Details of the Drug Combinations

General Information of This Drug (ID: DMRMS0L)

• Drug Name: Morphine (DMRMS0L)
• Synonyms: Avinza; Kadian; Morphine Sulfate; Depodur; Astramorph Pf; Duramorph Pf; Infumorph; Ms Contin; Oramorph Sr

Indication

Advanced cancer; ICD 11: 2A00-2F9Z; Status: Approved [1]; Chronic pain; ICD 11: MG30; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Approved [1]; Diarrhea; ICD 11: ME05.1; Status: Investigative [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

36 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Buprenorphine + Morphine	DCF0SLE	Buprenorphine	Opioid Abuse	[3]
Cannabidiol + Morphine	DCFZBNB	Cannabidiol	Cannabidiol	[4]
Diclofenac + Morphine	DC4EXXO	Diclofenac	Trauma	[5]
Fentanyl + Morphine	DCGWXIN	Fentanyl	Hip Fractures	[6]
Fentanyl + Morphine	DCDK1G7	Fentanyl	Anesthesia	[7]
Gabapentin + Morphine	DCKAE4Y	Gabapentin	Postoperative Pain	[8]
Hydromorphone + Morphine	DCDIPAY	Hydromorphone	Pain, Postoperative	[9]
Ibuprofen + Morphine	DCP2633	Ibuprofen	Postoperative Pain	[10]
Ibuprofen + Morphine	DC26UBS	Ibuprofen	Trauma	[11]
Ketamine + Morphine	DC0BTFI	Ketamine	Acute Pain	[12]
Levobupivacaine + Morphine	DC51BUZ	Levobupivacaine	Reconstruction Breast Surgery	[13]
Morphine + Sufentanil	DCU1UMB	Sufentanil	Post Operative Pain Management	[14]
Morphine + Sufentanil	DC18MJ1	Sufentanil	Analgesia	[15]
Morphine + Ropivacaine	DCBVFI7	Ropivacaine	Acute Pain	[16]
Morphine + Methadone	DCN4K8R	Methadone	Pain	[17]
Morphine + Methadone	DCX6HRV	Methadone	Cancer	[18]
Pramipexole + Morphine	DCAGSTX	Pramipexole	Renal Colic	[19]
Pregabalin + Morphine	DC1P69V	Pregabalin	Intervertebral Disk Displacement	[20]
Pregabalin + Morphine	DCYN3NZ	Pregabalin	Postoperative Pain	[21]
Ramosetron + Morphine	DCV66DD	Ramosetron	Postoperative Nausea and Vomiting	[22]
Alprazolam + Morphine	DCJPEI3	Alprazolam	Opioid Abuse	[23]
Ketamine + Morphine	DCTFQ3X	Ketamine	Progressive Infantile Idiopathic Scoliosis	[24]
Lidocaine + Morphine	DC2B6D3	Lidocaine	Cancer Debulking	[25]
Morphine + Remifentanil	DC73E55	Remifentanil	Progressive Infantile Idiopathic Scoliosis	[24]
Prilocaine + Morphine	DCWCX0J	Prilocaine	Pregnant Women	[26]
Fentanyl + Morphine	DC1UNX9	Fentanyl	Obesity	[27]
Brilinta + Morphine	DC4U6GN	Brilinta	Coronary Artery Disease	[28]
Brilinta + Morphine	DCKZ2UQ	Brilinta	ST-segment Elevation Myocardial Infarction	[29]
Fentanyl + Morphine	DCHIEYF	Fentanyl	Shoulder	[30]
Ketoprofen + Morphine	DC8GLA3	Ketoprofen	Pain, Postoperative	[31]
Morphine + Acetaminophen	DCCYZZ8	Acetaminophen	Head and Neck Cancer	[32]
Morphine + Ropivacaine	DCIKSEG	Ropivacaine	Postoperative Pain	[33]
Morphine + Midazolam	DC2M10U	Midazolam	Inflammatory Disorder of Immune System	[34]
Morphine + Acetaminophen	DC7GRAM	Acetaminophen	Analgesia	[35]
Morphine + Ropivacaine	DCRMGY3	Ropivacaine	Postoperative Pain	[36]
Morphine + Tramadol	DCSACKG	Tramadol	Postoperative Pain	[37]

References

• [1] Morphine FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] ClinicalTrials.gov (NCT01136356) A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals
• [4] ClinicalTrials.gov (NCT06192589) Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
• [5] ClinicalTrials.gov (NCT02094807) Pain as Indication for Operative Treatment of Traumatic Rib Fractures
• [6] ClinicalTrials.gov (NCT03596060) Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel
• [7] ClinicalTrials.gov (NCT05533229) Fentanyl Versus Morphine in Spinal Anesthesia for Caesarian Section - Study on Analgesia, Side Effects and Patient 's Satisfaction
• [8] ClinicalTrials.gov (NCT00726999) Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
• [9] ClinicalTrials.gov (NCT02880800) Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
• [10] ClinicalTrials.gov (NCT02605187) Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management
• [11] ClinicalTrials.gov (NCT05355441) Pain Multidisciplinar Intervention in Major Trauma Patients
• [12] ClinicalTrials.gov (NCT01900847) Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
• [13] ClinicalTrials.gov (NCT02677571) PVB vs PECS Block in Breast Surgery
• [14] ClinicalTrials.gov (NCT01917045) Different Lipid Soluble Opioids for Gynecologic Laparoscopic Surgery Postoperative Patient-controlled Analgesia
• [15] ClinicalTrials.gov (NCT05042817) Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery
• [16] ClinicalTrials.gov (NCT02460640) The Effects of TAP Block on Postsurgical Pain After Minimally Invasive Partial Nephrectomy:
• [17] ClinicalTrials.gov (NCT00558870) Role of Methadone As Co-Opioid Analgesic
• [18] ClinicalTrials.gov (NCT03324815) Methadone Associated With Morphine for Cancer Pain
• [19] ClinicalTrials.gov (NCT04160520) Pramipexole and Morphine for Renal Colic
• [20] ClinicalTrials.gov (NCT00353704) Analgetic and Anxiolytic Effect of Preoperative Pregabalin
• [21] ClinicalTrials.gov (NCT01940224) Evaluation of Preoperative Use of Pregabalin on Postoperative Analgesia After Laparoscopic Colorectal Surgery
• [22] ClinicalTrials.gov (NCT02416115) Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
• [23] ClinicalTrials.gov (NCT05006079) Opioid/Benzodiazepine Polydrug Abuse: Aim 3
• [24] ClinicalTrials.gov (NCT02571491) Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery
• [25] ClinicalTrials.gov (NCT05017246) Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
• [26] ClinicalTrials.gov (NCT03607916) Estimation of the Effective Dose (ED) 95 of Intrathecal Hyperbaric Prilocaine 2% for Scheduled Cesarean Delivery.
• [27] ClinicalTrials.gov (NCT02880540) Dexmedetomidine to Treat Bariatric Surgery-associated Pain
• [28] ClinicalTrials.gov (NCT02403830) Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine
• [29] ClinicalTrials.gov (NCT02217878) Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction
• [30] ClinicalTrials.gov (NCT00702416) Ultrasound Guidance for Interscalene Brachial Plexus Block
• [31] ClinicalTrials.gov (NCT02248493) Intravenous Paracetamol for Postoperative Pain
• [32] ClinicalTrials.gov (NCT04246697) Multimodal Pain Study in Free Flap Patients
• [33] ClinicalTrials.gov (NCT03570541) TQL-block for Laparoscopic Hemicolectomy
• [34] ClinicalTrials.gov (NCT02135055) Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
• [35] ClinicalTrials.gov (NCT01966172) Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
• [36] ClinicalTrials.gov (NCT02279628) Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section
• [37] ClinicalTrials.gov (NCT05956275) USG-Guided Infiltration Popliteal Artery Capsule Knee Block Versus Adductor Canal Block Application as Postoperative Analgesia