Details of the Drug Combinations

General Information of This Drug (ID: DMIZKOP)

Drug Name

Thiotepa DMIZKOP

Synonyms

thiotepa; THIO-TEPA; 52-24-4; Triethylenethiophosphoramide; Thiophosphamide; Tiofosyl; Tiofosfamid; Thiofozil; Tiofozil; Thioplex; Tespamin; Oncotepa; Tespamine; Girostan; Thiotef; Stepa; Tio-tef; Thio-Tep; Oncotiotepa; Tifosyl; Oncothio-tepa; TESPA; TSPA; Thio-tepa S; Ledertepa; Thiotriethylenephosphoramide; TIO TEF; N,N',N''-Triethylenethiophosphoramide; Tris(1-aziridinyl)phosphine sulfide; Thiophosphamidum; 1,1',1''-phosphorothioyltriaziridine; Triethylene thiophosphoramide; Triaziridinylphosphine sulfide

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[1]
Immunodeficiency	4A00-4A85	Approved	[2]
Leukemia	N.A.	Approved	[2]
Urinary bladder cancer	N.A.	Approved	[2]
Classic Hodgkin lymphoma	N.A.	Investigative	[2]
Neuroblastoma	2D11.2	Investigative	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acalabrutinib + Thiotepa	DCTO5NB	Acalabrutinib	Refractory and Relapsed Primary CNS Lymphoma	[3]
Methotrexate + Thiotepa	DCJWKYY	Methotrexate	Brain and Central Nervous System Tumors	[4]
Methotrexate + Thiotepa	DCRVSCR	Methotrexate	Lymphoma	[5]
Thiotepa + Fludarabine	DCFXMSL	Fludarabine	Leukemia	[6]
Thiotepa + DTI-015	DCJTCOB	DTI-015	Central Nervous System Lymphoma	[7]
Thiotepa + Melphalan	DCL1TVN	Melphalan	Hematologic Malignancies	[8]
Cyclophosphamide + Thiotepa	DCQY0XW	Cyclophosphamide	Lymphoma	[9]
Cyclophosphamide + Thiotepa	DCH9LKH	Cyclophosphamide	Leukemia, Myeloid, Acute	[10]
Thiotepa + Fludarabine	DCEDCHE	Fludarabine	Acute Myeloid Leukaemia	[11]
Cyclophosphamide + Thiotepa	DCW552D	Cyclophosphamide	Breast Cancer	[12]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7622).
2	Thiotepa FDA Label
3	ClinicalTrials.gov (NCT05021770) Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma
4	ClinicalTrials.gov (NCT00621036) Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma
5	ClinicalTrials.gov (NCT02724904) Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma
6	ClinicalTrials.gov (NCT00392782) Donor Stem Cell Transplant in Treating Patients With Myeloid Cancer or Other Disease
7	ClinicalTrials.gov (NCT01011920) Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma
8	ClinicalTrials.gov (NCT01350258) Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps
9	ClinicalTrials.gov (NCT02049580) Reduced Intensity Conditioning (RIC) Regimen and Post-transplant Cyclophosphamide in Haploidentical Bone Marrow Transplantation in in Patients With Poor Prognosis Lymphomas
10	ClinicalTrials.gov (NCT05565105) CD34+ Transplants for Leukemia and Lymphoma
11	ClinicalTrials.gov (NCT04217278) A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT
12	ClinicalTrials.gov (NCT00002836) Filgrastim Plus Chemotherapy Compared With Filgrastim Alone In Treating Women Undergoing Peripheral Stem Cell Transplantation For Breast Cancer