Details of the Drug Combination

General Information of Drug Combination (ID: DCJTCOB)

Drug Combination Name
Thiotepa DTI-015
Indication
Disease Entry Status REF
Central Nervous System Lymphoma Phase 1 [1]
Component Drugs Thiotepa   DMIZKOP DTI-015   DMXZRW0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Thiotepa
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [2]
Immunodeficiency 4A00-4A85 Approved [3]
Leukemia N.A. Approved [3]
Urinary bladder cancer N.A. Approved [3]
Classic Hodgkin lymphoma N.A. Investigative [3]
Neuroblastoma 2D11.2 Investigative [3]
Thiotepa Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [10]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [11]
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Thiotepa Interacts with 17 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Affects Export [12]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Affects Export [12]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Decreases Activity [13]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [9]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [9]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [9]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [9]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [9]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [9]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [14]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Affects Response To Substance [15]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Affects Response To Substance [15]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [16]
N-glycosylase/DNA lyase (OGG1) OTJ97TF3 OGG1_HUMAN Decreases Response To Substance [17]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Response To Substance [11]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Affects Response To Substance [18]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Export [12]
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⏷ Show the Full List of 17 DOT(s)
Indication(s) of DTI-015
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Approved [4]
Glioblastoma of brain 2A00.00 Approved [5]
Liver cancer 2C12 Approved [6]
Malignant glioma 2A00.0 Approved [7]
Plasma cell myeloma 2A83.1 Approved [8]
Classic Hodgkin lymphoma N.A. Investigative [8]
DTI-015 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Binder [6]
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DTI-015 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [22]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [23]
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DTI-015 Interacts with 386 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Response To Substance [20]
Probable G-protein coupled receptor 25 (GPR25) OTXTNEW3 GPR25_HUMAN Decreases Expression [19]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [19]
Ladinin-1 (LAD1) OT6YGTVX LAD1_HUMAN Decreases Expression [19]
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR) OTOLYLGI ISLR_HUMAN Decreases Expression [19]
Homeobox protein CDX-4 (CDX4) OTD1SQKM CDX4_HUMAN Decreases Expression [19]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [19]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Decreases Expression [19]
Actin-related protein 2/3 complex subunit 2 (ARPC2) OTSOKOMY ARPC2_HUMAN Decreases Expression [19]
Short stature homeobox protein (SHOX) OTE0YZJO SHOX_HUMAN Decreases Expression [19]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B) OTWQQ08W LX15B_HUMAN Decreases Expression [19]
Prosaposin receptor GPR37 (GPR37) OTIMDDI3 GPR37_HUMAN Decreases Expression [19]
Protein phosphatase 1G (PPM1G) OTLZL9CG PPM1G_HUMAN Decreases Expression [19]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) OTCDAVBQ SHIP2_HUMAN Decreases Expression [19]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [19]
Beta-1,4-galactosyltransferase 5 (B4GALT5) OTHMZY12 B4GT5_HUMAN Decreases Expression [19]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Decreases Expression [19]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [19]
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) OTW8KZAU DHX16_HUMAN Decreases Expression [19]
LIM homeobox transcription factor 1-beta (LMX1B) OTM8145D LMX1B_HUMAN Decreases Expression [19]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) OTG7NW98 F262_HUMAN Decreases Expression [19]
Sphingomyelin phosphodiesterase 2 (SMPD2) OTE5BVP9 NSMA_HUMAN Increases Expression [19]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) OT4CA13K ATS4_HUMAN Decreases Expression [19]
Probable G-protein coupled receptor 32 (GPR32) OTTWHSP9 GPR32_HUMAN Decreases Expression [19]
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) OTJFA4AV LRCH4_HUMAN Decreases Expression [19]
Gamma-synuclein (SNCG) OT3CPI8L SYUG_HUMAN Increases Expression [19]
Extracellular matrix protein 2 (ECM2) OTNGYVMR ECM2_HUMAN Increases Expression [19]
Aquaporin-8 (AQP8) OT99JKME AQP8_HUMAN Decreases Expression [19]
BAI1-associated protein 3 (BAIAP3) OTS1H0J0 BAIP3_HUMAN Decreases Expression [19]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [19]
Homeobox protein Nkx-2.2 (NKX2-2) OTDCOYNG NKX22_HUMAN Decreases Expression [19]
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) OTPUGCZO ASML_HUMAN Decreases Expression [19]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Decreases Expression [19]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Increases Expression [19]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Decreases Expression [19]
Gastrin (GAST) OTD0IP9N GAST_HUMAN Decreases Expression [19]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Decreases Expression [19]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [19]
Muellerian-inhibiting factor (AMH) OT5FH4BD MIS_HUMAN Decreases Expression [19]
Protamine-2 (PRM2) OTSAXTSQ PRM2_HUMAN Decreases Expression [19]
Non-histone chromosomal protein HMG-17 (HMGN2) OTN20MEF HMGN2_HUMAN Decreases Expression [19]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [19]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Decreases Expression [19]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Decreases Expression [19]
Acetylcholine receptor subunit gamma (CHRNG) OTXC2UR7 ACHG_HUMAN Decreases Expression [19]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [19]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Decreases Expression [19]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Decreases Expression [19]
U2 small nuclear ribonucleoprotein B'' (SNRPB2) OT6XISJD RU2B_HUMAN Increases Expression [19]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [19]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Decreases Expression [19]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Increases Expression [19]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [19]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [19]
Alpha-actinin-1 (ACTN1) OTUCLNXH ACTN1_HUMAN Decreases Expression [19]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Decreases Expression [19]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [19]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [19]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Expression [19]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [19]
Myoblast determination protein 1 (MYOD1) OTV2S79X MYOD1_HUMAN Decreases Expression [19]
Myogenin (MYOG) OTPLJKFA MYOG_HUMAN Decreases Expression [19]
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) OT7US3NO SIAT1_HUMAN Increases Expression [19]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [19]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [19]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Decreases Expression [19]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Decreases Expression [19]
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) OTH5IL2A RPAB1_HUMAN Decreases Expression [19]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Decreases Expression [19]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Decreases Expression [19]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Decreases Expression [19]
Collagen alpha-1(IX) chain (COL9A1) OTWBR27Y CO9A1_HUMAN Decreases Expression [19]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [19]
Macrophage scavenger receptor types I and II (MSR1) OTHANJ7A MSRE_HUMAN Decreases Expression [19]
Iduronate 2-sulfatase (IDS) OTZO94EO IDS_HUMAN Decreases Expression [19]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Decreases Expression [19]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [19]
Carbonic anhydrase 6 (CA6) OTIX56CJ CAH6_HUMAN Decreases Expression [19]
Sodium-dependent noradrenaline transporter (SLC6A2) OTMHQJMP SC6A2_HUMAN Increases Expression [19]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Decreases Expression [19]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Decreases Expression [19]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Increases Expression [19]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [19]
Cystatin-D (CST5) OTHJXNJG CYTD_HUMAN Decreases Expression [19]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Decreases Expression [19]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Decreases Expression [19]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Decreases Expression [19]
Gonadotropin-releasing hormone receptor (GNRHR) OTLE25K3 GNRHR_HUMAN Increases Expression [19]
Rab GDP dissociation inhibitor alpha (GDI1) OTYM3928 GDIA_HUMAN Increases Expression [19]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [19]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [19]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Increases Expression [19]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Decreases Expression [19]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [19]
General transcription factor IIF subunit 1 (GTF2F1) OTVXS75P T2FA_HUMAN Decreases Expression [19]
Small proline-rich protein 2B (SPRR2B) OTQ9WPKY SPR2B_HUMAN Decreases Expression [19]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Decreases Expression [19]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [19]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [19]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [19]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [19]
Signal recognition particle 14 kDa protein (SRP14) OTAVZ94Y SRP14_HUMAN Decreases Expression [19]
Vasopressin V1a receptor (AVPR1A) OTKR8AFL V1AR_HUMAN Increases Expression [19]
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) OTZG1W8W CEAM3_HUMAN Decreases Expression [19]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [19]
Carnitine O-acetyltransferase (CRAT) OTSCLZ04 CACP_HUMAN Decreases Expression [19]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [19]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [19]
RPE-retinal G protein-coupled receptor (RGR) OTKCF5AZ RGR_HUMAN Decreases Expression [19]
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) OT9TZ2E0 GBRA2_HUMAN Decreases Expression [19]
Olfactory marker protein (OMP) OT7JH0DY OMP_HUMAN Decreases Expression [19]
Neuropeptides B/W receptor type 2 (NPBWR2) OTABA9JW NPBW2_HUMAN Decreases Expression [19]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [19]
Cyclin-dependent kinase 8 (CDK8) OTMC3CWX CDK8_HUMAN Decreases Expression [19]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) OTCV2Q89 FNTA_HUMAN Decreases Expression [19]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Decreases Expression [19]
Rab GDP dissociation inhibitor beta (GDI2) OTGLY3I7 GDIB_HUMAN Increases Expression [19]
Potassium-transporting ATPase subunit beta (ATP4B) OTIP2EYJ ATP4B_HUMAN Decreases Expression [19]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [19]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Decreases Expression [19]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [19]
Diphosphomevalonate decarboxylase (MVD) OTGEX4SR MVD1_HUMAN Decreases Expression [19]
Beta-crystallin B1 (CRYBB1) OTDI4W3V CRBB1_HUMAN Decreases Expression [19]
Clathrin heavy chain 2 (CLTCL1) OT6W5BNR CLH2_HUMAN Increases Expression [19]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [19]
UV excision repair protein RAD23 homolog A (RAD23A) OTBPAWHX RD23A_HUMAN Decreases Expression [19]
Eukaryotic translation initiation factor 6 (EIF6) OTEXMUED IF6_HUMAN Decreases Expression [19]
Syntaxin-1B (STX1B) OTSW59X0 STX1B_HUMAN Decreases Expression [19]
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) OTDSRUD5 PHS_HUMAN Decreases Expression [19]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [19]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [19]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Decreases Expression [19]
Contactin-associated protein 1 (CNTNAP1) OT5Y03EU CNTP1_HUMAN Increases Expression [19]
Homeobox protein Hox-A4 (HOXA4) OTNVTQDT HXA4_HUMAN Decreases Expression [19]
S-adenosylmethionine synthase isoform type-1 (MAT1A) OTK72E4F METK1_HUMAN Decreases Expression [19]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Decreases Expression [19]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Decreases Expression [19]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Decreases Expression [19]
Transducin-like enhancer protein 3 (TLE3) OTR9PH95 TLE3_HUMAN Decreases Expression [19]
Sex-determining region Y protein (SRY) OT516T6D SRY_HUMAN Decreases Expression [19]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) OTE5XENW ACHB3_HUMAN Decreases Expression [19]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [19]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Decreases Expression [19]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Decreases Expression [19]
Lysyl oxidase homolog 1 (LOXL1) OTA0NEJU LOXL1_HUMAN Decreases Expression [19]
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) OTXI5X4T MGAT3_HUMAN Decreases Expression [19]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Expression [19]
Kinesin heavy chain isoform 5A (KIF5A) OT3ETTI6 KIF5A_HUMAN Decreases Expression [19]
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) OTM7V78U M4K2_HUMAN Decreases Expression [19]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Decreases Expression [19]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [19]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Decreases Expression [19]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Increases Expression [19]
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) OTZ7VLTP ADA15_HUMAN Decreases Expression [19]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [19]
Translation initiation factor eIF2B subunit alpha (EIF2B1) OT4NCVY1 EI2BA_HUMAN Increases Expression [19]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Decreases Expression [19]
Growth factor receptor-bound protein 7 (GRB7) OTF8Y9XY GRB7_HUMAN Decreases Expression [19]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Expression [19]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Increases Expression [19]
Procollagen C-endopeptidase enhancer 1 (PCOLCE) OTJXOAN4 PCOC1_HUMAN Decreases Expression [19]
Reticulocalbin-1 (RCN1) OT3JBGAG RCN1_HUMAN Decreases Expression [19]
Keratin, type I cuticular Ha1 (KRT31) OTB6RCAH K1H1_HUMAN Decreases Expression [19]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [19]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [19]
Striated muscle preferentially expressed protein kinase (SPEG) OTQXWJR4 SPEG_HUMAN Decreases Expression [19]
