General Information of This Drug (ID: DMOL5IU)

Drug Name
Mesalazine   DMOL5IU
Synonyms
Apriso; Asacol; Asacolitin; Asacolon; Asalit; Ascolitin; Canasa; Claversal; Fisalamine; Fivasa; Iialda; Ipocol; Lialda; Lixacol; Mesacol; Mesalamine; Mesalazina; Mesalazinum; Mesasal; Mesavance; Mesavancol; Mezavant; Pentacol; Pentasa; Rowasa; Salofalk; Salozinal; SfRowasa; Allphar Brand of Mesalamine; Antigen Brand of Mesalamine; Asacol HD; Axcan Brand of Mesalamine; Byk Brand of Mesalamine; Celltech Brand of Mesalamine; Falk Brand of Mesalamine; Farmasa Brand of Mesalamine; Ferring Brand of Mesalamine; GlaxoSmithKline Brand of Mesalamine; Henning Berlin Brand of Mesalamine; M Aminosalicylic Acid; Merckle Brand of Mesalamine; Mesalamine Hydrochloride; Mesalamine Monosodium Salt; Mesalamine [USAN]; Mesalazina[Spanish]; Mesalazine MMX; Mesalazinum [Latin]; Meta Aminosalicylic Acid; Mezavant XL; Minosalicylic acid; Norgine Brand of Mesalamine; Novopharm Brand of Mesalamine; Provalis Brand of Mesalamine; Sanofi Synthelabo Brand of Mesalamine; Schering Plough Brand of Mesalamine; SmithKline Brand of Mesalamine; Solvay Brand of Mesalamine; Yamanouchi Brand of Mesalamine; Novo 5 ASA; Novo5 ASA; AJG-501; Apriso (TN); Asacol (TN); Canasa (TN); Hydrochloride, Mesalamine; Iialda (TN); Ipocal (TN); Lialda (TN); M-A; M-Aminosalicylic acid; MAX-002; MD-0901; Masacol (TN); Mesalamine (USP); Meta-AminosalicylicAcid; Monosodium Salt, Mesalamine; Novo-5 ASA; P-Aminosalicylsaeure; P-Aminosalicylsaeure [German]; Pentasa (TN); Procter & Gamble Brand of Mesalamine; Rowasa (TN); SPD-476; SPD-480; Salofalk (TN); Salofalk Granu-Stix; Schering-Plough Brand of Mesalamine; Z-206; Mesalazine (JAN/INN); Salicylic acid, 5-amino-(8CI); 2-Hydroxy-5-aminobenzoic acid; 3-carboxy-4-hydroxyaniline; 5 Aminosalicylate; 5 Aminosalicylic Acid; 5-AS; 5-ASA; 5-Amino-2-hydroxybenzoic acid; 5-Aminosalicylate; 5-Aminosalicylic acid; 5-amino-2-hydroxy-benzoic acid; 5-aminosalicylic acid, Mesalazine, Asacol, Pentasa, Canasa, Mesalamine
Indication
Disease Entry ICD 11 Status REF
Diverticulitis N.A. Approved [1]
Proctitis DB33.Z Approved [2]
Ulcerative colitis DD71 Approved [3]
Ulcerative proctosigmoiditis N.A. Approved [4]
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Mesalazine DCSO1C5 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Acamprosate + Mesalazine DCJZEUU Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Arfolitixorin + Mesalazine DCK8IY5 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Asenapine + Mesalazine DCR2G2D Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bortezomib + Mesalazine DCC5UL2 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cerivastatin + Mesalazine DC9BLWC Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Chlorzoxazone + Mesalazine DCC0ATO Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cilastatin + Mesalazine DCM9G2X Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Ciprofibrate + Mesalazine DCI0KT6 Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Clindamycin + Mesalazine DCDE76B Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Clopidogrel + Mesalazine DC3T6AO Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Diazoxide + Mesalazine DCRGD4U Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Dihydroergotamine + Mesalazine DCTLLWP Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Fomepizole + Mesalazine DC5QDQN Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Idarubicin + Mesalazine DCOOR22 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Imatinib + Mesalazine DCHEGET Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Isosorbide dinitrate + Mesalazine DCUZXG5 Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
IT-141 + Mesalazine DCB1WFQ IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Levamisole + Mesalazine DCAMU99 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Maprotiline + Mesalazine DCQCT60 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Gefitinib DCDF59N Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Dantrolene DCFSQDL Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Diethylcarbamazine DC52PYC Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Epinephrine DCCWVGW Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Tacrine DC0RJ52 Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Methotrexate DCRJKQ3 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Miglustat DCAN2O6 Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Vinblastine DCBF4B6 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Everolimus DC0CCO2 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Metyrosine DCB20J1 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Terameprocol DCHSV6V Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + K-134 DCQKPTB K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Docetaxel DCBMYHG Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + BIO-300 DCFTWP4 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + PF-02545920 DCUFPXE PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Isoproterenol DCCGLLY Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Ibutilide DCGI3KU Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Methylene blue DCGHXFP Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Trimethobenzamide DCGL60C Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Maprotiline DCJSI6H Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Leflunomide DC4I2WZ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Brincidofovir DCQZT0U Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Quinine DCVMOMC Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Mycophenolic acid DCLOJN0 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Doxorubicin DCYW81C Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Sumatriptan DCK4DH6 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Cytarabine DCPM5RC Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mesalazine + Etomidate DCC769M Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Olanzapine + Mesalazine DCPEEEG Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pepstatin + Mesalazine DC7N7HD Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
SCH 727965 + Mesalazine DCC8I0G SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tacrolimus + Mesalazine DCMHN5U Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Tiagabine + Mesalazine DCP53KJ Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Topotecan + Mesalazine DCM6913 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [6]
Trihexyphenidyl + Mesalazine DCZ3Q2K Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Vorinostat + Mesalazine DCEIVAF Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
VR-776 + Mesalazine DCX9CQ6 VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
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⏷ Show the Full List of 57 DrugCom(s)
6 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Azathioprine + Mesalazine DCVMCOT Azathioprine Colitis, Ulcerative [7]
Mesalazine + Hydroxychloroquine DCYG0ZM Hydroxychloroquine Ulcerative Colitis (Disorder) [8]
Atorvastatin + Mesalazine DCG0980 Atorvastatin Inflammatory Bowel Diseases [9]
Dapagliflozin + Mesalazine DCBY75V Dapagliflozin Inflammatory Bowel Diseases [10]
Fenofibrate + Mesalazine DC9AVWL Fenofibrate Inflammatory Bowel Diseases [11]
Mesalazine + Minocycline DC6QED9 Minocycline Inflammatory Bowel Diseases [12]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 Colonic diverticular disease. Nat Rev Dis Primers. 2020 Mar 26;6(1):20.
2 Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. Digestion. 2018;97(1):59-63.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4655).
4 Efficacy of Oral, Topical, or Combined Oral and Topical 5-Aminosalicylates, in Ulcerative Colitis: Systematic Review and Network Meta-analysis. J Crohns Colitis. 2021 Jul 5;15(7):1184-1196.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
7 ClinicalTrials.gov (NCT00984568) Conventional Step-Up Versus Infliximab Monotherapy in Patients With Ulcerative Colitis (P05553)
8 ClinicalTrials.gov (NCT05119140) Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis
9 ClinicalTrials.gov (NCT05567068) Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis
10 ClinicalTrials.gov (NCT05986136) Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease
11 ClinicalTrials.gov (NCT05781698) Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis
12 ClinicalTrials.gov (NCT06201793) Minocyclin in Ulcerative Colitis as Added on Therapy