Details of the Drug Combinations

General Information of This Drug (ID: DMDMQIE)

Drug Name
THAPSIGARGIN   DMDMQIE
Synonyms
thapsigargin; 67526-95-8; UNII-Z96BQ26RZD; Z96BQ26RZD; CHEMBL96926; CHEBI:9516; OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

107 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + THAPSIGARGIN DC7U7NQ (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [1]
ABT-263 + THAPSIGARGIN DC78NLX ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
AEE-788 + THAPSIGARGIN DCW1BPE AEE-788 Ewing sarcoma (Cell Line: TC-71) [1]
AT7519 + THAPSIGARGIN DC4JUJ5 AT7519 Ewing sarcoma (Cell Line: TC-71) [1]
AZD8055 + THAPSIGARGIN DCCLX1Y AZD8055 Ewing sarcoma (Cell Line: TC-71) [1]
Bardoxolone methyl + THAPSIGARGIN DCRYJ82 Bardoxolone methyl Embryonal rhabdomyosarcoma (Cell Line: Rh36) [1]
Bardoxolone methyl + THAPSIGARGIN DCTJE1Y Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [1]
Bardoxolone methyl + THAPSIGARGIN DC6U8OG Bardoxolone methyl Ewing sarcoma (Cell Line: EW-8) [1]
Bardoxolone methyl + THAPSIGARGIN DCHKUJG Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [1]
BIIB-021 + THAPSIGARGIN DCQ31VZ BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
BIX-01294 + THAPSIGARGIN DCTL2VR BIX-01294 Ewing sarcoma (Cell Line: TC-71) [1]
BIX-01294 + THAPSIGARGIN DCEJJHR BIX-01294 Hodgkin lymphoma (Cell Line: U-HO1) [2]
BMS-754807 + THAPSIGARGIN DCHFFHD BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
BMS-754807 + THAPSIGARGIN DC5CYDL BMS-754807 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
CA4P + THAPSIGARGIN DCOGAGW CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Cantharidin + THAPSIGARGIN DCKZCV8 Cantharidin Ewing sarcoma (Cell Line: TC-71) [1]
Carfilzomib + THAPSIGARGIN DCNDRHF Carfilzomib Ewing sarcoma (Cell Line: TC-71) [1]
CUDC-101 + THAPSIGARGIN DCENVKB CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
CUDC-101 + THAPSIGARGIN DCNE1B3 CUDC-101 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
Dasatinib + THAPSIGARGIN DCYCJ4J Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Dasatinib + THAPSIGARGIN DC091YZ Dasatinib Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
Decitabine + THAPSIGARGIN DC2MEGX Decitabine Ewing sarcoma (Cell Line: TC-71) [1]
Etoposide + THAPSIGARGIN DCDCQUD Etoposide Ewing sarcoma (Cell Line: TC-71) [1]
Evacetrapib + THAPSIGARGIN DC98C7R Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
Everolimus + THAPSIGARGIN DCSOD22 Everolimus Ewing sarcoma (Cell Line: TC-71) [1]
Flavopiridol + THAPSIGARGIN DCU7OTF Flavopiridol Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Formononetin + THAPSIGARGIN DCCH2S6 Formononetin Ewing sarcoma (Cell Line: TC-71) [1]
Fostamatinib + THAPSIGARGIN DCNRAB0 Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
GDC-0084 + THAPSIGARGIN DCU0VM6 GDC-0084 Ewing sarcoma (Cell Line: TC-71) [1]
GDC-0980/RG7422 + THAPSIGARGIN DC3EMQ0 GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
GSK618334 + THAPSIGARGIN DCQG3R2 GSK618334 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
IMD-0354 + THAPSIGARGIN DCHEFHB IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Ispinesib + THAPSIGARGIN DCNRLFG Ispinesib Ewing sarcoma (Cell Line: TC-71) [1]
JQ1 + THAPSIGARGIN DC9J1WC JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
JQ1 + THAPSIGARGIN DCG95YV JQ1 Ewing sarcoma (Cell Line: TC-71) [1]
LY2523355 + THAPSIGARGIN DCT6GQG LY2523355 Ewing sarcoma (Cell Line: TC-71) [1]
LY2874455 + THAPSIGARGIN DCHLTPJ LY2874455 Ewing sarcoma (Cell Line: TC-71) [1]
Mebendazole + THAPSIGARGIN DC3DDUZ Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Mebendazole + THAPSIGARGIN DC68PZP Mebendazole Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
Mitomycin + THAPSIGARGIN DCHU26C Mitomycin Ewing sarcoma (Cell Line: TC-71) [1]
MK-1775 + THAPSIGARGIN DCS3FO4 MK-1775 Ewing sarcoma (Cell Line: TC-71) [1]
MK-2206 + THAPSIGARGIN DCADMA4 MK-2206 Ewing sarcoma (Cell Line: TC-71) [1]
MK-2206 + THAPSIGARGIN DCHUE4W MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [1]
NVP-AUY922 + THAPSIGARGIN DCAHWRZ NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [1]
Palbociclib + THAPSIGARGIN DC7PZ53 Palbociclib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Palbociclib + THAPSIGARGIN DCONAT1 Palbociclib Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
Panobinostat + THAPSIGARGIN DC40UE9 Panobinostat Ewing sarcoma (Cell Line: TC-71) [1]
Parthenolide + THAPSIGARGIN DCB3GZR Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
PD-0325901 + THAPSIGARGIN DC4296D PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
PD-0325901 + THAPSIGARGIN DCVZCFW PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
PD-0325901 + THAPSIGARGIN DCIAW22 PD-0325901 Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-04691502 + THAPSIGARGIN DC33LQL PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
