Details of the Drug Combinations

General Information of This Drug (ID: DMPFN6Y)

• Drug Name: Olanzapine (DMPFN6Y)
• Synonyms: Lanzac; Midax; Olansek; Olanzapina; Olanzapinum; Symbyax; Zalasta; Zydis; Zyprexa; Eli Lilly brand of olanzapine; Lilly brand of olanzapine; Zyprexa Intramuscular; Zyprexa Velotab; Zyprexa Zydis; LY 170053; ALKS-7921; KS-1090; LY-170052; LY-170053; Olanzapine (OLA); Olanzapine [USAN:INN]; Olzapin (TN); Rexapin (TN); Zalasta (TN); Zolafren (TN); Zydis (TN); Zyprexa (TN); Olanzapine (JAN/USAN/INN); 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno[2,3-b ] [1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine

Indication

Bipolar depression; ICD 11: N.A.; Status: Approved [1]; Major depressive disorder; ICD 11: 6A70.3; Status: Approved [1]; Schizoaffective disorder; ICD 11: 6A21; Status: Approved [1]; Schizophrenia; ICD 11: 6A20; Status: Approved [2]

• Therapeutic Class: Antipsychotic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bortezomib + Olanzapine	DCE3Q48	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Olanzapine	DCMXYH2	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Olanzapine	DCXM718	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlormezanone + Olanzapine	DCEX63Q	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cinacalcet + Olanzapine	DC48RY4	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clascoterone + Olanzapine	DCM2MCI	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diethylcarbamazine + Olanzapine	DCTPSC0	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Olanzapine	DCUHINJ	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Olanzapine	DCZ1PAJ	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Olanzapine	DCF9TY1	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Olanzapine	DCANA00	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Entacapone + Olanzapine	DCV4QHX	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethambutol + Olanzapine	DC7RCI7	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Olanzapine	DCI1RX9	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GSK2194069 + Olanzapine	DC43F4F	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Guanfacine + Olanzapine	DCDXQJE	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Olanzapine	DCC5WVO	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Olanzapine	DC3XT0A	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Kanamycin + Olanzapine	DCLMPJY	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Olanzapine	DCDTCH6	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Olanzapine	DC4BWDZ	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Olanzapine	DCN0TC6	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Olanzapine	DCY6JS5	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Mebutamate	DC3S845	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Panobinostat	DCLYPCD	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Olanzapine + Triapine	DCE5I22	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Everolimus	DCL6RK5	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Pepstatin	DCFOV9N	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Efavirenz	DCZPS4W	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Emetine	DCRSROC	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + PFK-158	DCCFDU0	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Arfolitixorin	DCC89TF	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Norcisapride	DCI7NF8	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Tiagabine	DCYVXDC	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Diazoxide	DC2WPP9	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Fenoprofen	DCDVYEP	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Idarubicin	DC6XZO1	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Olanzapine + Imatinib	DCVOFGS	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Probenecid	DCZWEU0	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Darunavir	DCWAADF	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Mesalazine	DCPEEEG	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Moricizine	DCFSRGC	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Trimethobenzamide	DCFFJXO	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Maprotiline	DC43Q65	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Oxyphenbutazone	DCCSX0W	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Brincidofovir	DCAXME9	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Quinine	DCZUE3C	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Spironolactone	DC7RXBH	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Hydralazine	DCZFQ85	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Zileuton	DCT6EX8	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Cytarabine	DCOMG5Q	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Etomidate	DCGM64D	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Olanzapine	DCGIGZ8	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PHA-739358 + Olanzapine	DCFNZR7	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Olanzapine	DCVMLAU	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ribavirin-TP + Olanzapine	DC1TQO5	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Olanzapine	DCN496W	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Olanzapine	DCM217X	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

17 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aripiprazole + Olanzapine	DC09CAJ	Aripiprazole	Depression	[4]
Fluoxetine + Olanzapine	DCRO2OM	Fluoxetine	Treatment Resistant Depression	[5]
Haloperidol + Olanzapine	DCTOVHA	Haloperidol	Insulin Resistance	[6]
MIN-101 + Olanzapine	DCG6G7J	MIN-101	Negative Symptoms in Schizophrenia	[7]
Olanzapine + Valproic Acid	DC1ZXZ6	Valproic Acid	Bipolar I Disorder	[8]
Olanzapine + Amisulpride	DC2RTAJ	Amisulpride	Schizophrenia	[9]
Ondansetron + Olanzapine	DCK3AT2	Ondansetron	Alcohol Dependence	[10]
Palonosetron + Olanzapine	DCIMDV2	Palonosetron	Chemotherapy-induced Nausea and Vomiting	[11]
Sertraline + Olanzapine	DCYTCPM	Sertraline	Major Depressive Disorder With Psychotic Features	[12]
Simvastatin + Olanzapine	DCIXI2O	Simvastatin	Schizophrenia	[13]
Ziprasidone + Olanzapine	DCFLM1J	Ziprasidone	Schizophrenia	[14]
Ziprasidone + Olanzapine	DCW7IXX	Ziprasidone	Hyperglycemia	[15]
Aprepitant + Olanzapine	DCKOO1K	Aprepitant	Chemotherapy Induced Nausea and Vomiting	[16]
Risperidone + Olanzapine	DC6PIXN	Risperidone	Schizophrenia	[17]
Clozapine + Olanzapine	DC83NZ2	Clozapine	Schizophrenia	[18]
Olanzapine + Buprenorphine	DC48Q2N	Buprenorphine	Suicide Crisis Syndrome	[19]
Olanzapine + Clonazepam	DC0K3JK	Clonazepam	Suicide Crisis Syndrome	[19]

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Fluoxetine + Olanzapine	DC2QR75	Fluoxetine	Depression	[20]

References

• [1] Olanzapine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 47).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01057329) Therapeutic Drug Monitoring in Child and Adolescent Psychiatry
• [5] ClinicalTrials.gov (NCT01687478) A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression
• [6] ClinicalTrials.gov (NCT00625170) Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
• [7] ClinicalTrials.gov (NCT06107803) A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia
• [8] ClinicalTrials.gov (NCT00402324) A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients
• [9] ClinicalTrials.gov (NCT01609153) Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy
• [10] ClinicalTrials.gov (NCT00678457) Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial
• [11] ClinicalTrials.gov (NCT02970643) Proof-of-Concept Trial of Palonosetron and Olanzapine Without Dexamethasone for the Prevention of CIN
• [12] ClinicalTrials.gov (NCT00056472) Study of Pharmacotherapy of Psychotic Depression
• [13] ClinicalTrials.gov (NCT00672464) Cardio Risk of Acute Schizophrenia Olanzapine Duke
• [14] ClinicalTrials.gov (NCT01185743) Antipsychotics and Gene Expression in Soft Tissues
• [15] ClinicalTrials.gov (NCT00910988) Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone
• [16] ClinicalTrials.gov (NCT02097823) Pilot Study of Olanzapine and Aprepitant to Prevent Nausea and Vomiting in Children Receiving Chemotherapy
• [17] ClinicalTrials.gov (NCT02717195) Effect of Lu AF35700 in Patients With Treatment-resistant Schizophrenia
• [18] ClinicalTrials.gov (NCT00981526) Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia
• [19] ClinicalTrials.gov (NCT06133114) Psychopharmacological Treatment of Emotional Distress
• [20] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015