Details of the Drug Combinations

General Information of This Drug (ID: DMQHBSX)

Drug Name
NITD609   DMQHBSX
Synonyms
Cipargamin; 1193314-23-6; NITD-609; NITD 609; UNII-Z7Q4FWA04P; (1'R,3'S)-5,7'-Dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one; Z7Q4FWA04P; CHEMBL1082723; Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7'-dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-; Cipargamin [INN]; 1252008-89-1; GTPL9721; SCHEMBL1306342; DTXSID70152424; MolPort-039-337-269; ZINC49037032; BDBM50318666; AKOS027253851; SB16518; DB12306; CS-7486; NCGC00263785-01
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

39 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Atovaquone + NITD609 DC39YHN Atovaquone DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + NITD609 DCMMMAB Bafilomycin A1 Hepatoblastoma (Cell Line: HB3) [3]
Docetaxel + NITD609 DCYBBV8 Docetaxel DD2 (Cell Line: DD2) [2]
Eltanexor oral + NITD609 DC1YDZ8 Eltanexor oral Hepatoblastoma (Cell Line: HB3) [3]
Miconazole + NITD609 DCCD6QM Miconazole DD2 (Cell Line: DD2) [2]
Midostaurin + NITD609 DCK0CRB Midostaurin DD2 (Cell Line: DD2) [2]
NITD609 + OZ277 DCY71Q9 OZ277 DD2 (Cell Line: DD2) [2]
NITD609 + Artemether DCFPKEE Artemether DD2 (Cell Line: DD2) [2]
NITD609 + Azelnidipine DCLP92R Azelnidipine DD2 (Cell Line: DD2) [2]
NITD609 + Verapamil DC8T65B Verapamil DD2 (Cell Line: DD2) [2]
NITD609 + Tetrandrine DCJOF8G Tetrandrine DD2 (Cell Line: DD2) [2]
NITD609 + Carvedilol DC831EP Carvedilol DD2 (Cell Line: DD2) [2]
NITD609 + Dofetilide DC9F1LF Dofetilide DD2 (Cell Line: DD2) [2]
NITD609 + Naltrexone DCN9YDS Naltrexone DD2 (Cell Line: DD2) [2]
NITD609 + Pyronaridine DCLMSRR Pyronaridine DD2 (Cell Line: DD2) [2]
NITD609 + Atovaquone DC3OYNW Atovaquone DD2 (Cell Line: DD2) [2]
NITD609 + Zonisamide DCS6VIB Zonisamide Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Clindamycin DCS120I Clindamycin Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Artemether DCTBVSF Artemether Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Calmidazolium DCREEWL Calmidazolium Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Nisoldipine DCL38ZQ Nisoldipine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Azelnidipine DC5D37D Azelnidipine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Verapamil DCVVKDA Verapamil Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Diltiazem DCRQWME Diltiazem Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Tetrandrine DCXT2OI Tetrandrine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + VR-776 DCH6L28 VR-776 Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + PHA-739358 DCAFFIJ PHA-739358 Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Perhexiline DC9WWBO Perhexiline Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Epothilone B DC7QOXF Epothilone B Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Gliclazide DCVQQA9 Gliclazide Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Bumetanide DCLZDIY Bumetanide Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Chloroquine DCPDP0P Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Piperaquine DCLM5CM Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Pyronaridine DCYYO8E Pyronaridine Hepatoblastoma (Cell Line: HB3) [3]
NITD609 + Atovaquone DCPX591 Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Pyrimethamine + NITD609 DCUFO9Z Pyrimethamine DD2 (Cell Line: DD2) [2]
T-3.5 + NITD609 DCFFYR4 T-3.5 Hepatoblastoma (Cell Line: HB3) [3]
Thiolactomycin + NITD609 DCAV25K Thiolactomycin DD2 (Cell Line: DD2) [2]
Thiolactomycin + NITD609 DCHSP0I Thiolactomycin Hepatoblastoma (Cell Line: HB3) [3]
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⏷ Show the Full List of 39 DrugCom(s)

References

1 ClinicalTrials.gov (NCT01836458) A Study to Find the Minimum Inhibitory Concentration of KAE609 in Adult Male Patients With P. Falciparum Monoinfection. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.