Details of the Drug Combination

General Information of Drug Combination (ID: DC83NZ2)

Drug Combination Name
Clozapine Olanzapine
Indication
Disease Entry Status REF
Schizophrenia Phase 4 [1]
Component Drugs Clozapine   DMFC71L Olanzapine   DMPFN6Y
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Clozapine
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Approved [2]
Treatment-refractory schizophrenia N.A. Investigative [3]
Clozapine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D4 receptor (D4R) TTE0A2F DRD4_HUMAN Modulator [10]
------------------------------------------------------------------------------------
Clozapine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
------------------------------------------------------------------------------------
Clozapine Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [13]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [14]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [15]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [16]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [16]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [12]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 DME(s)
Clozapine Interacts with 389 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [17]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Affects Response To Substance [18]
D(3) dopamine receptor (DRD3) OT0OFFKB DRD3_HUMAN Decreases Response To Substance [19]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Decreases Response To Substance [20]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Increases Response To Substance [21]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [6]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Increases Expression [6]
Serine protease hepsin (HPN) OT7QNA61 HEPS_HUMAN Increases Expression [6]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Increases Expression [6]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [6]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [6]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Increases Expression [6]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Increases Expression [6]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [6]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Increases Expression [6]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Increases Expression [6]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Increases Expression [6]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Increases Expression [6]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [6]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [22]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [22]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [22]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [22]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Increases Expression [23]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [23]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [23]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Expression [23]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [23]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Increases Expression [23]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Increases Expression [23]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [24]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [7]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Activity [25]
Uncharacterized protein CXorf49 (CXORF49) OTMZ66NA CX049_HUMAN Increases Expression [8]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Decreases Expression [8]
AP-3 complex subunit beta-1 (AP3B1) OTYTIH5Q AP3B1_HUMAN Increases Expression [8]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Increases Expression [26]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Increases Expression [8]
Syntenin-1 (SDCBP) OTS3NCC5 SDCB1_HUMAN Decreases Expression [8]
Importin subunit alpha-3 (KPNA4) OTP0EX18 IMA3_HUMAN Increases Expression [8]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Decreases Expression [8]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) OTZX703K CDIPT_HUMAN Increases Expression [8]
Serine palmitoyltransferase 1 (SPTLC1) OTN0Z98K SPTC1_HUMAN Decreases Expression [8]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) OTR7WJES DC1L2_HUMAN Decreases Expression [8]
E3 ubiquitin-protein ligase RNF13 (RNF13) OT7HNYF4 RNF13_HUMAN Increases Expression [26]
Calumenin (CALU) OTSYQN71 CALU_HUMAN Decreases Expression [8]
Kinesin heavy chain isoform 5C (KIF5C) OT35570Y KIF5C_HUMAN Decreases Expression [8]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [8]
Tetraspanin-3 (TSPAN3) OT7WS6ZI TSN3_HUMAN Decreases Expression [8]
Eukaryotic translation initiation factor 5B (EIF5B) OTZTT22W IF2P_HUMAN Increases Expression [8]
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) OTSAU864 U520_HUMAN Increases Expression [8]
Eukaryotic translation initiation factor 3 subunit J (EIF3J) OTJ4TAWK EIF3J_HUMAN Increases Expression [8]
Glutaredoxin-3 (GLRX3) OTUPAU1N GLRX3_HUMAN Increases Expression [8]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Decreases Expression [8]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Increases Expression [8]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Decreases Expression [27]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [28]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [8]
Neuroendocrine secretory protein 55 (GNAS) OTMH8BKJ GNAS3_HUMAN Increases Expression [8]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [8]
Adenylate kinase isoenzyme 1 (AK1) OT614AR3 KAD1_HUMAN Decreases Expression [8]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Increases Expression [8]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Secretion [29]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [30]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [27]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Increases Secretion [31]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Increases Expression [27]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Increases Expression [32]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [33]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Decreases Secretion [26]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Increases Expression [34]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Decreases Expression [8]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [35]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [36]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) OTJ1SKOA RPN2_HUMAN Decreases Expression [8]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [37]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [26]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Expression [26]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Affects Expression [27]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases Activity [38]
Myosin light chain 1/3, skeletal muscle isoform (MYL1) OTDUYR4U MYL1_HUMAN Increases Expression [8]
Prothymosin alpha (PTMA) OT2W4T1M PTMA_HUMAN Increases Expression [8]
Glucose-6-phosphate isomerase (GPI) OTEGSRXG G6PI_HUMAN Increases Expression [8]
Corticoliberin (CRH) OT2MOC4T CRF_HUMAN Decreases Expression [39]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Decreases Expression [8]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [26]
Annexin A5 (ANXA5) OTZS877V ANXA5_HUMAN Decreases Expression [8]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [26]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Increases Expression [26]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Decreases Expression [27]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [27]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [27]
Dihydropteridine reductase (QDPR) OTSKOIUX DHPR_HUMAN Decreases Expression [8]
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) OTB8HCED CN37_HUMAN Decreases Expression [8]
Leukotriene A-4 hydrolase (LTA4H) OTWSZ0QT LKHA4_HUMAN Decreases Expression [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Secretion [26]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [27]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) OT9LBJVN ODP2_HUMAN Increases Expression [8]
Myosin-3 (MYH3) OTOCCGEB MYH3_HUMAN Increases Expression [8]
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Affects Binding [40]
Lysosome-associated membrane glycoprotein 1 (LAMP1) OTYE92QY LAMP1_HUMAN Increases Expression [8]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [8]
Histidine--tRNA ligase, cytoplasmic (HARS1) OTHOEOTS HARS1_HUMAN Increases Expression [8]
ADP/ATP translocase 3 (SLC25A6) OT9KAJP7 ADT3_HUMAN Increases Expression [8]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Decreases Expression [8]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Increases Expression [26]
Plastin-3 (PLS3) OTYBM4PK PLST_HUMAN Decreases Expression [8]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Increases Expression [8]
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) OT3UJ4ZU RSMB_HUMAN Increases Expression [8]
Glutamine synthetase (GLUL) OTYGTCGF GLNA_HUMAN Decreases Expression [26]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Increases Expression [26]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [8]
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) OT8FQ7MN VATB1_HUMAN Decreases Expression [8]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Increases Expression [8]
26S proteasome regulatory subunit 6A (PSMC3) OTSKT0JI PRS6A_HUMAN Increases Expression [8]
V-type proton ATPase subunit B, brain isoform (ATP6V1B2) OTNX2V4Z VATB2_HUMAN Decreases Expression [8]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Increases Expression [8]
C-C motif chemokine 1 (CCL1) OT23NON8 CCL1_HUMAN Decreases Expression [27]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Increases Expression [8]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [8]
Small ribosomal subunit protein uS3 (RPS3) OT0K3TMH RS3_HUMAN Decreases Expression [8]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Increases Expression [26]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Increases Expression [8]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Decreases Expression [8]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Decreases Expression [8]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Decreases Expression [8]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Activity [41]
Elongation factor 1-delta (EEF1D) OTM5ZD8Y EF1D_HUMAN Decreases Expression [8]
Phosphatidylethanolamine-binding protein 1 (PEBP1) OTQ5FEI0 PEBP1_HUMAN Decreases Expression [8]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Decreases Expression [8]
Lipocalin-1 (LCN1) OT8BWXTV LCN1_HUMAN Decreases Expression [8]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [8]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [42]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [8]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) OTQHB52T P5CR1_HUMAN Increases Expression [8]
Cleavage stimulation factor subunit 2 (CSTF2) OTR6G4II CSTF2_HUMAN Decreases Expression [8]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Affects Binding [43]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Affects Binding [44]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Increases Expression [8]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [8]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [8]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) OTIOLNHE LICH_HUMAN Increases Expression [8]
V-type proton ATPase catalytic subunit A (ATP6V1A) OTYZ2S9E VATA_HUMAN Decreases Expression [8]
Stress-70 protein, mitochondrial (HSPA9) OT4TMVS9 GRP75_HUMAN Decreases Expression [8]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Increases Expression [8]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [8]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Decreases Expression [8]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Increases Expression [8]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Increases Expression [8]
N-alpha-acetyltransferase 10 (NAA10) OTYB9R6I NAA10_HUMAN Decreases Expression [8]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [45]
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) OTXSK5LP LPPRC_HUMAN Increases Expression [8]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Decreases Expression [27]
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) OTV232Y7 GPDM_HUMAN Decreases Expression [8]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Increases Expression [27]
Vesicle-fusing ATPase (NSF) OTKRJ2ZT NSF_HUMAN Decreases Expression [8]
Large ribosomal subunit protein uL18 (RPL5) OTM8EBRI RL5_HUMAN Increases Expression [8]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Decreases Expression [8]
3-hydroxyanthranilate 3,4-dioxygenase (HAAO) OTK9Y6SG 3HAO_HUMAN Decreases Expression [26]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Decreases Expression [8]
Phosphatidylinositol transfer protein beta isoform (PITPNB) OTNM6T78 PIPNB_HUMAN Increases Expression [8]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Increases Expression [8]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Increases Expression [8]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Decreases Expression [8]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2) OTAKUO27 ACOT2_HUMAN Increases Expression [8]
Transmembrane emp24 domain-containing protein 10 (TMED10) OTUXSHH7 TMEDA_HUMAN Decreases Expression [8]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [42]
Matrix metalloproteinase-14 (MMP14) OT9C197Z MMP14_HUMAN Increases Expression [26]
5-hydroxytryptamine receptor 6 (HTR6) OT8GTDDY 5HT6R_HUMAN Affects Binding [44]
Glycine amidinotransferase, mitochondrial (GATM) OTIJ4Z11 GATM_HUMAN Increases Expression [8]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [8]
Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) OTH70UHD GDS1_HUMAN Increases Expression [8]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1) OTDCSPXH SUCA_HUMAN Decreases Expression [8]
Ephrin type-B receptor 3 (EPHB3) OT4XD8O3 EPHB3_HUMAN Increases Expression [8]
Trifunctional enzyme subunit beta, mitochondrial (HADHB) OT4Y1I62 ECHB_HUMAN Increases Expression [8]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [45]
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) OTMGP4J7 HNRH2_HUMAN Decreases Expression [26]
Eukaryotic translation initiation factor 6 (EIF6) OTEXMUED IF6_HUMAN Decreases Expression [8]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Decreases Expression [8]
Protein transport protein Sec61 subunit beta (SEC61B) OTY1X6A2 SC61B_HUMAN Increases Expression [8]
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) OTS7YVHF GBRL2_HUMAN Increases Expression [26]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [8]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [8]
ATP-binding cassette sub-family E member 1 (ABCE1) OTH19LOA ABCE1_HUMAN Increases Expression [8]
26S proteasome regulatory subunit 8 (PSMC5) OTJOORMR PRS8_HUMAN Increases Expression [8]
Small ribosomal subunit protein uS17 (RPS11) OTILZE44 RS11_HUMAN Decreases Expression [8]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [26]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Decreases Expression [8]
Large ribosomal subunit protein eL30 (RPL30) OTLQVY1Z RL30_HUMAN Increases Expression [8]
Large ribosomal subunit protein uL5 (RPL11) OT3VZ6OE RL11_HUMAN Increases Expression [8]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Decreases Expression [8]
S-phase kinase-associated protein 1 (SKP1) OT5BPAZ4 SKP1_HUMAN Decreases Expression [8]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Decreases Expression [8]
BOS complex subunit NOMO3 (NOMO3) OTTOCIRA NOMO3_HUMAN Increases Expression [8]
Microtubule-associated protein 1A (MAP1A) OTHO8K43 MAP1A_HUMAN Decreases Expression [8]
Dermcidin (DCD) OTV5PBGJ DCD_HUMAN Decreases Expression [8]
Enhancer of rudimentary homolog (ERH) OTJDWX99 ERH_HUMAN Increases Expression [8]
Large ribosomal subunit protein eL19 (RPL19) OT33LM66 RL19_HUMAN Increases Expression [8]
Disabled homolog 2 (DAB2) OTRMQTMZ DAB2_HUMAN Increases Expression [26]
Protein Dr1 (DR1) OTR081M4 NC2B_HUMAN Decreases Expression [8]
Melanocyte-stimulating hormone receptor (MC1R) OTB95LIK MSHR_HUMAN Increases Expression [27]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [46]
Guanine nucleotide-binding protein subunit alpha-12 (GNA12) OT3IRZH3 GNA12_HUMAN Increases Expression [8]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Expression [47]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Increases Expression [26]
Cleavage stimulation factor subunit 1 (CSTF1) OTYSXAX6 CSTF1_HUMAN Decreases Expression [8]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases Expression [8]
Elongation factor 1-alpha 2 (EEF1A2) OT9Z23K5 EF1A2_HUMAN Increases Expression [8]
Cytoskeleton-associated protein 4 (CKAP4) OTDUC9ME CKAP4_HUMAN Increases Expression [8]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) OT5GO2PL KHDR1_HUMAN Decreases Expression [8]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [35]
Golgin subfamily A member 3 (GOLGA3) OT27354E GOGA3_HUMAN Increases Expression [8]
Fibrinogen-like protein 1 (FGL1) OTT0QHQ1 FGL1_HUMAN Increases Expression [26]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [8]
Nuclear cap-binding protein subunit 1 (NCBP1) OTYBR927 NCBP1_HUMAN Decreases Expression [8]
TBC1 domain family member 8B (TBC1D8B) OTSYGOXH TBC8B_HUMAN Increases Expression [8]
Nuclear pore complex protein Nup160 (NUP160) OTUKVV3I NU160_HUMAN Increases Expression [8]
Transducin beta-like protein 3 (TBL3) OT14XY62 TBL3_HUMAN Increases Expression [8]
Aspartyl/asparaginyl beta-hydroxylase (ASPH) OT3KGDEE ASPH_HUMAN Increases Expression [8]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) OT2LP7LJ SNF5_HUMAN Decreases Expression [8]
Oviduct-specific glycoprotein (OVGP1) OTL2W9M5 OVGP1_HUMAN Increases Expression [27]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Increases Expression [8]
Serine/arginine-rich splicing factor 5 (SRSF5) OTC5WP98 SRSF5_HUMAN Increases Expression [8]
Transcription intermediary factor 1-beta (TRIM28) OTE38OBF TIF1B_HUMAN Decreases Expression [8]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [35]
C-terminal-binding protein 1 (CTBP1) OTVYH2DH CTBP1_HUMAN Increases Expression [8]
NAD(P) transhydrogenase, mitochondrial (NNT) OTAIOGZK NNTM_HUMAN Decreases Expression [8]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [26]
Stromal interaction molecule 1 (STIM1) OT8CLQ1W STIM1_HUMAN Decreases Expression [8]
Sorting nexin-1 (SNX1) OTXQSJ1J SNX1_HUMAN Decreases Expression [8]
Cullin-2 (CUL2) OTPF83PG CUL2_HUMAN Increases Expression [8]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Increases Expression [8]
Nuclear receptor coactivator 4 (NCOA4) OTRVU0UA NCOA4_HUMAN Increases Expression [26]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [8]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [8]
Protein DGCR6 (DGCR6) OTBOXM33 DGCR6_HUMAN Decreases Expression [8]
Single-minded homolog 2 (SIM2) OT0QWHK4 SIM2_HUMAN Decreases Expression [8]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Decreases Expression [8]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Increases Expression [8]
Flotillin-2 (FLOT2) OTZ0QR5L FLOT2_HUMAN Increases Expression [8]
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) OT8RPSOC FKBP8_HUMAN Decreases Expression [8]
Protein RRP5 homolog (PDCD11) OTS1NJK2 RRP5_HUMAN Increases Expression [8]
Golgin subfamily B member 1 (GOLGB1) OT2S0GK8 GOGB1_HUMAN Increases Expression [8]
Chromodomain-helicase-DNA-binding protein 4 (CHD4) OTBDEHDP CHD4_HUMAN Decreases Expression [8]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [8]
Serum paraoxonase/lactonase 3 (PON3) OT80W9TA PON3_HUMAN Increases Expression [8]
Inorganic pyrophosphatase (PPA1) OTHZK1QB IPYR_HUMAN Increases Expression [8]
Periodic tryptophan protein 2 homolog (PWP2) OTG6BNPG PWP2_HUMAN Increases Expression [8]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Increases Expression [8]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [8]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Increases Expression [8]
Microtubule-associated protein RP/EB family member 1 (MAPRE1) OTCVQD60 MARE1_HUMAN Decreases Expression [8]
Disks large homolog 2 (DLG2) OTQ3BD8U DLG2_HUMAN Increases Expression [8]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [48]
Serine/arginine-rich splicing factor 7 (SRSF7) OTRS4W4S SRSF7_HUMAN Decreases Expression [8]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [36]
Histone H2A type 2-C (H2AC20) OTEIVLM1 H2A2C_HUMAN Increases Expression [8]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Decreases Expression [8]
La-related protein 7 (LARP7) OTLLOZTL LARP7_HUMAN Increases Expression [8]
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) OTW95XD4 DHB12_HUMAN Increases Expression [8]
Endoribonuclease LACTB2 (LACTB2) OTU4IFBU LACB2_HUMAN Increases Expression [8]
Beta-actin-like protein 2 (ACTBL2) OTD6B81U ACTBL_HUMAN Increases Expression [8]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) OTLS7C99 LRRK2_HUMAN Increases Expression [8]
ATPase family AAA domain-containing protein 3B (ATAD3B) OTL508AF ATD3B_HUMAN Increases Expression [8]
Tau-tubulin kinase 1 (TTBK1) OTYW316L TTBK1_HUMAN Increases Expression [8]
CD276 antigen (CD276) OTKHTFVO CD276_HUMAN Decreases Expression [8]
Microtubule-associated protein 1S (MAP1S) OT5WUD4C MAP1S_HUMAN Increases Expression [8]
Actin-binding LIM protein 2 (ABLIM2) OT62KOXF ABLM2_HUMAN Increases Expression [27]
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) OT3ZNGEL SCMC1_HUMAN Increases Expression [8]
Enhancer of mRNA-decapping protein 4 (EDC4) OTBBNIUJ EDC4_HUMAN Increases Expression [8]
Leiomodin-2 (LMOD2) OTFXHQFL LMOD2_HUMAN Increases Expression [8]
Septin-14 (SEPTIN14) OTCM6DDO SEP14_HUMAN Decreases Expression [8]
Probable ATP-dependent RNA helicase DDX46 (DDX46) OTB2X9TO DDX46_HUMAN Increases Expression [8]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Increases Expression [8]
ATP-dependent RNA helicase DHX30 (DHX30) OT7W9CEZ DHX30_HUMAN Increases Expression [8]
Probable helicase senataxin (SETX) OTG3JNOQ SETX_HUMAN Increases Expression [8]
Nucleoporin p54 (NUP54) OTHOIRMG NUP54_HUMAN Decreases Expression [8]
Low-density lipoprotein receptor-related protein 10 (LRP10) OT8490HT LRP10_HUMAN Increases Expression [26]
Centromere protein V (CENPV) OTPQ0KT9 CENPV_HUMAN Increases Expression [8]
RNA-binding Raly-like protein (RALYL) OT232N7Q RALYL_HUMAN Increases Expression [8]
THO complex subunit 4 (ALYREF) OTOF2ADD THOC4_HUMAN Decreases Expression [8]
GRIP and coiled-coil domain-containing protein 2 (GCC2) OTT5I9FM GCC2_HUMAN Decreases Expression [8]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [8]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) OT5Q6SVK SIR2_HUMAN Increases Expression [26]
Diacylglycerol lipase-beta (DAGLB) OT1S9869 DGLB_HUMAN Increases Expression [26]
Paraneoplastic antigen Ma1 (PNMA1) OTEUG8RL PNMA1_HUMAN Increases Expression [8]
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10) OT61XMYC NUD10_HUMAN Increases Expression [8]
Nuclear protein localization protein 4 homolog (NPLOC4) OTC1WUVF NPL4_HUMAN Decreases Expression [8]
TBC1 domain family member 15 (TBC1D15) OTIT3Y14 TBC15_HUMAN Increases Expression [26]
PEST proteolytic signal-containing nuclear protein (PCNP) OTJUQ122 PCNP_HUMAN Increases Expression [8]
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38) OTBVB3W5 PRP16_HUMAN Decreases Expression [8]
Nectin-2 (NECTIN2) OTIE0W6O NECT2_HUMAN Decreases Expression [8]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Expression [8]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [49]
Liver-expressed antimicrobial peptide 2 (LEAP2) OTUOPIS5 LEAP2_HUMAN Increases Expression [27]
DNA topoisomerase I, mitochondrial (TOP1MT) OT2H77ID TOP1M_HUMAN Increases Expression [8]
PAT complex subunit CCDC47 (CCDC47) OTUIN61P CCD47_HUMAN Increases Expression [8]
Far upstream element-binding protein 1 (FUBP1) OT77SC9N FUBP1_HUMAN Increases Expression [8]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) OTIUA60B SH3K1_HUMAN Increases Expression [8]
ADP-ribosylation factor-like protein 8A (ARL8A) OTEYM6FA ARL8A_HUMAN Decreases Expression [8]
Protein phosphatase 1 regulatory subunit 14B (PPP1R14B) OT9PTWAX PP14B_HUMAN Decreases Expression [8]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [8]
Small ribosomal subunit protein mS39 (PTCD3) OTHTOLE0 PTCD3_HUMAN Increases Expression [8]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Decreases Expression [8]
Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) OT6Q5M0C PGAM5_HUMAN Decreases Expression [8]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Increases Expression [47]
Proteasome subunit beta type-7 (PSMB7) OT2NKD2K PSB7_HUMAN Decreases Expression [8]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) OT7RJON4 HCD2_HUMAN Decreases Expression [8]
Nucleosome assembly protein 1-like 4 (NAP1L4) OTUEG3QY NP1L4_HUMAN Increases Expression [8]
Transmembrane 9 superfamily member 2 (TM9SF2) OTA0C202 TM9S2_HUMAN Decreases Expression [8]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Decreases Expression [8]
T-complex protein 1 subunit eta (CCT7) OTQNM3CY TCPH_HUMAN Decreases Expression [8]
Protein arginine N-methyltransferase 1 (PRMT1) OTN8GTXW ANM1_HUMAN Decreases Expression [8]
Endophilin-A2 (SH3GL1) OTXTBFWT SH3G1_HUMAN Increases Expression [8]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [26]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Increases Expression [8]
Myb-binding protein 1A (MYBBP1A) OTIVEMIU MBB1A_HUMAN Increases Expression [8]
Coronin-1B (CORO1B) OT7C4BMQ COR1B_HUMAN Decreases Expression [8]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Increases Expression [8]
MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK) OT20GHN3 MK67I_HUMAN Decreases Expression [8]
Fibroblast growth factor-binding protein 2 (FGFBP2) OT3NBPQO FGFP2_HUMAN Increases Expression [27]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) OT87E7HW B2L14_HUMAN Decreases Expression [8]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Lipidation [26]
RNA cytidine acetyltransferase (NAT10) OT6JQO26 NAT10_HUMAN Decreases Expression [8]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Increases Expression [8]
Damage-control phosphatase ARMT1 (ARMT1) OTS7WBCP ARMT1_HUMAN Increases Expression [8]
Exosome complex component RRP41 (EXOSC4) OTG4TICP EXOS4_HUMAN Increases Expression [8]
Synembryn-A (RIC8A) OT4YZOWE RIC8A_HUMAN Decreases Expression [8]
Kinesin-like protein KIF13B (KIF13B) OTAFS1YV KI13B_HUMAN Increases Expression [8]
Serine incorporator 1 (SERINC1) OTF3UASX SERC1_HUMAN Increases Expression [26]
Phenylalanine--tRNA ligase beta subunit (FARSB) OT8N9TT5 SYFB_HUMAN Increases Expression [8]
ATPase family AAA domain-containing protein 3A (ATAD3A) OTWF6HBP ATD3A_HUMAN Decreases Expression [8]
Endoplasmic reticulum aminopeptidase 1 (ERAP1) OT72S99B ERAP1_HUMAN Decreases Expression [8]
Methionine adenosyltransferase 2 subunit beta (MAT2B) OT4Y7T9L MAT2B_HUMAN Decreases Expression [8]
Very-long-chain (HACD3) OTISMCAF HACD3_HUMAN Increases Expression [8]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Increases Expression [26]
Ribosome-binding protein 1 (RRBP1) OT4ZTPTM RRBP1_HUMAN Decreases Expression [8]
Ataxin-10 (ATXN10) OTKRDUNN ATX10_HUMAN Increases Expression [8]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [26]
DnaJ homolog subfamily B member 11 (DNAJB11) OTDDK2SY DJB11_HUMAN Increases Expression [8]
Testin (TES) OTL8PP6V TES_HUMAN Decreases Expression [8]
Translocation protein SEC63 homolog (SEC63) OT1ICPMK SEC63_HUMAN Increases Expression [8]
Cysteine and histidine-rich domain-containing protein 1 (CHORDC1) OT3W6F1U CHRD1_HUMAN Increases Expression [8]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [8]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) OTTZVSK6 S2513_HUMAN Increases Expression [8]
Nuclear pore complex protein Nup50 (NUP50) OTOZ98K3 NUP50_HUMAN Increases Expression [8]
Serine/threonine-protein kinase TAO2 (TAOK2) OTNUMOZ1 TAOK2_HUMAN Increases Expression [8]
Sorting nexin-6 (SNX6) OTLKQYJU SNX6_HUMAN Increases Expression [8]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Decreases Expression [8]
DNA-binding protein SATB2 (SATB2) OT2W80XC SATB2_HUMAN Increases Expression [8]
Serine/arginine repetitive matrix protein 2 (SRRM2) OTSIMMC9 SRRM2_HUMAN Decreases Expression [8]
Phenylalanine--tRNA ligase alpha subunit (FARSA) OT3U1P20 SYFA_HUMAN Increases Expression [8]
Fanconi-associated nuclease 1 (FAN1) OT1LM1HZ FAN1_HUMAN Increases Expression [8]
Kelch domain-containing protein 2 (KLHDC2) OTBHH882 KLDC2_HUMAN Decreases Expression [8]
Thyroid hormone receptor-associated protein 3 (THRAP3) OTG25JOG TR150_HUMAN Decreases Expression [8]
Serine-threonine kinase receptor-associated protein (STRAP) OTT3T7QT STRAP_HUMAN Decreases Expression [8]
RNA-splicing ligase RtcB homolog (RTCB) OTUED31V RTCB_HUMAN Increases Expression [8]
Nucleolar complex protein 2 homolog (NOC2L) OTNT7R33 NOC2L_HUMAN Increases Expression [8]
TRPM8 channel-associated factor 1 (TCAF1) OTSQQ37P TCAF1_HUMAN Decreases Expression [8]
Talin-2 (TLN2) OT10QQBC TLN2_HUMAN Decreases Expression [8]
Beta-secretase 2 (BACE2) OTO5YQVK BACE2_HUMAN Increases Expression [26]
FH1/FH2 domain-containing protein 1 (FHOD1) OTROM7N3 FHOD1_HUMAN Decreases Expression [8]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [8]
Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) OTJUR82A DC1L1_HUMAN Decreases Expression [8]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Affects Response To Substance [50]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Increases Metabolism [51]
Sodium-dependent dopamine transporter (SLC6A3) OT39XG28 SC6A3_HUMAN Affects Response To Substance [52]
Disrupted in schizophrenia 1 protein (DISC1) OT43AW4H DISC1_HUMAN Decreases Response To Substance [53]
Oxytocin-neurophysin 1 (OXT) OT48M72Z NEU1_HUMAN Affects Response To Substance [54]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Affects Response To Substance [55]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Affects Response To Substance [56]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Affects Response To Substance [57]
5-hydroxytryptamine receptor 2C (HTR2C) OT6H8DE0 5HT2C_HUMAN Affects Response To Substance [58]
Dysbindin (DTNBP1) OT9UQT2S DTBP1_HUMAN Increases Response To Substance [59]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Decreases Activity [60]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Affects Response To Substance [61]
Ribosyldihydronicotinamide dehydrogenase (NQO2) OTGDAJRZ NQO2_HUMAN Increases Reduction [62]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Increases Metabolism [51]
D(1A) dopamine receptor (DRD1) OTLZPBT7 DRD1_HUMAN Affects Response To Substance [63]
Circadian locomoter output cycles protein kaput (CLOCK) OTNEOJY7 CLOCK_HUMAN Affects Response To Substance [64]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Response To Substance [65]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Activity [60]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Metabolism [51]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Increases Metabolism [51]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Affects Response To Substance [66]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Affects Response To Substance [67]
5-hydroxytryptamine receptor 2A (HTR2A) OTWXJX0M 5HT2A_HUMAN Increases Response To Substance [68]
------------------------------------------------------------------------------------
⏷ Show the Full List of 389 DOT(s)
Indication(s) of Olanzapine
Disease Entry ICD 11 Status REF
Bipolar depression N.A. Approved [4]
Major depressive disorder 6A70.3 Approved [4]
Schizoaffective disorder 6A21 Approved [4]
Schizophrenia 6A20 Approved [5]
Olanzapine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Agonist [70]
------------------------------------------------------------------------------------
Olanzapine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
------------------------------------------------------------------------------------
Olanzapine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [71]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [72]
------------------------------------------------------------------------------------
Olanzapine Interacts with 63 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [17]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Increases Response To Substance [21]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Increases Expression [23]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [23]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [23]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [23]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [73]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [28]
Ceruloplasmin (CP) OTM8JE4Y CERU_HUMAN Affects Phosphorylation [74]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Phosphorylation [74]
Complement factor B (CFB) OTZITNEJ CFAB_HUMAN Affects Phosphorylation [74]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Increases Phosphorylation [74]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Affects Phosphorylation [74]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Affects Phosphorylation [74]
Complement C5 (C5) OTSL3OIC CO5_HUMAN Affects Phosphorylation [74]
Kininogen-1 (KNG1) OT4X9LDE KNG1_HUMAN Affects Phosphorylation [74]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [75]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [76]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Phosphorylation [74]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Phosphorylation [74]
Complement component C9 (C9) OT7I5FDX CO9_HUMAN Affects Phosphorylation [74]
Beta-2-glycoprotein 1 (APOH) OTFMUX6O APOH_HUMAN Affects Phosphorylation [74]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Affects Phosphorylation [74]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Phosphorylation [74]
Vitamin D-binding protein (GC) OTWS63BY VTDB_HUMAN Affects Phosphorylation [74]
Hemopexin (HPX) OT14T7Q1 HEMO_HUMAN Affects Phosphorylation [74]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Increases Phosphorylation [74]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Affects Phosphorylation [74]
Alpha-1B-glycoprotein (A1BG) OTFVUGNQ A1BG_HUMAN Affects Phosphorylation [74]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Decreases Expression [77]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [35]
Plasma protease C1 inhibitor (SERPING1) OT6CVN45 IC1_HUMAN Affects Phosphorylation [74]
Apolipoprotein A-IV (APOA4) OT466POQ APOA4_HUMAN Affects Phosphorylation [74]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Increases Expression [73]
Complement factor H (CFH) OTAGKQTJ CFAH_HUMAN Decreases Phosphorylation [74]
Complement C4-A (C4A) OTXMOYXU CO4A_HUMAN Decreases Phosphorylation [74]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Phosphorylation [74]
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Affects Binding [44]
Complement component C6 (C6) OTCKR304 CO6_HUMAN Affects Phosphorylation [74]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Increases Expression [78]
Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) OTG3WBBE ITIH2_HUMAN Affects Phosphorylation [74]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [79]
5-hydroxytryptamine receptor 2A (HTR2A) OTWXJX0M 5HT2A_HUMAN Affects Binding [44]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [80]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Affects Binding [44]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Increases Expression [76]
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) OTNBHULA PACR_HUMAN Affects Expression [69]
Afamin (AFM) OTPOR8IO AFAM_HUMAN Affects Phosphorylation [74]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [80]
5-hydroxytryptamine receptor 6 (HTR6) OT8GTDDY 5HT6R_HUMAN Affects Binding [44]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [81]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [35]
Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) OT460OO1 ITIH4_HUMAN Affects Phosphorylation [74]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Increases Expression [73]
D(3) dopamine receptor (DRD3) OT0OFFKB DRD3_HUMAN Increases ADR [82]
5-hydroxytryptamine receptor 1A (HTR1A) OT38K9MK 5HT1A_HUMAN Increases Response [83]
5-hydroxytryptamine receptor 2C (HTR2C) OT6H8DE0 5HT2C_HUMAN Increases Response To Substance [84]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Response To Substance [85]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Increases Response To Substance [86]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Increases ADR [82]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases ADR [82]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Affects Response To Substance [66]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Affects Response To Substance [67]
------------------------------------------------------------------------------------
⏷ Show the Full List of 63 DOT(s)

References

1 ClinicalTrials.gov (NCT00981526) Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 38).
3 Clozapine FDA Label
4 Olanzapine FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 47).
6 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
7 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.
8 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
9 UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Drug Metab Dispos. 2005 May;33(5):672-5. doi: 10.1124/dmd.104.002576. Epub 2005 Feb 11.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75.
12 Drug metabolism and atypical antipsychotics. Eur Neuropsychopharmacol. 1999 Jun;9(4):301-9.
13 Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):4-22.
14 Characterization of human cytochrome P450s involved in the bioactivation of clozapine. Drug Metab Dispos. 2013 Mar;41(3):651-8.
15 Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84.
16 Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):592-9.
17 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
18 Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine. Int J Neurosci. 2005 Nov;115(11):1539-47. doi: 10.1080/00207450590957863.
19 Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010 Jun;10(3):200-18. doi: 10.1038/tpj.2009.65. Epub 2009 Dec 22.
20 G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics. Pharmacogenomics. 2008 Oct;9(10):1429-36. doi: 10.2217/14622416.9.10.1429.
21 Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenet Genomics. 2010 Jun;20(6):359-66. doi: 10.1097/FPC.0b013e3283397d06.
22 Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J. 2005;5(5):298-304.
23 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
24 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
25 Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites. Chem Res Toxicol. 2011 Aug 15;24(8):1263-74.
26 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
27 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
28 In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs. Chem Res Toxicol. 2012 Aug 20;25(8):1616-32. doi: 10.1021/tx300091x. Epub 2012 May 31.
29 Risperidone-associated hyperprolactinemia. Endocr Pract. 2000 Nov-Dec;6(6):425-9. doi: 10.4158/EP.6.6.425.
30 Effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia. Psychopharmacology (Berl). 2006 Jul;186(4):572-8. doi: 10.1007/s00213-006-0384-5. Epub 2006 Apr 7.
31 Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine. Acta Psychiatr Scand. 1994 May;89(5):346-51. doi: 10.1111/j.1600-0447.1994.tb01527.x.
32 Eosinophilia indicating subclinical clozapine-induced pericarditis. J Clin Psychiatry. 2007 Jul;68(7):1147-8. doi: 10.4088/jcp.v68n0726d.
33 Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content. Chem Biol Interact. 2019 Sep 25;311:108787. doi: 10.1016/j.cbi.2019.108787. Epub 2019 Aug 7.
34 Clozapine-induced interstitial nephritis - a rare but important complication: a case report. J Med Case Rep. 2009 Aug 27;3:8574. doi: 10.4076/1752-1947-3-8574.
35 Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
36 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
37 [Antipsychotic drugs can affect hormone balance. Weight gain, blood lipid disturbances and diabetes are important]. Lakartidningen. 2001 Nov 28;98(48):5462-4, 5467-9.
38 Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite. Chem Res Toxicol. 2022 Jun 20;35(6):1001-1010. doi: 10.1021/acs.chemrestox.2c00008. Epub 2022 May 16.
39 Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases. Neuropsychopharmacology. 2006 Apr;31(4):853-65. doi: 10.1038/sj.npp.1300911.
40 Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action. Neuroreport. 2002 May 7;13(6):831-5. doi: 10.1097/00001756-200205070-00019.
41 Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis. Toxicol Sci. 2022 Feb 28;186(1):70-82. doi: 10.1093/toxsci/kfab154.
42 Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation. Psychopharmacology (Berl). 2009 Aug;205(3):419-29. doi: 10.1007/s00213-009-1551-2. Epub 2009 May 14.
43 Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions. Psychopharmacology (Berl). 2010 Dec;212(4):687-97. doi: 10.1007/s00213-010-2001-x. Epub 2010 Sep 9.
44 No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation. Pharmacogenomics J. 2007 Aug;7(4):275-81. doi: 10.1038/sj.tpj.6500418. Epub 2006 Sep 19.
45 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
46 Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine. Schizophr Res. 2009 Sep;113(2-3):273-6. doi: 10.1016/j.schres.2009.05.015. Epub 2009 Jun 7.
47 Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
48 Adiponectin as a potential biomarker for the metabolic syndrome in Chinese patients taking clozapine for schizophrenia. J Clin Psychiatry. 2007 Dec;68(12):1834-9. doi: 10.4088/jcp.v68n1202.
49 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
50 Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation. Drug Metab Dispos. 2011 Aug;39(8):1388-95. doi: 10.1124/dmd.110.037077. Epub 2011 May 3.
51 Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug Metab Dispos. 2008 Dec;36(12):2547-55. doi: 10.1124/dmd.108.023671. Epub 2008 Sep 22.
52 Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1026-32.
53 Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia. Pharmacogenomics J. 2011 Aug;11(4):267-73. doi: 10.1038/tpj.2010.40. Epub 2010 Jun 8.
54 Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int J Neuropsychopharmacol. 2010 Jul;13(6):793-8. doi: 10.1017/S1461145710000167. Epub 2010 Mar 3.
55 Genetic association between TNF-alpha -308 G>A polymorphism and longitudinal weight change during clozapine treatment. Hum Psychopharmacol. 2010 Jun-Jul;25(4):303-9. doi: 10.1002/hup.1122.
56 Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol. 2007 Jun;27(3):246-51. doi: 10.1097/jcp.0b013e3180582412.
57 Influence of serotonin transporter gene polymorphisms on clozapine response in Brazilian schizophrenics. J Psychiatr Res. 2010 Dec;44(16):1158-62. doi: 10.1016/j.jpsychires.2010.04.003. Epub 2010 May 10.
58 HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study. J Clin Psychopharmacol. 2009 Feb;29(1):16-20. doi: 10.1097/JCP.0b013e3181934462.
59 The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenet Genomics. 2009 Jun;19(6):437-46. doi: 10.1097/FPC.0b013e32832b9cfc.
60 Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine. Chem Res Toxicol. 2010 Sep 20;23(9):1467-76. doi: 10.1021/tx100131f.
61 Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia. Pharmacogenet Genomics. 2010 Apr;20(4):274-6. doi: 10.1097/FPC.0b013e328337ce3e.
62 Reduction and scavenging of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations. Chem Res Toxicol. 2018 Feb 19;31(2):116-126.
63 Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. 2007 Sep;21(7):718-27. doi: 10.1177/0269881106072341. Epub 2006 Nov 8.
64 Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness. Neurosci Lett. 2004 Sep 2;367(2):152-5. doi: 10.1016/j.neulet.2004.05.084.
65 COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr Res. 2007 Feb;90(1-3):86-96. doi: 10.1016/j.schres.2006.10.002. Epub 2006 Nov 22.
66 MTHFR and risk of metabolic syndrome in patients with schizophrenia. Schizophr Res. 2010 Aug;121(1-3):193-8. doi: 10.1016/j.schres.2010.05.030. Epub 2010 Jun 12.
67 The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. Neurosci Lett. 2005 May 6;379(2):81-9. doi: 10.1016/j.neulet.2004.12.037. Epub 2005 Jan 26.
68 Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies. Pharmacogenomics J. 2006 Jan-Feb;6(1):42-51. doi: 10.1038/sj.tpj.6500342.
69 Neuroleptic Drugs and PACAP Differentially Affect the mRNA Expression of Genes Encoding PAC1/VPAC Type Receptors. Neurochem Res. 2017 Apr;42(4):943-952. doi: 10.1007/s11064-016-2127-2. Epub 2016 Nov 30.
70 Olanzapine: an updated review of its use in the management of schizophrenia. Drugs. 2001;61(1):111-61.
71 Interactions between the cytochrome P450 system and the second-generation antipsychotics. J Psychiatry Neurosci. 2003 Mar;28(2):99-112.
72 [Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring]. Fortschr Neurol Psychiatr. 2001 Nov;69(11):510-7.
73 Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis. Toxicol Lett. 2019 Nov;316:183-193. doi: 10.1016/j.toxlet.2019.08.013. Epub 2019 Aug 19.
74 Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. Proteomics Clin Appl. 2015 Oct;9(9-10):907-16. doi: 10.1002/prca.201400148. Epub 2015 May 15.
75 The effects of olanzapine, risperidone, and haloperidol on plasma prolactin levels in patients with schizophrenia. Clin Ther. 2000 Sep;22(9):1085-96. doi: 10.1016/S0149-2918(00)80086-7.
76 Recovery from new-onset diabetes in a schizophrenic man after withdrawal of olanzapine. Psychosomatics. 2002 Jan-Feb;43(1):67-70. doi: 10.1176/appi.psy.43.1.67.
77 Hormonal markers of metabolic dysregulation in patients with severe mental disorders after olanzapine treatment under real-life conditions. J Clin Psychopharmacol. 2009 Apr;29(2):109-16. doi: 10.1097/JCP.0b013e31819b95fc.
78 Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells. J Psychiatr Res. 2006 Jun;40(4):374-9. doi: 10.1016/j.jpsychires.2005.04.016. Epub 2005 Jul 5.
79 The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
80 Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3/-catenin signaling pathway in the SH-SY5Y cell line. Chem Biol Interact. 2019 Dec 1;314:108823. doi: 10.1016/j.cbi.2019.108823. Epub 2019 Sep 26.
81 Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs. Eur J Pharmacol. 2006 Feb 27;532(3):270-8. doi: 10.1016/j.ejphar.2005.12.079. Epub 2006 Feb 21.
82 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
83 Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia. Adv Ther. 2010 May;27(5):307-13. doi: 10.1007/s12325-010-0035-4. Epub 2010 Jun 8.
84 Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. Pharmacogenomics J. 2009 Aug;9(4):234-41. doi: 10.1038/tpj.2009.18. Epub 2009 May 12.
85 DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1158-63. doi: 10.1073/pnas.1013535108. Epub 2010 Dec 27.
86 Different impacts of aquaporin 4 and MAOA allele variation among olanzapine, risperidone, and paliperidone in schizophrenia. J Clin Psychopharmacol. 2012 Jun;32(3):394-7. doi: 10.1097/JCP.0b013e31825370f4.