Details of the Drug Combinations

General Information of This Drug (ID: DMINO7Z)

Drug Name

Perhexiline DMINO7Z

Synonyms

Perhexilene; Perhexilina; Perhexilinum; Perhexilline; Perhexilina [INN-Spanish]; Perhexiline (INN); Perhexiline [INN:BAN]; Perhexilinum [INN-Latin]; (+)-2-(2,2-Dicyclohexylethyl)piperidine; (-)-2-(2,2-Dicyclohexylethyl)piperidine; 2-(2,2-Dicyclohexylethyl)piperidine

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Approved	[1]
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Therapeutic Class

Vasodilator Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Artemether + Perhexiline	DCYSTON	Artemether	DD2 (Cell Line: DD2)	[2]
Artemether + Perhexiline	DCIEO6L	Artemether	Hepatoblastoma (Cell Line: HB3)	[2]
NITD609 + Perhexiline	DC9WWBO	NITD609	Hepatoblastoma (Cell Line: HB3)	[3]
Perhexiline + Artemisinin	DC2P7R8	Artemisinin	DD2 (Cell Line: DD2)	[2]
Perhexiline + Chloroquine	DC1VO1J	Chloroquine	DD2 (Cell Line: DD2)	[2]
Perhexiline + Piperaquine	DC8FN67	Piperaquine	DD2 (Cell Line: DD2)	[2]
Perhexiline + Ruxolitinib	DCNCVAE	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Perhexiline + Chloroquine	DCYD99P	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]
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⏷ Show the Full List of 8 DrugCom(s)

References

1	Perhexiline. Cardiovasc Drug Rev. 2007 Spring;25(1):76-97.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.