Details of the Drug

General Information of Drug (ID: DMPMYE8)

Drug Name

Miconazole

Synonyms

Dactarin; MCZ; Miconazol; Miconazolo; Miconazolum; Micozole; Minostate; Monistat; Vusion; Zimycan; Daktarin IV; Miconasil Nitrate; Miconazole nitrate salt; Miconazolo [DCIT]; Monistat IV; MJR 1762; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7 Combination Pack; Monazole 7; Monistat 1 Combination Pack; Monistat 3 Vaginal Ovules; Monistat 5 Tampon; Monistat 7 Vaginal Suppositories; R 18134; Aflorix(nitrate); Albistat(nitrate); Andergin(nitrate); Conofite(nitrate); Daktarin (TN); Femizol (TN); Femizol-M; Florid(nitrate); Lotrimin AF(nitrate); Micantin (nitrate); Micatin (TN); Miconazex (TN); Miconazol [INN-Spanish]; Miconazole-7; Miconazolum [INN-Latin]; Monista (nitrate); Monistat (TN); Monistat 3 Dual-Pak; Monistat 7 Dual-Pak; Monistat Dual-PAK; Monistat iv (TN); Monistat-Derm; Novo-Miconazole Vaginal Ovules; Epi-Monistat(nitrate); Gyno-Daktar(nitrate); Monistat-Derm (TN); R-14,889; Miconazole (JP15/USP/INN); Miconazole [USAN:BAN:INN:JAN]; Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-(9CI); Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-(9CI); (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole; 1-[2,4-Dichloro-beta-([2,4-dichloro-benzyl]oxy)phenethyl]imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole; 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

Indication

Disease Entry	ICD 11	Status	REF
Cutaneous candidiasis	1F23.14	Approved	[1]
Fungal infection	1F29-1F2F	Approved	[2]
Mycoses	1F2Z	Approved	[1]
Onychomycosis	EE12.1	Approved	[1]
Tinea corporis	1F28.Y	Approved	[1]
Tinea cruris	1F28.3	Approved	[1]
Tinea versicolor	1F2D.0	Approved	[1]
Tinea pedis	1F28.2	Investigative	[1]
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Therapeutic Class

Antifungal Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

416.1

Logarithm of the Partition Coefficient (xlogp)

5.3

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 55.2 +/- 35.1 mgh/L [3]
Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 15.1 +/- 16.2 mg/L [3]
Absorption Tmax: The time to maximum plasma concentration (Tmax) is 7 h [3]
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
Clearance: The drug present in the plasma can be removed from the body at the rate of 9.48 mL/min/kg [5]
Elimination: Miconazole is excreted through both urine and feces, and less than 1% of unchanged miconazole is recovered in urine [3]
Half-life: The concentration or amount of drug in body reduced by one-half in 24 hours [3]
Metabolism: The drug is metabolized via the liver [3]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 144.18326 micromolar/kg/day [6]
Unbound Fraction: The unbound fraction of drug in plasma is 0.08% [5]
Vd: The volume of distribution (Vd) of drug is 95,546 L [7]
Water Solubility: The ability of drug to dissolve in water is measured as 0.89 mg/mL [4]

Chemical Identifiers

Formula: C18H14Cl4N2O
IUPAC Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
InChI: InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
InChIKey: BYBLEWFAAKGYCD-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 4189
ChEBI ID: CHEBI:82892
CAS Number: 22916-47-8
DrugBank ID: DB01110
TTD ID: D00AXJ
VARIDT ID: DR00477
INTEDE ID: DR1084
ACDINA ID: D00429

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Cytochrome P450 51 (Candi ERG11)	TTTSOUD	CP51_CANAL	Modulator	[8]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)_{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[9]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adenylate cyclase type 9 (ADCY9)	OT1IZT5K	ADCY9_HUMAN	Gene/Protein Processing	[10]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[11]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Gene/Protein Processing	[12]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Gene/Protein Processing	[13]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Gene/Protein Processing	[14]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[15]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Gene/Protein Processing	[16]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Gene/Protein Processing	[16]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Drug Response	[17]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Post-Translational Modifications	[12]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Miconazole (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Midostaurin	DMI6E0R	Moderate	Decreased metabolism of Miconazole caused by Midostaurin mediated inhibition of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[18]
Gilteritinib	DMTI0ZO	Moderate	Decreased metabolism of Miconazole caused by Gilteritinib mediated inhibition of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[19]
Oliceridine	DM6MDCF	Moderate	Decreased metabolism of Miconazole caused by Oliceridine mediated inhibition of CYP450 enzyme.	Acute pain [MG31]	[20]
Dronedarone	DMA8FS5	Moderate	Decreased metabolism of Miconazole caused by Dronedarone mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[20]
Nifedipine	DMSVOZT	Moderate	Decreased metabolism of Miconazole caused by Nifedipine mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[21]
Budesonide	DMJIBAW	Moderate	Decreased metabolism of Miconazole caused by Budesonide mediated inhibition of CYP450 enzyme.	Asthma [CA23]	[22]
Dalfopristin	DM4LTKV	Moderate	Decreased metabolism of Miconazole caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[23]
Cariprazine	DMJYDVK	Moderate	Decreased metabolism of Miconazole caused by Cariprazine mediated inhibition of CYP450 enzyme.	Bipolar disorder [6A60]	[24]
Pexidartinib	DMS2J0Z	Major	Decreased metabolism of Miconazole caused by Pexidartinib mediated inhibition of CYP450 enzyme.	Bone/articular cartilage neoplasm [2F7B]	[25]
Lapatinib	DM3BH1Y	Moderate	Decreased metabolism of Miconazole caused by Lapatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[26]
Esterified estrogens	DM9KZDO	Moderate	Decreased metabolism of Miconazole caused by Esterified estrogens mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[27]
Palbociclib	DMD7L94	Moderate	Decreased metabolism of Miconazole caused by Palbociclib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
Quinestrol	DMJ6H1Z	Moderate	Decreased metabolism of Miconazole caused by Quinestrol mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[27]
Cabazitaxel	DMPAZHC	Moderate	Decreased metabolism of Miconazole caused by Cabazitaxel mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[28]
Bosutinib	DMTI8YE	Moderate	Decreased metabolism of Miconazole caused by Bosutinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
Macitentan	DMP79A1	Moderate	Decreased metabolism of Miconazole caused by Macitentan mediated inhibition of CYP450 enzyme.	Cardiovascular disease [BA00-BE2Z]	[29]
PF-04449913	DMSB068	Moderate	Decreased metabolism of Miconazole caused by PF-04449913 mediated inhibition of CYP450 enzyme.	Chronic myelomonocytic leukaemia [2A40]	[30]
Indacaterol	DMQJHR7	Minor	Decreased metabolism of Miconazole caused by Indacaterol mediated inhibition of CYP450 enzyme.	Chronic obstructive pulmonary disease [CA22]	[31]
Anisindione	DM2C48U	Major	Decreased metabolism of Miconazole caused by Anisindione mediated inhibition of CYP450 enzyme.	Coagulation defect [3B10]	[32]
Drospirenone	DM1A9W3	Moderate	Decreased metabolism of Miconazole caused by Drospirenone mediated inhibition of CYP450 enzyme.	Contraceptive management [QA21]	[27]
Levonorgestrel	DM1DP7T	Moderate	Decreased metabolism of Miconazole caused by Levonorgestrel mediated inhibition of CYP450 enzyme.	Contraceptive management [QA21]	[27]
Ulipristal	DMBNI20	Minor	Decreased metabolism of Miconazole caused by Ulipristal mediated inhibition of CYP450 enzyme.	Contraceptive management [QA21]	[19]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Miconazole caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[33]
Rivaroxaban	DMQMBZ1	Moderate	Decreased metabolism of Miconazole caused by Rivaroxaban mediated inhibition of CYP450 enzyme.	Deep vein thrombosis [BD71]	[34]
Vilazodone	DM4LECQ	Moderate	Decreased metabolism of Miconazole caused by Vilazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[35]
Nefazodone	DM4ZS8M	Moderate	Decreased metabolism of Miconazole caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[36]
Escitalopram	DMFK9HG	Minor	Decreased metabolism of Miconazole caused by Escitalopram mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[37]
Polatuzumab vedotin	DMF6Y0L	Moderate	Decreased metabolism of Miconazole caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme.	Diffuse large B-cell lymphoma [2A81]	[38]
[3H]estrone-3-sulphate	DMGPF0N	Moderate	Decreased metabolism of Miconazole caused by [3H]estrone-3-sulphate mediated inhibition of CYP450 enzyme.	Discovery agent [N.A.]	[39]
Ospemifene	DMC4GEI	Moderate	Decreased metabolism of Miconazole caused by Ospemifene mediated inhibition of CYP450 enzyme.	Dyspareunia [GA12]	[40]
Fosphenytoin	DMOX3LB	Moderate	Decreased metabolism of Miconazole caused by Fosphenytoin mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[41]
Solifenacin	DMG592Q	Moderate	Decreased metabolism of Miconazole caused by Solifenacin mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[42]
Mirabegron	DMS1GYT	Minor	Decreased metabolism of Miconazole caused by Mirabegron mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[43]
Ripretinib	DM958QB	Moderate	Decreased metabolism of Miconazole caused by Ripretinib mediated inhibition of CYP450 enzyme.	Gastrointestinal stromal tumour [2B5B]	[34]
Avapritinib	DMK2GZX	Moderate	Decreased metabolism of Miconazole caused by Avapritinib mediated inhibition of CYP450 enzyme.	Gastrointestinal stromal tumour [2B5B]	[19]
Colchicine	DM2POTE	Moderate	Decreased metabolism of Miconazole caused by Colchicine mediated inhibition of CYP450 enzyme.	Gout [FA25]	[20]
Boceprevir	DMBSHMF	Moderate	Decreased metabolism of Miconazole caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[44]
Telaprevir	DMMRV29	Moderate	Decreased metabolism of Miconazole caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[44]
Cobicistat	DM6L4H2	Moderate	Decreased metabolism of Miconazole caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[45]
Dolutegravir	DMCZGRE	Minor	Decreased metabolism of Miconazole caused by Dolutegravir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[46]
Saquinavir	DMG814N	Moderate	Decreased metabolism of Miconazole caused by Saquinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Etravirine	DMGV8QU	Moderate	Decreased metabolism of Miconazole caused by Etravirine mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[47]
BMS-201038	DMQTAGO	Moderate	Decreased metabolism of Miconazole caused by BMS-201038 mediated inhibition of CYP450 enzyme.	Hyper-lipoproteinaemia [5C80]	[20]
Aliskiren	DM1BV7W	Moderate	Decreased metabolism of Miconazole caused by Aliskiren mediated inhibition of CYP450 enzyme.	Hypertension [BA00-BA04]	[48]
Levamlodipine	DM92S6N	Moderate	Decreased metabolism of Miconazole caused by Levamlodipine mediated inhibition of CYP450 enzyme.	Hypertension [BA00-BA04]	[21]
Tolvaptan	DMIWFRL	Moderate	Decreased metabolism of Miconazole caused by Tolvaptan mediated inhibition of CYP450 enzyme.	Hypo-osmolality/hyponatraemia [5C72]	[20]
Pirfenidone	DM6VZFQ	Moderate	Decreased metabolism of Miconazole caused by Pirfenidone mediated inhibition of CYP450 enzyme.	Idiopathic interstitial pneumonitis [CB03]	[19]
Retapamulin	DM9JXB7	Minor	Decreased metabolism of Miconazole caused by Retapamulin mediated inhibition of CYP450 enzyme.	Impetigo [1B72]	[49]
Lesinurad	DMUR64T	Moderate	Decreased metabolism of Miconazole caused by Lesinurad mediated inhibition of CYP450 enzyme.	Inborn purine/pyrimidine/nucleotide metabolism error [5C55]	[50]
Suvorexant	DM0E6S3	Moderate	Decreased metabolism of Miconazole caused by Suvorexant mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[34]
Tasimelteon	DMLOQ1V	Moderate	Decreased metabolism of Miconazole caused by Tasimelteon mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[51]
ITI-007	DMUQ1DO	Moderate	Decreased metabolism of Miconazole caused by ITI-007 mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[52]
Crizotinib	DM4F29C	Moderate	Decreased metabolism of Miconazole caused by Crizotinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[53]
Brigatinib	DM7W94S	Moderate	Decreased metabolism of Miconazole caused by Brigatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[34]
Ceritinib	DMB920Z	Moderate	Decreased metabolism of Miconazole caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[54]
PF-06463922	DMKM7EW	Moderate	Decreased metabolism of Miconazole caused by PF-06463922 mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[55]
Osimertinib	DMRJLAT	Moderate	Decreased metabolism of Miconazole caused by Osimertinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[56]
Artemether	DM48QOT	Moderate	Decreased metabolism of Miconazole caused by Artemether mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[20]
Halofantrine	DMOMK1V	Moderate	Decreased metabolism of Miconazole caused by Halofantrine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[20]
GDC-0199	DMH0QKA	Moderate	Decreased metabolism of Miconazole caused by GDC-0199 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[34]
Acalabrutinib	DM7GCVW	Moderate	Decreased metabolism of Miconazole caused by Acalabrutinib mediated inhibition of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[57]
Ibrutinib	DMHZCPO	Moderate	Decreased metabolism of Miconazole caused by Ibrutinib mediated inhibition of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[58]
Ponatinib	DMYGJQO	Moderate	Decreased metabolism of Miconazole caused by Ponatinib mediated inhibition of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[59]
Ubrogepant	DM749I3	Moderate	Decreased metabolism of Miconazole caused by Ubrogepant mediated inhibition of CYP450 enzyme.	Migraine [8A80]	[60]
Flibanserin	DM70DTN	Moderate	Decreased metabolism of Miconazole caused by Flibanserin mediated inhibition of CYP450 enzyme.	Mood disorder [6A60-6E23]	[61]
Panobinostat	DM58WKG	Moderate	Decreased metabolism of Miconazole caused by Panobinostat mediated inhibition of CYP450 enzyme.	Multiple myeloma [2A83]	[62]
Romidepsin	DMT5GNL	Moderate	Decreased metabolism of Miconazole caused by Romidepsin mediated inhibition of CYP450 enzyme.	Mycosis fungoides [2B01]	[63]
Nilotinib	DM7HXWT	Moderate	Decreased metabolism of Miconazole caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[20]
Ruxolitinib	DM7Q98D	Minor	Decreased metabolism of Miconazole caused by Ruxolitinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[19]
Dasatinib	DMJV2EK	Moderate	Decreased metabolism of Miconazole caused by Dasatinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[20]
Entrectinib	DMMPTLH	Moderate	Decreased metabolism of Miconazole caused by Entrectinib mediated inhibition of CYP450 enzyme.	Non-small cell lung cancer [2C25]	[64]
Levomethadyl Acetate	DM06HG5	Moderate	Decreased metabolism of Miconazole caused by Levomethadyl Acetate mediated inhibition of CYP450 enzyme.	Opioid use disorder [6C43]	[20]
S-297995	DM26IH8	Moderate	Decreased metabolism of Miconazole caused by S-297995 mediated inhibition of CYP450 enzyme.	Opioid use disorder [6C43]	[19]
Olaparib	DM8QB1D	Moderate	Decreased metabolism of Miconazole caused by Olaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[65]
Istradefylline	DM20VSK	Moderate	Decreased metabolism of Miconazole caused by Istradefylline mediated inhibition of CYP450 enzyme.	Parkinsonism [8A00]	[20]
Pimavanserin	DMR7IVC	Moderate	Decreased metabolism of Miconazole caused by Pimavanserin mediated inhibition of CYP450 enzyme.	Parkinsonism [8A00]	[66]
Ergonovine	DM0VEC1	Moderate	Decreased metabolism of Miconazole caused by Ergonovine mediated inhibition of CYP450 enzyme.	Postpartum haemorrhage [JA43]	[67]
Lonafarnib	DMGM2Z6	Moderate	Decreased metabolism of Miconazole caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[20]
Enzalutamide	DMGL19D	Moderate	Decreased metabolism of Miconazole caused by Enzalutamide mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[68]
Darolutamide	DMV7YFT	Minor	Decreased metabolism of Miconazole caused by Darolutamide mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[69]
Silodosin	DMJSBT6	Moderate	Decreased metabolism of Miconazole caused by Silodosin mediated inhibition of CYP450 enzyme.	Prostate hyperplasia [GA90]	[70]
Dutasteride	DMQ4TJK	Moderate	Decreased metabolism of Miconazole caused by Dutasteride mediated inhibition of CYP450 enzyme.	Prostate hyperplasia [GA90]	[71]
Ambrisentan	DMD1QXW	Minor	Decreased metabolism of Miconazole caused by Ambrisentan mediated inhibition of CYP450 enzyme.	Pulmonary hypertension [BB01]	[72]
Everolimus	DM8X2EH	Moderate	Decreased metabolism of Miconazole caused by Everolimus mediated inhibition of CYP450 enzyme.	Renal cell carcinoma [2C90]	[20]
Axitinib	DMGVH6N	Moderate	Decreased metabolism of Miconazole caused by Axitinib mediated inhibition of CYP450 enzyme.	Renal cell carcinoma [2C90]	[19]
Temsirolimus	DMS104F	Moderate	Decreased metabolism of Miconazole caused by Temsirolimus mediated inhibition of CYP450 enzyme.	Renal cell carcinoma [2C90]	[73]
Ciclesonide	DM2NA4K	Moderate	Decreased metabolism of Miconazole caused by Ciclesonide mediated inhibition of CYP450 enzyme.	Respiratory system disease [CB40-CB7Z]	[74]
Upadacitinib	DM32B5U	Moderate	Decreased metabolism of Miconazole caused by Upadacitinib mediated inhibition of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[20]
Tofacitinib	DMBS370	Moderate	Decreased metabolism of Miconazole caused by Tofacitinib mediated inhibition of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[20]
Dexamethasone	DMMWZET	Moderate	Decreased metabolism of Miconazole caused by Dexamethasone mediated inhibition of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[75]
Quetiapine	DM1N62C	Moderate	Decreased metabolism of Miconazole caused by Quetiapine mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[76]
Aripiprazole	DM3NUMH	Moderate	Decreased metabolism of Miconazole caused by Aripiprazole mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[77]
Iloperidone	DM6AUFY	Moderate	Decreased metabolism of Miconazole caused by Iloperidone mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[20]
LDE225	DMM9F25	Moderate	Decreased metabolism of Miconazole caused by LDE225 mediated inhibition of CYP450 enzyme.	Skin cancer [2C30-2C37]	[78]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Miconazole caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[34]
Docetaxel	DMDI269	Moderate	Decreased metabolism of Miconazole caused by Docetaxel mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[79]
Trabectedin	DMG3Y89	Moderate	Decreased metabolism of Miconazole caused by Trabectedin mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[19]
Armodafinil	DMGB035	Minor	Decreased metabolism of Miconazole caused by Armodafinil mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[34]
LEE011	DMMX75K	Moderate	Decreased metabolism of Miconazole caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[34]
Taxol	DMUOT9V	Moderate	Decreased metabolism of Miconazole caused by Taxol mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[80]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Miconazole caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[81]
Apixaban	DM89JLN	Moderate	Decreased metabolism of Miconazole caused by Apixaban mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[19]
Brilinta	DMBR01X	Moderate	Decreased metabolism of Miconazole caused by Brilinta mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[19]
Cabozantinib	DMIYDT4	Moderate	Decreased metabolism of Miconazole caused by Cabozantinib mediated inhibition of CYP450 enzyme.	Thyroid cancer [2D10]	[82]
Tolbutamide	DM02AWV	Major	Decreased metabolism of Miconazole caused by Tolbutamide mediated inhibition of CYP450 enzyme.	Type 2 diabetes mellitus [5A11]	[83]
Saxagliptin	DMGXENV	Moderate	Decreased metabolism of Miconazole caused by Saxagliptin mediated inhibition of CYP450 enzyme.	Type 2 diabetes mellitus [5A11]	[19]
Amiodarone	DMUTEX3	Moderate	Decreased metabolism of Miconazole caused by Amiodarone mediated inhibition of CYP450 enzyme.	Ventricular tachyarrhythmia [BC71]	[20]
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⏷ Show the Full List of 107 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
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Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Miconazole 50 mg tablet	50 mg	Buccal Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1	Miconazole FDA Label
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3	FDA Approved Drug Products: Oravig (miconazole) buccal tablet
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31	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
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36	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
37	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
38	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
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42	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
43	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
44	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
45	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
46	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
47	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
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49	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
50	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
51	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
52	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
53	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
54	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
55	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
56	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
57	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
58	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
59	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
60	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
61	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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63	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
64	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
65	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
66	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
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68	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
69	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
70	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
71	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
72	Product Information. Letairis (ambrisentan). Gilead Sciences, Foster City, CA.
73	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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77	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
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81	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
82	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
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