Details of the Drug Combinations

General Information of This Drug (ID: DMHKS94)

• Drug Name: Valaciclovir (DMHKS94)
• Synonyms: Talavir; VACV; ValACV; Valacyclovir; Virval; Zelitrex; Valaciclovir Hcl; Valacyclover Hydrochloric; Valacyclover Hydrochloride; BW256U87; TBB067866; Acyclovir-valine; BW-256U; Valaciclovir (INN); Valaciclovir [INN:BAN]; Valaciclovir, Valtrex; Valtrex (TN); Zelitrex (TN); Valacyclovir, (L)-isomer; L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine; L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester; L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)methoxy]ethyl ester, monohydrochloride; 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate; 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate; 2-{[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]oxy}ethyl L-valinate

Indication

Genital herpes; ICD 11: 1A94; Status: Approved [1]; Herpes simplex labialis; ICD 11: 1F00.01; Status: Approved [2]; Varicella; ICD 11: 1E90; Status: Approved [3]; Virus infection; ICD 11: 1A24-1D9Z; Status: Approved [4]

• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Valaciclovir + Ruxolitinib	DC78DKN	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[5]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Isotretinoin + Valaciclovir	DC9GYYF	Isotretinoin	Acne Scars - Mixed Atrophic and Hypertrophic	[6]
Valaciclovir + Temozolomide	DCKH3I8	Temozolomide	Malignant Glioma	[7]
Valaciclovir + Sorivudine	DCKT8ES	Sorivudine	Herpes Zoster	[8]
Valaciclovir + Temozolomide	DCL6RSK	Temozolomide	Glioma, Malignant	[9]

References

• [1] Interventions for men and women with their first episode of genital herpes. Cochrane Database Syst Rev. 2016 Aug 30;2016(8):CD010684.
• [2] Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. 2015 Aug 7;2015(8):CD010095.
• [3] Chickenpox. BMJ Clin Evid. 2011 Apr 11;2011:0912.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4824).
• [5] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [6] ClinicalTrials.gov (NCT03514771) Early Non-Ablative Fractional Laser Resurfacing for Acne Scars After Treatment With Oral Isotretinoin
• [7] ClinicalTrials.gov (NCT00589875) Phase 2a Study of AdV-tk With Standard Radiation Therapy for Malignant Glioma (BrTK02). U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT00652184) Study to Compare Efficacy of Topical ARYS-01 (Sorivudine) Cream 3%, Oral Valaciclovir and Combination ARYS-01 Cream 3%/Oral Valaciclovir for Treatment of Herpes Zoster (Shingles)
• [9] ClinicalTrials.gov (NCT03576612) GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas