Details of the Drug Combination

General Information of Drug Combination (ID: DCFZBNB)

• Drug Combination Name: Cannabidiol + Morphine
• Indication: Cannabidiol; Status: Phase 1 [1]
• Component Drugs:
  Cannabidiol (DM0659E): Small molecular drug
  Morphine (DMRMS0L): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Cannabidiol

Disease Entry	ICD 11	Status	REF
Dravet syndrome	8A61.11	Approved	[2]
LennoxGastaut syndrome	8A62.1	Approved	[2]
Infantile spasm	8A62.0	Phase 3	[3]
Epilepsy	8A60-8A68	Phase 2	[3]

Cannabidiol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Cannabinoid receptor (CB)	TT94IAG	NOUNIPROTAC	Binder	[18]

Cannabidiol Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[19]

Cannabidiol Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[20]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[21]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[21]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[20]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[20]

Cannabidiol Interacts with 739 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Activity	[22]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[22]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Activity	[23]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Decreases Activity	[22]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Decreases Activity	[22]
Transient receptor potential cation channel subfamily V member 2 (TRPV2)	OT0A9AVD	TRPV2_HUMAN	Increases Activity	[24]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Activity	[25]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[26]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Expression	[26]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[22]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Decreases Activity	[22]
AP-3 complex subunit beta-1 (AP3B1)	OTYTIH5Q	AP3B1_HUMAN	Increases Expression	[10]
Huntingtin-interacting protein 1 (HIP1)	OT7AKCFQ	HIP1_HUMAN	Increases Expression	[10]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[17]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Decreases Expression	[6]
RNA polymerase II elongation factor ELL2 (ELL2)	OTZJRTFM	ELL2_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase 25 (STK25)	OT4YPNTF	STK25_HUMAN	Increases Expression	[15]
B-cell CLL/lymphoma 9 protein (BCL9)	OTRBIPR4	BCL9_HUMAN	Increases Expression	[7]
Fatty-acid amide hydrolase 1 (FAAH)	OT9DX3N1	FAAH1_HUMAN	Decreases Expression	[27]
Importin subunit alpha-3 (KPNA4)	OTP0EX18	IMA3_HUMAN	Increases Expression	[10]
Claudin-4 (CLDN4)	OT9C4PZ4	CLD4_HUMAN	Increases Expression	[28]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Decreases Expression	[17]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Decreases Expression	[8]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Decreases Expression	[17]
Apolipoprotein L1 (APOL1)	OT8QBVTY	APOL1_HUMAN	Decreases Expression	[9]
Transcription regulator protein BACH1 (BACH1)	OTY8004K	BACH1_HUMAN	Decreases Expression	[12]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[8]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Decreases Expression	[6]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Decreases Expression	[8]
Apoptosis regulatory protein Siva (SIVA1)	OTDT0XZK	SIVA_HUMAN	Decreases Expression	[17]
Fanconi anemia group A protein (FANCA)	OTPEFJD4	FANCA_HUMAN	Decreases Expression	[8]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[12]
Transcription factor MafG (MAFG)	OTBQFUZH	MAFG_HUMAN	Increases Expression	[12]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)	OTUXEASC	M3K7_HUMAN	Decreases Expression	[6]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Decreases Expression	[9]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Decreases Expression	[15]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[29]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[8]
Origin recognition complex subunit 5 (ORC5)	OTFPW8DE	ORC5_HUMAN	Increases Expression	[7]
Kinesin heavy chain isoform 5C (KIF5C)	OT35570Y	KIF5C_HUMAN	Decreases Expression	[10]
Trafficking kinesin-binding protein 2 (TRAK2)	OTXVA7FN	TRAK2_HUMAN	Decreases Expression	[15]
Dynamin-like 120 kDa protein, mitochondrial (OPA1)	OTJGNWPW	OPA1_HUMAN	Increases Expression	[15]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[8]
Growth arrest-specific protein 7 (GAS7)	OT0M5TNY	GAS7_HUMAN	Increases Expression	[30]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Increases Expression	[13]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[9]
Liprin-alpha-2 (PPFIA2)	OT34BLXJ	LIPA2_HUMAN	Increases Expression	[31]
Nuclear receptor corepressor 1 (NCOR1)	OT04XNOU	NCOR1_HUMAN	Increases Expression	[6]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Phosphorylation	[16]
Ribosomal protein S6 kinase alpha-5 (RPS6KA5)	OTAVZJ3J	KS6A5_HUMAN	Increases Expression	[7]
Transient receptor potential cation channel subfamily A member 1 (TRPA1)	OTRDIR5M	TRPA1_HUMAN	Increases Expression	[7]
Ribonuclease H2 subunit A (RNASEH2A)	OT8G3G7K	RNH2A_HUMAN	Decreases Expression	[8]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[29]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)	OTKYMT99	CABYR_HUMAN	Increases Expression	[7]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Increases Expression	[9]
monooxygenase MICAL2 (MICAL2)	OT04OQQJ	MICA2_HUMAN	Decreases Expression	[15]
Endonuclease domain-containing 1 protein (ENDOD1)	OTME0ZW5	ENDD1_HUMAN	Decreases Expression	[10]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[8]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[8]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[8]
Cyclin-D1-binding protein 1 (CCNDBP1)	OTBWG1M0	CCDB1_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 subunit C2 (NDUFC2)	OT9M119L	NDUC2_HUMAN	Increases Expression	[15]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10)	OTL32QH7	GTR10_HUMAN	Increases Expression	[12]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Increases Expression	[28]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Decreases Expression	[8]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[8]
NADH-cytochrome b5 reductase 3 (CYB5R3)	OTUGT3G8	NB5R3_HUMAN	Decreases Expression	[10]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Decreases Activity	[32]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Increases Expression	[12]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[33]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[7]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Increases Expression	[12]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[6]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Increases Expression	[8]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Secretion	[34]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases Expression	[9]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[17]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases Expression	[35]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Increases Expression	[35]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Increases Expression	[12]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Increases Expression	[12]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[9]
Osteocalcin (BGLAP)	OTK1YLWQ	OSTCN_HUMAN	Increases Expression	[28]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[8]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Activity	[32]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[36]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Expression	[30]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[17]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[36]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[30]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[29]
Metallothionein-1F (MT1F)	OTZVUYG1	MT1F_HUMAN	Increases Expression	[9]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Increases Expression	[15]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[37]
Histone H2A type 1-B/E (H2AC4)	OTMFQ662	H2A1B_HUMAN	Decreases Expression	[9]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Increases Expression	[9]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[38]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Increases Expression	[35]
Fibroblast growth factor 1 (FGF1)	OT8I64X8	FGF1_HUMAN	Decreases Expression	[9]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[9]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Increases Expression	[33]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[39]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Increases Expression	[17]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[8]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Increases Expression	[7]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Decreases Expression	[11]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Decreases Expression	[15]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[17]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Decreases Expression	[9]
Muscarinic acetylcholine receptor M2 (CHRM2)	OTUMZ2WR	ACM2_HUMAN	Increases Expression	[7]
Complement decay-accelerating factor (CD55)	OTZ3HWTO	DAF_HUMAN	Increases Expression	[17]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Increases Expression	[11]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[29]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[17]
Keratin, type II cytoskeletal 7 (KRT7)	OTLT3JFN	K2C7_HUMAN	Increases Expression	[7]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Expression	[7]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Expression	[12]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Increases Expression	[9]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[9]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[29]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Decreases Expression	[9]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[8]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[17]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Increases Expression	[9]
Furin (FURIN)	OTM2665Z	FURIN_HUMAN	Increases Expression	[6]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[10]
Histone H2A type 1 (H2AC11)	OTN9P0BO	H2A1_HUMAN	Decreases Expression	[9]
Keratin-associated protein 2-3 (KRTAP2-3)	OTE97BCI	KRA23_HUMAN	Increases Expression	[9]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Increases Expression	[29]
Chimeric ERCC6-PGBD3 protein (ERCC6)	OT2QZKSF	ERPG3_HUMAN	Decreases Expression	[8]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[40]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[9]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[35]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[11]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Increases Expression	[7]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[11]
Myosin-3 (MYH3)	OTOCCGEB	MYH3_HUMAN	Increases Expression	[10]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Increases Expression	[11]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[10]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[12]
Spectrin beta chain, erythrocytic (SPTB)	OT1Q9ABM	SPTB1_HUMAN	Decreases Expression	[10]
Lysosome-associated membrane glycoprotein 1 (LAMP1)	OTYE92QY	LAMP1_HUMAN	Increases Expression	[10]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Activity	[41]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Decreases Expression	[10]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Activity	[42]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[14]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases Expression	[9]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[9]
Neurofilament heavy polypeptide (NEFH)	OTMSCW5I	NFH_HUMAN	Increases Expression	[7]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Decreases Expression	[9]
Metallothionein-1G (MT1G)	OTAV1OCR	MT1G_HUMAN	Increases Expression	[29]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[43]
Troponin T, slow skeletal muscle (TNNT1)	OT8PBOAR	TNNT1_HUMAN	Increases Expression	[44]
Sodium/glucose cotransporter 1 (SLC5A1)	OT0T78JI	SC5A1_HUMAN	Increases Expression	[12]
CD59 glycoprotein (CD59)	OTSUMQDH	CD59_HUMAN	Decreases Expression	[17]
CD99 antigen (CD99)	OTPUZ5DE	CD99_HUMAN	Decreases Expression	[17]
Endoplasmin (HSP90B1)	OT02XLBR	ENPL_HUMAN	Increases Expression	[11]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[8]
Insulin-degrading enzyme (IDE)	OT5GQTJ5	IDE_HUMAN	Increases Expression	[11]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Decreases Expression	[17]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Decreases Expression	[45]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Increases Expression	[9]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Increases Expression	[17]
Myogenin (MYOG)	OTPLJKFA	MYOG_HUMAN	Increases Expression	[44]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Decreases Expression	[17]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Decreases Expression	[10]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[9]
Membrane cofactor protein (CD46)	OTQ8NWJD	MCP_HUMAN	Decreases Expression	[17]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[12]
Replication protein A 32 kDa subunit (RPA2)	OTZ54WAF	RFA2_HUMAN	Decreases Expression	[8]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[17]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[46]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Increases Phosphorylation	[13]
Beta-galactosidase (GLB1)	OTB0TKAG	BGAL_HUMAN	Increases Activity	[8]
Histone H1.5 (H1-5)	OTAN7RD9	H15_HUMAN	Decreases Expression	[9]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[29]
Calpain-2 catalytic subunit (CAPN2)	OTIAPE5J	CAN2_HUMAN	Decreases Expression	[11]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[9]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[35]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[29]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Increases Expression	[12]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[29]
DNA ligase 1 (LIG1)	OTEEQS43	DNLI1_HUMAN	Decreases Expression	[8]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Decreases Expression	[10]
Nucleolin (NCL)	OTBXPKMP	NUCL_HUMAN	Increases Expression	[7]
ETS domain-containing protein Elk-1 (ELK1)	OTH9MXD6	ELK1_HUMAN	Decreases Expression	[36]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[6]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[9]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Increases Expression	[9]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[36]
Nuclear receptor subfamily 1 group D member 1 (NR1D1)	OTJ38PTB	NR1D1_HUMAN	Increases Expression	[9]
Calpain-3 (CAPN3)	OTCHG3YK	CAN3_HUMAN	Decreases Expression	[17]
Pleiotrophin (PTN)	OTYC7M2A	PTN_HUMAN	Decreases Expression	[17]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[17]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[9]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Increases Expression	[8]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[17]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Increases Expression	[7]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[12]
Cornifin-B (SPRR1B)	OTXNW3P6	SPR1B_HUMAN	Increases Expression	[9]
Small proline-rich protein 2D (SPRR2D)	OT47THNK	SPR2D_HUMAN	Increases Expression	[9]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[7]
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC)	OTDLEJ4T	SRCH_HUMAN	Decreases Expression	[10]
Small ribosomal subunit protein uS3 (RPS3)	OT0K3TMH	RS3_HUMAN	Decreases Expression	[10]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[47]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[29]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[9]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[8]
Laminin subunit alpha-1 (LAMA1)	OTQZMP86	LAMA1_HUMAN	Increases Expression	[8]
Small ribosomal subunit protein eS12 (RPS12)	OTBRQ8MS	RS12_HUMAN	Increases Expression	[10]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[29]
ATP synthase subunit alpha, mitochondrial (ATP5F1A)	OT3FZDLX	ATPA_HUMAN	Decreases Expression	[10]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[9]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Expression	[17]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[17]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Increases Expression	[7]
Threonine--tRNA ligase 1, cytoplasmic (TARS1)	OT0PWST5	SYTC_HUMAN	Increases Expression	[10]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[13]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Decreases Expression	[8]
CD82 antigen (CD82)	OTH8MC64	CD82_HUMAN	Decreases Expression	[17]
5-hydroxytryptamine receptor 1D (HTR1D)	OTLS74AF	5HT1D_HUMAN	Decreases Expression	[9]
DNA polymerase delta catalytic subunit (POLD1)	OTWO4UCJ	DPOD1_HUMAN	Decreases Expression	[8]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Expression	[17]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[9]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Decreases Expression	[8]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[9]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Decreases Expression	[17]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Decreases Expression	[17]
Flavin reductase (BLVRB)	OTHCFN2C	BLVRB_HUMAN	Increases Expression	[12]
D-dopachrome decarboxylase (DDT)	OTF5HTYL	DOPD_HUMAN	Decreases Expression	[17]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[8]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[8]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[8]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[8]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[10]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[8]
Sodium/glucose cotransporter 2 (SLC5A2)	OT93UUDI	SC5A2_HUMAN	Increases Expression	[12]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[30]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[8]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Increases Expression	[15]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Increases Expression	[29]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM5 (MCM5)	OTAHLB62	MCM5_HUMAN	Decreases Expression	[8]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[8]
Macrosialin (CD68)	OTOYEY3J	CD68_HUMAN	Decreases Expression	[17]
Heat shock 70 kDa protein 4 (HSPA4)	OT5HR0AR	HSP74_HUMAN	Increases Expression	[11]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Affects Expression	[48]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Phosphorylation	[39]
Polycomb group RING finger protein 2 (PCGF2)	OTIY1J5L	PCGF2_HUMAN	Decreases Expression	[7]
Prohibitin 1 (PHB1)	OTZNXYS2	PHB1_HUMAN	Increases Expression	[10]
Replication protein A 14 kDa subunit (RPA3)	OT8JAQGL	RFA3_HUMAN	Decreases Expression	[8]
Replication factor C subunit 4 (RFC4)	OTWALD2R	RFC4_HUMAN	Decreases Expression	[8]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Decreases Expression	[8]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Increases Expression	[7]
Histamine H1 receptor (HRH1)	OT8F9FV6	HRH1_HUMAN	Increases Expression	[7]
Sodium channel protein type 1 subunit alpha (SCN1A)	OTJ9ZTYI	SCN1A_HUMAN	Decreases Activity	[49]
Sodium channel protein type 4 subunit alpha (SCN4A)	OT0MYDHC	SCN4A_HUMAN	Decreases Activity	[49]
Basigin (BSG)	OTD0CVEC	BASI_HUMAN	Decreases Expression	[46]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[29]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	OTUE7Z91	MP2K2_HUMAN	Increases Expression	[36]
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)	OTBUSUTE	ACHA7_HUMAN	Decreases Activity	[50]
TGF-beta receptor type-1 (TGFBR1)	OT40S1SJ	TGFR1_HUMAN	Increases Expression	[6]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)	OTBDF9HJ	ODO2_HUMAN	Decreases Expression	[10]
Transgelin-2 (TAGLN2)	OTUXZGDQ	TAGL2_HUMAN	Decreases Expression	[10]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[9]
Interferon gamma receptor 2 (IFNGR2)	OTVOPCHW	INGR2_HUMAN	Decreases Expression	[17]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[7]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[9]
L-dopachrome tautomerase (DCT)	OTYVNTBG	TYRP2_HUMAN	Increases Expression	[13]
Interleukin-6 receptor subunit beta (IL6ST)	OT1N9C70	IL6RB_HUMAN	Decreases Expression	[17]
T-complex protein 1 subunit zeta (CCT6A)	OTCYWL5F	TCPZ_HUMAN	Increases Expression	[10]
All-trans-retinol dehydrogenase ADH7 (ADH7)	OTO2ZATJ	ADH7_HUMAN	Increases Expression	[12]
Large ribosomal subunit protein uL13 (RPL13A)	OTME3VXN	RL13A_HUMAN	Increases Expression	[10]
ADP-ribosylation factor-like protein 1 (ARL1)	OTB6N6BR	ARL1_HUMAN	Increases Expression	[7]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Expression	[17]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Increases Expression	[8]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[8]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[8]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Decreases Expression	[9]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Decreases Expression	[51]
