Details of the Drug Combinations

General Information of This Drug (ID: DMEV954)

Drug Name
Sulfinpyrazone   DMEV954
Synonyms
Anturan; Anturane; Anturanil; Anturano; Anturen; Anturidin; Diphenylpyrazone; Enturan; Enturen; Novopyrazone; Sulfinpirazona; Sulfinpyrazine; Sulfinpyrazon; Sulfinpyrazonum; Sulfoxyphenylpyrazolidin; Sulfoxyphenylpyrazolidine; Sulphinpyrazone; Apo Sulfinpyrazone; Apotex Brand of Sulfinpyrazone; Novartis Brand of Sulfinpyrazone; Nu Pharm Brand of Sulfinpyrazone; Nu Sulfinpyrazone; G 28315; Anturane (TN); Apo-Sulfinpyrazone; G 28,315; Nu-Pharm Brand of Sulfinpyrazone; Nu-Sulfinpyrazone; Sulfinpirazona [INN-Spanish]; Sulfinpyrazone (SPZ); Sulfinpyrazonum [INN-Latin]; USAF GE-13; Sulfinpyrazone [USAN:INN:JAN]; Sulfinpyrazone (JP15/USP/INN); (+/-)-SULFINPYRAZONE; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin [German]; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl) pyrazolidine; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine; 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione; 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione; 4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Approved [1]
Therapeutic Class
Uricosuric Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

51 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Sulfinpyrazone DCLE7T8 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Sulfinpyrazone DCP40UN Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Sulfinpyrazone DCWD31D Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Sulfinpyrazone DCNJCQC Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Daidzin + Sulfinpyrazone DCVRAQH Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dexmedetomidine + Sulfinpyrazone DCYFGMG Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diphenidol + Sulfinpyrazone DCLUK46 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Sulfinpyrazone DCBETH2 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Sulfinpyrazone DCA3IET Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hydralazine + Sulfinpyrazone DCTJY5N Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lacosamide + Sulfinpyrazone DC99BZH Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Sulfinpyrazone DCGH8OV Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Sulfinpyrazone DC6VIE1 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oseltamivir + Sulfinpyrazone DCOL71V Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Sulfinpyrazone DC0P334 PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Ribavirin-TP DCO6TBV Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Dantrolene DC6TSF5 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Diethylcarbamazine DC00VHB Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Methotrexate DC29EQU Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Fomepizole DCHYSXO Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Testosterone DCUS0XL Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Flavonoid derivative 1 DCI9LVY Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Emetine DCELZBV Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + K-134 DCP4QK2 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Methoxsalen DC2UZRR Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Aminosalicylic acid DCR9YX3 Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Nizatidine DCL8XQL Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Triflupromazine DCA4LVP Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Norcisapride DCR9OXX Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Tiagabine DCCVLFD Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Allopurinol DCUHWZ9 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Imatinib DCRB2S2 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Moricizine DC5WZMM Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Maprotiline DCDQOX1 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Leflunomide DCXZOXZ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Brincidofovir DCEAS36 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Hydralazine DCBUD2X Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Mefloquine DCCM02Q Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Doxorubicin DC4T8EJ Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + PMID28870136-Compound-43 DCXDIWN PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Cerivastatin DCKQGP7 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + AS-1949490 DC8HE9M AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + Cytarabine DCVY0SZ Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrolimus + Sulfinpyrazone DCJBTG6 Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Sulfinpyrazone DC3KPP1 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Sulfinpyrazone DC2XW1G Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + Sulfinpyrazone DC65B6L Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trifluoperazine + Sulfinpyrazone DCASK4E Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Sulfinpyrazone DC4NE6C Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Sulfinpyrazone DC1KXKQ Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Sulfinpyrazone DCQL3ZB WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 51 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5826).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.