Details of the Drug Combination

General Information of Drug Combination (ID: DCIOP1M)

Drug Combination Name
Niclosamide PFK-158
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Niclosamide   DMJAGXQ PFK-158   DMIR21F
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 27.36
Bliss Independence Score: 27.36
Loewe Additivity Score: 34.46
LHighest Single Agent (HSA) Score: 34.49

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Niclosamide
Disease Entry ICD 11 Status REF
Cestodes infection 1F70-1F76 Approved [2]
Haemophilus influenza 1G40 Approved [3]
Taeniasis N.A. Approved [3]
Niclosamide Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [14]
Nitroreductase (NTR) DE0K82S A0A5K1UB29_SALTM Metabolism [15]
------------------------------------------------------------------------------------
Niclosamide Interacts with 766 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Activity [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [16]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Activity [16]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Activity [17]
Frizzled-9 (FZD9) OTTZ9MKK FZD9_HUMAN Decreases Expression [5]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8) OTMEAWKO NDUS8_HUMAN Decreases Expression [5]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Increases Expression [5]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Increases Expression [5]
NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7) OTIRMB2O NDUS7_HUMAN Decreases Expression [5]
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) OTBT8KW9 NDUS2_HUMAN Decreases Expression [5]
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) OTX61TQQ NDUS3_HUMAN Decreases Expression [5]
ATP synthase subunit g, mitochondrial (ATP5MG) OTD569IJ ATP5L_HUMAN Decreases Expression [5]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Decreases Expression [5]
NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) OT8CV3H5 NDUA7_HUMAN Decreases Expression [5]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Decreases Expression [5]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Increases Cleavage [5]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) OTFLILEO NDUBA_HUMAN Decreases Expression [5]
Aspartate aminotransferase, mitochondrial (GOT2) OT6XBWN0 AATM_HUMAN Increases Expression [5]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Increases Expression [5]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Decreases Expression [5]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [5]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [5]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [5]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [5]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Increases Expression [5]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Decreases Expression [5]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Increases Expression [5]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [5]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Decreases Expression [5]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Increases Expression [5]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Increases Expression [5]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Decreases Expression [5]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) OTYA3GB4 2AAA_HUMAN Increases Expression [5]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [5]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Decreases Expression [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [5]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [5]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Increases Expression [5]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [5]
NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8) OTBO0YKI NDUA8_HUMAN Decreases Expression [5]
ATP synthase subunit f, mitochondrial (ATP5MF) OTE4TBG9 ATPK_HUMAN Decreases Expression [5]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [5]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [5]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Decreases Expression [5]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) OTSFVC82 2ABB_HUMAN Decreases Expression [5]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [5]
Protein kinase C theta type (PRKCQ) OTH2VABH KPCT_HUMAN Increases Expression [5]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Increases Expression [5]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [5]
C-terminal-binding protein 1 (CTBP1) OTVYH2DH CTBP1_HUMAN Increases Expression [5]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Increases Expression [5]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [5]
V-type proton ATPase subunit S1 (ATP6AP1) OTX1K0SJ VAS1_HUMAN Decreases Expression [5]
2,4-dienoyl-CoA reductase , mitochondrial (DECR1) OTCDIR6X DECR_HUMAN Decreases Expression [5]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [5]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Increases Expression [5]
Segment polarity protein dishevelled homolog DVL-3 (DVL3) OTPRROHJ DVL3_HUMAN Increases Expression [5]
Protein naked cuticle homolog 1 (NKD1) OTY3MO97 NKD1_HUMAN Increases Expression [5]
ATP synthase subunit s, mitochondrial (DMAC2L) OT2OQ1UD ATP5S_HUMAN Decreases Expression [5]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) OTK0PG7R NUA4L_HUMAN Increases Expression [5]
Ethylmalonyl-CoA decarboxylase (ECHDC1) OTMS00PY ECHD1_HUMAN Decreases Expression [5]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Decreases Expression [5]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Decreases Expression [5]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [18]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [6]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [6]
Low-density lipoprotein receptor-related protein 6 (LRP6) OTM7PSUR LRP6_HUMAN Decreases Expression [6]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [6]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [6]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [6]
Phosphatidylcholine-sterol acyltransferase (LCAT) OTRLMLK0 LCAT_HUMAN Increases Expression [6]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [6]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [6]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [6]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [6]
All-trans-retinol dehydrogenase ADH4 (ADH4) OTKDKKNG ADH4_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Decreases Expression [6]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [6]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Expression [6]
Properdin (CFP) OTHZBLQK PROP_HUMAN Increases Expression [6]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [6]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [6]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [6]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [6]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [6]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [6]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [6]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [6]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [6]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Expression [6]
Apolipoprotein F (APOF) OT12S5QS APOF_HUMAN Decreases Expression [6]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [6]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [6]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [6]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [6]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [6]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) OT7XYA2T ES8L3_HUMAN Increases Expression [6]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [6]
DNA repair and recombination protein RAD54-like (RAD54L) OTEGMAKG RAD54_HUMAN Increases Expression [6]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [6]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [6]
