalTrials.gov (NCT02945163) Dosing of Tenofovir and Efavirenz in Antiretroviral Therapy
22 ClinicalTrials.gov (NCT02935075) Optimization of Antiretroviral Therapy