Details of the Drug Combinations

General Information of This Drug (ID: DMJAGXQ)

Drug Name

Niclosamide DMJAGXQ

Synonyms

niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I

Indication

Disease Entry	ICD 11	Status	REF
Cestodes infection	1F70-1F76	Approved	[1]
Haemophilus influenza	1G40	Approved	[2]
Taeniasis	N.A.	Approved	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

109 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Niclosamide	DCZ7HIF	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetohydroxamic Acid + Niclosamide	DC7PALE	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Niclosamide	DCWLTC4	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Niclosamide	DCOHIOE	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + Niclosamide	DCQ81YX	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Armodafinil + Niclosamide	DCEUZJ3	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Niclosamide	DCDZEHW	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Baclofen + Niclosamide	DCFKKK8	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Niclosamide	DCW3V27	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bosentan + Niclosamide	DCZIEZU	Bosentan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Niclosamide	DCT49NH	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BRL-15572 + Niclosamide	DCZZLVL	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorambucil + Niclosamide	DCGRCXA	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlormezanone + Niclosamide	DCZKB1G	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorphenesin + Niclosamide	DCV3YUS	Chlorphenesin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilostazol + Niclosamide	DCGKXVB	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cycloguanil + Niclosamide	DCXAHKA	Cycloguanil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Daporinad + Niclosamide	DCFHIGY	Daporinad	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
Desoxycorticosterone pivalate + Niclosamide	DCCKF98	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dextromethorphan + Niclosamide	DC0S5IL	Dextromethorphan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Niclosamide	DC8UKQ2	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethambutol + Niclosamide	DCKAGAR	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethinyl estradiol + Niclosamide	DCWOYPJ	Ethinyl estradiol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
ETHISTERONE + Niclosamide	DC2HELJ	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Niclosamide	DCU4PVD	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
FORMESTANE + Niclosamide	DCSIYBR	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Furazolidone + Niclosamide	DCJXWAA	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GS4071 + Niclosamide	DCWU77P	GS4071	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imipramine + Niclosamide	DC45JGT	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Niclosamide	DC4AWQK	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
LIAROZOLE + Niclosamide	DCGSA5P	LIAROZOLE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lithium Citrate + Niclosamide	DCVE5DJ	Lithium Citrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lubiprostone + Niclosamide	DCCN7UL	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Niclosamide	DCCRIZA	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Niclosamide	DCB98HQ	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mephenytoin + Niclosamide	DCVW2NI	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methocarbamol + Niclosamide	DCSF39B	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylergonovine + Niclosamide	DCK979J	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Niclosamide	DCZAHQB	Miconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Moricizine + Niclosamide	DCP65VH	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nabilone + Niclosamide	DCF255T	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Naltrexone + Niclosamide	DCG5ITJ	Naltrexone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Meclofenamic acid	DCY7YQT	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Sertraline	DCI5OHM	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Gefitinib	DCDLKMC	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Diethylcarbamazine	DCU85GR	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Tindamax	DC6WWCU	Tindamax	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Tacrine	DCP7I98	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Panobinostat	DCP1THQ	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Niclosamide + Miglustat	DC9CFRE	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Pazopanib HCl	DCBYVFT	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Fomepizole	DCQ3YHD	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Ramelteon	DCYVV1C	Ramelteon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Acitretin	DCQANWT	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Dexmedetomidine	DCA3U1N	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Pepstatin	DCB6S2L	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + 10-hydroxycamptothecin	DCU26H6	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + IT-141	DCRIBPF	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Guanfacine	DCTTQ10	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Carglumic acid	DCY5RIK	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Doxapram	DCBFRP5	Doxapram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Chlorzoxazone	DC2SAHQ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Cilastatin	DC16KTD	Cilastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Aminosalicylic acid	DCD1W9J	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Naringenin	DCAGVF5	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + PFK-158	DCIOP1M	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Tolvaptan	DC5PIKV	Tolvaptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Arfolitixorin	DC9Q9LU	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Eflornithine	DCWHLTZ	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Ibutilide	DCWN6TF	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Diazoxide	DC4JKN3	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Fenoprofen	DCBAX1X	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Pargyline	DCZMSMV	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Idarubicin	DCIUQLC	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Linagliptin	DCTMIN9	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Acamprosate	DCHSGXC	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Clascoterone	DC24DDC	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Maprotiline	DCZAXD5	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Leflunomide	DC53SLP	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Amantadine	DC4RNQ8	Amantadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Valproic Acid	DCQSC20	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Quinine	DC98IRK	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Spironolactone	DCWLNXH	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Endoxifen	DCH1QRK	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Mycophenolic acid	DCXX4TF	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Testolactone	DC5P7A9	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Vorinostat	DC2T8NS	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Enoxacin	DCX0BZJ	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Raltegravir	DC7FJDW	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Nitrosoglutathione	DCM8KYZ	Nitrosoglutathione	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Etomidate	DCEY6AA	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olmesartan medoxomil + Niclosamide	DCGWPI3	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-04691502 + Niclosamide	DC7FYVW	PF-04691502	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
PF-04691502 + Niclosamide	DCNH51H	PF-04691502	Primitive neuroectodermal tumor (Cell Line: TC-32)	[3]
Phenprocoumon + Niclosamide	DCSA9U2	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Niclosamide	DCISBKS	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Niclosamide	DCBC1UO	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Procarbazine + Niclosamide	DCCRSHV	Procarbazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Niclosamide	DCIBPD9	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Rifampin + Niclosamide	DCB4G88	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Rufinamide + Niclosamide	DCR5NMQ	Rufinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
THAPSIGARGIN + Niclosamide	DC220SV	THAPSIGARGIN	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
THAPSIGARGIN + Niclosamide	DC5EZO6	THAPSIGARGIN	Primitive neuroectodermal tumor (Cell Line: TC-32)	[3]
Trametinib + Niclosamide	DCYIQL2	Trametinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
Triamterene + Niclosamide	DC767H0	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triflupromazine + Niclosamide	DC7DULM	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Niclosamide	DCRREWQ	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
WAY-100635 + Niclosamide	DCS8O14	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ym155 + Niclosamide	DC6LQLY	Ym155	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[3]
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⏷ Show the Full List of 109 DrugCom(s)

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Enzalutamide + Niclosamide	DC3RWU5	Enzalutamide	Metastatic Prostate Carcinoma	[5]
Enzalutamide + Niclosamide	DCJ1HEN	Enzalutamide	Castration Levels of Testosterone	[6]
ABIRATERONE + Niclosamide	DCRFN2Y	ABIRATERONE	Metastatic Prostate Carcinoma	[7]
Diltiazem + Niclosamide	DC92H2M	Diltiazem	Coronavirus Disease 2019 (COVID-19)	[8]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8494).
2	Niclosamide FDA Label
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT03123978) Enzalutamide and Niclosamide in Treating Patients With Recurrent or Metastatic Castration-Resistant Prostate Cancer
6	ClinicalTrials.gov (NCT02532114) Niclosamide and Enzalutamide in Treating Patients With Castration-Resistant, Metastatic Prostate Cancer
7	ClinicalTrials.gov (NCT02807805) Abiraterone Acetate, Niclosamide, and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer
8	ClinicalTrials.gov (NCT04372082) Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19. U.S. National Institutes of Health.