Details of the Drug Combinations

General Information of This Drug (ID: DMCR1MV)

Drug Name

Itraconazole DMCR1MV

Synonyms

Canadiol; Hyphanox; ITCZ; ITZ; Intraconazole; Itraconazol; Itraconazolum; Itrizole; Oriconazole; Orungal; Prokanazol; Sempera; Spherazole; Sporal; Sporanos; Sporanox; Sporonox; Triasporn; Itraconazol [Spanish]; Itraconazole oral solution; Itraconazolum [Latin]; R 51211; Cis-Itraconazole; Itraconazole & Bovine Lactoferrin; Itraconazole & Nyotran; Itrizole (TN); R-51211; Sporanox (TN); Itraconazole & Nyotran(Liposomal Nystatin); Itraconazole (JAN/USAN); Oriconazole, R51211, Sporanox; Itraconazole [USAN:BAN:INN:JAN]; (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one; (1)-cis-4-(4-(4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-2-sec-butyl-3H-1,2,4-triazol-3-one; 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl); 4-(4-{4-[4-({[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}oxy)phenyl]piperazin-1-yl}phenyl)-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Indication

Disease Entry	ICD 11	Status	REF
Aspergillosis	1F20	Approved	[1]
Blastomycosis	1F22	Approved	[1]
Fungal infection	1F29-1F2F	Approved	[2]
Fusariosis	N.A.	Approved	[1]
Histoplasmosis	N.A.	Approved	[1]
Invasive candidiasis	1F23	Approved	[1]
Mycoses	1F2Z	Approved	[1]
Candidemia	1F23.3Y	Investigative	[1]
Esophageal candidiasis	N.A.	Investigative	[1]
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⏷ Show the Full List of Indication(s)

Therapeutic Class

Antifungal Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

78 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Itraconazole	DCNQ5DC	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Itraconazole	DCL0HWQ	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Itraconazole	DCNBTUB	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Itraconazole	DCKPDTV	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Itraconazole	DCOTVOR	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Carglumic acid + Itraconazole	DCZORZS	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Itraconazole	DCO1OON	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilostazol + Itraconazole	DC4XDZ8	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clopidogrel + Itraconazole	DCCVCJ9	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Desoxycorticosterone pivalate + Itraconazole	DCLEMOM	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diphenidol + Itraconazole	DCEXZZE	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Itraconazole	DCS6I8C	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Itraconazole	DC0UU8T	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GINKGOLIDE A + Itraconazole	DCBELAY	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GYKI-52466 + Itraconazole	DCZ0P4D	GYKI-52466	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Meclofenamic acid	DCNKCYF	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Lefaxin	DCFTPZ9	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Sertraline	DCUK556	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Mebutamate	DC16WOF	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Bepridil	DCIRWKS	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Clindamycin	DCRL3XB	Clindamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Dantrolene	DCPXO03	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Diethylcarbamazine	DC1DYPT	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Ruxolitinib	DCCOP01	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[3]
Itraconazole + Anamorelin	DC3Z5BB	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Triapine	DCYOGN3	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Rifampin	DC4571C	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + IT-141	DCP7TU3	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Isosorbide dinitrate	DCUHLZH	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Memantine	DC5JWUU	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Methoxsalen	DCPH593	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Galantamine	DCJZDG0	Galantamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + PF-02545920	DCQZDAW	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Tiagabine	DCBC83I	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Pargyline	DCM2TWG	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Idarubicin	DC3AO83	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Itraconazole + Imatinib	DCH297L	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Bortezomib	DC84RIN	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Moricizine	DCI2ZHU	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Clascoterone	DC6QV2N	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Maprotiline	DCO0S4U	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Eptifibatide	DC6UV0B	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Chlorambucil	DCYKG6G	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Acarbose	DCJ7EO0	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Brincidofovir	DCC8LM4	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Sorafenib	DC800LF	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Chloroquine	DCSGB6K	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Quinine	DCVT685	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Mycophenolic acid	DC3BJV6	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Doxorubicin	DCOHRE8	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + ML323	DCN9KN4	ML323	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Enoxacin	DCGAQ2A	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Azatadine	DCEFJYE	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Cytarabine	DCTJGQ7	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Kanamycin + Itraconazole	DCJ3NLI	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Itraconazole	DCL5AXH	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Itraconazole	DC6Y9RS	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lubiprostone + Itraconazole	DC3PC3O	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebendazole + Itraconazole	DC847E7	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Itraconazole	DC9R94I	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxandrolone + Itraconazole	DC7XYRX	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pepstatin + Itraconazole	DC84F4M	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phensuximide + Itraconazole	DCHX6UV	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Picoplatin + Itraconazole	DCE83Z6	Picoplatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Itraconazole	DC29K6P	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pizotyline + Itraconazole	DCU5ANF	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28870136-Compound-43 + Itraconazole	DCZL11P	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tacrine + Itraconazole	DCWD30E	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testosterone + Itraconazole	DCD0G67	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + Itraconazole	DC5FMR2	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Itraconazole	DCUS7NH	Tolvaptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trifluoperazine + Itraconazole	DCRQ5W8	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triflupromazine + Itraconazole	DC40T5G	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trioxsalen + Itraconazole	DCDXWDO	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ursodeoxycholic acid + Itraconazole	DCR5LSF	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Itraconazole	DCN8WJC	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Itraconazole	DCKKWN1	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zaleplon + Itraconazole	DCHNROA	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 78 DrugCom(s)

27 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esomeprazole + Itraconazole	DCRW12B	Esomeprazole	Achlorhydria	[4]
Itraconazole + Midostaurin	DC69NA5	Midostaurin	Acute Myeloid Leukemia	[5]
Itraconazole + Pemetrexed	DCRSO9C	Pemetrexed	Recurrent Non Small Cell Lung Cancer	[6]
Itraconazole + Hydroxychloroquine	DC273GQ	Hydroxychloroquine	Platinum-resistant Epithelial Ovarian Cancer	[7]
Itraconazole + Risdiplam	DC2TBRF	Risdiplam	Spinal Muscular Atrophy	[8]
Itraconazole + Mifepristone	DC5W95F	Mifepristone	Drug Interaction Potentiation	[9]
Itraconazole + Ecopipam	DCIZNOY	Ecopipam	Drug Interaction	[10]
Itraconazole + KAF156	DCMXVCB	KAF156	Malaria	[11]
Itraconazole + MLN8237	DCOHHDZ	MLN8237	Advanced Solid Tumors	[12]
Itraconazole + Ritonavir	DCPNBQ9	Ritonavir	HER2-positive Advanced Solid Tumor	[13]
Itraconazole + Fluconazole	DCQDFVA	Fluconazole	Tinea Versicolor	[14]
Itraconazole + Bay 80-6946	DCQHHEM	Bay 80-6946	Medical Oncology	[15]
Itraconazole + Fruquintinib	DCT8F95	Fruquintinib	Drug Drug Interaction	[16]
Itraconazole + Relugolix	DCTCVPY	Relugolix	Prostate Cancer	[17]
Itraconazole + CC-220	DCV7DHT	CC-220	Pharmacokinetics	[18]
Itraconazole + Tazemetostat	DCWVYM0	Tazemetostat	All Malignancies	[19]
Itraconazole + BAY 10-00394	DCXUGNE	BAY 10-00394	Medical Oncology	[20]
Lumacaftor + Itraconazole	DCTURSU	Lumacaftor	Cystic Fibrosis	[21]
MK-1775 + Itraconazole	DC0DPZ7	MK-1775	Advanced Solid Tumours	[22]
Rilapladib + Itraconazole	DCQ3ZVG	Rilapladib	Alzheimer's Disease	[23]
Savolitinib + Itraconazole	DCX85H4	Savolitinib	Solid Tumour	[24]
Talazoparib + Itraconazole	DCDSWL6	Talazoparib	Advanced Solid Tumors	[25]
Tesetaxel + Itraconazole	DCME3T7	Tesetaxel	Advanced Solid Tumors	[26]
Tucatinib + Itraconazole	DCX8YWU	Tucatinib	Drug-drug Interaction	[27]
Isotretinoin + Itraconazole	DCCXGFS	Isotretinoin	Tinea	[28]
Itraconazole + Terbinafine	DCO58NW	Terbinafine	Tinea Corporis	[29]
Itraconazole + Prednisolone	DC0XWW6	Prednisolone	Allergic Bronchopulmonary Aspergillosis	[30]
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⏷ Show the Full List of 27 DrugCom(s)

References

1	Itraconazole FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076104.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT04942652) Study to Evaluate Effects of Food or Proton Pump Inhibitor on the Pharmacokinetics of Itraconazole in Healthy Volunteers
5	ClinicalTrials.gov (NCT00045942) PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome (CPKC412A2104 Core); and PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome With Either Wild Type or Mutated FMS-like Tyrosine Kinase 3 (FLT3) (CPKC412A2104E1 and CPKC412A2104E2)
6	ClinicalTrials.gov (NCT00769600) Phase II Study of Itraconazole and Pemetrexed in Patients With Previously Treated Non-Squamous NSCLC
7	ClinicalTrials.gov (NCT03081702) A Study of the Safety, Tolerability and Effectiveness of Hydroxychloroquine and Itraconazole in Platinum-resistant Epithelial Ovarian Cancer
8	ClinicalTrials.gov (NCT02633709) A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers
9	ClinicalTrials.gov (NCT03259542) Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor
10	ClinicalTrials.gov (NCT06194864) Drug Interaction Study
11	ClinicalTrials.gov (NCT05084651) Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole
12	ClinicalTrials.gov (NCT02259010) A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of Alisertib in Participants With Advanced Solid Tumors or Relapsed/Refractory Lymphoma
13	ClinicalTrials.gov (NCT05150691) A Study of DB-1303 in Advanced/Metastatic Solid Tumors
14	ClinicalTrials.gov (NCT05862714) Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor
15	ClinicalTrials.gov (NCT02253420) COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients
16	ClinicalTrials.gov (NCT04557397) Fruquintinib CYP3A Inhibitor and Inducer Study
17	ClinicalTrials.gov (NCT05679388) A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients
18	ClinicalTrials.gov (NCT02820935) Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects
19	ClinicalTrials.gov (NCT04537715) Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer
20	ClinicalTrials.gov (NCT02457351) Roniciclib (BAY 1000394) Drug-Drug Interaction (DDI) Study
21	ClinicalTrials.gov (NCT01768663) A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
22	ClinicalTrials.gov (NCT04959266) A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib
23	ClinicalTrials.gov (NCT02130661) Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
24	ClinicalTrials.gov (NCT04121910) A Study to Evaluate the Amount of Drug That Becomes Available in the Blood Circulation When Savolitinib is Administered Alone and in Combination With Itraconazole
25	ClinicalTrials.gov (NCT03077607) A Study to Evaluate the Effect of Itraconazole and Rifampin on the Pharmacokinetics of Talazoparib in Patients With Advanced Solid Tumors
26	ClinicalTrials.gov (NCT04312282) The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors
27	ClinicalTrials.gov (NCT03723395) A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
28	ClinicalTrials.gov (NCT03471455) Isotretinoin In Preventing Recurrences In Chronic Recurrent Dermatophytosis
29	ClinicalTrials.gov (NCT05881980) Efficacy and Safety of Terbinafine and Itraconazole
30	ClinicalTrials.gov (NCT06174922) A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis