Details of the Drug Combination

General Information of Drug Combination (ID: DCWLNXH)

• Drug Combination Name: Niclosamide + Spironolactone
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Niclosamide (DMJAGXQ): Small molecular drug
  Spironolactone (DM2AQ5N): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 28.14
  Bliss Independence Score: 28.14
  Loewe Additivity Score: 35.03
  LHighest Single Agent (HSA) Score: 35.04

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Niclosamide

Disease Entry	ICD 11	Status	REF
Cestodes infection	1F70-1F76	Approved	[2]
Haemophilus influenza	1G40	Approved	[3]
Taeniasis	N.A.	Approved	[3]

Niclosamide Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[16]
Nitroreductase (NTR)	DE0K82S	A0A5K1UB29_SALTM	Metabolism	[17]

Niclosamide Interacts with 766 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Activity	[18]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Activity	[18]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Activity	[18]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Activity	[19]
Frizzled-9 (FZD9)	OTTZ9MKK	FZD9_HUMAN	Decreases Expression	[7]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8)	OTMEAWKO	NDUS8_HUMAN	Decreases Expression	[7]
Segment polarity protein dishevelled homolog DVL-1 (DVL1)	OTD67RF1	DVL1_HUMAN	Increases Expression	[7]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)	OTJ5TNHB	NDUC1_HUMAN	Increases Expression	[7]
NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7)	OTIRMB2O	NDUS7_HUMAN	Decreases Expression	[7]
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2)	OTBT8KW9	NDUS2_HUMAN	Decreases Expression	[7]
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3)	OTX61TQQ	NDUS3_HUMAN	Decreases Expression	[7]
ATP synthase subunit g, mitochondrial (ATP5MG)	OTD569IJ	ATP5L_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)	OTIXNT91	NDUB6_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7)	OT8CV3H5	NDUA7_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)	OTBURQ3A	NDUAA_HUMAN	Decreases Expression	[7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Increases Cleavage	[7]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10)	OTFLILEO	NDUBA_HUMAN	Decreases Expression	[7]
Aspartate aminotransferase, mitochondrial (GOT2)	OT6XBWN0	AATM_HUMAN	Increases Expression	[7]
Fructose-bisphosphate aldolase B (ALDOB)	OT7FR69A	ALDOB_HUMAN	Increases Expression	[7]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM)	OT1QY9JM	PFKAM_HUMAN	Decreases Expression	[7]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Increases Expression	[7]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[7]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[7]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Decreases Expression	[7]
Pyruvate carboxylase, mitochondrial (PC)	OT6O0V51	PYC_HUMAN	Increases Expression	[7]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Decreases Expression	[7]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Increases Expression	[7]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Increases Expression	[7]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)	OTPOAAUW	AT5F1_HUMAN	Decreases Expression	[7]
ATP synthase subunit alpha, mitochondrial (ATP5F1A)	OT3FZDLX	ATPA_HUMAN	Increases Expression	[7]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Increases Expression	[7]
Enoyl-CoA hydratase, mitochondrial (ECHS1)	OTS0593S	ECHM_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)	OTYA3GB4	2AAA_HUMAN	Increases Expression	[7]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[7]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Decreases Expression	[7]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[7]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3)	OTX674BU	AT5G3_HUMAN	Decreases Expression	[7]
Casein kinase I isoform epsilon (CSNK1E)	OTF0UXX6	KC1E_HUMAN	Increases Expression	[7]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8)	OTBO0YKI	NDUA8_HUMAN	Decreases Expression	[7]
ATP synthase subunit f, mitochondrial (ATP5MF)	OTE4TBG9	ATPK_HUMAN	Decreases Expression	[7]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3)	OTSCYB9P	NDUV3_HUMAN	Increases Expression	[7]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[7]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)	OT24GMCM	PP2AB_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B)	OTSFVC82	2ABB_HUMAN	Decreases Expression	[7]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Increases Expression	[7]
Protein kinase C theta type (PRKCQ)	OTH2VABH	KPCT_HUMAN	Increases Expression	[7]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Increases Expression	[7]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Expression	[7]
C-terminal-binding protein 1 (CTBP1)	OTVYH2DH	CTBP1_HUMAN	Increases Expression	[7]
Frizzled-5 (FZD5)	OTXFFY56	FZD5_HUMAN	Increases Expression	[7]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Decreases Expression	[7]
V-type proton ATPase subunit S1 (ATP6AP1)	OTX1K0SJ	VAS1_HUMAN	Decreases Expression	[7]
2,4-dienoyl-CoA reductase , mitochondrial (DECR1)	OTCDIR6X	DECR_HUMAN	Decreases Expression	[7]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Decreases Expression	[7]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Increases Expression	[7]
Segment polarity protein dishevelled homolog DVL-3 (DVL3)	OTPRROHJ	DVL3_HUMAN	Increases Expression	[7]
Protein naked cuticle homolog 1 (NKD1)	OTY3MO97	NKD1_HUMAN	Increases Expression	[7]
ATP synthase subunit s, mitochondrial (DMAC2L)	OT2OQ1UD	ATP5S_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)	OTK0PG7R	NUA4L_HUMAN	Increases Expression	[7]
Ethylmalonyl-CoA decarboxylase (ECHDC1)	OTMS00PY	ECHD1_HUMAN	Decreases Expression	[7]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)	OTXK0SDM	2ABG_HUMAN	Decreases Expression	[7]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[20]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Decreases Expression	[8]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[8]
Low-density lipoprotein receptor-related protein 6 (LRP6)	OTM7PSUR	LRP6_HUMAN	Decreases Expression	[8]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Decreases Expression	[8]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[8]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[8]
Phosphatidylcholine-sterol acyltransferase (LCAT)	OTRLMLK0	LCAT_HUMAN	Increases Expression	[8]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[8]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[8]
Metallothionein-1F (MT1F)	OTZVUYG1	MT1F_HUMAN	Increases Expression	[8]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Expression	[8]
All-trans-retinol dehydrogenase ADH4 (ADH4)	OTKDKKNG	ADH4_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase A-Raf (ARAF)	OTZJ0FNO	ARAF_HUMAN	Decreases Expression	[8]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[8]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Expression	[8]
Properdin (CFP)	OTHZBLQK	PROP_HUMAN	Increases Expression	[8]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[8]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Expression	[8]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[8]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Decreases Expression	[8]
Kinesin-like protein KIF11 (KIF11)	OTHRGLCQ	KIF11_HUMAN	Decreases Expression	[8]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[8]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[8]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[8]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[8]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Decreases Expression	[8]
Apolipoprotein F (APOF)	OT12S5QS	APOF_HUMAN	Decreases Expression	[8]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Decreases Expression	[8]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[8]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[8]
Cell division cycle-associated protein 2 (CDCA2)	OTX8UF9J	CDCA2_HUMAN	Decreases Expression	[8]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[8]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3)	OT7XYA2T	ES8L3_HUMAN	Increases Expression	[8]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[8]