Syntaxin-binding protein 2 (STXBP2) OTX8GUC4 STXB2_HUMAN Decreases Expression [19]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [19]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) OTX4UC3O GBRA6_HUMAN Decreases Expression [19]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Increases Expression [19]
Alpha-sarcoglycan (SGCA) OTCLJVZV SGCA_HUMAN Decreases Expression [19]
Cardiotrophin-1 (CTF1) OT6P9QBG CTF1_HUMAN Decreases Expression [19]
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) OTYMDAYV GLO2_HUMAN Decreases Expression [19]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [19]
Artemin (ARTN) OTWIWGL6 ARTN_HUMAN Decreases Expression [19]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) OTXIGC6I LAIR1_HUMAN Increases Expression [19]
Psychosine receptor (GPR65) OTCF5O4G PSYR_HUMAN Increases Expression [19]
Ataxin-2-like protein (ATXN2L) OTP5M3R9 ATX2L_HUMAN Decreases Expression [19]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) OTGND2YZ SIA8A_HUMAN Increases Expression [19]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Increases Expression [19]
Signal transducing adapter molecule 1 (STAM) OT6X5RR1 STAM1_HUMAN Decreases Expression [19]
Growth hormone secretagogue receptor type 1 (GHSR) OT1Y8ARK GHSR_HUMAN Decreases Expression [19]
Deoxyribonuclease-1-like 2 (DNASE1L2) OT56VFRL DNSL2_HUMAN Decreases Expression [19]
Forkhead box protein J1 (FOXJ1) OT7LLBZ7 FOXJ1_HUMAN Decreases Expression [19]
snRNA-activating protein complex subunit 3 (SNAPC3) OTSGZZCJ SNPC3_HUMAN Increases Expression [19]
Transcription factor IIIB 90 kDa subunit (BRF1) OTQC6DMG TF3B_HUMAN Decreases Expression [19]
Protein bicaudal D homolog 1 (BICD1) OT78IYPF BICD1_HUMAN Decreases Expression [19]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) OTHFFT6G SMRD1_HUMAN Increases Expression [19]
GTP-binding protein Rit2 (RIT2) OTSNYG0D RIT2_HUMAN Decreases Expression [19]
Cell cycle checkpoint control protein RAD9A (RAD9A) OTJ3AJQU RAD9A_HUMAN Decreases Expression [19]
Septin-5 (SEPTIN5) OT6JTJBO SEPT5_HUMAN Decreases Expression [19]
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) OTEY876E ZNT3_HUMAN Decreases Expression [19]
Neuronal PAS domain-containing protein 1 (NPAS1) OTZKO6ZN NPAS1_HUMAN Decreases Expression [19]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Decreases Expression [19]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [19]
Chorion-specific transcription factor GCMa (GCM1) OT5CPAUT GCM1_HUMAN Increases Expression [19]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [19]
Intercellular adhesion molecule 5 (ICAM5) OTDGGAFH ICAM5_HUMAN Decreases Expression [19]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Decreases Expression [19]
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) OT1KKMYZ BAIP2_HUMAN Decreases Expression [19]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) OTJCX8K9 MD1L1_HUMAN Decreases Expression [19]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [19]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Activity [24]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Activity [24]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Decreases Expression [25]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [25]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [26]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Increases Expression [27]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [28]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [29]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [29]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [30]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [31]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [32]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [28]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [31]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [33]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [34]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [32]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Increases Ubiquitination [35]
Three-prime repair exonuclease 1 (TREX1) OTQG7K12 TREX1_HUMAN Increases Expression [36]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Response To Substance [37]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Affects Response To Substance [20]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Affects Response To Substance [20]
Sodium channel protein type 8 subunit alpha (SCN8A) OT0JGIZN SCN8A_HUMAN Affects Response To Substance [20]
Transmembrane protein 158 (TMEM158) OT0KUBBI TM158_HUMAN Affects Response To Substance [20]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [20]
Glutaminyl-peptide cyclotransferase (QPCT) OT0TSHP4 QPCT_HUMAN Affects Response To Substance [20]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Affects Response To Substance [38]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Affects Response To Substance [20]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Affects Response To Substance [20]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Affects Response To Substance [20]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Affects Response To Substance [20]