Cysteine/serine-rich nuclear protein 1 (CSRNP1) OTDK1FPH CSRN1_HUMAN Increases Expression [6]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [6]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [6]
Protein FAM83D (FAM83D) OTQWZ1UO FA83D_HUMAN Decreases Expression [6]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Expression [6]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [6]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Expression [6]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) OT8P6QNJ CELR3_HUMAN Increases Expression [6]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Decreases Expression [6]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [6]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [6]
Collectin-10 (COLEC10) OTMBADGZ COL10_HUMAN Increases Expression [6]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [19]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Decreases Expression [19]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Decreases Expression [19]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) OTQ0BYK6 LX12B_HUMAN Increases Expression [20]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Increases Expression [20]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [20]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [20]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [20]
SPEG neighbor protein (SPEGNB) OTAC32TJ SPEGN_HUMAN Increases Expression [7]
Glucoside xylosyltransferase 2 (GXYLT2) OTMLQQKP GXLT2_HUMAN Increases Expression [7]
Homeobox protein HMX2 (HMX2) OTBRXY6D HMX2_HUMAN Increases Expression [7]
Protein FAM221A (FAM221A) OT13M8XE F221A_HUMAN Increases Expression [7]
Transmembrane protein 8B (TMEM8B) OTJZWPS6 TMM8B_HUMAN Increases Expression [7]
Nuclear protein 2 (NUPR2) OTNS6IEC NUPR2_HUMAN Increases Expression [7]
Arginine-fifty homeobox (ARGFX) OTV7LGJV ARGFX_HUMAN Decreases Expression [7]
Ras association domain-containing protein 10 (RASSF10) OTGB7EBG RASFA_HUMAN Decreases Expression [7]
Choriogonadotropin subunit beta variant 1 (CGB1) OT7NFGXF CGB1_HUMAN Increases Expression [7]
LYR motif-containing protein 9 (LYRM9) OT1MILTK LYRM9_HUMAN Increases Expression [7]
Putative transmembrane protein INAFM1 (INAFM1) OTXC8QBG INAM1_HUMAN Increases Expression [7]
Fibronectin type III domain-containing protein 10 (FNDC10) OT06NW7W FND10_HUMAN Increases Expression [7]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Decreases Expression [7]
E3 SUMO-protein ligase CBX4 (CBX4) OT4XVRRF CBX4_HUMAN Increases Expression [7]
Synaptotagmin-5 (SYT5) OT718PRY SYT5_HUMAN Increases Expression [7]
Butyrophilin subfamily 3 member A1 (BTN3A1) OTGZADIX BT3A1_HUMAN Increases Expression [7]
SH2B adapter protein 2 (SH2B2) OTEDHHDH SH2B2_HUMAN Increases Expression [7]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Increases Expression [7]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Increases Expression [7]
Receptor-type tyrosine-protein phosphatase T (PTPRT) OTV5TXNN PTPRT_HUMAN Decreases Expression [7]
F-BAR domain only protein 1 (FCHO1) OTDNDGI9 FCHO1_HUMAN Increases Expression [7]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [7]
Segment polarity protein dishevelled homolog DVL-2 (DVL2) OTMNYNCM DVL2_HUMAN Decreases Expression [21]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Decreases Expression [7]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Expression [7]
Serine/threonine-protein phosphatase with EF-hands 2 (PPEF2) OT0KW3GX PPE2_HUMAN Decreases Expression [7]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Affects Localization [22]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [7]
Protein KHNYN (KHNYN) OT5ZFS95 KHNYN_HUMAN Increases Expression [7]
Lysine-specific demethylase 6B (KDM6B) OTMZVHSG KDM6B_HUMAN Increases Expression [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [7]
Glutamate receptor ionotropic, NMDA 2D (GRIN2D) OTTEKYKQ NMDE4_HUMAN Increases Expression [7]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [7]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [7]
Ras GTPase-activating protein 4 (RASA4) OTW0178L RASL2_HUMAN Increases Expression [7]
Regulator of G-protein signaling 14 (RGS14) OTYN79AG RGS14_HUMAN Increases Expression [7]
Lysine-specific demethylase hairless (HR) OTHEZWPW HAIR_HUMAN Increases Expression [7]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [8]
Regulator of G-protein signaling 10 (RGS10) OTQ8N1QH RGS10_HUMAN Increases Expression [7]
Peptidase inhibitor 15 (PI15) OTPJL6ML PI15_HUMAN Decreases Expression [7]
ER lumen protein-retaining receptor 3 (KDELR3) OTW8C1V0 ERD23_HUMAN Increases Expression [7]
Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) OTONIS87 MYPT2_HUMAN Increases Expression [7]
Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1) OTABV7D2 H6ST1_HUMAN Decreases Expression [7]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) OTHS1L0E GBG7_HUMAN Increases Expression [7]
tRNA wybutosine-synthesizing protein 4 (LCMT2) OT4RUVCM TYW4_HUMAN Decreases Expression [7]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Increases Expression [7]
ATP-binding cassette sub-family C member 9 (ABCC9) OTGAXLQN ABCC9_HUMAN Decreases Expression [7]
Liprin-alpha-3 (PPFIA3) OTNPZ6HT LIPA3_HUMAN Increases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [7]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [7]
Cytokine receptor-like factor 1 (CRLF1) OT55PXIN CRLF1_HUMAN Decreases Expression [7]
GSK-3-binding protein FRAT2 (FRAT2) OT481GQ4 FRAT2_HUMAN Increases Expression [7]
Transcription initiation protein SPT3 homolog (SUPT3H) OT7B6FRO SUPT3_HUMAN Increases Expression [7]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) OTAVZJ3J KS6A5_HUMAN Increases Expression [7]
Paralemmin-1 (PALM) OTTZONUX PALM_HUMAN Increases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [7]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [7]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [7]
Olfactory receptor 7C1 (OR7C1) OTQKD84O OR7C1_HUMAN Increases Expression [7]
Tubulin polymerization-promoting protein (TPPP) OTCFMSUF TPPP_HUMAN Increases Expression [7]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11) OTBOY3WH KBTBB_HUMAN Increases Expression [7]
Rho-related BTB domain-containing protein 1 (RHOBTB1) OTGE8K45 RHBT1_HUMAN Increases Expression [7]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [7]
Neurexophilin-2 (NXPH2) OTHD8HPU NXPH2_HUMAN Decreases Expression [7]
Neurexophilin-4 (NXPH4) OTV057AG NXPH4_HUMAN Increases Expression [7]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) OTM705TH CAC1H_HUMAN Increases Expression [7]
Uncharacterized protein C1orf105 (C1ORF105) OTALIGHW CA105_HUMAN Decreases Expression [7]
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) OTP9A2BQ ETHE1_HUMAN Increases Expression [7]
Follistatin-related protein 3 (FSTL3) OT75489W FSTL3_HUMAN Increases Expression [7]
Fibroblast growth factor 19 (FGF19) OT2DVJWY FGF19_HUMAN Increases Expression [7]
Probable G-protein coupled receptor 75 (GPR75) OT8SPUGC GPR75_HUMAN Decreases Expression [7]
Echinoderm microtubule-associated protein-like 2 (EML2) OTRX2NTA EMAL2_HUMAN Increases Expression [7]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Decreases Expression [11]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Increases Expression [7]
Uncharacterized protein C6orf47 (C6ORF47) OTMKBNDD CF047_HUMAN Affects Expression [7]
Polyglutamylase complex subunit TTLL1 (TTLL1) OTCE097J TTLL1_HUMAN Increases Expression [7]
T-box transcription factor TBX6 (TBX6) OTW1Q8RM TBX6_HUMAN Increases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [7]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Decreases Expression [7]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [7]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [23]