DNA repair and recombination protein RAD54-like (RAD54L)	OTEGMAKG	RAD54_HUMAN	Increases Expression	[8]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[8]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[8]
Cysteine/serine-rich nuclear protein 1 (CSRNP1)	OTDK1FPH	CSRN1_HUMAN	Increases Expression	[8]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[8]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[8]
Protein FAM83D (FAM83D)	OTQWZ1UO	FA83D_HUMAN	Decreases Expression	[8]
Transcriptional and immune response regulator (TCIM)	OTARUXQF	TCIM_HUMAN	Increases Expression	[8]
Histone chaperone ASF1B (ASF1B)	OTKXX12I	ASF1B_HUMAN	Decreases Expression	[8]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Increases Expression	[8]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)	OT8P6QNJ	CELR3_HUMAN	Increases Expression	[8]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Decreases Expression	[8]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[8]
Transforming acidic coiled-coil-containing protein 3 (TACC3)	OTRNEZTA	TACC3_HUMAN	Decreases Expression	[8]
Collectin-10 (COLEC10)	OTMBADGZ	COL10_HUMAN	Increases Expression	[8]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Decreases Expression	[21]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Decreases Expression	[21]
Dipeptidyl peptidase 1 (CTSC)	OT79WJZZ	CATC_HUMAN	Decreases Expression	[21]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)	OTQ0BYK6	LX12B_HUMAN	Increases Expression	[22]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Increases Expression	[22]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[22]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[22]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[22]
SPEG neighbor protein (SPEGNB)	OTAC32TJ	SPEGN_HUMAN	Increases Expression	[9]
Glucoside xylosyltransferase 2 (GXYLT2)	OTMLQQKP	GXLT2_HUMAN	Increases Expression	[9]
Homeobox protein HMX2 (HMX2)	OTBRXY6D	HMX2_HUMAN	Increases Expression	[9]
Protein FAM221A (FAM221A)	OT13M8XE	F221A_HUMAN	Increases Expression	[9]
Transmembrane protein 8B (TMEM8B)	OTJZWPS6	TMM8B_HUMAN	Increases Expression	[9]
Nuclear protein 2 (NUPR2)	OTNS6IEC	NUPR2_HUMAN	Increases Expression	[9]
Arginine-fifty homeobox (ARGFX)	OTV7LGJV	ARGFX_HUMAN	Decreases Expression	[9]
Ras association domain-containing protein 10 (RASSF10)	OTGB7EBG	RASFA_HUMAN	Decreases Expression	[9]
Choriogonadotropin subunit beta variant 1 (CGB1)	OT7NFGXF	CGB1_HUMAN	Increases Expression	[9]
LYR motif-containing protein 9 (LYRM9)	OT1MILTK	LYRM9_HUMAN	Increases Expression	[9]
Putative transmembrane protein INAFM1 (INAFM1)	OTXC8QBG	INAM1_HUMAN	Increases Expression	[9]
Fibronectin type III domain-containing protein 10 (FNDC10)	OT06NW7W	FND10_HUMAN	Increases Expression	[9]
Galectin-8 (LGALS8)	OT71LJ8T	LEG8_HUMAN	Decreases Expression	[9]
E3 SUMO-protein ligase CBX4 (CBX4)	OT4XVRRF	CBX4_HUMAN	Increases Expression	[9]
Synaptotagmin-5 (SYT5)	OT718PRY	SYT5_HUMAN	Increases Expression	[9]
Butyrophilin subfamily 3 member A1 (BTN3A1)	OTGZADIX	BT3A1_HUMAN	Increases Expression	[9]
SH2B adapter protein 2 (SH2B2)	OTEDHHDH	SH2B2_HUMAN	Increases Expression	[9]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Increases Expression	[9]
Suppressor of cytokine signaling 2 (SOCS2)	OTBPNKJQ	SOCS2_HUMAN	Increases Expression	[9]
Receptor-type tyrosine-protein phosphatase T (PTPRT)	OTV5TXNN	PTPRT_HUMAN	Decreases Expression	[9]
F-BAR domain only protein 1 (FCHO1)	OTDNDGI9	FCHO1_HUMAN	Increases Expression	[9]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Increases Expression	[9]
Segment polarity protein dishevelled homolog DVL-2 (DVL2)	OTMNYNCM	DVL2_HUMAN	Decreases Expression	[23]
Golgi SNAP receptor complex member 2 (GOSR2)	OTYHIYN2	GOSR2_HUMAN	Decreases Expression	[9]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Increases Expression	[9]
Serine/threonine-protein phosphatase with EF-hands 2 (PPEF2)	OT0KW3GX	PPE2_HUMAN	Decreases Expression	[9]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Affects Localization	[24]
Regulator of G-protein signaling 13 (RGS13)	OTPAMQ18	RGS13_HUMAN	Decreases Expression	[9]
Protein KHNYN (KHNYN)	OT5ZFS95	KHNYN_HUMAN	Increases Expression	[9]
Lysine-specific demethylase 6B (KDM6B)	OTMZVHSG	KDM6B_HUMAN	Increases Expression	[9]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[9]
Glutamate receptor ionotropic, NMDA 2D (GRIN2D)	OTTEKYKQ	NMDE4_HUMAN	Increases Expression	[9]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[9]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)	OTIK337D	TGFI1_HUMAN	Increases Expression	[9]
Ras GTPase-activating protein 4 (RASA4)	OTW0178L	RASL2_HUMAN	Increases Expression	[9]
Regulator of G-protein signaling 14 (RGS14)	OTYN79AG	RGS14_HUMAN	Increases Expression	[9]
Lysine-specific demethylase hairless (HR)	OTHEZWPW	HAIR_HUMAN	Increases Expression	[9]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Decreases Expression	[10]
Regulator of G-protein signaling 10 (RGS10)	OTQ8N1QH	RGS10_HUMAN	Increases Expression	[9]
Peptidase inhibitor 15 (PI15)	OTPJL6ML	PI15_HUMAN	Decreases Expression	[9]
ER lumen protein-retaining receptor 3 (KDELR3)	OTW8C1V0	ERD23_HUMAN	Increases Expression	[9]
Protein phosphatase 1 regulatory subunit 12B (PPP1R12B)	OTONIS87	MYPT2_HUMAN	Increases Expression	[9]
Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1)	OTABV7D2	H6ST1_HUMAN	Decreases Expression	[9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7)	OTHS1L0E	GBG7_HUMAN	Increases Expression	[9]
tRNA wybutosine-synthesizing protein 4 (LCMT2)	OT4RUVCM	TYW4_HUMAN	Decreases Expression	[9]
HMG box-containing protein 1 (HBP1)	OTDPGGDV	HBP1_HUMAN	Increases Expression	[9]
ATP-binding cassette sub-family C member 9 (ABCC9)	OTGAXLQN	ABCC9_HUMAN	Decreases Expression	[9]
Liprin-alpha-3 (PPFIA3)	OTNPZ6HT	LIPA3_HUMAN	Increases Expression	[9]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[9]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Increases Expression	[9]
Cytokine receptor-like factor 1 (CRLF1)	OT55PXIN	CRLF1_HUMAN	Decreases Expression	[9]
GSK-3-binding protein FRAT2 (FRAT2)	OT481GQ4	FRAT2_HUMAN	Increases Expression	[9]
Transcription initiation protein SPT3 homolog (SUPT3H)	OT7B6FRO	SUPT3_HUMAN	Increases Expression	[9]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5)	OTAVZJ3J	KS6A5_HUMAN	Increases Expression	[9]
Paralemmin-1 (PALM)	OTTZONUX	PALM_HUMAN	Increases Expression	[9]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[9]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[9]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Increases Expression	[9]
Olfactory receptor 7C1 (OR7C1)	OTQKD84O	OR7C1_HUMAN	Increases Expression	[9]
Tubulin polymerization-promoting protein (TPPP)	OTCFMSUF	TPPP_HUMAN	Increases Expression	[9]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11)	OTBOY3WH	KBTBB_HUMAN	Increases Expression	[9]
Rho-related BTB domain-containing protein 1 (RHOBTB1)	OTGE8K45	RHBT1_HUMAN	Increases Expression	[9]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[9]
Neurexophilin-2 (NXPH2)	OTHD8HPU	NXPH2_HUMAN	Decreases Expression	[9]
Neurexophilin-4 (NXPH4)	OTV057AG	NXPH4_HUMAN	Increases Expression	[9]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)	OTM705TH	CAC1H_HUMAN	Increases Expression	[9]
Uncharacterized protein C1orf105 (C1ORF105)	OTALIGHW	CA105_HUMAN	Decreases Expression	[9]
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)	OTP9A2BQ	ETHE1_HUMAN	Increases Expression	[9]
Follistatin-related protein 3 (FSTL3)	OT75489W	FSTL3_HUMAN	Increases Expression	[9]
Fibroblast growth factor 19 (FGF19)	OT2DVJWY	FGF19_HUMAN	Increases Expression	[9]
Probable G-protein coupled receptor 75 (GPR75)	OT8SPUGC	GPR75_HUMAN	Decreases Expression	[9]
Echinoderm microtubule-associated protein-like 2 (EML2)	OTRX2NTA	EMAL2_HUMAN	Increases Expression	[9]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Decreases Expression	[13]
Putative hydrolase DDAH2 (DDAH2)	OT8Q40G2	DDAH2_HUMAN	Increases Expression	[9]
Uncharacterized protein C6orf47 (C6ORF47)	OTMKBNDD	CF047_HUMAN	Affects Expression	[9]
Polyglutamylase complex subunit TTLL1 (TTLL1)	OTCE097J	TTLL1_HUMAN	Increases Expression	[9]
T-box transcription factor TBX6 (TBX6)	OTW1Q8RM	TBX6_HUMAN	Increases Expression	[9]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[9]
L-lactate dehydrogenase A chain (LDHA)	OTN7K4XB	LDHA_HUMAN	Decreases Expression	[9]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[9]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[25]
Coagulation factor X (F10)	OT2BLK17	FA10_HUMAN	Increases Expression	[9]
Coagulation factor XII (F12)	OTBFD2FU	FA12_HUMAN	Increases Expression	[9]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Decreases Expression	[9]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[26]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Expression	[25]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Activity	[15]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[12]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Expression	[9]
Alpha-1B-glycoprotein (A1BG)	OTFVUGNQ	A1BG_HUMAN	Increases Expression	[9]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[27]
Fibroblast growth factor 1 (FGF1)	OT8I64X8	FGF1_HUMAN	Decreases Expression	[10]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[28]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Decreases Expression	[9]
Prostate-specific antigen (KLK3)	OTFGSBFJ	KLK3_HUMAN	Decreases Expression	[11]
Complement decay-accelerating factor (CD55)	OTZ3HWTO	DAF_HUMAN	Increases Expression	[9]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Expression	[14]
Alpha-2A adrenergic receptor (ADRA2A)	OTZFGOTP	ADA2A_HUMAN	Decreases Expression	[9]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Increases Expression	[9]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Increases Expression	[9]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Decreases Expression	[27]
Protein ELFN1 (ELFN1)	OTM7M52U	ELFN1_HUMAN	Increases Expression	[9]
Proline-rich protein 29 (PRR29)	OT8GLHGQ	PRR29_HUMAN	Decreases Expression	[9]
Glutathione S-transferase theta-2 (GSTT2)	OTANW3TJ	GST2_HUMAN	Decreases Expression	[9]
Small integral membrane protein 10-like protein 2A (SMIM10L2B)	OT04IG2N	SIL2A_HUMAN	Increases Expression	[9]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[11]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Increases Expression	[9]
Acetylcholine receptor subunit beta (CHRNB1)	OTTJXD24	ACHB_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[9]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Affects Binding	[29]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[30]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[9]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Increases Expression	[9]
Protein L-Myc (MYCL)	OT1MFQ5U	MYCL_HUMAN	Increases Expression	[9]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[13]
Platelet glycoprotein Ib beta chain (GP1BB)	OTD7XNLL	GP1BB_HUMAN	Increases Expression	[9]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Increases Expression	[9]
Insulin receptor-related protein (INSRR)	OT3F75WA	INSRR_HUMAN	Decreases Expression	[9]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Decreases Expression	[13]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Increases Expression	[9]
Metalloproteinase inhibitor 2 (TIMP2)	OT8S1RRP	TIMP2_HUMAN	Increases Expression	[13]
Atrial natriuretic peptide receptor 1 (NPR1)	OTRWART5	ANPRA_HUMAN	Increases Expression	[9]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[9]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[9]
Endoglin (ENG)	OTL2LSMI	EGLN_HUMAN	Increases Expression	[9]
Galectin-3 (LGALS3)	OTYQT0ZI	LEG3_HUMAN	Increases Expression	[9]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Decreases Expression	[9]
Arylamine N-acetyltransferase 1 (NAT1)	OTCCNQ3H	ARY1_HUMAN	Decreases Expression	[9]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1)	OT4L2SSB	GBRB1_HUMAN	Increases Expression	[9]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[27]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[27]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Affects Localization	[24]
Ras-related protein Rab-3A (RAB3A)	OT2GIUO5	RAB3A_HUMAN	Increases Expression	[9]
Nuclear receptor subfamily 1 group D member 1 (NR1D1)	OTJ38PTB	NR1D1_HUMAN	Increases Expression	[9]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Increases Expression	[9]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[9]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Increases Expression	[9]
D(4) dopamine receptor (DRD4)	OTAJTO7N	DRD4_HUMAN	Increases Expression	[9]
Cartilage matrix protein (MATN1)	OTBRTCTQ	MATN1_HUMAN	Increases Expression	[9]
Fibroblast growth factor receptor 4 (FGFR4)	OTRQERG2	FGFR4_HUMAN	Increases Expression	[9]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[9]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)	OTGP6GA4	NR4A1_HUMAN	Increases Expression	[9]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Phosphorylation	[31]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Decreases Expression	[9]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4)	OTOCBX7P	TNFL4_HUMAN	Increases Expression	[9]
Stromelysin-3 (MMP11)	OTRTXDBM	MMP11_HUMAN	Increases Expression	[9]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[26]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[9]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[30]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Phosphorylation	[24]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Increases Expression	[9]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[32]
CD27 antigen (CD27)	OTH7NA58	CD27_HUMAN	Increases Expression	[9]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[24]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[24]
5-hydroxytryptamine receptor 1E (HTR1E)	OTOK64JC	5HT1E_HUMAN	Decreases Expression	[9]
Ephrin type-A receptor 8 (EPHA8)	OTHOESG6	EPHA8_HUMAN	Increases Expression	[9]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[9]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[9]
Transcription factor HIVEP2 (HIVEP2)	OTVOMCW4	ZEP2_HUMAN	Increases Expression	[9]
DnaJ homolog subfamily A member 1 (DNAJA1)	OT38BZQQ	DNJA1_HUMAN	Decreases Expression	[9]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Expression	[33]
ETS-related transcription factor Elf-1 (ELF1)	OTV5LKIA	ELF1_HUMAN	Increases Expression	[9]
Lymphocyte-specific protein 1 (LSP1)	OTSPSIFO	LSP1_HUMAN	Decreases Expression	[9]
DNA replication licensing factor MCM5 (MCM5)	OTAHLB62	MCM5_HUMAN	Decreases Expression	[9]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[30]
Macrosialin (CD68)	OTOYEY3J	CD68_HUMAN	Increases Expression	[9]
Histamine H1 receptor (HRH1)	OT8F9FV6	HRH1_HUMAN	Increases Expression	[9]
Prostaglandin E2 receptor EP4 subtype (PTGER4)	OT2GBV06	PE2R4_HUMAN	Decreases Expression	[9]
Apelin receptor (APLNR)	OT8585HU	APJ_HUMAN	Decreases Expression	[9]
Thrombospondin-4 (THBS4)	OTA1T9KK	TSP4_HUMAN	Increases Expression	[9]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[27]
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)	OTRO9RII	HMGCL_HUMAN	Increases Expression	[9]
Monocarboxylate transporter 8 (SLC16A2)	OTLRA7C0	MOT8_HUMAN	Increases Expression	[9]
Transcription factor 7 (TCF7)	OT1ID822	TCF7_HUMAN	Decreases Expression	[9]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Expression	[9]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Expression	[9]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[9]
Pre-B-cell leukemia transcription factor 1 (PBX1)	OTORABGO	PBX1_HUMAN	Increases Expression	[9]
Pre-B-cell leukemia transcription factor 2 (PBX2)	OTEBYCAW	PBX2_HUMAN	Increases Expression	[9]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[9]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[9]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Increases Expression	[9]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Increases Expression	[33]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Expression	[33]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Expression	[15]
Phosphorylase b kinase regulatory subunit alpha, liver isoform (PHKA2)	OTJE1KXL	KPB2_HUMAN	Decreases Expression	[9]
C-C chemokine receptor type 10 (CCR10)	OT7ZWSSD	CCR10_HUMAN	Increases Expression	[9]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Decreases Activity	[26]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[9]
Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4)	OT5I7OI2	GBRA4_HUMAN	Increases Expression	[9]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Decreases Expression	[9]
Mannan-binding lectin serine protease 1 (MASP1)	OTWWCNZP	MASP1_HUMAN	Increases Expression	[9]
Anion exchange protein 3 (SLC4A3)	OTXIRX39	B3A3_HUMAN	Increases Expression	[9]
Transmembrane ascorbate-dependent reductase CYB561 (CYB561)	OT61GMNV	CY561_HUMAN	Decreases Expression	[9]
Presenilin-2 (PSEN2)	OTOW778B	PSN2_HUMAN	Decreases Expression	[9]
PDZ and LIM domain protein 4 (PDLIM4)	OT23LZYY	PDLI4_HUMAN	Increases Expression	[9]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Increases Expression	[9]
Amiloride-sensitive sodium channel subunit delta (SCNN1D)	OTTX2G9M	SCNND_HUMAN	Increases Expression	[9]
Matrix metalloproteinase-15 (MMP15)	OT1XF517	MMP15_HUMAN	Increases Expression	[9]
Calponin-1 (CNN1)	OTVPG39Z	CNN1_HUMAN	Increases Expression	[9]
Tyrosine-protein kinase JAK3 (JAK3)	OTQ8QW2L	JAK3_HUMAN	Increases Expression	[9]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Increases Expression	[9]
Hexokinase-3 (HK3)	OTZKONGB	HXK3_HUMAN	Decreases Expression	[9]
Ephrin-A3 (EFNA3)	OTJGOUMZ	EFNA3_HUMAN	Increases Expression	[9]
Beta-crystallin B1 (CRYBB1)	OTDI4W3V	CRBB1_HUMAN	Increases Expression	[9]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[24]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[9]
Cadherin-4 (CDH4)	OT8LH3HN	CADH4_HUMAN	Increases Expression	[9]
Cadherin-6 (CDH6)	OT81Y80S	CADH6_HUMAN	Decreases Expression	[9]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Decreases Expression	[9]
Transmembrane protein 50B (TMEM50B)	OTWJK2XZ	TM50B_HUMAN	Decreases Expression	[9]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Expression	[9]
Regulator of G-protein signaling 8 (RGS8)	OTX60JDJ	RGS8_HUMAN	Decreases Expression	[9]
Inhibin beta E chain (INHBE)	OTOI2NYG	INHBE_HUMAN	Increases Expression	[9]
Lysyl oxidase homolog 3 (LOXL3)	OTLLY1QI	LOXL3_HUMAN	Increases Expression	[9]
Neurexin-2-beta (NRXN2)	OTB04QSU	NRX2B_HUMAN	Increases Expression	[9]
Neurexophilin-1 (NXPH1)	OTGKX860	NXPH1_HUMAN	Decreases Expression	[9]
Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2)	OTDGVXJ6	MNARL_HUMAN	Decreases Expression	[9]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Expression	[33]
Cell division control protein 42 homolog (CDC42)	OT5QBC5M	CDC42_HUMAN	Decreases Expression	[14]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Decreases Expression	[12]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Affects Phosphorylation	[31]
Disks large homolog 4 (DLG4)	OTD9E2LU	DLG4_HUMAN	Increases Expression	[9]
Butyrophilin subfamily 3 member A2 (BTN3A2)	OT3DIBU3	BT3A2_HUMAN	Increases Expression	[9]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[9]
Hepcidin (HAMP)	OT607RBL	HEPC_HUMAN	Decreases Expression	[34]
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)	OTV3T64P	FGD1_HUMAN	Increases Expression	[9]
Forkhead box protein O4 (FOXO4)	OT90X9LN	FOXO4_HUMAN	Increases Expression	[9]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Increases Expression	[35]
Cdc42 effector protein 1 (CDC42EP1)	OTT525WA	BORG5_HUMAN	Increases Expression	[9]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Increases Expression	[9]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[33]
Sodium channel protein type 7 subunit alpha (SCN7A)	OTK05PXY	SCN7A_HUMAN	Decreases Expression	[9]
Serine/arginine-rich splicing factor 2 (SRSF2)	OTVDHO6U	SRSF2_HUMAN	Decreases Expression	[9]
Transcription factor RelB (RELB)	OTU3QYEF	RELB_HUMAN	Increases Expression	[9]
DNA-binding protein SATB1 (SATB1)	OTT7SUVW	SATB1_HUMAN	Increases Expression	[9]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Phosphorylation	[36]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)	OT8LCZCT	MMSA_HUMAN	Increases Expression	[9]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Increases Expression	[9]
POU domain, class 3, transcription factor 1 (POU3F1)	OTYARA94	PO3F1_HUMAN	Increases Expression	[9]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Decreases Expression	[9]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[37]
P protein (OCA2)	OTDWIGBF	P_HUMAN	Increases Expression	[9]
Transducin-like enhancer protein 4 (TLE4)	OT4QEH6T	TLE4_HUMAN	Decreases Expression	[9]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Expression	[9]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1)	OT6OCR3H	CCG1_HUMAN	Increases Expression	[9]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Increases Expression	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Decreases Expression	[11]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[15]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Increases Expression	[9]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[37]
Epithelial discoidin domain-containing receptor 1 (DDR1)	OTYW1SH8	DDR1_HUMAN	Increases Expression	[9]
Golgin subfamily A member 2 (GOLGA2)	OT5S9KYM	GOGA2_HUMAN	Increases Expression	[9]
Kelch-like protein 30 (KLHL30)	OTKVRLU3	KLH30_HUMAN	Increases Expression	[9]
Protein INCA1 (INCA1)	OTTTN3EW	INCA1_HUMAN	Increases Expression	[9]
D site-binding protein (DBP)	OTE0W7LN	DBP_HUMAN	Increases Expression	[9]
Proline-rich nuclear receptor coactivator 1 (PNRC1)	OTQMLEE1	PNRC1_HUMAN	Increases Expression	[9]
Forkhead box protein L1 (FOXL1)	OT89XFPN	FOXL1_HUMAN	Increases Expression	[9]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Increases Expression	[9]
Chromatin assembly factor 1 subunit A (CHAF1A)	OTXSSY4H	CAF1A_HUMAN	Decreases Expression	[9]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 8 (DUSP8)	OTPLMPG9	DUS8_HUMAN	Increases Expression	[9]
Serine/arginine-rich splicing factor 6 (SRSF6)	OTGLOSYE	SRSF6_HUMAN	Decreases Expression	[9]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Increases Expression	[9]
Syntaxin-3 (STX3)	OT4CIWLJ	STX3_HUMAN	Increases Expression	[9]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Decreases Expression	[11]
Rho-associated protein kinase 1 (ROCK1)	OTSXYVW1	ROCK1_HUMAN	Decreases Expression	[14]
Ras and Rab interactor 1 (RIN1)	OTPBROUD	RIN1_HUMAN	Increases Expression	[9]
Krueppel-like factor 9 (KLF9)	OTBFEJRQ	KLF9_HUMAN	Increases Expression	[9]
Calcyphosin (CAPS)	OTC9GZ2M	CAYP1_HUMAN	Increases Expression	[9]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[9]
Eukaryotic initiation factor 4A-II (EIF4A2)	OT08H03R	IF4A2_HUMAN	Increases Expression	[9]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Expression	[9]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Decreases Expression	[26]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[9]
Next to BRCA1 gene 1 protein (NBR1)	OTVRL7J9	NBR1_HUMAN	Increases Expression	[9]
Transmembrane protein 187 (TMEM187)	OTOE4G8T	TM187_HUMAN	Increases Expression	[9]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Decreases Expression	[9]
Major vault protein (MVP)	OTJGHJRB	MVP_HUMAN	Increases Expression	[9]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Cleavage	[12]
Myocyte-specific enhancer factor 2D (MEF2D)	OT7CEIG0	MEF2D_HUMAN	Increases Expression	[9]
Nuclear factor 1 X-type (NFIX)	OT1DPZAE	NFIX_HUMAN	Increases Expression	[9]
Opioid-binding protein/cell adhesion molecule (OPCML)	OT93PQ6Y	OPCM_HUMAN	Increases Expression	[9]
Nuclear receptor subfamily 1 group D member 2 (NR1D2)	OT9CVF41	NR1D2_HUMAN	Increases Expression	[9]
FAST kinase domain-containing protein 3, mitochondrial (FASTKD3)	OT1TI8K0	FAKD3_HUMAN	Decreases Expression	[9]
P2Y purinoceptor 6 (P2RY6)	OT7VNPQ0	P2RY6_HUMAN	Decreases Expression	[9]
kinase isozyme 3, mitochondrial (PDK3)	OTCPSTID	PDK3_HUMAN	Decreases Expression	[9]
Plectin (PLEC)	OTU4XDEG	PLEC_HUMAN	Increases Expression	[9]
Cdc42-interacting protein 4 (TRIP10)	OTGOUILO	CIP4_HUMAN	Increases Expression	[9]
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J)	OT8M7KWA	PI5PA_HUMAN	Increases Expression	[9]
Ephrin-B3 (EFNB3)	OT12WTXQ	EFNB3_HUMAN	Increases Expression	[9]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)	OTHATMLU	CAC1E_HUMAN	Increases Expression	[9]