Neurotrypsin (PRSS12) OT1MYL3L NETR_HUMAN Affects Response To Substance [20]
ATP-binding cassette sub-family G member 5 (ABCG5) OT1OMY93 ABCG5_HUMAN Affects Response To Substance [20]
Protein Lines homolog 1 (LINS1) OT1USO08 LINES_HUMAN Affects Response To Substance [20]
Protein ERGIC-53-like (LMAN1L) OT2CSBR3 LMA1L_HUMAN Affects Response To Substance [20]
Spermatogenesis-associated protein 12 (SPATA12) OT2EPI7P SPT12_HUMAN Affects Response To Substance [20]
Importin-4 (IPO4) OT2N5020 IPO4_HUMAN Affects Response To Substance [20]
Msx2-interacting protein (SPEN) OT37A2MD MINT_HUMAN Affects Response To Substance [20]
Protein-cysteine N-palmitoyltransferase HHAT (HHAT) OT3IXYII HHAT_HUMAN Affects Response To Substance [20]
Probable RNA-binding protein 19 (RBM19) OT3Q6UIM RBM19_HUMAN Affects Response To Substance [20]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Affects Response To Substance [20]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Affects Response To Substance [20]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Affects Response To Substance [20]
Microsomal glutathione S-transferase 2 (MGST2) OT4UGTDO MGST2_HUMAN Affects Response To Substance [20]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Affects Response To Substance [20]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [39]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Affects Response To Substance [20]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Affects Response To Substance [20]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) OT64TTGC PITC1_HUMAN Affects Response To Substance [20]
CCN family member 4 (CCN4) OT69BER9 CCN4_HUMAN Affects Response To Substance [20]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Affects Response To Substance [20]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Affects Response To Substance [20]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Affects Response To Substance [20]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Response To Substance [40]
Golgin subfamily A member 8B (GOLGA8B) OT807QHZ GOG8B_HUMAN Affects Response To Substance [20]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Affects Response To Substance [38]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Affects Response To Substance [20]
Glial cell line-derived neurotrophic factor (GDNF) OT8ICC4Z GDNF_HUMAN Decreases Response To Substance [41]
Paired mesoderm homeobox protein 2 (PRRX2) OT8UR4AU PRRX2_HUMAN Affects Response To Substance [20]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Affects Response To Substance [20]
Serine/threonine-protein kinase LMTK2 (LMTK2) OT93MVIC LMTK2_HUMAN Affects Response To Substance [20]
Doublesex- and mab-3-related transcription factor C2 (DMRTC2) OT959L3E DMRTD_HUMAN Affects Response To Substance [20]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Affects Response To Substance [20]
Secretory carrier-associated membrane protein 5 (SCAMP5) OT9MXA2J SCAM5_HUMAN Affects Response To Substance [20]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Response To Substance [20]
N-acetylneuraminate lyase (NPL) OTA7P0TO NPL_HUMAN Affects Response To Substance [20]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Response To Substance [20]
DNA-3-methyladenine glycosylase (MPG) OTAHW80B 3MG_HUMAN Decreases Response To Substance [42]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Response To Substance [20]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [20]
Enteropeptidase (TMPRSS15) OTB277NN ENTK_HUMAN Affects Response To Substance [20]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) OTBML9D9 CGAT1_HUMAN Affects Response To Substance [20]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Response To Substance [43]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Affects Response To Substance [20]
Organic cation/carnitine transporter 2 (SLC22A5) OTC36TYB S22A5_HUMAN Affects Response To Substance [20]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Affects Response To Substance [20]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Affects Response To Substance [20]
Protein naked cuticle homolog 2 (NKD2) OTCYT3I6 NKD2_HUMAN Affects Response To Substance [20]
Cadherin-13 (CDH13) OTD2CYM5 CAD13_HUMAN Affects Response To Substance [20]
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) OTD5QPCI NT2NA_HUMAN Affects Response To Substance [20]
DNA polymerase subunit gamma-2 (POLG2) OTDBMZJB DPOG2_HUMAN Affects Response To Substance [20]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Affects Response To Substance [44]
Solute carrier family 15 member 2 (SLC15A2) OTDV7YES S15A2_HUMAN Affects Response To Substance [20]
Maturin (MTURN) OTEBJNVG MTURN_HUMAN Affects Response To Substance [20]
Cysteine and glycine-rich protein 3 (CSRP3) OTECBJMV CSRP3_HUMAN Affects Response To Substance [20]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Affects Response To Substance [20]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Affects Response To Substance [20]