Coagulation factor X (F10) OT2BLK17 FA10_HUMAN Increases Expression [7]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Increases Expression [7]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [24]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Expression [23]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Activity [13]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [10]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [7]
Alpha-1B-glycoprotein (A1BG) OTFVUGNQ A1BG_HUMAN Increases Expression [7]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [25]
Fibroblast growth factor 1 (FGF1) OT8I64X8 FGF1_HUMAN Decreases Expression [8]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [26]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [7]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Decreases Expression [9]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Increases Expression [7]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [12]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Decreases Expression [7]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [7]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [25]
Protein ELFN1 (ELFN1) OTM7M52U ELFN1_HUMAN Increases Expression [7]
Proline-rich protein 29 (PRR29) OT8GLHGQ PRR29_HUMAN Decreases Expression [7]
Glutathione S-transferase theta-2 (GSTT2) OTANW3TJ GST2_HUMAN Decreases Expression [7]
Small integral membrane protein 10-like protein 2A (SMIM10L2B) OT04IG2N SIL2A_HUMAN Increases Expression [7]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [9]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Increases Expression [7]
Acetylcholine receptor subunit beta (CHRNB1) OTTJXD24 ACHB_HUMAN Increases Expression [7]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [7]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Affects Binding [27]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [28]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [7]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Expression [7]
Protein L-Myc (MYCL) OT1MFQ5U MYCL_HUMAN Increases Expression [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [11]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Increases Expression [7]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Increases Expression [7]
Insulin receptor-related protein (INSRR) OT3F75WA INSRR_HUMAN Decreases Expression [7]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [11]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [7]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Increases Expression [11]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Increases Expression [7]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [7]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [7]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Increases Expression [7]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Increases Expression [7]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [7]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Decreases Expression [7]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) OT4L2SSB GBRB1_HUMAN Increases Expression [7]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [25]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [25]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Affects Localization [22]
Ras-related protein Rab-3A (RAB3A) OT2GIUO5 RAB3A_HUMAN Increases Expression [7]
Nuclear receptor subfamily 1 group D member 1 (NR1D1) OTJ38PTB NR1D1_HUMAN Increases Expression [7]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Increases Expression [7]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [7]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [7]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Increases Expression [7]
Cartilage matrix protein (MATN1) OTBRTCTQ MATN1_HUMAN Increases Expression [7]
Fibroblast growth factor receptor 4 (FGFR4) OTRQERG2 FGFR4_HUMAN Increases Expression [7]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [7]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Increases Expression [7]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [29]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Increases Expression [7]
Stromelysin-3 (MMP11) OTRTXDBM MMP11_HUMAN Increases Expression [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [24]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [28]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Phosphorylation [22]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Increases Expression [7]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [30]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [22]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [22]
5-hydroxytryptamine receptor 1E (HTR1E) OTOK64JC 5HT1E_HUMAN Decreases Expression [7]
Ephrin type-A receptor 8 (EPHA8) OTHOESG6 EPHA8_HUMAN Increases Expression [7]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [7]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [7]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Increases Expression [7]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Decreases Expression [7]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [31]
ETS-related transcription factor Elf-1 (ELF1) OTV5LKIA ELF1_HUMAN Increases Expression [7]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM5 (MCM5) OTAHLB62 MCM5_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [28]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Increases Expression [7]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Increases Expression [7]
Prostaglandin E2 receptor EP4 subtype (PTGER4) OT2GBV06 PE2R4_HUMAN Decreases Expression [7]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [7]
Thrombospondin-4 (THBS4) OTA1T9KK TSP4_HUMAN Increases Expression [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [25]
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) OTRO9RII HMGCL_HUMAN Increases Expression [7]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [7]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [7]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [7]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [7]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [7]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [7]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Increases Expression [7]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [7]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [7]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Increases Expression [7]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Expression [31]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Increases Expression [31]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [13]
Phosphorylase b kinase regulatory subunit alpha, liver isoform (PHKA2) OTJE1KXL KPB2_HUMAN Decreases Expression [7]
C-C chemokine receptor type 10 (CCR10) OT7ZWSSD CCR10_HUMAN Increases Expression [7]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Decreases Activity [24]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [7]
Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) OT5I7OI2 GBRA4_HUMAN Increases Expression [7]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Decreases Expression [7]
Mannan-binding lectin serine protease 1 (MASP1) OTWWCNZP MASP1_HUMAN Increases Expression [7]
Anion exchange protein 3 (SLC4A3) OTXIRX39 B3A3_HUMAN Increases Expression [7]
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) OT61GMNV CY561_HUMAN Decreases Expression [7]
Presenilin-2 (PSEN2) OTOW778B PSN2_HUMAN Decreases Expression [7]
PDZ and LIM domain protein 4 (PDLIM4) OT23LZYY PDLI4_HUMAN Increases Expression [7]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Increases Expression [7]
Amiloride-sensitive sodium channel subunit delta (SCNN1D) OTTX2G9M SCNND_HUMAN Increases Expression [7]
Matrix metalloproteinase-15 (MMP15) OT1XF517 MMP15_HUMAN Increases Expression [7]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [7]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Increases Expression [7]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [7]
Hexokinase-3 (HK3) OTZKONGB HXK3_HUMAN Decreases Expression [7]
Ephrin-A3 (EFNA3) OTJGOUMZ EFNA3_HUMAN Increases Expression [7]
Beta-crystallin B1 (CRYBB1) OTDI4W3V CRBB1_HUMAN Increases Expression [7]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [22]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [7]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Increases Expression [7]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Decreases Expression [7]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [7]
Transmembrane protein 50B (TMEM50B) OTWJK2XZ TM50B_HUMAN Decreases Expression [7]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Expression [7]
Regulator of G-protein signaling 8 (RGS8) OTX60JDJ RGS8_HUMAN Decreases Expression [7]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Increases Expression [7]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Increases Expression [7]
Neurexin-2-beta (NRXN2) OTB04QSU NRX2B_HUMAN Increases Expression [7]
Neurexophilin-1 (NXPH1) OTGKX860 NXPH1_HUMAN Decreases Expression [7]
Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2) OTDGVXJ6 MNARL_HUMAN Decreases Expression [7]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [31]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [12]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Decreases Expression [10]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Affects Phosphorylation [29]
Disks large homolog 4 (DLG4) OTD9E2LU DLG4_HUMAN Increases Expression [7]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Increases Expression [7]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [7]
Hepcidin (HAMP) OT607RBL HEPC_HUMAN Decreases Expression [32]
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) OTV3T64P FGD1_HUMAN Increases Expression [7]
Forkhead box protein O4 (FOXO4) OT90X9LN FOXO4_HUMAN Increases Expression [7]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [33]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Increases Expression [7]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Increases Expression [7]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [31]
Sodium channel protein type 7 subunit alpha (SCN7A) OTK05PXY SCN7A_HUMAN Decreases Expression [7]
Serine/arginine-rich splicing factor 2 (SRSF2) OTVDHO6U SRSF2_HUMAN Decreases Expression [7]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [7]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Increases Expression [7]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Phosphorylation [34]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [7]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [7]
POU domain, class 3, transcription factor 1 (POU3F1) OTYARA94 PO3F1_HUMAN Increases Expression [7]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [7]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [35]
P protein (OCA2) OTDWIGBF P_HUMAN Increases Expression [7]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Decreases Expression [7]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Expression [7]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Increases Expression [7]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [7]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [13]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [7]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [35]
Epithelial discoidin domain-containing receptor 1 (DDR1) OTYW1SH8 DDR1_HUMAN Increases Expression [7]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Increases Expression [7]
Kelch-like protein 30 (KLHL30) OTKVRLU3 KLH30_HUMAN Increases Expression [7]
Protein INCA1 (INCA1) OTTTN3EW INCA1_HUMAN Increases Expression [7]
D site-binding protein (DBP) OTE0W7LN DBP_HUMAN Increases Expression [7]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [7]
Forkhead box protein L1 (FOXL1) OT89XFPN FOXL1_HUMAN Increases Expression [7]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Expression [7]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 8 (DUSP8) OTPLMPG9 DUS8_HUMAN Increases Expression [7]
Serine/arginine-rich splicing factor 6 (SRSF6) OTGLOSYE SRSF6_HUMAN Decreases Expression [7]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Increases Expression [7]
Syntaxin-3 (STX3) OT4CIWLJ STX3_HUMAN Increases Expression [7]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [9]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Decreases Expression [12]
Ras and Rab interactor 1 (RIN1) OTPBROUD RIN1_HUMAN Increases Expression [7]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Increases Expression [7]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Increases Expression [7]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [7]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Increases Expression [7]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Expression [7]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Decreases Expression [24]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [7]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Increases Expression [7]
Transmembrane protein 187 (TMEM187) OTOE4G8T TM187_HUMAN Increases Expression [7]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [7]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Increases Expression [7]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [10]
Myocyte-specific enhancer factor 2D (MEF2D) OT7CEIG0 MEF2D_HUMAN Increases Expression [7]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Increases Expression [7]
Opioid-binding protein/cell adhesion molecule (OPCML) OT93PQ6Y OPCM_HUMAN Increases Expression [7]
Nuclear receptor subfamily 1 group D member 2 (NR1D2) OT9CVF41 NR1D2_HUMAN Increases Expression [7]
FAST kinase domain-containing protein 3, mitochondrial (FASTKD3) OT1TI8K0 FAKD3_HUMAN Decreases Expression [7]
P2Y purinoceptor 6 (P2RY6) OT7VNPQ0 P2RY6_HUMAN Decreases Expression [7]
kinase isozyme 3, mitochondrial (PDK3) OTCPSTID PDK3_HUMAN Decreases Expression [7]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Expression [7]
Cdc42-interacting protein 4 (TRIP10) OTGOUILO CIP4_HUMAN Increases Expression [7]
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) OT8M7KWA PI5PA_HUMAN Increases Expression [7]
Ephrin-B3 (EFNB3) OT12WTXQ EFNB3_HUMAN Increases Expression [7]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) OTHATMLU CAC1E_HUMAN Increases Expression [7]
Glutamate receptor ionotropic, kainate 5 (GRIK5) OTBW671W GRIK5_HUMAN Increases Expression [7]
Neuronatin (NNAT) OTNRLO7G NNAT_HUMAN Decreases Expression [7]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [7]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Decreases Expression [7]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [23]
Anti-Muellerian hormone type-2 receptor (AMHR2) OT95APPM AMHR2_HUMAN Increases Expression [7]
Histone H2B type 2-E (H2BC21) OT0FDCUC H2B2E_HUMAN Increases Expression [7]
NADP-dependent malic enzyme, mitochondrial (ME3) OT3XMLYG MAON_HUMAN Decreases Expression [7]
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) OT0S9MFX LONF1_HUMAN Increases Expression [7]
Centrosomal protein kizuna (KIZ) OT5VCKSM KIZ_HUMAN Increases Expression [7]
Leucine-rich repeat-containing protein 75B (LRRC75B) OTAHOBSS LR75B_HUMAN Increases Expression [7]
DDB1- and CUL4-associated factor 4-like protein 1 (DCAF4L1) OT50KJQ6 DC4L1_HUMAN Decreases Expression [7]
Annexin-2 receptor (ANXA2R) OT82TU39 AX2R_HUMAN Increases Expression [7]
Protein FAM135B (FAM135B) OTCSYBI7 F135B_HUMAN Increases Expression [7]
Angiomotin (AMOT) OTWHDG9B AMOT_HUMAN Increases Expression [7]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Increases Expression [7]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [7]
Puratrophin-1 (PLEKHG4) OT3RBPFL PKHG4_HUMAN Increases Expression [7]
RILP-like protein 1 (RILPL1) OTW4LHU8 RIPL1_HUMAN Increases Expression [7]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [7]
F-box only protein 48 (FBXO48) OTVMFNOK FBX48_HUMAN Increases Expression [7]
BCL-6 corepressor-like protein 1 (BCORL1) OTPTFQN5 BCORL_HUMAN Increases Expression [7]
Protein crumbs homolog 2 (CRB2) OTG0L2CE CRUM2_HUMAN Increases Expression [7]
Germinal center-associated signaling and motility-like protein (GCSAML) OTYWDOA6 GSAML_HUMAN Decreases Expression [7]
Leucine-rich repeat-containing protein 73 (LRRC73) OTNFHROL LRC73_HUMAN Increases Expression [7]
Solute carrier family 35 member D3 (SLC35D3) OTHKRBGM S35D3_HUMAN Decreases Expression [7]
Cilia- and flagella-associated protein 70 (CFAP70) OTIRTNXU CFA70_HUMAN Increases Expression [7]
Arginine vasopressin-induced protein 1 (AVPI1) OTXSBR60 AVPI1_HUMAN Increases Expression [7]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [7]
NEDD4-binding protein 2-like 1 (N4BP2L1) OTEGV3GO N42L1_HUMAN Increases Expression [7]
Radial spoke head protein 4 homolog A (RSPH4A) OTNDPGEE RSH4A_HUMAN Decreases Expression [7]
Myomesin-3 (MYOM3) OT8GGH11 MYOM3_HUMAN Increases Expression [7]
Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4) OTDXI4H8 SDHF4_HUMAN Increases Expression [7]
OTU domain-containing protein 1 (OTUD1) OTE6O5XB OTUD1_HUMAN Increases Expression [7]
Uncharacterized protein KIAA1614 (KIAA1614) OTCG3B86 K1614_HUMAN Decreases Expression [7]
Janus kinase and microtubule-interacting protein 3 (JAKMIP3) OT4EDANR JKIP3_HUMAN Increases Expression [7]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Expression [7]
Formin-1 (FMN1) OT9CID5R FMN1_HUMAN Increases Expression [7]
BTB/POZ domain-containing protein KCTD11 (KCTD11) OT64DFBU KCD11_HUMAN Increases Expression [7]
Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) OT04I3OW S6A19_HUMAN Decreases Expression [7]
Transmembrane protein 42 (TMEM42) OTCG6EZ0 TMM42_HUMAN Increases Expression [7]
Ankyrin repeat domain-containing protein 34A (ANKRD34A) OTI00ROL AN34A_HUMAN Increases Expression [7]
Tigger transposable element-derived protein 3 (TIGD3) OT61NEUF TIGD3_HUMAN Decreases Expression [7]
Fc receptor-like B (FCRLB) OTL0PMQX FCRLB_HUMAN Increases Expression [7]
Rab15 effector protein (REP15) OTGOX4E7 REP15_HUMAN Decreases Expression [7]
Pleckstrin homology-like domain family B member 3 (PHLDB3) OTPFKXFA PHLB3_HUMAN Increases Expression [7]
Probable G-protein coupled receptor 153 (GPR153) OT81CA1Z GP153_HUMAN Increases Expression [7]
Golgi-associated RAB2 interactor protein 1A (GARIN1A) OTSJROUO GAR1A_HUMAN Increases Expression [7]
Transmembrane protein 53 (TMEM53) OTSXTGQK TMM53_HUMAN Increases Expression [7]
Pre-mRNA-processing-splicing factor 8 (PRPF8) OTU39JZI PRP8_HUMAN Decreases Expression [7]
PiggyBac transposable element-derived protein 2 (PGBD2) OT82WVBH PGBD2_HUMAN Decreases Expression [7]
ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT) OTMPVCHS ACKMT_HUMAN Decreases Expression [7]
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) OT03MYQ2 NOTUM_HUMAN Increases Expression [7]
Potassium voltage-gated channel subfamily V member 1 (KCNV1) OTU2MLSU KCNV1_HUMAN Decreases Expression [7]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [7]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [7]
Ankyrin repeat domain-containing protein 12 (ANKRD12) OTK16BL9 ANR12_HUMAN Increases Expression [7]
Kin of IRRE-like protein 2 (KIRREL2) OTSLTR4Y KIRR2_HUMAN Increases Expression [7]
Protein SNORC (SNORC) OTY3IJK5 SNORC_HUMAN Increases Expression [7]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (B3GNT9) OTO385AU B3GN9_HUMAN Increases Expression [7]
Transcription factor LBX2 (LBX2) OTGWRSI2 LBX2_HUMAN Increases Expression [7]
SH3 and cysteine-rich domain-containing protein 2 (STAC2) OTRJ9PG0 STAC2_HUMAN Increases Expression [7]
Lysine-specific demethylase 7A (KDM7A) OT1VGYCX KDM7A_HUMAN Increases Expression [7]
GDP-D-glucose phosphorylase 1 (GDPGP1) OT40ETFK GDPP1_HUMAN Decreases Expression [7]
Leucine-rich repeat-containing protein 55 (LRRC55) OT8LQI1W LRC55_HUMAN Decreases Expression [7]
Protein FAM43B (FAM43B) OTLND7C6 FA43B_HUMAN Increases Expression [7]
Tripartite motif-containing protein 67 (TRIM67) OTXRZN27 TRI67_HUMAN Increases Expression [7]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 (NYAP1) OT8FPF5F NYAP1_HUMAN Increases Expression [7]
8-oxo-dGDP phosphatase NUDT18 (NUDT18) OT03IQA5 NUD18_HUMAN Increases Expression [7]
Uncharacterized protein C16orf86 (C16ORF86) OTUT18HF CP086_HUMAN Increases Expression [7]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [7]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [7]
Atos homolog protein B (ATOSB) OTU2TXCA ATOSB_HUMAN Increases Expression [7]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Increases Expression [7]
Stereocilin (STRC) OT3JQYVJ STRC_HUMAN Increases Expression [7]
Monocarboxylate transporter 14 (SLC16A14) OTUGDEUV MOT14_HUMAN Increases Expression [7]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Increases Expression [7]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Increases Expression [7]
Low-density lipoprotein receptor-related protein 10 (LRP10) OT8490HT LRP10_HUMAN Increases Expression [7]
Protein ADM2 (ADM2) OTJVN41C ADM2_HUMAN Increases Expression [7]
Cytochrome c oxidase subunit 8C, mitochondrial (COX8C) OT6G8E4Q COX8C_HUMAN Increases Expression [7]
Microtubule organization protein AKNA (AKNA) OTQ6E2C8 AKNA_HUMAN Increases Expression [7]
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) OTSSRRCA I2BP2_HUMAN Increases Expression [7]
Protein TAMALIN (TAMALIN) OTK75X47 GRASP_HUMAN Increases Expression [7]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW) OTT9SMTF PIGW_HUMAN Decreases Expression [7]
Synaptotagmin-9 (SYT9) OT7S8WU0 SYT9_HUMAN Decreases Expression [7]
Store-operated calcium entry regulator STIMATE (STIMATE) OTEDLKEW STIMA_HUMAN Decreases Expression [7]
Glucosylceramide transporter ABCA12 (ABCA12) OTKH9YQZ ABCAC_HUMAN Decreases Expression [7]
Reticulon-4 receptor-like 1 (RTN4RL1) OTDKKOE7 R4RL1_HUMAN Increases Expression [7]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) OTHH06X8 SESD1_HUMAN Decreases Expression [7]
Caytaxin (ATCAY) OTSIAM08 ATCAY_HUMAN Increases Expression [7]
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) OT7XETW4 HOGA1_HUMAN Increases Expression [7]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) OTVCRXEZ PPR3B_HUMAN Decreases Expression [7]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2) OTL0DWCO ECHD2_HUMAN Decreases Expression [7]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Increases Expression [7]
Homer protein homolog 1 (HOMER1) OTWFD3SI HOME1_HUMAN Decreases Expression [7]
Complement C1q-like protein 4 (C1QL4) OT9L6DLK C1QL4_HUMAN Increases Expression [7]
Unconventional myosin-XVIIIb (MYO18B) OTGYY4NK MY18B_HUMAN Increases Expression [7]
RNA-binding protein 45 (RBM45) OTWTHD77 RBM45_HUMAN Decreases Expression [7]
Neuronal PAS domain-containing protein 4 (NPAS4) OTA3HH6W NPAS4_HUMAN Increases Expression [7]
CREB3 regulatory factor (CREBRF) OT2GK1HI CRERF_HUMAN Increases Expression [7]
Protein HID1 (HID1) OTVJIFSU HID1_HUMAN Increases Expression [7]
Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2) OTMOGNCV ANKY2_HUMAN Increases Expression [7]
Nostrin (NOSTRIN) OT0LDSGS NOSTN_HUMAN Decreases Expression [7]
Glucose-induced degradation protein 4 homolog (GID4) OT0TOD0M GID4_HUMAN Increases Expression [7]
Cyclin-dependent kinase-like 3 (CDKL3) OTJ0TQ9T CDKL3_HUMAN Increases Expression [7]
Transmembrane protein 151B (TMEM151B) OTTEDBUJ T151B_HUMAN Increases Expression [7]
Sphingosine-1-phosphate phosphatase 2 (SGPP2) OTIDIJCR SGPP2_HUMAN Decreases Expression [7]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [7]
Kelch domain-containing protein 8B (KLHDC8B) OTKP6LCR KLD8B_HUMAN Increases Expression [7]
