Details of the Drug Combinations

General Information of This Drug (ID: DMMIQ7G)

Drug Name

Rosuvastatin DMMIQ7G

Synonyms

Astende; Cirantan; Cresadex; Creston; Crestor; Provisacor; Razel; Rosedex; Rosimol; Rosumed; Rosustatin; Rosuvas; Rosuvast; Rosvel; Rovartal; Simestat; Sinlip; Vivacor; Rosuvastatin [INN]; Rosuvastatin calcium; Rosuvastatin calcium [USAN]; Rosuvastatin hemicalcium; S 4522; ZD 4522; ZD4522; AZD-4522; Creston (TN);Crestor (TN); Pyrimidine Compound, 26; Rosuvastatin (INN); S-4522; ZD 4522, calcium salt; ZD-4522; Rosuvastatin calcium (JAN/USAN); Bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhelpt-6-enoic acid] calcium salt; Calcium (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid; (3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid; (E,3R,5R)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (S-((R*,S*-(E)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1); (S-(R*,S*-(E)))-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1); 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, (3R,5S,6E); 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia, familial combined, LPL related	N.A.	Approved	[1]
Hypertriglyceridemia	5C80.1	Approved	[1]
Elevated C-reactive protein	MA14.15	Phase 3	[2]
Colon cancer	2B90.Z	Investigative	[1]
Precancerous condition	N.A.	Investigative	[1]
Stroke	8B20	Investigative	[1]
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Therapeutic Class

Anticholesteremic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

31 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AKB-6548 + Rosuvastatin	DCDGXNZ	AKB-6548	Drug Interaction Potentiation	[3]
Amlodipine + Rosuvastatin	DC547K2	Amlodipine	Hypertension and Dyslipidemia	[4]
Amlodipine + Rosuvastatin	DC3GIF6	Amlodipine	Hypertension	[5]
Atorvastatin + Rosuvastatin	DC4DJ66	Atorvastatin	Hypercholesterolemia	[6]
Atorvastatin + Rosuvastatin	DCLHRM0	Atorvastatin	Type IIa and IIb Hypercholesterolaemia	[7]
Brilinta + Rosuvastatin	DC9WTUP	Brilinta	Pharmacokinetics	[8]
Caffeine + Rosuvastatin	DCU31AS	Caffeine	Atherosclerosis	[9]
Dolutegravir + Rosuvastatin	DCB3E7O	Dolutegravir	Malaria	[10]
Ezetimibe + Rosuvastatin	DCT8XLP	Ezetimibe	Hypercholesterolemia	[11]
Fenofibrate + Rosuvastatin	DCOV22X	Fenofibrate	Dyslipidemia, Renal Insufficiency	[12]
Fidaxomicin + Rosuvastatin	DCHAQER	Fidaxomicin	Drug-Drug Interaction (DDI)	[13]
Fostamatinib + Rosuvastatin	DC3PON3	Fostamatinib	Rheumatoid Arthritis	[14]
Fruquintinib + Rosuvastatin	DCS4W0D	Fruquintinib	Metastatic Colorectal Cancer	[15]
Pitavastatin + Rosuvastatin	DCATKSL	Pitavastatin	Hypercholesterolemia	[6]
Pravastatin + Rosuvastatin	DCT4VKM	Pravastatin	Type IIa and IIb Hypercholesterolaemia	[7]
Regorafenib + Rosuvastatin	DCSV7DS	Regorafenib	Neoplasms	[16]
Rosuvastatin + Darapladib	DCSCSQE	Darapladib	Atherosclerosis	[17]
Rosuvastatin + BMS-986012	DC0XSL9	BMS-986012	Immunosuppression For Disease	[18]
Sivextro + Rosuvastatin	DCTY45U	Sivextro	Skin Diseases, Bacterial	[19]
Tipranavir + Rosuvastatin	DCS97YB	Tipranavir	HIV Infections	[20]
Apabetalone + Rosuvastatin	DC8KRUV	Apabetalone	Dyslipidemia	[21]
Carvedilol + Rosuvastatin	DCPFYP9	Carvedilol	Cirrhosis	[22]
Propranolol + Rosuvastatin	DCVSF6Y	Propranolol	Cirrhosis	[22]
Ezetimibe + Rosuvastatin	DCNNWGS	Ezetimibe	Hypercholesterolemia	[23]
Rosuvastatin + Empagliflozin	DC3BTJ5	Empagliflozin	Dyslipidemia Associated With Type II Diabetes Mellitus	[24]
Rosuvastatin + Telmisartan	DCSVG4B	Telmisartan	Hypertension With Hyperlipidemia	[25]
Rosuvastatin + Empagliflozin	DCYI9W8	Empagliflozin	Type 2 Diabetes Mellitus	[26]
Valsartan + Rosuvastatin	DCS2118	Valsartan	Hypertension,	[27]
Dapagliflozin + Rosuvastatin	DC5Z90K	Dapagliflozin	Diabetes Mellitus, Type 2	[28]
Rosuvastatin + Colchicine	DCY13M2	Colchicine	Coronary Artery Disease	[29]
Rosuvastatin + Telmisartan	DCYY4KO	Telmisartan	Metabolic Syndrome	[30]
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⏷ Show the Full List of 31 DrugCom(s)

References

1	Rosuvastatin FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2954).
3	ClinicalTrials.gov (NCT03801733) Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin
4	ClinicalTrials.gov (NCT02933658) Study of Multiple Oral Dosing to Evaluate the Safety and the Pharmacokinetic Drug-drug Interaction of Telmisartan/Amlodipine and Rosuvastatin in Healthy Male Volunteers
5	ClinicalTrials.gov (NCT02789475) DP-R212 Pharmacokinetic Study
6	ClinicalTrials.gov (NCT01660191) A Study Comparing CoQ10 Levels While Taking 3 Different Statins. U.S. National Institutes of Health.
7	ClinicalTrials.gov (NCT00631189) Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients
8	ClinicalTrials.gov (NCT05373277) KF2019#1-trial: Effects of a Thrombocyte Inhibitor on a Cholesterol-lowering Drug
9	ClinicalTrials.gov (NCT00851175) Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
10	ClinicalTrials.gov (NCT05236530) Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir
11	ClinicalTrials.gov (NCT00653445) Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg
12	ClinicalTrials.gov (NCT00585143) Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the Pharmacokinetics of ABT-335 and Rosuvastatin When Administered Concomitantly
13	ClinicalTrials.gov (NCT02083627) A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects
14	ClinicalTrials.gov (NCT01725230) Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With Fostamatinib
15	ClinicalTrials.gov (NCT05368805) Fruquintinib DDI Study With P-gp and BCRP Substrates
16	ClinicalTrials.gov (NCT02106845) Effect of Regorafenib on Digoxin and Rosuvastatin in Patients With Advanced Solid Malignant Tumors.
17	ClinicalTrials.gov (NCT01751074) To Estimate the Potential Effects of Repeat Doses of Darapladib on the Pharmacokinetics (PK) of Rosuvastatin as Well as Evaluating Safety and Tolerability in Healthy Volunteers
18	ClinicalTrials.gov (NCT02101125) Drug Interaction Study With Rosuvastatin
19	ClinicalTrials.gov (NCT02477514) A Study to Evaluate the Effects of Tedizolid Phosphate on the Pharmacokinetics and Safety of Midazolam and Rosuvastatin (MK-1986-004)
20	ClinicalTrials.gov (NCT00344123) Pharmacokinetic (PK) Study of Single-dose Rosuvastatin and Tipranavir/Ritonavir in Healthy Subjects
21	ClinicalTrials.gov (NCT01863225) Characterization of Multi-dose RVX000222 in Combination With Statin Treatment in Dyslipidemia
22	ClinicalTrials.gov (NCT03720067) Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension
23	ClinicalTrials.gov (NCT02741245) A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)
24	ClinicalTrials.gov (NCT04602754) Efficacy and Safety of Berlim 25/20 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia.
25	ClinicalTrials.gov (NCT03566316) Efficacy/Safety of Telmisartan/Amlodipine/Rosuvastatin in Hypertensive Patients With Hyperlipidemia
26	ClinicalTrials.gov (NCT04603508) Efficacy and Safety of Berlim 25/10 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia
27	ClinicalTrials.gov (NCT01918332) Efficacy and Safety of Valsartan 160mg and Rosuvastatin 20mg in Patients With Hypertension and Hyperlipidemia
28	ClinicalTrials.gov (NCT03074630) Dapagliflozin and Cholesterol Metabolism in Type 2 Diabetes (DM2)
29	ClinicalTrials.gov (NCT05850091) Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
30	ClinicalTrials.gov (NCT02968160) A Clinical Trial of YMC017 in Hypertensive and Hypercholesterolemic Patients With Metabolic Syndrome