Details of the Drug Combinations

General Information of This Drug (ID: DMIR21F)

Drug Name
PFK-158   DMIR21F
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

59 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + PFK-158 DCURUR2 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acarbose + PFK-158 DC5YUQW Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + PFK-158 DCHAKYC Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + PFK-158 DCHLYOQ BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chloroquine + PFK-158 DCA5R6I Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + PFK-158 DCYOR1N Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clascoterone + PFK-158 DCPWWJ3 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + PFK-158 DCVAGDQ Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Desoxycorticosterone pivalate + PFK-158 DCFTGK7 Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + PFK-158 DCUTJ7C Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dronedarone + PFK-158 DCFKIWS Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ezetimibe + PFK-158 DC2P43O Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + PFK-158 DC66QUL Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + PFK-158 DCF6B76 GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + PFK-158 DCMQTDG Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + PFK-158 DCX3NF0 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + PFK-158 DCWAZ49 Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + PFK-158 DCN10DO Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + PFK-158 DCIOP1M Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + PFK-158 DCBPZ4Q Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Olanzapine + PFK-158 DCCFDU0 Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + PFK-158 DCTNSAI Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Ribavirin-TP DCIKMAZ Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Gefitinib DC91BM2 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Imipramine DCZD8LK Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Epinephrine DC84DDR Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + PMID28460551-Compound-2 DCH9RJZ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Methotrexate DCYUAR2 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Vinblastine DCFP9A0 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Rifampin DCTQLWY Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Metyrosine DCB5LYJ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Terameprocol DCKCWL8 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Emetine DC2Y3TS Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Doxapram DCZ98EW Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Sulfinpyrazone DC0P334 Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Nizatidine DCTWZUZ Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Dichlorphenamide DCKDRPS Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Eflornithine DCIB7S7 Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Trazodone DCAPIZS Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Imatinib DCKX2D5 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Bortezomib DCHBFD5 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Methylene blue DCPTBI5 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Acamprosate DCDCVC7 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Artemisinin DCLHNMZ Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Trimethobenzamide DCA33QM Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Eptifibatide DCS0M0G Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Hyodeoxycholic acid DCTARK5 Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Oxandrolone DCIN5MR Oxandrolone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Lacosamide DC5EDNT Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Nabilone DCZHH3I Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Auranofin DC4AIDO Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + PMID28870136-Compound-43 DC6N677 PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Vorinostat DCBHLWF Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + PFK-158 DC9EA85 Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + PFK-158 DC3QBUP Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terazosin + PFK-158 DC8OKPU Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + PFK-158 DCHRRRW Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + PFK-158 DCOL80W Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trimethobenzamide + PFK-158 DCGLC84 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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References

1 ClinicalTrials.gov (NCT02044861) Phase 1 Safety Study of ACT-PFK-158, 2HCl in Patients With Advanced Solid Malignancies. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.