Details of the Drug Combinations

General Information of This Drug (ID: DMIK367)

Drug Name
Procarbazine   DMIK367
Synonyms
Ibenzmethyzin; Ibenzmethyzine; MBH; MIH; Natulan; Natulanar; PCX; Procarbazin; Procarbazina; Procarbazinum; Procarbazin [German]; Procarbazine Monohydrochloride; CB 400-497; Indicarb (TN); Matulane (TN); Natulan (TN); Procarbazina [INN-Spanish]; Procarbazine (INN); Procarbazine [INN:BAN]; Procarbazinum [INN-Latin];Ro 4-6467; SRI-10847; Ro 4-6467/1; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; P-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide; P-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide; N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-(9CI); 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
Indication
Disease Entry ICD 11 Status REF
Hodgkin lymphoma 2B30 Approved [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

52 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Arfolitixorin + Procarbazine DCAAKQB Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Procarbazine DCBMRGX Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Procarbazine DCIDSTK Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Procarbazine DCF8H6J Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Procarbazine DC66EXL Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Procarbazine DCO3VOQ Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Desoxycorticosterone pivalate + Procarbazine DCCA86A Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Procarbazine DCQ79FX Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Procarbazine DCO20M1 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Procarbazine DCTTTIO IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Procarbazine DC5WEBT Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Procarbazine DC7W5P7 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Moricizine + Procarbazine DCQHVYF Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Procarbazine DCEXOAO Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + Procarbazine DCP1FPY Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Procarbazine DCRWJBC Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Procarbazine DCN9YBD PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pomalidomide + Procarbazine DCRDZTZ Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Triiodothyronine DCUZ1OL Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Aliskiren DCITIN8 Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Diethylcarbamazine DC8X3I1 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Terazosin DCWXKD9 Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Miglustat DCLMWWX Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Vinblastine DCI87W6 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Acitretin DC99MFK Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Methylergonovine DC5SO63 Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Terameprocol DCHDZWU Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Emetine DCECIHU Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Carglumic acid DCIDY1R Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Docetaxel DCUKVG5 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Zaleplon DCD32FY Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + PFK-158 DC9EA85 PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Triflupromazine DCHCRTO Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + BIO-300 DCZEGC0 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Niclosamide DCCRSHV Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Diazoxide DC71PVO Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Fenoprofen DCUXTNB Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Idarubicin DCX82IP Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Probenecid DCHEEWJ Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Maprotiline DCTNH7W Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Leflunomide DCYLPQA Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Hyodeoxycholic acid DC2DZCS Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Chlormezanone DCYXYW2 Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Mycophenolic acid DCPIOTM Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Iloprost DCKN3W0 Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Auranofin DCGZDXZ Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Vorinostat DCIRVXF Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Nitrosoglutathione DCIWV99 Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Procarbazine DC5HQ9Q Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sorafenib + Procarbazine DCC1WC7 Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Procarbazine DCW7NX8 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Theophylline + Procarbazine DCSO885 Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 52 DrugCom(s)
5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Isotretinoin + Procarbazine DC1HX12 Isotretinoin Brain and Central Nervous System Tumors [3]
Thioguanine + Procarbazine DCZBFOJ Thioguanine Brain Tumors [4]
Methotrexate + Procarbazine DC04JPN Methotrexate Chemotherapeutic Agent Toxicity [5]
Procarbazine + Vincristine DC487YF Vincristine Brain and Central Nervous System Tumors [6]
Procarbazine + Vincristine DC98V7V Vincristine Brain and Central Nervous System Tumors [7]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7278).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT00003564) Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas
4 ClinicalTrials.gov (NCT00002944) Combination Chemotherapy in Treating Children With Progressive Brain Tumors
5 ClinicalTrials.gov (NCT01399372) Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma
6 ClinicalTrials.gov (NCT00002806) Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma
7 ClinicalTrials.gov (NCT00002569) Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma