Details of the Drug Combinations

General Information of This Drug (ID: DMK7MEY)

Drug Name
Isoproterenol   DMK7MEY
Synonyms
isoproterenol; Isoprenaline; Isoprenalin; Norisodrine; Novodrin; Isopropydrin; Isopropylarterenol; Respifral; Assiprenol; Asiprenol; Bellasthman; Asmalar; Aludrine; Aludrin; N-Isopropylnoradrenaline; Bronkephrine; Neodrenal; Lomupren; Isonorene; Isopropyladrenaline; 7683-59-2; N-Isopropylnorepinephrine; Isopropylnorepinephrine; neo-Epinine; Isadrine; Saventrine; Isorenin; Isonorin; Proternol; Isopropylnoradrenaline; Isopropyl noradrenaline; Racemic isoprenaline; dl-Isadrine; Racemic isoproterenol; (+-)-Isoproterenol; Vapo-N-iso; Aerolone; Aleudrine; Dihydroxyphenylethanolisopropylamine; Euspiran; ISOPROP; Isadrin; Isoproterenolum; Isuprel; Isupren; Izadrin; Epinephrine isopropyl homolog; Isoprenaline hydrochloride; Isoproterenol Chloride; Isoproterenol [JAN]; Isuprel Mistometer; WIN 5162; D-Isoprenaline; D-Isopropylarterenol; D-Isoproterenol; DL-Isopropylnorepinephrine; Dl-Ipr; Dl-Isadrine; Dl-Isopropylnoradrenaline; Isoprenalina [INN-Spanish]; Isoprenaline (INN); Isoprenalinum [INN-Latin]; Isuprel (TN); L-Isopropylnoradrenaline; L-Isoproterenol; Medihaler-ISO; Neo-Epinine; Vapo-Iso; Alpha-(Isopropylaminomethyl)protocatechuyl alcohol; Alpha-(Isopropylaminomoethyl)protocatechuyl alcohol; D-N-Isopropylnorepinephrine; Dl-N-Isopropylnoradrenaline; Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol; Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol; DL(+-)-Isoproterenol; N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine; (+)-Isoprenaline; (+)-Isoproterenol; (+-)-Isoprenaline; (-)-Isoproterenol hydrochloride; (S)-(+)-Isoproterenol; (S)-Isoprenaline; (S)-Isoproterenol; 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI); 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)-(9CI); 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol; 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol; 3,4-Dihydroxy-alpha-(isopropylaminomethyl)-benzyl alcohol; 3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol; 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol; 4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol; AS1409
Indication
Disease Entry ICD 11 Status REF
Atrioventricular block N.A. Approved [1]
Cardiac arrest MC82 Approved [1]
Common cold CA00 Approved [1]
Heart block BC63 Approved [2]
Melanoma 2C30 Phase 1 [3]
Therapeutic Class
Cardiotonic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

72 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Isoproterenol DCBY3J2 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Allopurinol + Isoproterenol DCUJA7C Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Aminosalicylic acid + Isoproterenol DCHCKN9 Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Armodafinil + Isoproterenol DC7H6EH Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
AS-1949490 + Isoproterenol DCLFKGC AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BIO-300 + Isoproterenol DC3OVEB BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Isoproterenol DCJ7RMX Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Chlorzoxazone + Isoproterenol DCMNYR8 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cisatracurium + Isoproterenol DC8ADWM Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cycloguanil + Isoproterenol DC83MOF Cycloguanil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cytarabine + Isoproterenol DCMDXA8 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Darunavir + Isoproterenol DCSTFDL Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diazoxide + Isoproterenol DCZ7LBG Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diphenidol + Isoproterenol DCLO9B5 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Docetaxel + Isoproterenol DCKTZ2Q Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Entacapone + Isoproterenol DC72S5Q Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Estramustine + Isoproterenol DCEUDFM Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
ETHISTERONE + Isoproterenol DCU82SH ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Etonogestrel + Isoproterenol DC9I6R6 Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fomepizole + Isoproterenol DCMVFYJ Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Furazolidone + Isoproterenol DCQLZ6N Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Galantamine + Isoproterenol DC60L7C Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Kanamycin DCNDTIB Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Imipramine DCA8JCV Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Crotamiton DC850O5 Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Methotrexate DCSZJIN Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Repaglinide DCF950S Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Testosterone DCYZMAT Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + IT-141 DCCJLEU IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Ursodeoxycholic acid DCKAKJF Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Sulfapyridine DCH5VIU Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Tolvaptan DCQKK7B Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Arfolitixorin DCG0IAX Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Trazodone DCSR8H1 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Trifluoperazine DC56ANW Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + GINKGOLIDE A DCOZZPE GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Imatinib DCKYH61 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Trimethobenzamide DC5PT4J Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Bumetanide DCFXKJO Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Hyodeoxycholic acid DCHOEOI Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Spironolactone DCVE0JL Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Chlormezanone DCPYQKA Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Mycophenolic acid DCIGMQG Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Hydralazine DCEB38Z Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Mefloquine DCD2MY6 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Auranofin DCBKPNT Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Vorinostat DCY3RIH Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Isoproterenol + Aciclovir DC26LCR Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
L-165041 + Isoproterenol DC12NZQ L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lacosamide + Isoproterenol DCDY2PP Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Maprotiline + Isoproterenol DC0OOCT Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mebendazole + Isoproterenol DCMZYAN Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mesalazine + Isoproterenol DCCGLLY Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methoxsalen + Isoproterenol DCRSHYA Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metyrosine + Isoproterenol DC44SVW Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Naltrexone + Isoproterenol DCKA08Y Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olmesartan medoxomil + Isoproterenol DCCDCBH Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Oseltamivir + Isoproterenol DCWI4OO Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pargyline + Isoproterenol DCEHXCS Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pazopanib + Isoproterenol DCXZGA7 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
PF-02545920 + Isoproterenol DCPW1O3 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pinacidil + Isoproterenol DCD0FID Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pyrazinamide + Isoproterenol DC908LT Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ramelteon + Isoproterenol DCH3RPB Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Terameprocol + Isoproterenol DCMZWCF Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Terazosin + Isoproterenol DCBOAE9 Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tetracycline + Isoproterenol DCZ03MW Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tiagabine + Isoproterenol DCVU8PH Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triiodothyronine + Isoproterenol DCXM5OW Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vinblastine + Isoproterenol DCXTKO4 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
VR-776 + Isoproterenol DC5LGD1 VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
WAY-100635 + Isoproterenol DCZWTHU WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 72 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Isoproterenol + Phenylephrine DC814W2 Phenylephrine Postural Tachycardia Syndrome [5]
Propranolol + Isoproterenol DCQK95J Propranolol Obesity [6]
Isoproterenol + Adenosine DCRPON6 Adenosine Atrial Fibrillation [7]
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References

1 Isoproterenol FDA Label
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083346.
3 A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 ClinicalTrials.gov (NCT02673996) POTS Adrenergic Ab (CIHR Aims #1&2)
6 ClinicalTrials.gov (NCT05219799) Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
7 ClinicalTrials.gov (NCT03032965) Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation