Details of the Drug Combinations

General Information of This Drug (ID: DMFGLXB)

Drug Name
Phensuximide   DMFGLXB
Synonyms
Phensuximide; Milontin; Succitimal; Lifene; Phenylsuximide; Epimid; Fensuccimide; Fenosuccimide; Phensuximidum; 86-34-0; phensuccimide; Fensuximida; Phensuximid; Methylphenylsuccinimide; Fensuccimide [DCIT]; Succinimide, N-methyl-2-phenyl-; Phensuximidum [INN-Latin]; Fensuximida [INN-Spanish]; 1-methyl-3-phenylpyrrolidine-2,5-dione; Mirontin; Milonton; N-Methyl-alpha-phenylsuccinimide; PM 334; N-Methyl-2-phenylsuccinimide; Milontin (TN); 1-Methyl-3-phenylpyrrolidin-2,5-dione; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; EINECS 201-664-6
Indication
Disease Entry ICD 11 Status REF
Absence epilepsy N.A. Approved [1]
Epilepsy 8A60-8A68 Approved [1]
Seizure disorder 8A6Z Approved [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

74 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
10-hydroxycamptothecin + Phensuximide DCQ5M3D 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acitretin + Phensuximide DCGZD54 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Amiloride + Phensuximide DCAOCCB Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Anamorelin + Phensuximide DCAISCK Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Phensuximide DCTWV3V Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Auranofin + Phensuximide DC66FXU Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Phensuximide DCK096I BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chloroquine + Phensuximide DCWM4GX Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Phensuximide DC8GTD3 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dactinomycin + Phensuximide DC5WJ0S Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Daidzin + Phensuximide DCP0J3R Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dexmedetomidine + Phensuximide DCSO5IW Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Phensuximide DCHH1G2 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dopamine + Phensuximide DCKDKDZ Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Phensuximide DC8TPMZ Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Endoxifen + Phensuximide DC9F5L7 Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Phensuximide DCCZKK9 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
ETHISTERONE + Phensuximide DCY0E29 ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Phensuximide DCZAKKG Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fenoprofen + Phensuximide DCEHFH3 Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Phensuximide DCXCTHH Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hyodeoxycholic acid + Phensuximide DCU3Z19 Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imatinib + Phensuximide DCHPPU0 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
L-165041 + Phensuximide DCX6HU1 L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maraviroc + Phensuximide DC4GQFZ Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mefloquine + Phensuximide DCE6YJW Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metaxalone + Phensuximide DCT5F34 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methotrexate + Phensuximide DCCVTBB Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Phensuximide DC6LLAN Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Miglustat + Phensuximide DCG808H Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Phensuximide DCTFOLI Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pentostatin + Phensuximide DCEC1K4 Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Aprepitant DCZ2OPN Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Ribavirin-TP DCMQ4U0 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Sertraline DCI4BBL Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Gefitinib DC3072W Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Dantrolene DCCF7PH Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Dihydroergotamine DCY48WT Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Fomepizole DCHRQVR Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Triapine DC6ZIK3 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Buspirone DCA7VO9 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Metyrosine DCWMNVD Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Itraconazole DCHX6UV Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Chlorzoxazone DCX2X61 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Sitagliptin DC0V1YC Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Eflornithine DC1ZMIC Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Norcisapride DC19MI1 Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Fenoprofen DCWSO1C Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Idarubicin DC150DB Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Idarubicin DCFAMO3 Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Phensuximide + Probenecid DCOB4BR Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Artemisinin DCW6R72 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Trimethobenzamide DCN8LK4 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Maprotiline DC2VZDN Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Leflunomide DCHX625 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Brincidofovir DC9ORXH Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Amantadine DC41COW Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Quinine DCHRLXQ Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Chlormezanone DCRI83L Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Mycophenolic acid DCU4IUY Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Cisatracurium DC7TY8V Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Olmesartan medoxomil DCCSWEV Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Cevimeline DCSCYQ2 Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + Metaxalone DCEB8T1 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phensuximide + AS-1949490 DC0OA7K AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Phensuximide DCHXXPO Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Phensuximide DCAMRF8 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ramelteon + Phensuximide DCQDZCI Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rifampin + Phensuximide DCIEQCS Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
SCH 727965 + Phensuximide DCFETI2 SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sorafenib + Phensuximide DC72YME Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triamterene + Phensuximide DCKGUTS Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ursodeoxycholic acid + Phensuximide DC2719Q Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vorinostat + Phensuximide DCV171R Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 74 DrugCom(s)

References

1 Phensuximide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7612).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.