Details of the Drug Combinations

General Information of This Drug (ID: DMOMBJW)

Drug Name
Moricizine   DMOMBJW
Synonyms
Moracizin; Moracizina; Moracizine; Moracizinum; Moricizine [USAN]; G 214; EN-313; Moracizina [INN-Spanish]; Moracizine (INN); Moracizinum [INN-Latin]; Moricizine (USAN); Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate; Ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate; Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate; Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester; Ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate; Ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamate; Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester
Indication
Disease Entry ICD 11 Status REF
Arrhythmia BC9Z Approved [1]
Long QT syndrome BC65.0 Approved [2]
Heart arrhythmia BC65 Withdrawn from market [3]
Therapeutic Class
Antiarrhythmic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acarbose + Moricizine DCQ07YH Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Acetazolamide + Moricizine DC8CIG8 Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Amiloride + Moricizine DC7NR2G Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Arfolitixorin + Moricizine DCAYIF7 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Artemisinin + Moricizine DCXEC4M Artemisinin Hepatoblastoma (Cell Line: HB3) [4]
BIO-300 + Moricizine DC2O1VV BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Bortezomib + Moricizine DCZ6324 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Moricizine DCCDSC2 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cerivastatin + Moricizine DCT39TQ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cinacalcet + Moricizine DCM47CE Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cytarabine + Moricizine DC65MBV Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Dactinomycin + Moricizine DCHYZ2F Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Dantrolene + Moricizine DCTTEWN Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Endoxifen + Moricizine DCMN83G Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Epinephrine + Moricizine DC2C5TM Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fibrates + Moricizine DCJBDCV Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Imatinib + Moricizine DC6WOL7 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Itraconazole + Moricizine DCI2ZHU Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Leflunomide + Moricizine DC90QJR Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lumefantrine + Moricizine DCY7K04 Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mebutamate + Moricizine DC1X30U Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Meclofenamic acid + Moricizine DC3C1SP Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mefloquine + Moricizine DCBFEPM Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methotrexate + Moricizine DC4FMV0 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Gefitinib DCITU68 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Ezetimibe DCN75M1 Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Everolimus DC3UA5U Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Methoxsalen DCAD48U Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Sitagliptin DCDXJDI Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Pentamidine DCYLIKN Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Procarbazine DCQHVYF Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Niclosamide DCP65VH Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Lubiprostone DCNW7JU Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Fenoprofen DCFE5YW Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Probenecid DCLMLQY Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Methylene blue DCGJN95 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Artemisinin DC8O6DC Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Maprotiline DCEP2JB Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Brincidofovir DCR67QQ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Asenapine DCAYZ69 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Doxorubicin DC0MD15 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Zileuton DCAIUMG Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + Auranofin DCST63J Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Moricizine + ML323 DC8Y3W9 ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Norcisapride + Moricizine DC7B5NZ Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Olanzapine + Moricizine DCFSRGC Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Oseltamivir + Moricizine DCVO7UU Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
PMID28460551-Compound-2 + Moricizine DC1I349 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pramipexole + Moricizine DC688UN Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pyrazinamide + Moricizine DCHH6FJ Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Rufinamide + Moricizine DC2DT5Z Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sulfinpyrazone + Moricizine DC5WZMM Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sumatriptan + Moricizine DCQMEHG Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Terameprocol + Moricizine DCT89BM Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tiagabine + Moricizine DCFRQBX Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triamterene + Moricizine DC05R7K Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Moricizine DC0RF5G Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Trimethobenzamide + Moricizine DCDMABB Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vinblastine + Moricizine DCXWVRA Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vorinostat + Moricizine DCA6731 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 60 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Moricizine FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7244).
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.