Details of the Drug Combinations

General Information of This Drug (ID: DMDO279)

Drug Name

Phenprocoumon DMDO279

Synonyms

Falithiom; Falithrom; Fencumar; Fenprocoumona; Fenprocumon; Fenprocumone; Liquamar; Marcoumar; Marcumar; Marcuphen; Phenprocoumalol; Phenprocoumarol; Phenprocoumarole; Phenprocoumone; Phenprocoumonum; Phenprocumone; Phenprocumonum; Phenprogramma; Phenylpropylhydroxycumarinum; Fenprocumone [DCIT]; Hexal Brand of Phenprocoumon; Roche Brand of Phenprocoumon; Worwag Brand of Phenprocoumon; U29342; Falithrom (TN); Fenprocoumona [INN-Spanish]; Liquamar (TN); Marcoumar (TN); Marcumar (TN); Phenprocoumone [INN-French]; Phenprocoumonum [INN-Latin]; Ro 1-4849; Phenprocoumon (USAN/INN); Phenprocoumon [USAN:INN:BAN]; 2-hydroxy-3-(1-phenylpropyl)chromen-4-one; 3-(1'-Phenyl-propyl)-4-oxycoumarin; 3-(1'-Phenyl-propyl)-4-oxycoumarin [German]; 3-(1-Phenylpropyl)-4-hydroxycoumarin; 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin; 3-(alpha-Phenylpropyl)-4-hydroxycoumarin; 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one

Indication

Disease Entry	ICD 11	Status	REF
Myocardial infarction	BA41-BA43	Approved	[1]
Thrombosis	DB61-GB90	Approved	[2]
Venous thromboembolism	BD72	Investigative	[1]
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Therapeutic Class

Anticoagulants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amodiaquine + Phenprocoumon	DCO9ECE	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Phenprocoumon	DCQ9HXF	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Phenprocoumon	DCE4MOQ	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Phenprocoumon	DCI8L5R	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Phenprocoumon	DCCJNZB	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cisatracurium + Phenprocoumon	DCM3VZO	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clascoterone + Phenprocoumon	DCCMBV7	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Phenprocoumon	DCLJXGP	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Phenprocoumon	DCHSOWK	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Phenprocoumon	DC2GK7Q	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Efavirenz + Phenprocoumon	DCO9M6I	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Entacapone + Phenprocoumon	DCWI33G	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etonogestrel + Phenprocoumon	DC5CDN9	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Phenprocoumon	DCF1C6Z	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fenoprofen + Phenprocoumon	DC5QKEP	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Phenprocoumon	DC4ADZY	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GINKGOLIDE A + Phenprocoumon	DC1HT2Z	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Phenprocoumon	DCYZ8QQ	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Phenprocoumon	DCWVSJO	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
JZL195 + Phenprocoumon	DCD5VXP	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Phenprocoumon	DCLKVS8	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Linagliptin + Phenprocoumon	DC05LBF	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metaxalone + Phenprocoumon	DC9ZKE9	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Phenprocoumon	DCYW9SW	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pazopanib HCl + Phenprocoumon	DC38S1L	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pepstatin + Phenprocoumon	DCIUZKM	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Aprepitant	DCA1DL1	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Mebutamate	DC6AUP2	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Epinephrine	DCO0HH6	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Panobinostat	DCSQ2KW	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Phenprocoumon + Carglumic acid	DCBJS8S	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Pentamidine	DCLX0OX	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Niclosamide	DCSA9U2	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + PF-02545920	DCJX8Q9	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Norcisapride	DCXDGAM	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Tiagabine	DCUULAN	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Bortezomib	DC0Z9FZ	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Hyodeoxycholic acid	DCBS1I6	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Mycophenolic acid	DCE5DND	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Mefloquine	DCX35IZ	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Fosfomycin	DCVOJ8B	Fosfomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Olmesartan medoxomil	DCW27HK	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Auranofin	DC4SDAF	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Vorinostat	DCUYIBX	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Cerivastatin	DCC1GJC	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + Tetracycline	DC6ZCCY	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Phenprocoumon	DCKK30R	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Phenprocoumon	DCT8OLQ	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Phenprocoumon	DCS3PBR	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfapyridine + Phenprocoumon	DCZ3TKU	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Phenprocoumon	DC5TV8P	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terazosin + Phenprocoumon	DCQIB45	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Phenprocoumon	DCFIY0C	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Phenprocoumon	DC8S19P	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trimethobenzamide + Phenprocoumon	DCWJ3CV	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Phenprocoumon	DC1YFAE	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
WAY-100635 + Phenprocoumon	DCPSAY9	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 57 DrugCom(s)

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Phenprocoumon + Acenocoumarol	DC2E6KU	Acenocoumarol	Atrial Fibrillation	[4]
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References

1	Phenprocoumon FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6839).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT02942576) Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation