Details of the Drug Combinations

General Information of This Drug (ID: DMRM3AW)

• Drug Name: Acarbose (DMRM3AW)
• Synonyms: acarbose; 56180-94-0; Glucobay; Precose; Prandase; C25H43NO18; CHEBI:2376; CHEMBL3734896; BAY-g 5421; 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose; SMR000466376; SR-01000759407; Acarbose/; Acarbose [USAN:BAN:INN:JAN]; Acarbose,(S); Precose (TN); AC1L26GM; Acarbose (JAN/USAN/INN); MLS006011898; MLS000759506; MLS001424056; SPECTRUM1505172; SCHEMBL5316305; CHEMBL404271; BDBM23406; MolPort-002-507-369

Indication

Diabetic complication; ICD 11: 5A2Y; Status: Approved [1]; Non-insulin dependent diabetes; ICD 11: 5A11; Status: Approved [2]; Cardiovascular disease; ICD 11: BA00-BE2Z; Status: Phase 3 [1]

• Therapeutic Class: Hypoglycemic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

59 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acarbose + Ribavirin-TP	DCYSTAX	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Sertraline	DCOYX5Z	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Mebutamate	DCP9YPI	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Gefitinib	DC3EIBH	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Kanamycin	DCHNW5L	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Everolimus	DCWN9E5	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Guanfacine	DC50G32	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Emetine	DCDYTZD	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Carglumic acid	DCGUA58	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Memantine	DCJP2YQ	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Aminosalicylic acid	DCV2T2Q	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + PFK-158	DC5YUQW	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + PF-02545920	DCGEFLJ	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Trazodone	DCQIXFF	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Trifluoperazine	DC3EUDO	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Fenoprofen	DC9GMLP	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Imatinib	DCK2QKY	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Methylene blue	DCL92IM	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Moricizine	DCQ07YH	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Acetohexamide	DC0DUAL	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Leflunomide	DCTFS41	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Brincidofovir	DCDBCHF	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Hyodeoxycholic acid	DCSC8RI	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Hydralazine	DC7CU2Z	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Doxorubicin	DCEC4N8	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Cerivastatin	DCZHZ4V	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Metaxalone	DCAK0NT	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + Nitrosoglutathione	DCC18CY	Nitrosoglutathione	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Auranofin + Acarbose	DCVK8VN	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Acarbose	DCHWYDR	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Acarbose	DC1LUY5	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cisatracurium + Acarbose	DCOWSGP	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Acarbose	DC3LOA3	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Acarbose	DCZC8TS	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Acarbose	DCZLZ1Z	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Darunavir + Acarbose	DCY5AFT	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Acarbose	DCNLIFF	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Eflornithine + Acarbose	DCLW538	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Eptifibatide + Acarbose	DC8LD4T	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Flavonoid derivative 1 + Acarbose	DCA7Y10	Flavonoid derivative 1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GYKI-52466 + Acarbose	DCTBTZV	GYKI-52466	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ibutilide + Acarbose	DCRHF47	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Acarbose	DCUZLQS	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Acarbose	DC4G0X9	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Acarbose	DCJ7EO0	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
LY03004 + Acarbose	DCIOVOY	LY03004	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maraviroc + Acarbose	DCI6W5T	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebutamate + Acarbose	DCP3EY9	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Acarbose	DC48OAN	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oseltamivir + Acarbose	DCXVAW6	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Acarbose	DC017SC	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Acarbose	DCHICDH	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Repaglinide + Acarbose	DCV9Y5A	Repaglinide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sivelestat + Acarbose	DCZ27UX	Sivelestat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tindamax + Acarbose	DCLGDPS	Tindamax	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trimethobenzamide + Acarbose	DCFYSAQ	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Acarbose	DCYFRLB	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
VR-776 + Acarbose	DCUJ7XI	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Acarbose	DCYDH0X	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acarbose + Exenatide	DC98LUG	Exenatide	Hyperinsulinemic Hypoglycemia	[4]
Metformin + Acarbose	DCP3JVE	Metformin	Diabetes, Type 2	[5]
Saxagliptin + Acarbose	DCTED2T	Saxagliptin	Type 2 Diabetes	[6]
Saxagliptin + Acarbose	DCIF1RC	Saxagliptin	Type 2 Diabetes Mellitus	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6791).
• [2] Acarbose FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT02685852) Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia
• [5] ClinicalTrials.gov (NCT01624116) Comparison of Hypoglycaemic Regimens During Ramadan Fasting in Type 2 Diabetes
• [6] ClinicalTrials.gov (NCT02315495) Combining Saxagliptin and Acarbose to Improve Postprandial Glycaemia in Type 2 Diabetes
• [7] ClinicalTrials.gov (NCT02605772) Safety and Efficacy of Acarbose+Saxagliptin Compared With Metformin+Saxagliptin in Patients With Type 2 Diabetes