Glycine receptor subunit beta (GLRB) OTF37UG4 GLRB_HUMAN Affects Response To Substance [20]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Affects Response To Substance [20]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Response To Substance [45]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Response To Substance [20]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Decreases Nitrosation [46]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Affects Response To Substance [38]
Polyhomeotic-like protein 2 (PHC2) OTG7ZO80 PHC2_HUMAN Affects Response To Substance [20]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Affects Response To Substance [20]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Affects Response To Substance [20]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Response To Substance [20]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Affects Uptake [47]
Urea transporter 1 (SLC14A1) OTH7UUV0 UT1_HUMAN Affects Response To Substance [20]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Affects Response To Substance [20]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Affects Response To Substance [20]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Affects Response To Substance [20]
Phosphopentomutase (PGM2) OTIR1VDW PGM2_HUMAN Affects Response To Substance [20]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Affects Response To Substance [20]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Affects Response To Substance [20]
N-glycosylase/DNA lyase (OGG1) OTJ97TF3 OGG1_HUMAN Decreases Response To Substance [17]
Protocadherin beta-2 (PCDHB2) OTJ9UCIH PCDB2_HUMAN Affects Response To Substance [20]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Affects Response To Substance [20]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [20]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Affects Response To Substance [20]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Affects Response To Substance [20]
Nuclear factor of activated T-cells 5 (NFAT5) OTKIE59S NFAT5_HUMAN Affects Response To Substance [20]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Response To Substance [48]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Affects Response To Substance [20]
Transmembrane protein 19 (TMEM19) OTKWMDYH TMM19_HUMAN Affects Response To Substance [20]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) OTL0S21W PKHG5_HUMAN Affects Response To Substance [20]
Glutathione S-transferase Mu 3 (GSTM3) OTLA2WJT GSTM3_HUMAN Decreases Nitrosation [46]
Splicing factor 1 (SF1) OTLEDM2S SF01_HUMAN Affects Response To Substance [20]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Response To Substance [49]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) OTLUM9L7 PK3C3_HUMAN Affects Response To Substance [20]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Affects Response To Substance [20]
T-box transcription factor TBX3 (TBX3) OTM64N7K TBX3_HUMAN Affects Response To Substance [20]
Neuronal PAS domain-containing protein 2 (NPAS2) OTMRT2TS NPAS2_HUMAN Affects Response To Substance [20]
Exostosin-like 1 (EXTL1) OTMSNY9N EXTL1_HUMAN Affects Response To Substance [20]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Response To Substance [50]
Popeye domain-containing protein 3 (POPDC3) OTN4FJ5J POPD3_HUMAN Affects Response To Substance [20]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Increases Response To Substance [20]
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) OTO7O3CU DYR1B_HUMAN Affects Response To Substance [20]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Affects Response To Substance [20]
Anterior gradient protein 3 (AGR3) OTONJPDP AGR3_HUMAN Affects Response To Substance [20]
Histone-lysine N-methyltransferase MECOM (MECOM) OTP983W8 MECOM_HUMAN Affects Response To Substance [20]
Ras-related protein Rab-27B (RAB27B) OTPF9D0K RB27B_HUMAN Affects Response To Substance [20]
Plakophilin-3 (PKP3) OTPL1HRB PKP3_HUMAN Affects Response To Substance [20]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Affects Response To Substance [20]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Affects Response To Substance [20]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Response To Substance [20]
Lipopolysaccharide-binding protein (LBP) OTQXAH4L LBP_HUMAN Affects Response To Substance [20]
Prolyl 3-hydroxylase 3 (P3H3) OTRC8QCM P3H3_HUMAN Affects Response To Substance [20]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Increases Response To Substance [34]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Decreases Nitrosation [46]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Affects Response To Substance [20]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Affects Response To Substance [20]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Affects Response To Substance [20]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Affects Response To Substance [20]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Increases Response To Substance [51]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Response To Substance [52]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Affects Response To Substance [20]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Affects Response To Substance [20]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Affects Response To Substance [20]
