Details of the Drug Combinations

General Information of This Drug (ID: DMLS39E)

Drug Name

Proparacaine DMLS39E

Synonyms

Alcaine; Diocaine; Kainair; Ophthaine; Ophthetic; Paracaine; Prossimetacaina; Proximetacaina; Proximetacainum; Proxymetacaine; Proxymetacainum; Prossimetacaina [DCIT]; Proxymetacaine Hcl; Ak-taine; Alcaine (TN); Ocu-Caine; Proximetacaina [INN-Spanish]; Proxymetacaine (INN); Proxymetacaine [INN:BAN]; Proxymetacainum [INN-Latin]; Spectro-Caine; Ak-Taine (TN); Beta-(Diethylamino)ethyl 4-n-propoxybenzoate; BENZOIC ACID, 3-AMINO-4-PROPOXY-, 2-(DIETHYLAMINO)ETHYL ESTER; 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate; 2-diethylaminoethyl 3-amino-4-propoxybenzoate; 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
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Therapeutic Class

Anesthetics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Proparacaine + Artemisinin	DCOF3O6	Artemisinin	DD2 (Cell Line: DD2)	[2]
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6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dexamethasone + Proparacaine	DCCAQ4J	Dexamethasone	Cataract	[3]
Proparacaine + Acetaminophen	DC28WK8	Acetaminophen	Vitreoretinal Surgeries	[4]
Proparacaine + Ropivacaine	DC8IXD7	Ropivacaine	Cataract Unilateral Pending Extraction	[5]
Proparacaine + Pilocarpine	DCDXRKC	Pilocarpine	Glaucoma, Angle-Closure	[6]
Tropicamide + Proparacaine	DCF22HP	Tropicamide	Cataract	[7]
Tropicamide + Proparacaine	DCOJF9R	Tropicamide	Anisocoria	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7283).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT02609997) Comparison of In-the-bag Stability Between Single-piece and Three-piece Intraocular Lens
4	ClinicalTrials.gov (NCT02973581) SPI-directed Analgesia for Vitreoretinal Surgeries
5	ClinicalTrials.gov (NCT02925832) Comparing Ropivacaine and Bupivacaine in DTFNB Anesthesia in Patients Undergoing Phacoemulsification
6	ClinicalTrials.gov (NCT02613013) Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure
7	ClinicalTrials.gov (NCT02895074) Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts
8	ClinicalTrials.gov (NCT05238233) Wearing-Off Period of Pharmacological Dilation and Anisocoria