Details of the Drug Combinations

General Information of This Drug (ID: DMG592Q)

Drug Name

Solifenacin DMG592Q

Synonyms

Vesicare; Vesikur; Solifenacin succinate; Solifenacin succinate [USAN]; YM 905; Solifenacin (INN); Solifenacin [INN:BAN]; Vesicare (TN); YM-53705; YM-67905; YM-905; Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylatemonosuccinate; [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; Butanedioic acid, compd with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1); Butanedioic acid, cmpd. with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1); 1-azabicyclo[2.2.2]oct-8-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; 1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo(2.2.2)oct-3-yl ester, (1S)-, butanedioate (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Approved	[1]
Priapism	N.A.	Investigative	[2]
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Therapeutic Class

Antispasmodics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Solifenacin + Mirabegron	DC59FGX	Mirabegron	Overactive Bladder	[3]
Tamsulosin + Solifenacin	DCKLHEQ	Tamsulosin	LUTS	[4]
Solifenacin + Solifenacin	DCZRT6E	Solifenacin	Urge Urinary Incontinence	[5]
Solifenacin + Tadalafil	DC89HDS	Tadalafil	Benign Prostatic Hyperplasia	[6]
Solifenacin + Mirabegron	DCXDZR6	Mirabegron	Overactive Bladder (OAB)	[7]
Tamsulosin + Solifenacin	DCDHYLX	Tamsulosin	Lower Urinary Tract Symptoms	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7483).
2	Solifenacin FDA Label
3	ClinicalTrials.gov (NCT01745094) A Study to Evaluate the Effect of Mirabegron + Solifenacin in Overactive Bladder Patients
4	ClinicalTrials.gov (NCT02180997) Clinical Trial to Investigate the Pharmacokinetic Drug Interaction Between Solifenacin and Tamsulosin
5	ClinicalTrials.gov (NCT01166438) Anticholinergic vs. Botox Comparison Study
6	ClinicalTrials.gov (NCT05494567) Efficacy of Tadalafil/Solifenacin VS Tamsulosin/Solifenacin Combination Therapy for BPH/OAB
7	ClinicalTrials.gov (NCT02294396) Postmarketing Study to Evaluate add-on Therapy With Anticholinergics in Patients With Overactive Bladder (OAB) on Mirabegron.
8	ClinicalTrials.gov (NCT02715024) Study to Evaluate the Clinical Efficacy and Safety of Tamsulosin Alone or in Combination With Solifenacin for the Treatment in Men With Lower Urinary Tract Symptoms Including Overactive Bladder Symptoms