Glutamate receptor ionotropic, kainate 5 (GRIK5)	OTBW671W	GRIK5_HUMAN	Increases Expression	[9]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Decreases Expression	[9]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[9]
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Decreases Expression	[9]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[25]
Anti-Muellerian hormone type-2 receptor (AMHR2)	OT95APPM	AMHR2_HUMAN	Increases Expression	[9]
Histone H2B type 2-E (H2BC21)	OT0FDCUC	H2B2E_HUMAN	Increases Expression	[9]
NADP-dependent malic enzyme, mitochondrial (ME3)	OT3XMLYG	MAON_HUMAN	Decreases Expression	[9]
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1)	OT0S9MFX	LONF1_HUMAN	Increases Expression	[9]
Centrosomal protein kizuna (KIZ)	OT5VCKSM	KIZ_HUMAN	Increases Expression	[9]
Leucine-rich repeat-containing protein 75B (LRRC75B)	OTAHOBSS	LR75B_HUMAN	Increases Expression	[9]
DDB1- and CUL4-associated factor 4-like protein 1 (DCAF4L1)	OT50KJQ6	DC4L1_HUMAN	Decreases Expression	[9]
Annexin-2 receptor (ANXA2R)	OT82TU39	AX2R_HUMAN	Increases Expression	[9]
Protein FAM135B (FAM135B)	OTCSYBI7	F135B_HUMAN	Increases Expression	[9]
Angiomotin (AMOT)	OTWHDG9B	AMOT_HUMAN	Increases Expression	[9]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Increases Expression	[9]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Increases Expression	[9]
Puratrophin-1 (PLEKHG4)	OT3RBPFL	PKHG4_HUMAN	Increases Expression	[9]
RILP-like protein 1 (RILPL1)	OTW4LHU8	RIPL1_HUMAN	Increases Expression	[9]
UMP-CMP kinase 2, mitochondrial (CMPK2)	OTOG90R0	CMPK2_HUMAN	Decreases Expression	[9]
F-box only protein 48 (FBXO48)	OTVMFNOK	FBX48_HUMAN	Increases Expression	[9]
BCL-6 corepressor-like protein 1 (BCORL1)	OTPTFQN5	BCORL_HUMAN	Increases Expression	[9]
Protein crumbs homolog 2 (CRB2)	OTG0L2CE	CRUM2_HUMAN	Increases Expression	[9]
Germinal center-associated signaling and motility-like protein (GCSAML)	OTYWDOA6	GSAML_HUMAN	Decreases Expression	[9]
Leucine-rich repeat-containing protein 73 (LRRC73)	OTNFHROL	LRC73_HUMAN	Increases Expression	[9]
Solute carrier family 35 member D3 (SLC35D3)	OTHKRBGM	S35D3_HUMAN	Decreases Expression	[9]
Cilia- and flagella-associated protein 70 (CFAP70)	OTIRTNXU	CFA70_HUMAN	Increases Expression	[9]
Arginine vasopressin-induced protein 1 (AVPI1)	OTXSBR60	AVPI1_HUMAN	Increases Expression	[9]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Increases Expression	[9]
NEDD4-binding protein 2-like 1 (N4BP2L1)	OTEGV3GO	N42L1_HUMAN	Increases Expression	[9]
Radial spoke head protein 4 homolog A (RSPH4A)	OTNDPGEE	RSH4A_HUMAN	Decreases Expression	[9]
Myomesin-3 (MYOM3)	OT8GGH11	MYOM3_HUMAN	Increases Expression	[9]
Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4)	OTDXI4H8	SDHF4_HUMAN	Increases Expression	[9]
OTU domain-containing protein 1 (OTUD1)	OTE6O5XB	OTUD1_HUMAN	Increases Expression	[9]
Uncharacterized protein KIAA1614 (KIAA1614)	OTCG3B86	K1614_HUMAN	Decreases Expression	[9]
Janus kinase and microtubule-interacting protein 3 (JAKMIP3)	OT4EDANR	JKIP3_HUMAN	Increases Expression	[9]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Increases Expression	[9]
Formin-1 (FMN1)	OT9CID5R	FMN1_HUMAN	Increases Expression	[9]
BTB/POZ domain-containing protein KCTD11 (KCTD11)	OT64DFBU	KCD11_HUMAN	Increases Expression	[9]
Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19)	OT04I3OW	S6A19_HUMAN	Decreases Expression	[9]
Transmembrane protein 42 (TMEM42)	OTCG6EZ0	TMM42_HUMAN	Increases Expression	[9]
Ankyrin repeat domain-containing protein 34A (ANKRD34A)	OTI00ROL	AN34A_HUMAN	Increases Expression	[9]
Tigger transposable element-derived protein 3 (TIGD3)	OT61NEUF	TIGD3_HUMAN	Decreases Expression	[9]
Fc receptor-like B (FCRLB)	OTL0PMQX	FCRLB_HUMAN	Increases Expression	[9]
Rab15 effector protein (REP15)	OTGOX4E7	REP15_HUMAN	Decreases Expression	[9]
Pleckstrin homology-like domain family B member 3 (PHLDB3)	OTPFKXFA	PHLB3_HUMAN	Increases Expression	[9]
Probable G-protein coupled receptor 153 (GPR153)	OT81CA1Z	GP153_HUMAN	Increases Expression	[9]
Golgi-associated RAB2 interactor protein 1A (GARIN1A)	OTSJROUO	GAR1A_HUMAN	Increases Expression	[9]
Transmembrane protein 53 (TMEM53)	OTSXTGQK	TMM53_HUMAN	Increases Expression	[9]
Pre-mRNA-processing-splicing factor 8 (PRPF8)	OTU39JZI	PRP8_HUMAN	Decreases Expression	[9]
PiggyBac transposable element-derived protein 2 (PGBD2)	OT82WVBH	PGBD2_HUMAN	Decreases Expression	[9]
ATP synthase subunit C lysine N-methyltransferase (ATPSCKMT)	OTMPVCHS	ACKMT_HUMAN	Decreases Expression	[9]
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM)	OT03MYQ2	NOTUM_HUMAN	Increases Expression	[9]
Potassium voltage-gated channel subfamily V member 1 (KCNV1)	OTU2MLSU	KCNV1_HUMAN	Decreases Expression	[9]
Fidgetin-like protein 1 (FIGNL1)	OTKII63K	FIGL1_HUMAN	Decreases Expression	[9]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Increases Expression	[9]
Ankyrin repeat domain-containing protein 12 (ANKRD12)	OTK16BL9	ANR12_HUMAN	Increases Expression	[9]
Kin of IRRE-like protein 2 (KIRREL2)	OTSLTR4Y	KIRR2_HUMAN	Increases Expression	[9]
Protein SNORC (SNORC)	OTY3IJK5	SNORC_HUMAN	Increases Expression	[9]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (B3GNT9)	OTO385AU	B3GN9_HUMAN	Increases Expression	[9]
Transcription factor LBX2 (LBX2)	OTGWRSI2	LBX2_HUMAN	Increases Expression	[9]
SH3 and cysteine-rich domain-containing protein 2 (STAC2)	OTRJ9PG0	STAC2_HUMAN	Increases Expression	[9]
Lysine-specific demethylase 7A (KDM7A)	OT1VGYCX	KDM7A_HUMAN	Increases Expression	[9]
GDP-D-glucose phosphorylase 1 (GDPGP1)	OT40ETFK	GDPP1_HUMAN	Decreases Expression	[9]
Leucine-rich repeat-containing protein 55 (LRRC55)	OT8LQI1W	LRC55_HUMAN	Decreases Expression	[9]
Protein FAM43B (FAM43B)	OTLND7C6	FA43B_HUMAN	Increases Expression	[9]
Tripartite motif-containing protein 67 (TRIM67)	OTXRZN27	TRI67_HUMAN	Increases Expression	[9]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 (NYAP1)	OT8FPF5F	NYAP1_HUMAN	Increases Expression	[9]
8-oxo-dGDP phosphatase NUDT18 (NUDT18)	OT03IQA5	NUD18_HUMAN	Increases Expression	[9]
Uncharacterized protein C16orf86 (C16ORF86)	OTUT18HF	CP086_HUMAN	Increases Expression	[9]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[9]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[9]
Atos homolog protein B (ATOSB)	OTU2TXCA	ATOSB_HUMAN	Increases Expression	[9]
Equilibrative nucleoside transporter 4 (SLC29A4)	OTWTZXMX	S29A4_HUMAN	Increases Expression	[9]
Stereocilin (STRC)	OT3JQYVJ	STRC_HUMAN	Increases Expression	[9]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Increases Expression	[9]
Monocarboxylate transporter 9 (SLC16A9)	OTVCLKQQ	MOT9_HUMAN	Increases Expression	[9]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Increases Expression	[9]
Low-density lipoprotein receptor-related protein 10 (LRP10)	OT8490HT	LRP10_HUMAN	Increases Expression	[9]
Protein ADM2 (ADM2)	OTJVN41C	ADM2_HUMAN	Increases Expression	[9]
Cytochrome c oxidase subunit 8C, mitochondrial (COX8C)	OT6G8E4Q	COX8C_HUMAN	Increases Expression	[9]
Microtubule organization protein AKNA (AKNA)	OTQ6E2C8	AKNA_HUMAN	Increases Expression	[9]
Interferon regulatory factor 2-binding protein 2 (IRF2BP2)	OTSSRRCA	I2BP2_HUMAN	Increases Expression	[9]
Protein TAMALIN (TAMALIN)	OTK75X47	GRASP_HUMAN	Increases Expression	[9]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW)	OTT9SMTF	PIGW_HUMAN	Decreases Expression	[9]
Synaptotagmin-9 (SYT9)	OT7S8WU0	SYT9_HUMAN	Decreases Expression	[9]
Store-operated calcium entry regulator STIMATE (STIMATE)	OTEDLKEW	STIMA_HUMAN	Decreases Expression	[9]
Glucosylceramide transporter ABCA12 (ABCA12)	OTKH9YQZ	ABCAC_HUMAN	Decreases Expression	[9]
Reticulon-4 receptor-like 1 (RTN4RL1)	OTDKKOE7	R4RL1_HUMAN	Increases Expression	[9]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)	OTHH06X8	SESD1_HUMAN	Decreases Expression	[9]
Caytaxin (ATCAY)	OTSIAM08	ATCAY_HUMAN	Increases Expression	[9]
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1)	OT7XETW4	HOGA1_HUMAN	Increases Expression	[9]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)	OTVCRXEZ	PPR3B_HUMAN	Decreases Expression	[9]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2)	OTL0DWCO	ECHD2_HUMAN	Decreases Expression	[9]
Testis development-related protein (TDRP)	OTEFLMGF	TDRP_HUMAN	Increases Expression	[9]
Homer protein homolog 1 (HOMER1)	OTWFD3SI	HOME1_HUMAN	Decreases Expression	[9]
Complement C1q-like protein 4 (C1QL4)	OT9L6DLK	C1QL4_HUMAN	Increases Expression	[9]
Unconventional myosin-XVIIIb (MYO18B)	OTGYY4NK	MY18B_HUMAN	Increases Expression	[9]
RNA-binding protein 45 (RBM45)	OTWTHD77	RBM45_HUMAN	Decreases Expression	[9]
Neuronal PAS domain-containing protein 4 (NPAS4)	OTA3HH6W	NPAS4_HUMAN	Increases Expression	[9]
CREB3 regulatory factor (CREBRF)	OT2GK1HI	CRERF_HUMAN	Increases Expression	[9]
Protein HID1 (HID1)	OTVJIFSU	HID1_HUMAN	Increases Expression	[9]
Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2)	OTMOGNCV	ANKY2_HUMAN	Increases Expression	[9]
Nostrin (NOSTRIN)	OT0LDSGS	NOSTN_HUMAN	Decreases Expression	[9]
Glucose-induced degradation protein 4 homolog (GID4)	OT0TOD0M	GID4_HUMAN	Increases Expression	[9]
Cyclin-dependent kinase-like 3 (CDKL3)	OTJ0TQ9T	CDKL3_HUMAN	Increases Expression	[9]
Transmembrane protein 151B (TMEM151B)	OTTEDBUJ	T151B_HUMAN	Increases Expression	[9]
Sphingosine-1-phosphate phosphatase 2 (SGPP2)	OTIDIJCR	SGPP2_HUMAN	Decreases Expression	[9]
DNA damage-induced apoptosis suppressor protein (DDIAS)	OTTGG2PM	DDIAS_HUMAN	Decreases Expression	[9]
Kelch domain-containing protein 8B (KLHDC8B)	OTKP6LCR	KLD8B_HUMAN	Increases Expression	[9]
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6)	OTOZQMQE	PPIL6_HUMAN	Increases Expression	[9]
Kelch domain-containing protein 8A (KLHDC8A)	OTIZA3AM	KLD8A_HUMAN	Increases Expression	[9]
REST corepressor 2 (RCOR2)	OTXRQS9E	RCOR2_HUMAN	Increases Expression	[9]
B-cell CLL/lymphoma 6 member B protein (BCL6B)	OT1T5KM6	BCL6B_HUMAN	Increases Expression	[9]
Glypican-2 (GPC2)	OT3WSQE1	GPC2_HUMAN	Increases Expression	[9]
Homeobox protein SIX5 (SIX5)	OTT1I9WY	SIX5_HUMAN	Increases Expression	[9]
Kelch-like protein 34 (KLHL34)	OTHU2OSE	KLH34_HUMAN	Decreases Expression	[9]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[9]
Latent-transforming growth factor beta-binding protein 4 (LTBP4)	OTC8WL2V	LTBP4_HUMAN	Increases Expression	[9]
Transmembrane protein 256 (TMEM256)	OTLNGZLX	TM256_HUMAN	Increases Expression	[9]
Ligand-dependent nuclear receptor corepressor-like protein (LCORL)	OTJNQRC5	LCORL_HUMAN	Increases Expression	[9]
Protein limb expression 1 homolog (LIX1)	OT1CPNCC	LIX1_HUMAN	Decreases Expression	[9]
T-complex protein 11-like protein 2 (TCP11L2)	OTTIZO7B	T11L2_HUMAN	Increases Expression	[9]
DnaJ homolog subfamily C member 22 (DNAJC22)	OTGGDK70	DJC22_HUMAN	Increases Expression	[9]
Tetratricopeptide repeat protein 9B (TTC9B)	OTHBKTIU	TTC9B_HUMAN	Increases Expression	[9]
Protein NATD1 (NATD1)	OTQF3C4I	NATD1_HUMAN	Increases Expression	[9]
Protocadherin-20 (PCDH20)	OTFSNRXK	PCD20_HUMAN	Decreases Expression	[9]
Probable N-acetyltransferase 16 (NAT16)	OTGRHAJQ	NAT16_HUMAN	Increases Expression	[9]
Stabilizer of axonemal microtubules 5 (SAXO5)	OTS9VCFR	SAXO5_HUMAN	Increases Expression	[9]
Fanconi anemia group B protein (FANCB)	OTMZTXB5	FANCB_HUMAN	Decreases Expression	[9]
Zinc finger protein GLIS1 (GLIS1)	OTBDNB26	GLIS1_HUMAN	Increases Expression	[9]
NFATC2-interacting protein (NFATC2IP)	OTOQ4AZ9	NF2IP_HUMAN	Decreases Expression	[9]
Beta-galactosidase-1-like protein 3 (GLB1L3)	OTWAWGX4	GLBL3_HUMAN	Decreases Expression	[9]
Structural maintenance of chromosomes protein 1B (SMC1B)	OTQVMF74	SMC1B_HUMAN	Decreases Expression	[9]
Lymphocyte antigen 6 complex locus protein G5b (LY6G5B)	OTW89R8K	LY65B_HUMAN	Decreases Expression	[9]
Transmembrane protein 52 (TMEM52)	OTDLQSAX	TMM52_HUMAN	Increases Expression	[9]
Cytosolic carboxypeptidase 3 (AGBL3)	OTVH64PO	CBPC3_HUMAN	Decreases Expression	[9]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7)	OT8UTTXF	B3GN7_HUMAN	Increases Expression	[9]
Interleukin-17 receptor E (IL17RE)	OTMFTNLS	I17RE_HUMAN	Increases Expression	[9]
Olfactory receptor 2L3 (OR2L3)	OTL6ZMOC	OR2L3_HUMAN	Decreases Expression	[9]
Olfactory receptor 4F17 (OR4F17)	OTJZ7HYD	O4F17_HUMAN	Decreases Expression	[9]
Protocadherin-19 (PCDH19)	OTSOW3MV	PCD19_HUMAN	Decreases Expression	[9]
Arrestin domain-containing protein 2 (ARRDC2)	OTVEOXAG	ARRD2_HUMAN	Increases Expression	[9]
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1)	OT18H5HD	R3GEF_HUMAN	Increases Expression	[9]
Large ribosomal subunit protein uL30m (MRPL30)	OT26OPYV	RM30_HUMAN	Decreases Expression	[9]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)	OT0EDNV9	GTR12_HUMAN	Increases Expression	[9]
Transient receptor potential cation channel subfamily M member 4 (TRPM4)	OT354X8E	TRPM4_HUMAN	Increases Expression	[9]
A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAMTS17)	OTCFITM9	ATS17_HUMAN	Decreases Expression	[9]
ATP-dependent RNA helicase DQX1 (DQX1)	OTE7BT00	DQX1_HUMAN	Increases Expression	[9]
Partitioning defective 3 homolog B (PARD3B)	OTGZ43YI	PAR3L_HUMAN	Increases Expression	[9]
SH3 domain and tetratricopeptide repeat-containing protein 2 (SH3TC2)	OTJ6XY2A	S3TC2_HUMAN	Decreases Expression	[9]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5)	OTUM65JL	GDPD5_HUMAN	Increases Expression	[9]
Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)	OTOGC15N	CHAC2_HUMAN	Decreases Expression	[9]
DnaJ homolog subfamily A member 4 (DNAJA4)	OTT7YCD2	DNJA4_HUMAN	Decreases Expression	[9]
G2/mitotic-specific cyclin-B3 (CCNB3)	OT5V72D3	CCNB3_HUMAN	Decreases Expression	[9]
Junctophilin-3 (JPH3)	OTHTJO2I	JPH3_HUMAN	Increases Expression	[9]
DnaJ homolog subfamily C member 9 (DNAJC9)	OTDBQBNZ	DNJC9_HUMAN	Decreases Expression	[9]
Jun dimerization protein 2 (JDP2)	OTW35WKX	JDP2_HUMAN	Increases Expression	[9]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Decreases Expression	[9]
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)	OTENME7S	SIA8D_HUMAN	Increases Expression	[9]
Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP)	OTPC9JBM	PHYIP_HUMAN	Increases Expression	[9]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[9]
General transcription factor IIH subunit 4 (GTF2H4)	OTPD1DIU	TF2H4_HUMAN	Decreases Expression	[9]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Increases Expression	[9]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Decreases Expression	[38]
N-alpha-acetyltransferase 80 (NAA80)	OTLWR71Z	NAA80_HUMAN	Increases Expression	[9]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)	OTFYDEES	AT2A3_HUMAN	Increases Expression	[9]
Glycine N-acyltransferase-like protein 1 (GLYATL1)	OTS8JSRY	GLYL1_HUMAN	Decreases Expression	[9]
Terminal nucleotidyltransferase 5B (TENT5B)	OTO2P28B	TET5B_HUMAN	Increases Expression	[9]
Ras-related protein Rab-7b (RAB7B)	OT60A0E9	RAB7B_HUMAN	Increases Expression	[9]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1)	OTEAAUBY	PBIP1_HUMAN	Increases Expression	[9]
Protein FAM131C (FAM131C)	OTQPI1OZ	F131C_HUMAN	Increases Expression	[9]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Decreases Expression	[9]
Dapper homolog 3 (DACT3)	OTSNQ55G	DACT3_HUMAN	Increases Expression	[9]
Repulsive guidance molecule A (RGMA)	OTZAMDO2	RGMA_HUMAN	Decreases Expression	[9]
Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2)	OTWWAHTV	TMIG2_HUMAN	Increases Expression	[9]
Solute carrier family 22 member 18 (SLC22A18)	OT9C3KR4	S22AI_HUMAN	Increases Expression	[9]
ELL-associated factor 2 (EAF2)	OTSOET5L	EAF2_HUMAN	Decreases Expression	[9]
Netrin-G2 (NTNG2)	OTTY88DL	NTNG2_HUMAN	Increases Expression	[9]
Reticulocalbin-3 (RCN3)	OTHWE0NF	RCN3_HUMAN	Increases Expression	[9]
Voltage-gated hydrogen channel 1 (HVCN1)	OT4ALYU4	HVCN1_HUMAN	Increases Expression	[9]
Protein shisa-4 (SHISA4)	OTJ8H832	SHSA4_HUMAN	Increases Expression	[9]
CAP-Gly domain-containing linker protein 3 (CLIP3)	OTGJEGIB	CLIP3_HUMAN	Increases Expression	[9]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)	OTDCBTBS	LIGO1_HUMAN	Increases Expression	[9]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)	OTWE5G4T	P3IP1_HUMAN	Increases Expression	[9]
BLOC-1-related complex subunit 6 (BORCS6)	OTTO4SWD	BORC6_HUMAN	Increases Expression	[9]
Receptor expression-enhancing protein 6 (REEP6)	OTY4FPO8	REEP6_HUMAN	Increases Expression	[9]
Terminal nucleotidyltransferase 5A (TENT5A)	OTSYF511	TET5A_HUMAN	Decreases Expression	[9]
Putative protein-lysine deacylase ABHD14B (ABHD14B)	OTFIYC6Y	ABHEB_HUMAN	Increases Expression	[9]
