Details of the Drug Combinations

General Information of This Drug (ID: DMPMYE8)

• Drug Name: Miconazole (DMPMYE8)
• Synonyms: Dactarin; MCZ; Miconazol; Miconazolo; Miconazolum; Micozole; Minostate; Monistat; Vusion; Zimycan; Daktarin IV; Miconasil Nitrate; Miconazole nitrate salt; Miconazolo [DCIT]; Monistat IV; MJR 1762; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7 Combination Pack; Monazole 7; Monistat 1 Combination Pack; Monistat 3 Vaginal Ovules; Monistat 5 Tampon; Monistat 7 Vaginal Suppositories; R 18134; Aflorix(nitrate); Albistat(nitrate); Andergin(nitrate); Conofite(nitrate); Daktarin (TN); Femizol (TN); Femizol-M; Florid(nitrate); Lotrimin AF(nitrate); Micantin (nitrate); Micatin (TN); Miconazex (TN); Miconazol [INN-Spanish]; Miconazole-7; Miconazolum [INN-Latin]; Monista (nitrate); Monistat (TN); Monistat 3 Dual-Pak; Monistat 7 Dual-Pak; Monistat Dual-PAK; Monistat iv (TN); Monistat-Derm; Novo-Miconazole Vaginal Ovules; Epi-Monistat(nitrate); Gyno-Daktar(nitrate); Monistat-Derm (TN); R-14,889; Miconazole (JP15/USP/INN); Miconazole [USAN:BAN:INN:JAN]; Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-(9CI); Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-(9CI); (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole; 1-[2,4-Dichloro-beta-([2,4-dichloro-benzyl]oxy)phenethyl]imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole; 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

Indication

Cutaneous candidiasis; ICD 11: 1F23.14; Status: Approved [1]; Fungal infection; ICD 11: 1F29-1F2F; Status: Approved [2]; Mycoses; ICD 11: 1F2Z; Status: Approved [1]; Onychomycosis; ICD 11: EE12.1; Status: Approved [1]; Tinea corporis; ICD 11: 1F28.Y; Status: Approved [1]; Tinea cruris; ICD 11: 1F28.3; Status: Approved [1]; Tinea versicolor; ICD 11: 1F2D.0; Status: Approved [1]; Tinea pedis; ICD 11: 1F28.2; Status: Investigative [1]

• Therapeutic Class: Antifungal Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

70 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Miconazole	DCKQCM0	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxepin + Miconazole	DC0F50P	Doxepin	DD2 (Cell Line: DD2)	[3]
JTC-801 + Miconazole	DCMF7R4	JTC-801	DD2 (Cell Line: DD2)	[3]
Lumefantrine + Miconazole	DCKICWE	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Miconazole + Dantrolene	DCA8ICG	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Diethylcarbamazine	DCBN20X	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Lumefantrine	DCFSGF8	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Miconazole + Dactinomycin	DCXPL3H	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Dihydroergotamine	DCX79OO	Dihydroergotamine	DD2 (Cell Line: DD2)	[3]
Miconazole + Fluocinonide	DCUN9ES	Fluocinonide	DD2 (Cell Line: DD2)	[3]
Miconazole + Diltiazem	DCCBYN2	Diltiazem	DD2 (Cell Line: DD2)	[3]
Miconazole + Trihexyphenidyl	DCU37NH	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Thiolactomycin	DCS62J0	Thiolactomycin	DD2 (Cell Line: DD2)	[3]
Miconazole + Metyrosine	DCPRIUM	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Terameprocol	DCUYP4H	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Cinacalcet	DCCILRU	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Docetaxel	DC4XZI5	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Docetaxel	DCUROLB	Docetaxel	DD2 (Cell Line: DD2)	[3]
Miconazole + Mifepristone	DC3SHVQ	Mifepristone	DD2 (Cell Line: DD2)	[3]
Miconazole + BIO-300	DC7BFG2	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Niclosamide	DCZAHQB	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + SB 228357	DCXQEQL	SB 228357	DD2 (Cell Line: DD2)	[3]
Miconazole + Tiagabine	DC28W9P	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Diazoxide	DC6JHFO	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Idarubicin	DCFB8WP	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Miconazole + Bortezomib	DC9OTR6	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Methylene blue	DCRXY69	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Trimethobenzamide	DC0DTG2	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Omacetaxine mepesuccinate	DCB9VGZ	Omacetaxine mepesuccinate	DD2 (Cell Line: DD2)	[3]
Miconazole + Oxyphenbutazone	DCDB206	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + NITD609	DCCD6QM	NITD609	DD2 (Cell Line: DD2)	[3]
Miconazole + Leflunomide	DC86ALB	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Fluticasone propionate	DCS3CKB	Fluticasone propionate	DD2 (Cell Line: DD2)	[3]
Miconazole + Brincidofovir	DCARDTW	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Quinine	DCL4KK2	Quinine	DD2 (Cell Line: DD2)	[3]
Miconazole + Lacosamide	DC4IYMP	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Nitisinone	DCPSS31	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Olmesartan medoxomil	DCK1BYF	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Vorinostat	DCZV7JC	Vorinostat	DD2 (Cell Line: DD2)	[3]
Miconazole + Estramustine	DCIXHBY	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Atovaquone	DC2WKJI	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Atovaquone	DC6A8NA	Atovaquone	DD2 (Cell Line: DD2)	[3]
Miconazole + Cytarabine	DC24N6K	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Lumefantrine	DC2PJQG	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + T-3.5	DCNHUW7	T-3.5	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Artemether	DCLT5QF	Artemether	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Dihydroergotamine	DCDE3MC	Dihydroergotamine	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Cholic acid	DCE5WAO	Cholic acid	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Steroid derivative 1	DCZM50T	Steroid derivative 1	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Thiolactomycin	DC1CO7J	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Mifepristone	DCMFIQ0	Mifepristone	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + SB 228357	DC526CX	SB 228357	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Epothilone B	DC90YHX	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Omacetaxine mepesuccinate	DCL8V0R	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Fluticasone propionate	DCRTK86	Fluticasone propionate	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Quinine	DCWECGR	Quinine	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Piperaquine	DCR516Y	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Ritonavir	DCVC590	Ritonavir	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Mefloquine	DCI5Q59	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[4]
Miconazole + Atovaquone	DCUWOIO	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[4]
Omacetaxine mepesuccinate + Miconazole	DC76MCW	Omacetaxine mepesuccinate	DD2 (Cell Line: DD2)	[3]
Omacetaxine mepesuccinate + Miconazole	DCW85BC	Omacetaxine mepesuccinate	Hepatoblastoma (Cell Line: HB3)	[4]
Pepstatin + Miconazole	DC4LZXY	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrimethamine + Miconazole	DCY86ZW	Pyrimethamine	Hepatoblastoma (Cell Line: HB3)	[3]
Sarpogrelate + Miconazole	DCLPUFC	Sarpogrelate	Hepatoblastoma (Cell Line: HB3)	[4]
SB 228357 + Miconazole	DCZ48VV	SB 228357	DD2 (Cell Line: DD2)	[3]
SB 228357 + Miconazole	DCCV1DO	SB 228357	Hepatoblastoma (Cell Line: HB3)	[4]
Sorafenib + Miconazole	DC2EZUS	Sorafenib	DD2 (Cell Line: DD2)	[3]
Thiolactomycin + Miconazole	DC6SGNP	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[4]
ZM-447439 + Miconazole	DC7C247	ZM-447439	DD2 (Cell Line: DD2)	[3]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dapivirine + Miconazole	DC57F5E	Dapivirine	HIV	[5]

References

• [1] Miconazole FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2449).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT01731574) DDI Potential: Dapivirine Vaginal Ring and Miconazole Nitrate