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) OTT8Q1AP PDE5A_HUMAN Affects Response To Substance [20]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Affects Response To Substance [20]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Affects Response To Substance [20]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Affects Response To Substance [20]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Affects Response To Substance [20]
RAB6A-GEF complex partner protein 2 (RGP1) OTTZ63A6 RGP1_HUMAN Affects Response To Substance [20]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Decreases Response To Substance [53]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Affects Response To Substance [20]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Affects Response To Substance [20]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Affects Response To Substance [20]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Response To Substance [20]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Affects Response To Substance [20]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Affects Response To Substance [20]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) OTUTPVA9 PREX1_HUMAN Affects Response To Substance [20]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Affects Response To Substance [20]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Affects Response To Substance [20]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Affects Response To Substance [20]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Affects Response To Substance [20]
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) OTVK9EHD GLT15_HUMAN Affects Response To Substance [20]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Response To Substance [20]
Ankyrin-2 (ANK2) OTWB4R1Y ANK2_HUMAN Affects Response To Substance [20]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Increases Response To Substance [54]
Syndecan-1 (SDC1) OTWKRVZC SDC1_HUMAN Affects Response To Substance [20]
Mannan-binding lectin serine protease 1 (MASP1) OTWWCNZP MASP1_HUMAN Affects Response To Substance [20]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Affects Response To Substance [20]
E3 ubiquitin-protein ligase TRIM50 (TRIM50) OTXA2IXF TRI50_HUMAN Affects Response To Substance [20]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Affects Response To Substance [20]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Affects Response To Substance [20]
Engulfment and cell motility protein 1 (ELMO1) OTY2ORXK ELMO1_HUMAN Affects Response To Substance [20]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Affects Response To Substance [20]
GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3) OTYK950M GARL3_HUMAN Affects Response To Substance [20]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Response To Substance [55]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [20]
AP-1 complex subunit sigma-2 (AP1S2) OTZHJFYI AP1S2_HUMAN Affects Response To Substance [20]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Affects Response To Substance [20]
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References

1 ClinicalTrials.gov (NCT01011920) Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7622).
3 Thiotepa FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
5 Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol). Neuro Oncol. 2007 Jan;9(1):12-9.
6 Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.
7 Stereotactic injection of DTI-015 into recurrent malignant gliomas: phase I/II trial. Neoplasia. 2003 Jan-Feb;5(1):9-16.
8 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
9 Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
10 Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol. 2002 Jun;49(6):461-7.
11 Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys. 1999 Jun 1;366(1):89-94.
12 Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol. 2009 Jan;67(1):50-60. doi: 10.1111/j.1365-2125.2008.03321.x. Epub 2008 Nov 17.
13 The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation. Drug Metab Dispos. 2005 Jun;33(6):795-802.
14 Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.
15 Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenet Genomics. 2008 Nov;18(11):1009-15. doi: 10.1097/FPC.0b013e328313aaa4.
16 [Establishment of MRP-overexpression subline of bladder carcinoma and its MDR phenotype]. Zhonghua Zhong Liu Za Zhi. 2000 Jul;22(4):273-5.
17 Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications. J Pharmacol Exp Ther. 2001 Mar;296(3):825-31.
18 Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene. 1999 Apr 1;18(13):2241-51. doi: 10.1038/sj.onc.1202526.
19 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
20 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
21 Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol. 2011 May;103(1):87-102. doi: 10.1007/s11060-010-0374-7. Epub 2010 Sep 4.