CUGBP Elav-like family member 6 (CELF6)	OT111JZ3	CELF6_HUMAN	Increases Expression	[9]
Junctophilin-4 (JPH4)	OTRLNPJK	JPH4_HUMAN	Increases Expression	[9]
HHIP-like protein 1 (HHIPL1)	OT3GMU2X	HIPL1_HUMAN	Increases Expression	[9]
Cadherin-related family member 1 (CDHR1)	OT1ORXCM	CDHR1_HUMAN	Increases Expression	[9]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Increases Expression	[9]
Uncharacterized protein C8orf48 (C8ORF48)	OT4KE69P	CH048_HUMAN	Decreases Expression	[9]
Cyclic nucleotide-binding domain-containing protein 2 (CNBD2)	OTF42F52	CNBD2_HUMAN	Increases Expression	[9]
Lysophospholipid acyltransferase 7 (MBOAT7)	OTHRCBLK	MBOA7_HUMAN	Increases Expression	[9]
Sideroflexin-2 (SFXN2)	OTRFKK0G	SFXN2_HUMAN	Decreases Expression	[9]
Sterile alpha motif domain-containing protein 11 (SAMD11)	OT6WRQOX	SAM11_HUMAN	Increases Expression	[9]
AP-1 complex subunit sigma-3 (AP1S3)	OTPCMV24	AP1S3_HUMAN	Decreases Expression	[9]
Trafficking protein particle complex subunit 9 (TRAPPC9)	OTF0CVMC	TPPC9_HUMAN	Increases Expression	[9]
Cyclin-dependent kinase 15 (CDK15)	OT8S67QS	CDK15_HUMAN	Decreases Expression	[9]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Increases Expression	[9]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[9]
Protein ABHD1 (ABHD1)	OTY56U02	ABHD1_HUMAN	Increases Expression	[9]
Histone-lysine N-methyltransferase SETDB2 (SETDB2)	OTBVVP9Q	SETB2_HUMAN	Increases Expression	[9]
Calponin-2 (CNN2)	OTH3CSXA	CNN2_HUMAN	Increases Expression	[9]
TSC22 domain family protein 3 (TSC22D3)	OT03UM03	T22D3_HUMAN	Increases Expression	[9]
Transcriptional enhancer factor TEF-5 (TEAD3)	OTJ1ER44	TEAD3_HUMAN	Increases Expression	[9]
Monoglyceride lipase (MGLL)	OT5ES4IE	MGLL_HUMAN	Increases Expression	[9]
Homeobox protein Meis3 (MEIS3)	OTQXB3XL	MEIS3_HUMAN	Increases Expression	[9]
Septin-5 (SEPTIN5)	OT6JTJBO	SEPT5_HUMAN	Increases Expression	[9]
Chemerin-like receptor 1 (CMKLR1)	OTHA8ESR	CML1_HUMAN	Decreases Expression	[9]
Homeobox protein Nkx-3.1 (NKX3-1)	OT0DO6ZU	NKX31_HUMAN	Decreases Expression	[11]
Dual specificity protein phosphatase 9 (DUSP9)	OTZZWEQL	DUS9_HUMAN	Increases Expression	[9]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[9]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)	OT0ETO72	DHB14_HUMAN	Increases Expression	[9]
Synaptotagmin-3 (SYT3)	OT8XTGQ8	SYT3_HUMAN	Increases Expression	[9]
Phosphatidate phosphatase LPIN3 (LPIN3)	OTK1C2KL	LPIN3_HUMAN	Increases Expression	[9]
Calsyntenin-3 (CLSTN3)	OTPUFK4C	CSTN3_HUMAN	Increases Expression	[9]
Transcription factor COE4 (EBF4)	OTGK0V7W	COE4_HUMAN	Increases Expression	[9]
Mesoderm posterior protein 1 (MESP1)	OTY5QDBN	MESP1_HUMAN	Increases Expression	[9]
Protein orai-3 (ORAI3)	OTUP3OH3	ORAI3_HUMAN	Increases Expression	[9]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Increases Expression	[9]
DNA replication complex GINS protein SLD5 (GINS4)	OTCVOO3S	SLD5_HUMAN	Decreases Expression	[9]
DNA replication complex GINS protein PSF3 (GINS3)	OT8NVXTD	PSF3_HUMAN	Decreases Expression	[9]
Polycomb group RING finger protein 1 (PCGF1)	OTHOU68T	PCGF1_HUMAN	Increases Expression	[9]
Synaptotagmin-17 (SYT17)	OTTW4MI3	SYT17_HUMAN	Increases Expression	[9]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7)	OTJVS8CF	ALKB7_HUMAN	Increases Expression	[9]
CDK5 and ABL1 enzyme substrate 2 (CABLES2)	OTGD9A2A	CABL2_HUMAN	Decreases Expression	[9]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Decreases Expression	[9]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[9]
Transcriptional repressor scratch 1 (SCRT1)	OTWTE24S	SCRT1_HUMAN	Increases Expression	[9]
Transcription factor GATA-5 (GATA5)	OTO81B63	GATA5_HUMAN	Increases Expression	[9]
Bardet-Biedl syndrome 2 protein (BBS2)	OTPF9JIB	BBS2_HUMAN	Increases Expression	[9]
TBC1 domain family member 10A (TBC1D10A)	OTR2CI46	TB10A_HUMAN	Increases Expression	[9]
S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER)	OT7S3B3P	SCAPE_HUMAN	Increases Expression	[9]
Cadherin-related family member 2 (CDHR2)	OTTHEUPO	CDHR2_HUMAN	Decreases Expression	[9]
3'-5' exoribonuclease HELZ2 (HELZ2)	OTM6HVO6	HELZ2_HUMAN	Increases Expression	[9]
Leucine-rich repeat-containing protein 2 (LRRC2)	OTX6P291	LRRC2_HUMAN	Increases Expression	[9]
Zinc finger protein GLIS2 (GLIS2)	OTOUUV1X	GLIS2_HUMAN	Increases Expression	[9]
Reticulon-4 receptor (RTN4R)	OT8J693X	RTN4R_HUMAN	Increases Expression	[9]
Glutamate receptor-interacting protein 2 (GRIP2)	OT8DGYZ5	GRIP2_HUMAN	Increases Expression	[9]
DNA-directed RNA polymerase II subunit RPB11-b1 (POLR2J3)	OTXTSHH8	RPB1B_HUMAN	Decreases Expression	[9]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)	OT9AGAIJ	LHPP_HUMAN	Increases Expression	[9]
Coiled-coil domain-containing protein 113 (CFAP263)	OTE206QS	CC113_HUMAN	Increases Expression	[9]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Increases Expression	[9]
Stathmin-4 (STMN4)	OT7ZUKW6	STMN4_HUMAN	Increases Expression	[9]
ATP-binding cassette sub-family G member 4 (ABCG4)	OT2XJIOG	ABCG4_HUMAN	Increases Expression	[9]
Opsin-3 (OPN3)	OTON6BFU	OPN3_HUMAN	Increases Expression	[9]
Spectrin beta chain, non-erythrocytic 4 (SPTBN4)	OTAJAVP9	SPTN4_HUMAN	Increases Expression	[9]
Carbohydrate sulfotransferase 8 (CHST8)	OTQT4TKR	CHST8_HUMAN	Increases Expression	[9]
Coiled-coil domain-containing protein 68 (CCDC68)	OT4KF6TL	CCD68_HUMAN	Decreases Expression	[9]
Solute carrier organic anion transporter family member 5A1 (SLCO5A1)	OTNXXTH0	SO5A1_HUMAN	Increases Expression	[9]
Potassium voltage-gated channel subfamily F member 1 (KCNF1)	OTEROKP4	KCNF1_HUMAN	Increases Expression	[9]
Semaphorin-4A (SEMA4A)	OT8901H3	SEM4A_HUMAN	Increases Expression	[9]
Semaphorin-6B (SEMA6B)	OT3VVVUO	SEM6B_HUMAN	Increases Expression	[9]
Actin-like protein 8 (ACTL8)	OTUDD0QT	ACTL8_HUMAN	Decreases Expression	[9]
PDZ domain-containing protein 7 (PDZD7)	OTX3VAOB	PDZD7_HUMAN	Increases Expression	[9]
Fibronectin type III domain-containing protein 4 (FNDC4)	OTOQK0WK	FNDC4_HUMAN	Increases Expression	[9]
Proline-rich protein 36 (PRR36)	OTUJII07	PRR36_HUMAN	Increases Expression	[9]
Transmembrane protein 231 (TMEM231)	OTF4UYIE	TM231_HUMAN	Increases Expression	[9]
PDZ domain-containing protein MAGIX (MAGIX)	OT8EU651	MAGIX_HUMAN	Increases Expression	[9]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Decreases Expression	[9]
Exonuclease V (EXO5)	OTIN7L7I	EXO5_HUMAN	Decreases Expression	[9]
Dedicator of cytokinesis protein 5 (DOCK5)	OT63I0CL	DOCK5_HUMAN	Decreases Expression	[9]
RING finger protein 122 (RNF122)	OT8RE3IM	RN122_HUMAN	Increases Expression	[9]
TBC1 domain family member 17 (TBC1D17)	OT75ZWLB	TBC17_HUMAN	Increases Expression	[9]
Claspin (CLSPN)	OTZZXNDK	CLSPN_HUMAN	Decreases Expression	[9]
Potassium channel subfamily K member 13 (KCNK13)	OTMOT2KX	KCNKD_HUMAN	Decreases Expression	[9]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Increases Expression	[9]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Increases Expression	[9]
Nuclear receptor coactivator 5 (NCOA5)	OTOGWTWB	NCOA5_HUMAN	Decreases Expression	[9]
DNA polymerase delta subunit 4 (POLD4)	OTG578YH	DPOD4_HUMAN	Increases Expression	[9]
Receptor-type tyrosine-protein phosphatase H (PTPRH)	OTDUHQGF	PTPRH_HUMAN	Increases Expression	[9]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)	OTJF73BA	NT5M_HUMAN	Increases Expression	[9]
Transcriptional repressor scratch 2 (SCRT2)	OTXN2VYF	SCRT2_HUMAN	Increases Expression	[9]
G-protein coupled receptor family C group 5 member C (GPRC5C)	OT45AJT3	GPC5C_HUMAN	Increases Expression	[9]
Fructose-2,6-bisphosphatase TIGAR (TIGAR)	OTR7NMRJ	TIGAR_HUMAN	Decreases Expression	[9]
E3 ubiquitin-protein ligase Jade-2 (JADE2)	OTVG2MYF	JADE2_HUMAN	Increases Expression	[9]
Nectin-3 (NECTIN3)	OTS8N7MK	NECT3_HUMAN	Decreases Expression	[9]
Beta-catenin-interacting protein 1 (CTNNBIP1)	OTX9SBJG	CNBP1_HUMAN	Increases Expression	[9]
Homer protein homolog 3 (HOMER3)	OTQ6D9X1	HOME3_HUMAN	Increases Expression	[9]
Cytokine-inducible SH2-containing protein (CISH)	OT8T5NYL	CISH_HUMAN	Increases Expression	[9]
Kinesin light chain 4 (KLC4)	OTACUFB2	KLC4_HUMAN	Increases Expression	[9]
SERTA domain-containing protein 4 (SERTAD4)	OTZ1GUD9	SRTD4_HUMAN	Decreases Expression	[9]
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL)	OTZ4771K	SHFL_HUMAN	Increases Expression	[9]
Inactive ubiquitin thioesterase OTULINL (OTULINL)	OTNOC9L1	OTULL_HUMAN	Decreases Expression	[9]
Protein eva-1 homolog B (EVA1B)	OTDNAKQD	EVA1B_HUMAN	Increases Expression	[9]
Transmembrane protein 45A (TMEM45A)	OT54KJG6	TM45A_HUMAN	Increases Expression	[9]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Increases Expression	[9]
Nicotinamide riboside kinase 1 (NMRK1)	OT0STQLV	NRK1_HUMAN	Increases Expression	[9]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[9]
Protein FAM13B (FAM13B)	OTNQTYSM	FA13B_HUMAN	Decreases Expression	[9]
BET1-like protein (BET1L)	OT5QVYBZ	BET1L_HUMAN	Increases Expression	[9]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[9]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Expression	[27]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Decreases Expression	[12]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)	OT3XMZU3	FLRT3_HUMAN	Decreases Expression	[9]
Calcium permeable stress-gated cation channel 1 (TMEM63C)	OTKDX01I	CSC1_HUMAN	Increases Expression	[9]
Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3)	OTQGT916	CAMP3_HUMAN	Increases Expression	[9]
BTB/POZ domain-containing protein 7 (BTBD7)	OTNUV6MQ	BTBD7_HUMAN	Decreases Expression	[9]
Armadillo repeat-containing X-linked protein 1 (ARMCX1)	OTOGL58Z	ARMX1_HUMAN	Increases Expression	[9]
Vesicular glutamate transporter 1 (SLC17A7)	OTTYXG3C	VGLU1_HUMAN	Increases Expression	[9]
Homologous-pairing protein 2 homolog (PSMC3IP)	OT9UB5UO	HOP2_HUMAN	Decreases Expression	[9]
NF-kappa-B inhibitor-like protein 1 (NFKBIL1)	OTYFTPS0	IKBL1_HUMAN	Increases Expression	[9]
C-type mannose receptor 2 (MRC2)	OTLWQAX1	MRC2_HUMAN	Increases Expression	[9]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)	OTU4J3ZI	HEY2_HUMAN	Increases Expression	[26]
Heat shock protein beta-7 (HSPB7)	OTLATAOV	HSPB7_HUMAN	Increases Expression	[9]
CAP-Gly domain-containing linker protein 2 (CLIP2)	OTSCIQIY	CLIP2_HUMAN	Increases Expression	[9]
Small conductance calcium-activated potassium channel protein 3 (KCNN3)	OT11KYA8	KCNN3_HUMAN	Increases Expression	[9]
Lysine-specific demethylase 5B (KDM5B)	OT5DL94T	KDM5B_HUMAN	Increases Expression	[9]
NADPH-dependent diflavin oxidoreductase 1 (NDOR1)	OTKEA582	NDOR1_HUMAN	Decreases Expression	[9]
rRNA methyltransferase 2, mitochondrial (MRM2)	OTRYA1HU	MRM2_HUMAN	Decreases Expression	[9]
Krueppel-like factor 15 (KLF15)	OTGMQMVR	KLF15_HUMAN	Increases Expression	[9]
F-box only protein 2 (FBXO2)	OTF3677S	FBX2_HUMAN	Increases Expression	[9]
Peroxisomal carnitine O-octanoyltransferase (CROT)	OTWK68MM	OCTC_HUMAN	Decreases Expression	[9]
Zinc finger protein Helios (IKZF2)	OTZIMARJ	IKZF2_HUMAN	Increases Expression	[9]
Polyadenylate-binding protein-interacting protein 2B (PAIP2B)	OT7MUY3B	PAI2B_HUMAN	Increases Expression	[9]
Ras-related protein Rab-26 (RAB26)	OTHMPRJK	RAB26_HUMAN	Increases Expression	[9]
Intercellular adhesion molecule 5 (ICAM5)	OTDGGAFH	ICAM5_HUMAN	Increases Expression	[9]
Ornithine decarboxylase antizyme 3 (OAZ3)	OT8Q5PVB	OAZ3_HUMAN	Increases Expression	[9]
RNA-binding protein Nova-2 (NOVA2)	OTQ2X3Q4	NOVA2_HUMAN	Increases Expression	[9]
Frizzled-1 (FZD1)	OTZATHVS	FZD1_HUMAN	Affects Localization	[23]
Cytosolic phospholipase A2 gamma (PLA2G4C)	OTIK5GT5	PA24C_HUMAN	Increases Expression	[9]
LIM/homeobox protein Lhx6 (LHX6)	OT47UQZ5	LHX6_HUMAN	Increases Expression	[9]
IQ motif and SEC7 domain-containing protein 3 (IQSEC3)	OTBHQK29	IQEC3_HUMAN	Increases Expression	[9]
PHD finger protein 24 (PHF24)	OTTIYK64	PHF24_HUMAN	Increases Expression	[9]
GRB2-associated-binding protein 2 (GAB2)	OTBFN705	GAB2_HUMAN	Increases Expression	[9]
Histone deacetylase 5 (HDAC5)	OTWG387P	HDAC5_HUMAN	Increases Expression	[9]
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)	OTJGX19T	KCC2A_HUMAN	Increases Expression	[9]
C-type lectin domain family 11 member A (CLEC11A)	OT9KBH7C	CLC11_HUMAN	Increases Expression	[9]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[9]
Nuclease EXOG, mitochondrial (EXOG)	OTZAI8L7	EXOG_HUMAN	Decreases Expression	[9]
Myelin regulatory factor (MYRF)	OTKF6AEB	MYRF_HUMAN	Increases Expression	[9]
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)	OTEYFN5O	MAST1_HUMAN	Increases Expression	[9]
R3H domain-containing protein 2 (R3HDM2)	OTMJ3S6J	R3HD2_HUMAN	Increases Expression	[9]
Lambda-crystallin homolog (CRYL1)	OT0SJSJM	CRYL1_HUMAN	Increases Expression	[9]
Mediator of RNA polymerase II transcription subunit 31 (MED31)	OTFVKXJE	MED31_HUMAN	Decreases Expression	[9]
RWD domain-containing protein 3 (RWDD3)	OTE76DY5	RWDD3_HUMAN	Decreases Expression	[9]
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B)	OTO7O3CU	DYR1B_HUMAN	Increases Expression	[9]
Tesmin (TESMIN)	OTZ5UILU	MTL5_HUMAN	Increases Expression	[9]
Tubulin monoglycylase TTLL3 (TTLL3)	OT7JWXHA	TTLL3_HUMAN	Increases Expression	[9]
NADPH oxidase 1 (NOX1)	OTZPJQCC	NOX1_HUMAN	Decreases Expression	[9]
Endothelial lipase (LIPG)	OTHEE942	LIPG_HUMAN	Decreases Expression	[9]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Affects Localization	[24]
Diacylglycerol kinase beta (DGKB)	OTTT9SZJ	DGKB_HUMAN	Increases Expression	[9]
RING finger protein 215 (RNF215)	OT44XNT7	RN215_HUMAN	Increases Expression	[9]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Response To Substance	[22]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Affects Response To Substance	[39]

Indication(s) of Spironolactone

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Approved	[4]
Congestive heart failure	BD10	Approved	[5]
Edema	MG29	Approved	[4]
Hyperaldosteronism	5A72	Approved	[4]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[6]

Spironolactone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Mineralocorticoid receptor (MR)	TT26PHO	MCR_HUMAN	Modulator	[40]

Spironolactone Interacts with 21 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[41]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[42]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[43]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[44]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[45]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Increases Expression	[46]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Decreases Expression	[47]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[48]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[47]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[49]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[45]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[50]
Mineralocorticoid receptor (NR3C2)	OT0F2V2Z	MCR_HUMAN	Increases Activity	[51]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Increases Expression	[44]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Affects Binding	[52]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Decreases Expression	[47]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[53]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[53]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[44]
Renin (REN)	OT52GZR2	RENI_HUMAN	Decreases Response To Substance	[54]
Serum paraoxonase/lactonase 3 (PON3)	OT80W9TA	PON3_HUMAN	Increases Hydrolysis	[55]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8494).
• [3] Niclosamide FDA Label
• [4] Spironolactone FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2875).
• [6] Spironolactone in Covid-19 Induced ARDS
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• [8] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
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• [13] The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear -catenin/c-Myc axis in OSCC. Sci Rep. 2018 Aug 24;8(1):12776. doi: 10.1038/s41598-018-30692-3.
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• [15] Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010 Mar 15;70(6):2516-27. doi: 10.1158/0008-5472.CAN-09-3950. Epub 2010 Mar 9.
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• [17] CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
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• [19] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
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