Details of the Drug Combinations

General Information of This Drug (ID: DMM5SCF)

Drug Name
ONC201   DMM5SCF
Synonyms
Onc-201; TIC10; 1616632-77-9; UNII-9U35A31JAI; 9U35A31JAI; TIC10(ONC-201); 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one; TIC 10 active isomer; ONC201(TIC10 isomer); TIC 10; GTPL9978; SCHEMBL16227974; EX-A669; ONC 201; AOB2892; MolPort-039-137-731; HY-15615A; 3388AH; s7963; ZINC169620396; AKOS025404904; NSC 350625; CS-3564; AS-16735; AK174891; KB-335104; FT-0700231; J-690224; 1342897-86-2; 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimid
Indication
Disease Entry ICD 11 Status REF
Endometrial cancer 2C76 Phase 2 [1]
Glioma 2A00.0 Phase 2 [1]
Multiple myeloma 2A83 Phase 2 [1]
Neuroendocrine cancer 2B72.1 Phase 2 [1]
Recurring respiratory infection CA07-CA45 Phase 2 [1]
leukaemia 2A60-2B33 Phase 1/2 [1]
Lymphoma 2A80-2A86 Phase 1/2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
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Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

21 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Doxorubicin + ONC201 DCTCJOV Doxorubicin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Evacetrapib + ONC201 DCJ8024 Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
GSK-2256098 + ONC201 DCIXC8N GSK-2256098 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Lenalidomide + ONC201 DCZ00QE Lenalidomide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-2206 + ONC201 DCEQ7W8 MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Buparlisib DCF4PWQ Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Trametinib DC9WG4C Trametinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + JQ1 DCU7KJB JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Panobinostat DC09D02 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Alvespimycin hydrochloride DCIQUG5 Alvespimycin hydrochloride Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Selumetinib DCIFHQQ Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Plinabulin DC0YU19 Plinabulin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Mitomycin DC4LZ7H Mitomycin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Mebendazole DCU01NB Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + BMS-754807 DCGVQZG BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + THZ1 DCS27ZC THZ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Doxorubicin DCRBBQ8 Doxorubicin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Vorinostat DCTYV52 Vorinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Pyrazinamide + ONC201 DCLNWMA Pyrazinamide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THAPSIGARGIN + ONC201 DCHE69R THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Venglustat + ONC201 DC1IM8K Venglustat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.