PF-04691502 + THAPSIGARGIN DCBJEA7 PF-04691502 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
PF-3758309 + THAPSIGARGIN DCI0Y15 PF-3758309 Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + THAPSIGARGIN DCR3KU9 PF-562271 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
PHA-739358 + THAPSIGARGIN DCWB9NV PHA-739358 Ewing sarcoma (Cell Line: TC-71) [1]
PMID25656651-Compound-5 + THAPSIGARGIN DC8VOMV PMID25656651-Compound-5 Ewing sarcoma (Cell Line: TC-71) [1]
Romidepsin + THAPSIGARGIN DCAUEF3 Romidepsin Ewing sarcoma (Cell Line: EW-8) [1]
Romidepsin + THAPSIGARGIN DC3I5NE Romidepsin Ewing sarcoma (Cell Line: TC-71) [1]
Romidepsin + THAPSIGARGIN DCXAIY5 Romidepsin Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
Romidepsin + THAPSIGARGIN DCTZ6X3 Romidepsin Hodgkin lymphoma (Cell Line: U-HO1) [2]
RTB101 + THAPSIGARGIN DCY7G9P RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
RTB101 + THAPSIGARGIN DC5OWWA RTB101 Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
SNDX-275 + THAPSIGARGIN DCTAK3P SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
Steroid derivative 1 + THAPSIGARGIN DCK6OL7 Steroid derivative 1 Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Gefitinib DCGSUIN Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Gefitinib DCGMGCM Gefitinib Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
THAPSIGARGIN + Buparlisib DCG1ESX Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Buparlisib DCXROIL Buparlisib Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Ruxolitinib DCQ8JL5 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [1]
THAPSIGARGIN + Carfilzomib DCILW5C Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Artemether DCQUIUI Artemether Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Ixazomib DCA9N31 Ixazomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Eltanexor oral DCTV9J6 Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Everolimus DCC6Z63 Everolimus Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + LY2835219 DCTD8U8 LY2835219 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Lenvatinib DCJ6HGL Lenvatinib Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Selumetinib DCVOXN4 Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Cantharidin DCBGZCT Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Exherin DC7TYPE Exherin Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Plinabulin DCIUJ8G Plinabulin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Docetaxel DCXQ8IS Docetaxel Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Etoposide DCBG6PS Etoposide Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Marizomib DCHNST4 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Chloroxine DCBSMVM Chloroxine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Chloroxine DCET5EB Chloroxine Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
THAPSIGARGIN + Mifepristone DCT1YLE Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Niclosamide DC220SV Niclosamide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Niclosamide DC5EZO6 Niclosamide Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
THAPSIGARGIN + Tamoxifen DC5HNSW Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Tamoxifen DCH3NF2 Tamoxifen Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
THAPSIGARGIN + ONC201 DCHE69R ONC201 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Ciclopirox DCPJ8TQ Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Bardoxolone methyl DCPH2XA Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + BMS-754807 DC5E51X BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Prazosin DCL9I1D Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Romidepsin DCS8JQ5 Romidepsin Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Bafilomycin A1 DCM6BM8 Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
THAPSIGARGIN + Mefloquine DCMTDJ0 Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Mefloquine DCA718A Mefloquine Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
THAPSIGARGIN + Doxorubicin DCSTQVR Doxorubicin Ewing sarcoma (Cell Line: TC-71) [1]
THAPSIGARGIN + Auranofin DCC1CT0 Auranofin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
THAPSIGARGIN + Auranofin DCU3QFD Auranofin Primitive neuroectodermal tumor (Cell Line: TC-32) [1]
Tivantinib + THAPSIGARGIN DCQZU6W Tivantinib Ewing sarcoma (Cell Line: TC-71) [2]
Trametinib + THAPSIGARGIN DCMEWB8 Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Verteporfin + THAPSIGARGIN DCM7OGP Verteporfin Ewing sarcoma (Cell Line: TC-71) [1]
Ym155 + THAPSIGARGIN DCGESH1 Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [1]
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⏷ Show the Full List of 107 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.