Details of the Drug Combinations

General Information of This Drug (ID: DMIOGBU)

• Drug Name: Bosentan (DMIOGBU)
• Synonyms: Actelion; Bosentanum; Tracleer; Bosentan (INN); KS-5062; Ro 47-0203; Tracleer (TN); Bosentan [USAN:INN:BAN]; Ro 47-0203/039; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039; P-tert-Butyl-N-[6-(2-hydroxyethoxy); P-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide; 4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

Indication

Pulmonary arterial hypertension; ICD 11: BB01.0; Status: Approved [1]; Pulmonary hypertension; ICD 11: BB01; Status: Approved [2]; Scleroderma; ICD 11: 4A42; Status: Investigative [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

52 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Bosentan	DC6W59P	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetazolamide + Bosentan	DC3MY34	Acetazolamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Bosentan	DCHFDZO	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Pentostatin	DCVITCU	Pentostatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Bepridil	DC8Y0LF	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Testosterone	DCEQNDY	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Triapine	DCDG949	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Pepstatin	DCPCZ53	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + IT-141	DCV09QX	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Metyrosine	DCS4B4D	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Terameprocol	DC4NM7D	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Chlorzoxazone	DCNEDFK	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Pazopanib	DCX0KT7	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + WAY-100635	DC4VTNF	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Dichlorphenamide	DCKV9IV	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Arfolitixorin	DCFDOE7	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Niclosamide	DCZIEZU	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Lubiprostone	DC4Q46F	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Trazodone	DCER7QL	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Entacapone	DCD4AFD	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Idarubicin	DCK7ORX	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Methylene blue	DCOJYBD	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Cefmenoxime	DC9QK69	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Maprotiline	DC2VBMA	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Leflunomide	DCHSAOD	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Brincidofovir	DCH3W8M	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Hyodeoxycholic acid	DC1X21S	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Endoxifen	DC21UOZ	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Cisatracurium	DC1C0DG	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Doxorubicin	DCVFG4D	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Auranofin	DC4W1O8	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Cerivastatin	DCHA3K8	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Cytarabine	DCLZDNO	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Bosentan	DCUBLLJ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cycloguanil + Bosentan	DCPGAAL	Cycloguanil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Bosentan	DCMJLPF	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Efavirenz + Bosentan	DCBQAEL	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Bosentan	DCOUN8T	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Bosentan	DCQWWM1	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Estramustine + Bosentan	DCRX9BN	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Bosentan	DCQNFAA	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Bosentan	DCSK3Z6	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Bosentan	DCHAF3I	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lithium Citrate + Bosentan	DCEGMYL	Lithium Citrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebutamate + Bosentan	DC8X5HA	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mephenytoin + Bosentan	DCYQQJH	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Bosentan	DC6W7L3	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Naringenin + Bosentan	DCUGBAC	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Bosentan	DC97R26	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Bosentan	DCA1VMD	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Bosentan	DCB3GPZ	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Bosentan	DCXLHRT	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bosentan + Alprostadil	DCQ9UT1	Alprostadil	Raynaud's Phenomenon	[4]
Bosentan + Iloprost	DCVW4L7	Iloprost	Pulmonary Arterial Hypertension	[5]
Lurbinectedin + Bosentan	DCSVAAX	Lurbinectedin	Advanced Solid Tumor	[6]
Sildenafil + Bosentan	DCZ1DCR	Sildenafil	Persistent Pulmonary Hypertension of the Newborn	[7]
Sildenafil + Bosentan	DC70BCK	Sildenafil	Pulmonary Arterial Hypertension	[8]
Sildenafil + Bosentan	DCBTMZ7	Sildenafil	Pulmonary Hypertension	[9]
Sildenafil + Bosentan	DCE3E40	Sildenafil	Pulmonary Arterial Hypertension	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3494).
• [2] Bosentan FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01378845) Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on Hands
• [5] ClinicalTrials.gov (NCT01712997) Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients
• [6] ClinicalTrials.gov (NCT05072106) Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced Solid Tumors
• [7] ClinicalTrials.gov (NCT04379180) Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN
• [8] ClinicalTrials.gov (NCT00433329) Combination Therapy in Pulmonary Arterial Hypertension
• [9] ClinicalTrials.gov (NCT00302211) The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
• [10] ClinicalTrials.gov (NCT01392469) Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants