Details of the Drug Combinations

General Information of This Drug (ID: DMPQBWY)

Drug Name
(-)-englerin A   DMPQBWY
Synonyms Englerin A; (-)-englerin A; CHEBI:72441; (1R,3aR,4S,5R,7R,8S,8aR)-5-(glycoloyloxy)-7-isopropyl-1,4-dimethyldecahydro-4,7-epoxyazulen-8-yl (2E)-3-phenylacrylate; GTPL8372; SCHEMBL12280306
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

46 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Buparlisib DCQA23U Buparlisib Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + MK-1775 DC3ADN9 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + JQ1 DC8RL9H JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Carfilzomib DC6XR0Z Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Artemether DCQSS5B Artemether Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Panobinostat DCHRS2K Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Fomepizole DCSLS03 Fomepizole Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Eltanexor oral DCO1CGT Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + AZD8055 DC9XF10 AZD8055 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Formononetin DC1Q8UX Formononetin Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Everolimus DCLG9G5 Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Pralatrexate DC9X7XN Pralatrexate Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Lenvatinib DCPQHMH Lenvatinib Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Cantharidin DCNV0RE Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Exherin DC4EB9W Exherin Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + AT7519 DC6PA4H AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Daporinad DC09KZR Daporinad Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + LY2523355 DCX9FPN LY2523355 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Docetaxel DCRF1J5 Docetaxel Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + THAPSIGARGIN DC7U7NQ THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Etoposide DCXM1PJ Etoposide Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Cycloheximide DCOFG47 Cycloheximide Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Withaferin A DCEUQY6 Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + PHA-739358 DCES5N8 PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + OSI-906 DC5JZBN OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Vincristine DC14MGP Vincristine Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + SNX-5422 DCVUFX1 SNX-5422 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Pelitinib DCTO0H5 Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + ABT-263 DCCUPMS ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Bardoxolone methyl DC7ES4T Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Ispinesib DCDAEPR Ispinesib Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Decitabine DCH6JX0 Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + CHS-828 DCGXXAE CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + NVP-AUY922 DCXUIBR NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Mitotane DCICNOQ Mitotane Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + LY2874455 DCEZP78 LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
(-)-englerin A + Cytarabine DCKCLXM Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + (-)-englerin A DC7J2O7 ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Efaproxyn + (-)-englerin A DCHSBUX Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + (-)-englerin A DCSPJJD Exherin Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + (-)-englerin A DC0VTEM GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + (-)-englerin A DCB5F80 JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + (-)-englerin A DCA74UX MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Nintedanib + (-)-englerin A DCHY1AH Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
NVP-AUY922 + (-)-englerin A DCF4U0X NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-027 + (-)-englerin A DC3EM7S OSI-027 Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 46 DrugCom(s)

References

1 Enantioselective synthesis of (-)-englerins A and B. Angew Chem Int Ed Engl. 2010 May 3;49(20):3517-9.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.