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6) OTOZQMQE PPIL6_HUMAN Increases Expression [7]
Kelch domain-containing protein 8A (KLHDC8A) OTIZA3AM KLD8A_HUMAN Increases Expression [7]
REST corepressor 2 (RCOR2) OTXRQS9E RCOR2_HUMAN Increases Expression [7]
B-cell CLL/lymphoma 6 member B protein (BCL6B) OT1T5KM6 BCL6B_HUMAN Increases Expression [7]
Glypican-2 (GPC2) OT3WSQE1 GPC2_HUMAN Increases Expression [7]
Homeobox protein SIX5 (SIX5) OTT1I9WY SIX5_HUMAN Increases Expression [7]
Kelch-like protein 34 (KLHL34) OTHU2OSE KLH34_HUMAN Decreases Expression [7]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [7]
Latent-transforming growth factor beta-binding protein 4 (LTBP4) OTC8WL2V LTBP4_HUMAN Increases Expression [7]
Transmembrane protein 256 (TMEM256) OTLNGZLX TM256_HUMAN Increases Expression [7]
Ligand-dependent nuclear receptor corepressor-like protein (LCORL) OTJNQRC5 LCORL_HUMAN Increases Expression [7]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Decreases Expression [7]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [7]
DnaJ homolog subfamily C member 22 (DNAJC22) OTGGDK70 DJC22_HUMAN Increases Expression [7]
Tetratricopeptide repeat protein 9B (TTC9B) OTHBKTIU TTC9B_HUMAN Increases Expression [7]
Protein NATD1 (NATD1) OTQF3C4I NATD1_HUMAN Increases Expression [7]
Protocadherin-20 (PCDH20) OTFSNRXK PCD20_HUMAN Decreases Expression [7]
Probable N-acetyltransferase 16 (NAT16) OTGRHAJQ NAT16_HUMAN Increases Expression [7]
Stabilizer of axonemal microtubules 5 (SAXO5) OTS9VCFR SAXO5_HUMAN Increases Expression [7]
Fanconi anemia group B protein (FANCB) OTMZTXB5 FANCB_HUMAN Decreases Expression [7]
Zinc finger protein GLIS1 (GLIS1) OTBDNB26 GLIS1_HUMAN Increases Expression [7]
NFATC2-interacting protein (NFATC2IP) OTOQ4AZ9 NF2IP_HUMAN Decreases Expression [7]
Beta-galactosidase-1-like protein 3 (GLB1L3) OTWAWGX4 GLBL3_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 1B (SMC1B) OTQVMF74 SMC1B_HUMAN Decreases Expression [7]
Lymphocyte antigen 6 complex locus protein G5b (LY6G5B) OTW89R8K LY65B_HUMAN Decreases Expression [7]
Transmembrane protein 52 (TMEM52) OTDLQSAX TMM52_HUMAN Increases Expression [7]
Cytosolic carboxypeptidase 3 (AGBL3) OTVH64PO CBPC3_HUMAN Decreases Expression [7]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) OT8UTTXF B3GN7_HUMAN Increases Expression [7]
Interleukin-17 receptor E (IL17RE) OTMFTNLS I17RE_HUMAN Increases Expression [7]
Olfactory receptor 2L3 (OR2L3) OTL6ZMOC OR2L3_HUMAN Decreases Expression [7]
Olfactory receptor 4F17 (OR4F17) OTJZ7HYD O4F17_HUMAN Decreases Expression [7]
Protocadherin-19 (PCDH19) OTSOW3MV PCD19_HUMAN Decreases Expression [7]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Increases Expression [7]
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) OT18H5HD R3GEF_HUMAN Increases Expression [7]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Increases Expression [7]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [7]
A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAMTS17) OTCFITM9 ATS17_HUMAN Decreases Expression [7]
ATP-dependent RNA helicase DQX1 (DQX1) OTE7BT00 DQX1_HUMAN Increases Expression [7]
Partitioning defective 3 homolog B (PARD3B) OTGZ43YI PAR3L_HUMAN Increases Expression [7]
SH3 domain and tetratricopeptide repeat-containing protein 2 (SH3TC2) OTJ6XY2A S3TC2_HUMAN Decreases Expression [7]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) OTUM65JL GDPD5_HUMAN Increases Expression [7]
Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2) OTOGC15N CHAC2_HUMAN Decreases Expression [7]
DnaJ homolog subfamily A member 4 (DNAJA4) OTT7YCD2 DNJA4_HUMAN Decreases Expression [7]
G2/mitotic-specific cyclin-B3 (CCNB3) OT5V72D3 CCNB3_HUMAN Decreases Expression [7]
Junctophilin-3 (JPH3) OTHTJO2I JPH3_HUMAN Increases Expression [7]
DnaJ homolog subfamily C member 9 (DNAJC9) OTDBQBNZ DNJC9_HUMAN Decreases Expression [7]
Jun dimerization protein 2 (JDP2) OTW35WKX JDP2_HUMAN Increases Expression [7]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [7]
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4) OTENME7S SIA8D_HUMAN Increases Expression [7]
Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP) OTPC9JBM PHYIP_HUMAN Increases Expression [7]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [7]
General transcription factor IIH subunit 4 (GTF2H4) OTPD1DIU TF2H4_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Increases Expression [7]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Decreases Expression [36]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Increases Expression [7]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Expression [7]
Glycine N-acyltransferase-like protein 1 (GLYATL1) OTS8JSRY GLYL1_HUMAN Decreases Expression [7]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Expression [7]
Ras-related protein Rab-7b (RAB7B) OT60A0E9 RAB7B_HUMAN Increases Expression [7]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) OTEAAUBY PBIP1_HUMAN Increases Expression [7]
Protein FAM131C (FAM131C) OTQPI1OZ F131C_HUMAN Increases Expression [7]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [7]
Dapper homolog 3 (DACT3) OTSNQ55G DACT3_HUMAN Increases Expression [7]
Repulsive guidance molecule A (RGMA) OTZAMDO2 RGMA_HUMAN Decreases Expression [7]
Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) OTWWAHTV TMIG2_HUMAN Increases Expression [7]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Increases Expression [7]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Decreases Expression [7]
Netrin-G2 (NTNG2) OTTY88DL NTNG2_HUMAN Increases Expression [7]
Reticulocalbin-3 (RCN3) OTHWE0NF RCN3_HUMAN Increases Expression [7]
Voltage-gated hydrogen channel 1 (HVCN1) OT4ALYU4 HVCN1_HUMAN Increases Expression [7]
Protein shisa-4 (SHISA4) OTJ8H832 SHSA4_HUMAN Increases Expression [7]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [7]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) OTDCBTBS LIGO1_HUMAN Increases Expression [7]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Increases Expression [7]
BLOC-1-related complex subunit 6 (BORCS6) OTTO4SWD BORC6_HUMAN Increases Expression [7]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [7]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Decreases Expression [7]
Putative protein-lysine deacylase ABHD14B (ABHD14B) OTFIYC6Y ABHEB_HUMAN Increases Expression [7]
CUGBP Elav-like family member 6 (CELF6) OT111JZ3 CELF6_HUMAN Increases Expression [7]
Junctophilin-4 (JPH4) OTRLNPJK JPH4_HUMAN Increases Expression [7]
HHIP-like protein 1 (HHIPL1) OT3GMU2X HIPL1_HUMAN Increases Expression [7]
Cadherin-related family member 1 (CDHR1) OT1ORXCM CDHR1_HUMAN Increases Expression [7]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [7]
Uncharacterized protein C8orf48 (C8ORF48) OT4KE69P CH048_HUMAN Decreases Expression [7]
Cyclic nucleotide-binding domain-containing protein 2 (CNBD2) OTF42F52 CNBD2_HUMAN Increases Expression [7]
Lysophospholipid acyltransferase 7 (MBOAT7) OTHRCBLK MBOA7_HUMAN Increases Expression [7]
Sideroflexin-2 (SFXN2) OTRFKK0G SFXN2_HUMAN Decreases Expression [7]
Sterile alpha motif domain-containing protein 11 (SAMD11) OT6WRQOX SAM11_HUMAN Increases Expression [7]
AP-1 complex subunit sigma-3 (AP1S3) OTPCMV24 AP1S3_HUMAN Decreases Expression [7]
Trafficking protein particle complex subunit 9 (TRAPPC9) OTF0CVMC TPPC9_HUMAN Increases Expression [7]
Cyclin-dependent kinase 15 (CDK15) OT8S67QS CDK15_HUMAN Decreases Expression [7]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [7]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [7]
Protein ABHD1 (ABHD1) OTY56U02 ABHD1_HUMAN Increases Expression [7]
Histone-lysine N-methyltransferase SETDB2 (SETDB2) OTBVVP9Q SETB2_HUMAN Increases Expression [7]
Calponin-2 (CNN2) OTH3CSXA CNN2_HUMAN Increases Expression [7]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [7]
Transcriptional enhancer factor TEF-5 (TEAD3) OTJ1ER44 TEAD3_HUMAN Increases Expression [7]
Monoglyceride lipase (MGLL) OT5ES4IE MGLL_HUMAN Increases Expression [7]
Homeobox protein Meis3 (MEIS3) OTQXB3XL MEIS3_HUMAN Increases Expression [7]
Septin-5 (SEPTIN5) OT6JTJBO SEPT5_HUMAN Increases Expression [7]
Chemerin-like receptor 1 (CMKLR1) OTHA8ESR CML1_HUMAN Decreases Expression [7]
Homeobox protein Nkx-3.1 (NKX3-1) OT0DO6ZU NKX31_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Increases Expression [7]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [7]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) OT0ETO72 DHB14_HUMAN Increases Expression [7]
Synaptotagmin-3 (SYT3) OT8XTGQ8 SYT3_HUMAN Increases Expression [7]
Phosphatidate phosphatase LPIN3 (LPIN3) OTK1C2KL LPIN3_HUMAN Increases Expression [7]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Increases Expression [7]
Transcription factor COE4 (EBF4) OTGK0V7W COE4_HUMAN Increases Expression [7]
Mesoderm posterior protein 1 (MESP1) OTY5QDBN MESP1_HUMAN Increases Expression [7]
Protein orai-3 (ORAI3) OTUP3OH3 ORAI3_HUMAN Increases Expression [7]
La-related protein 6 (LARP6) OTUQ9QS9 LARP6_HUMAN Increases Expression [7]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [7]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Decreases Expression [7]
Polycomb group RING finger protein 1 (PCGF1) OTHOU68T PCGF1_HUMAN Increases Expression [7]
Synaptotagmin-17 (SYT17) OTTW4MI3 SYT17_HUMAN Increases Expression [7]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7) OTJVS8CF ALKB7_HUMAN Increases Expression [7]
CDK5 and ABL1 enzyme substrate 2 (CABLES2) OTGD9A2A CABL2_HUMAN Decreases Expression [7]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [7]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [7]
Transcriptional repressor scratch 1 (SCRT1) OTWTE24S SCRT1_HUMAN Increases Expression [7]
Transcription factor GATA-5 (GATA5) OTO81B63 GATA5_HUMAN Increases Expression [7]
Bardet-Biedl syndrome 2 protein (BBS2) OTPF9JIB BBS2_HUMAN Increases Expression [7]
TBC1 domain family member 10A (TBC1D10A) OTR2CI46 TB10A_HUMAN Increases Expression [7]
S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER) OT7S3B3P SCAPE_HUMAN Increases Expression [7]
Cadherin-related family member 2 (CDHR2) OTTHEUPO CDHR2_HUMAN Decreases Expression [7]
3'-5' exoribonuclease HELZ2 (HELZ2) OTM6HVO6 HELZ2_HUMAN Increases Expression [7]
Leucine-rich repeat-containing protein 2 (LRRC2) OTX6P291 LRRC2_HUMAN Increases Expression [7]
Zinc finger protein GLIS2 (GLIS2) OTOUUV1X GLIS2_HUMAN Increases Expression [7]
Reticulon-4 receptor (RTN4R) OT8J693X RTN4R_HUMAN Increases Expression [7]
Glutamate receptor-interacting protein 2 (GRIP2) OT8DGYZ5 GRIP2_HUMAN Increases Expression [7]
DNA-directed RNA polymerase II subunit RPB11-b1 (POLR2J3) OTXTSHH8 RPB1B_HUMAN Decreases Expression [7]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) OT9AGAIJ LHPP_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 113 (CFAP263) OTE206QS CC113_HUMAN Increases Expression [7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [7]
Stathmin-4 (STMN4) OT7ZUKW6 STMN4_HUMAN Increases Expression [7]
ATP-binding cassette sub-family G member 4 (ABCG4) OT2XJIOG ABCG4_HUMAN Increases Expression [7]
Opsin-3 (OPN3) OTON6BFU OPN3_HUMAN Increases Expression [7]
Spectrin beta chain, non-erythrocytic 4 (SPTBN4) OTAJAVP9 SPTN4_HUMAN Increases Expression [7]
Carbohydrate sulfotransferase 8 (CHST8) OTQT4TKR CHST8_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 68 (CCDC68) OT4KF6TL CCD68_HUMAN Decreases Expression [7]
Solute carrier organic anion transporter family member 5A1 (SLCO5A1) OTNXXTH0 SO5A1_HUMAN Increases Expression [7]
Potassium voltage-gated channel subfamily F member 1 (KCNF1) OTEROKP4 KCNF1_HUMAN Increases Expression [7]
Semaphorin-4A (SEMA4A) OT8901H3 SEM4A_HUMAN Increases Expression [7]
Semaphorin-6B (SEMA6B) OT3VVVUO SEM6B_HUMAN Increases Expression [7]
Actin-like protein 8 (ACTL8) OTUDD0QT ACTL8_HUMAN Decreases Expression [7]
PDZ domain-containing protein 7 (PDZD7) OTX3VAOB PDZD7_HUMAN Increases Expression [7]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Increases Expression [7]
Proline-rich protein 36 (PRR36) OTUJII07 PRR36_HUMAN Increases Expression [7]
Transmembrane protein 231 (TMEM231) OTF4UYIE TM231_HUMAN Increases Expression [7]
PDZ domain-containing protein MAGIX (MAGIX) OT8EU651 MAGIX_HUMAN Increases Expression [7]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Decreases Expression [7]
Exonuclease V (EXO5) OTIN7L7I EXO5_HUMAN Decreases Expression [7]
Dedicator of cytokinesis protein 5 (DOCK5) OT63I0CL DOCK5_HUMAN Decreases Expression [7]
RING finger protein 122 (RNF122) OT8RE3IM RN122_HUMAN Increases Expression [7]
TBC1 domain family member 17 (TBC1D17) OT75ZWLB TBC17_HUMAN Increases Expression [7]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [7]
Potassium channel subfamily K member 13 (KCNK13) OTMOT2KX KCNKD_HUMAN Decreases Expression [7]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Increases Expression [7]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) OTNA9G8V MKNK2_HUMAN Increases Expression [7]
Nuclear receptor coactivator 5 (NCOA5) OTOGWTWB NCOA5_HUMAN Decreases Expression [7]
DNA polymerase delta subunit 4 (POLD4) OTG578YH DPOD4_HUMAN Increases Expression [7]
Receptor-type tyrosine-protein phosphatase H (PTPRH) OTDUHQGF PTPRH_HUMAN Increases Expression [7]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) OTJF73BA NT5M_HUMAN Increases Expression [7]
Transcriptional repressor scratch 2 (SCRT2) OTXN2VYF SCRT2_HUMAN Increases Expression [7]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Increases Expression [7]
Fructose-2,6-bisphosphatase TIGAR (TIGAR) OTR7NMRJ TIGAR_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase Jade-2 (JADE2) OTVG2MYF JADE2_HUMAN Increases Expression [7]
Nectin-3 (NECTIN3) OTS8N7MK NECT3_HUMAN Decreases Expression [7]
Beta-catenin-interacting protein 1 (CTNNBIP1) OTX9SBJG CNBP1_HUMAN Increases Expression [7]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [7]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Increases Expression [7]
Kinesin light chain 4 (KLC4) OTACUFB2 KLC4_HUMAN Increases Expression [7]
SERTA domain-containing protein 4 (SERTAD4) OTZ1GUD9 SRTD4_HUMAN Decreases Expression [7]
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) OTZ4771K SHFL_HUMAN Increases Expression [7]
Inactive ubiquitin thioesterase OTULINL (OTULINL) OTNOC9L1 OTULL_HUMAN Decreases Expression [7]
Protein eva-1 homolog B (EVA1B) OTDNAKQD EVA1B_HUMAN Increases Expression [7]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Increases Expression [7]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Increases Expression [7]
Nicotinamide riboside kinase 1 (NMRK1) OT0STQLV NRK1_HUMAN Increases Expression [7]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [7]
Protein FAM13B (FAM13B) OTNQTYSM FA13B_HUMAN Decreases Expression [7]
BET1-like protein (BET1L) OT5QVYBZ BET1L_HUMAN Increases Expression [7]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [25]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [10]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) OT3XMZU3 FLRT3_HUMAN Decreases Expression [7]
Calcium permeable stress-gated cation channel 1 (TMEM63C) OTKDX01I CSC1_HUMAN Increases Expression [7]
Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) OTQGT916 CAMP3_HUMAN Increases Expression [7]
BTB/POZ domain-containing protein 7 (BTBD7) OTNUV6MQ BTBD7_HUMAN Decreases Expression [7]
Armadillo repeat-containing X-linked protein 1 (ARMCX1) OTOGL58Z ARMX1_HUMAN Increases Expression [7]
Vesicular glutamate transporter 1 (SLC17A7) OTTYXG3C VGLU1_HUMAN Increases Expression [7]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [7]
NF-kappa-B inhibitor-like protein 1 (NFKBIL1) OTYFTPS0 IKBL1_HUMAN Increases Expression [7]
C-type mannose receptor 2 (MRC2) OTLWQAX1 MRC2_HUMAN Increases Expression [7]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Increases Expression [24]
Heat shock protein beta-7 (HSPB7) OTLATAOV HSPB7_HUMAN Increases Expression [7]
CAP-Gly domain-containing linker protein 2 (CLIP2) OTSCIQIY CLIP2_HUMAN Increases Expression [7]
Small conductance calcium-activated potassium channel protein 3 (KCNN3) OT11KYA8 KCNN3_HUMAN Increases Expression [7]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Increases Expression [7]
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) OTKEA582 NDOR1_HUMAN Decreases Expression [7]
rRNA methyltransferase 2, mitochondrial (MRM2) OTRYA1HU MRM2_HUMAN Decreases Expression [7]
Krueppel-like factor 15 (KLF15) OTGMQMVR KLF15_HUMAN Increases Expression [7]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Increases Expression [7]
Peroxisomal carnitine O-octanoyltransferase (CROT) OTWK68MM OCTC_HUMAN Decreases Expression [7]
Zinc finger protein Helios (IKZF2) OTZIMARJ IKZF2_HUMAN Increases Expression [7]
Polyadenylate-binding protein-interacting protein 2B (PAIP2B) OT7MUY3B PAI2B_HUMAN Increases Expression [7]
Ras-related protein Rab-26 (RAB26) OTHMPRJK RAB26_HUMAN Increases Expression [7]
Intercellular adhesion molecule 5 (ICAM5) OTDGGAFH ICAM5_HUMAN Increases Expression [7]
Ornithine decarboxylase antizyme 3 (OAZ3) OT8Q5PVB OAZ3_HUMAN Increases Expression [7]
RNA-binding protein Nova-2 (NOVA2) OTQ2X3Q4 NOVA2_HUMAN Increases Expression [7]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Affects Localization [21]
Cytosolic phospholipase A2 gamma (PLA2G4C) OTIK5GT5 PA24C_HUMAN Increases Expression [7]
LIM/homeobox protein Lhx6 (LHX6) OT47UQZ5 LHX6_HUMAN Increases Expression [7]
IQ motif and SEC7 domain-containing protein 3 (IQSEC3) OTBHQK29 IQEC3_HUMAN Increases Expression [7]
PHD finger protein 24 (PHF24) OTTIYK64 PHF24_HUMAN Increases Expression [7]
GRB2-associated-binding protein 2 (GAB2) OTBFN705 GAB2_HUMAN Increases Expression [7]
Histone deacetylase 5 (HDAC5) OTWG387P HDAC5_HUMAN Increases Expression [7]
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) OTJGX19T KCC2A_HUMAN Increases Expression [7]
C-type lectin domain family 11 member A (CLEC11A) OT9KBH7C CLC11_HUMAN Increases Expression [7]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [7]
Nuclease EXOG, mitochondrial (EXOG) OTZAI8L7 EXOG_HUMAN Decreases Expression [7]
Myelin regulatory factor (MYRF) OTKF6AEB MYRF_HUMAN Increases Expression [7]
Microtubule-associated serine/threonine-protein kinase 1 (MAST1) OTEYFN5O MAST1_HUMAN Increases Expression [7]
R3H domain-containing protein 2 (R3HDM2) OTMJ3S6J R3HD2_HUMAN Increases Expression [7]
Lambda-crystallin homolog (CRYL1) OT0SJSJM CRYL1_HUMAN Increases Expression [7]
Mediator of RNA polymerase II transcription subunit 31 (MED31) OTFVKXJE MED31_HUMAN Decreases Expression [7]
RWD domain-containing protein 3 (RWDD3) OTE76DY5 RWDD3_HUMAN Decreases Expression [7]
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) OTO7O3CU DYR1B_HUMAN Increases Expression [7]
Tesmin (TESMIN) OTZ5UILU MTL5_HUMAN Increases Expression [7]
Tubulin monoglycylase TTLL3 (TTLL3) OT7JWXHA TTLL3_HUMAN Increases Expression [7]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Decreases Expression [7]
Endothelial lipase (LIPG) OTHEE942 LIPG_HUMAN Decreases Expression [7]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Affects Localization [22]
Diacylglycerol kinase beta (DGKB) OTTT9SZJ DGKB_HUMAN Increases Expression [7]
RING finger protein 215 (RNF215) OT44XNT7 RN215_HUMAN Increases Expression [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [20]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Affects Response To Substance [37]
------------------------------------------------------------------------------------
⏷ Show the Full List of 766 DOT(s)
Indication(s) of PFK-158
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
PFK-158 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Renal carcinoma antigen NY-REN-56 (PFKFB3) TTTHMQJ F263_HUMAN Inhibitor [38]
------------------------------------------------------------------------------------

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8494).
3 Niclosamide FDA Label
4 ClinicalTrials.gov (NCT02044861) Phase 1 Safety Study of ACT-PFK-158, 2HCl in Patients With Advanced Solid Malignancies. U.S. National Institutes of Health.
5 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
6 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
7 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
8 WNT7A/-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015 Jun;34(26):3452-62. doi: 10.1038/onc.2014.277. Epub 2014 Sep 1.
9 Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. Mol Cancer Ther. 2017 Aug;16(8):1521-1530. doi: 10.1158/1535-7163.MCT-16-0912. Epub 2017 May 12.
10 The anthelmintic drug niclosamide induces GSK--mediated -catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. Cell Death Dis. 2022 Feb 3;13(2):112. doi: 10.1038/s41419-022-04573-7.
11 The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear -catenin/c-Myc axis in OSCC. Sci Rep. 2018 Aug 24;8(1):12776. doi: 10.1038/s41598-018-30692-3.
12 Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncol Rep. 2018 Feb;39(2):827-833. doi: 10.3892/or.2017.6146. Epub 2017 Dec 11.
13 Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010 Mar 15;70(6):2516-27. doi: 10.1158/0008-5472.CAN-09-3950. Epub 2010 Mar 9.
14 Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87.
15 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
16 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
17 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
18 Inhibition of Wnt/beta-catenin pathway by niclosamide: a therapeutic target for ovarian cancer. Gynecol Oncol. 2014 Jul;134(1):112-20.
19 Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression. Environ Toxicol. 2018 Jun;33(6):659-669.
20 Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
21 The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677.
22 Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015 Aug 14;464(1):221-228. doi: 10.1016/j.bbrc.2015.06.120. Epub 2015 Jun 23.
23 EGF promotes HIF-1 expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3. Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1055-1062. doi: 10.26355/eurrev_201902_16993.
24 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
25 Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells. BMC Gastroenterol. 2016 Feb 25;16:25. doi: 10.1186/s12876-016-0442-3.
26 Niclosamide enhances ROS-mediated cell death through c-Jun activation. Biomed Pharmacother. 2014 Jun;68(5):619-24. doi: 10.1016/j.biopha.2014.03.018. Epub 2014 Mar 28.
27 Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. Toxicol In Vitro. 2023 Jun;89:105579. doi: 10.1016/j.tiv.2023.105579. Epub 2023 Mar 3.
28 Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells. Biomed Pharmacother. 2017 Dec;96:434-442. doi: 10.1016/j.biopha.2017.09.149. Epub 2017 Oct 12.
29 Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds. Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318.
30 Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst. 2011 Jul 6;103(13):1018-36. doi: 10.1093/jnci/djr190. Epub 2011 Jun 17.
31 Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells. Cell Physiol Biochem. 2018;47(3):957-971. doi: 10.1159/000490140. Epub 2018 May 24.
32 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
33 Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Int Immunopharmacol. 2016 Feb;31:45-9. doi: 10.1016/j.intimp.2015.11.002. Epub 2015 Dec 17.
34 Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal. 2013 Apr;25(4):961-9. doi: 10.1016/j.cellsig.2013.01.007. Epub 2013 Jan 16.
35 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
36 Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
37 A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities. Cell Physiol Biochem. 2016;39(3):871-88. doi: 10.1159/000447797. Epub 2016 Aug 9.
38 Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib. Cancer Metab. 2014; 2(Suppl 1): P14.