22 Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo. Leuk Res. 1994 Nov;18(11):829-35.
23 Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol. 2006 Nov;21(11):1199-207.
24 Proline analogue of nitrosourea as a new cytotoxic prodrug. Arch Pharm (Weinheim). 2009 Nov;342(11):632-9.
25 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
26 Decreased GSSG reductase activity enhances cellular zinc toxicity in three human lung cell lines. Arch Toxicol. 2003 Mar;77(3):131-7. doi: 10.1007/s00204-002-0421-z. Epub 2003 Jan 4.
27 Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. Bone Marrow Transplant. 2004 Oct;34(7):609-14. doi: 10.1038/sj.bmt.1704616.
28 Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. Oncogene. 2005 Mar 24;24(13):2175-83. doi: 10.1038/sj.onc.1208250.
29 Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells. Pharmacol Rep. 2008 Mar-Apr;60(2):171-82.
30 Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
31 Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
32 BCNU down-regulates anti-apoptotic proteins bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells. J Neurooncol. 2004 Jul;68(3):233-41. doi: 10.1023/b:neon.0000033382.40601.5a.
33 Noninvasive assessment of E2F-1-mediated transcriptional regulation in vivo. Cancer Res. 2008 Jul 15;68(14):5932-40. doi: 10.1158/0008-5472.CAN-07-6373.
34 Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU. J Exp Clin Cancer Res. 2010 Oct 4;29(1):131. doi: 10.1186/1756-9966-29-131.
35 The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol Med (Berl). 2007 May;85(5):497-509. doi: 10.1007/s00109-006-0153-2. Epub 2007 Jan 13.
36 Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
37 Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Mol Pharmacol. 2003 Jan;63(1):192-202. doi: 10.1124/mol.63.1.192.
38 Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance. Mol Pharmacol. 2008 Jul;74(1):82-91. doi: 10.1124/mol.107.041988. Epub 2008 Apr 22.
39 A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res. 2007 Jan;5(1):61-70. doi: 10.1158/1541-7786.MCR-06-0329.
40 Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. Med Oncol. 2011 Mar;28(1):24-30. doi: 10.1007/s12032-010-9445-z. Epub 2010 Feb 24.
41 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci. 2009 Mar;16(3):427-36. doi: 10.1016/j.jocn.2008.06.002. Epub 2009 Jan 12.
42 Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res. 2005 Nov 15;65(22):10472-7. doi: 10.1158/0008-5472.CAN-05-1495.
43 Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. Cancer Res. 2000 Oct 1;60(19):5464-9.
44 The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18;99(8):639-52. doi: 10.1093/jnci/djk135.
45 Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. J Neurooncol. 2003 Feb;61(3):187-96. doi: 10.1023/a:1022554824129.
46 The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochem Pharmacol. 2002 Jan 15;63(2):191-7. doi: 10.1016/s0006-2952(01)00846-2.
47 Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients. Cancer Chemother Pharmacol. 2002 Jun;49(6):487-98. doi: 10.1007/s00280-002-0437-3. Epub 2002 Mar 21.
48 Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. Free Radic Biol Med. 2004 May 15;36(10):1317-28. doi: 10.1016/j.freeradbiomed.2004.02.010.
49 In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4523-32. doi: 10.1158/1078-0432.CCR-05-1830.
50 Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas. Oncol Rep. 2006 Jul;16(1):127-32.
51 Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. J Neurochem. 2009 Dec;111(5):1238-51. doi: 10.1111/j.1471-4159.2009.06410.x. Epub 2009 Oct 5.
52 Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line. Cancer Sci. 2010 Mar;101(3):767-73. doi: 10.1111/j.1349-7006.2009.01432.x. Epub 2010 Jan 7.
53 HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. Neuro Oncol. 2010 Sep;12(9):956-66. doi: 10.1093/neuonc/noq045. Epub 2010 May 14.
54 Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
55 Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. Biochem Biophys Res Commun. 2008 Sep 5;373(4):539-44. doi: 10.1016/j.bbrc.2008.06.070. Epub 2008 Jun 30.