Peripherin (PRPH)	OT6VUH78	PERI_HUMAN	Increases Expression	[9]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Increases Expression	[7]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Decreases Expression	[17]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Decreases Expression	[15]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Increases Expression	[17]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Expression	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[30]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Decreases Expression	[9]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[8]
Endothelin-converting enzyme 1 (ECE1)	OTPFHC6F	ECE1_HUMAN	Increases Expression	[11]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[8]
Biotinidase (BTD)	OTJYTQ69	BTD_HUMAN	Increases Expression	[7]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Increases Expression	[15]
Elongation factor Ts, mitochondrial (TSFM)	OTP6OKPJ	EFTS_HUMAN	Increases Expression	[15]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[39]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[39]
Chemerin-like receptor 2 (CMKLR2)	OTDNO0SL	CML2_HUMAN	Increases Expression	[7]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[9]
Lys-63-specific deubiquitinase BRCC36 (BRCC3)	OTK0ZN7Y	BRCC3_HUMAN	Decreases Expression	[17]
Large ribosomal subunit protein eL21 (RPL21)	OT74GE74	RL21_HUMAN	Decreases Expression	[10]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Increases Expression	[15]
Large ribosomal subunit protein eL29 (RPL29)	OTUFIBJL	RL29_HUMAN	Increases Expression	[10]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)	OTHRUON2	SC6A9_HUMAN	Increases Expression	[12]
NADP-dependent malic enzyme (ME1)	OTSVEUQE	MAOX_HUMAN	Increases Expression	[12]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Increases Expression	[7]
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC)	OT0AQD93	PP2BC_HUMAN	Decreases Expression	[15]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[12]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Increases Expression	[12]
CD151 antigen (CD151)	OTF3UZS7	CD151_HUMAN	Decreases Expression	[17]
Serpin B4 (SERPINB4)	OT88LHZ8	SPB4_HUMAN	Increases Expression	[10]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Increases Expression	[7]
Heat shock 70 kDa protein 13 (HSPA13)	OTYXMC4G	HSP13_HUMAN	Decreases Expression	[15]
Troponin I, fast skeletal muscle (TNNI2)	OTGGZFSC	TNNI2_HUMAN	Decreases Expression	[9]
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	OTNWHUJ1	AL9A1_HUMAN	Decreases Expression	[10]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[8]
DNA primase large subunit (PRIM2)	OTGT0KTF	PRI2_HUMAN	Decreases Expression	[8]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Decreases Expression	[17]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Decreases Expression	[9]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)	OT50L4XB	ACADV_HUMAN	Decreases Expression	[10]
Transmembrane emp24 domain-containing protein 10 (TMED10)	OTUXSHH7	TMEDA_HUMAN	Increases Expression	[11]
Presenilin-1 (PSEN1)	OTKL39RT	PSN1_HUMAN	Decreases Expression	[11]
Fms-related tyrosine kinase 3 ligand (FLT3LG)	OTU0YGC4	FLT3L_HUMAN	Decreases Expression	[17]
Presenilin-2 (PSEN2)	OTOW778B	PSN2_HUMAN	Decreases Expression	[11]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Decreases Expression	[11]
Double-strand break repair protein MRE11 (MRE11)	OTGU8TZM	MRE11_HUMAN	Decreases Expression	[8]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)	OTLMZGBE	GBG10_HUMAN	Decreases Expression	[17]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Increases Expression	[15]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[8]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[36]
Sulfite oxidase, mitochondrial (SUOX)	OTEJQ9FC	SUOX_HUMAN	Decreases Expression	[9]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[8]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Decreases Expression	[7]
Tricarboxylate transport protein, mitochondrial (SLC25A1)	OTIDXQ9F	TXTP_HUMAN	Increases Expression	[10]
Serine/threonine-protein phosphatase 5 (PPP5C)	OTC3HT6Y	PPP5_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[8]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[29]
Mitogen-activated protein kinase 12 (MAPK12)	OTTCKE27	MK12_HUMAN	Decreases Expression	[15]
RecQ-like DNA helicase BLM (BLM)	OTEJOAJX	BLM_HUMAN	Decreases Expression	[8]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Decreases Expression	[9]
Galactocerebrosidase (GALC)	OT1F6BZK	GALC_HUMAN	Decreases Expression	[7]
Growth arrest-specific protein 1 (GAS1)	OTKJXG52	GAS1_HUMAN	Decreases Expression	[17]
Aquaporin-4 (AQP4)	OTA9MYD5	AQP4_HUMAN	Affects Expression	[52]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[45]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[9]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Decreases Expression	[17]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[17]
Homeobox protein DLX-5 (DLX5)	OTEEFBEU	DLX5_HUMAN	Increases Expression	[28]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3)	OTSCYB9P	NDUV3_HUMAN	Increases Expression	[15]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Decreases Expression	[8]
Period circadian protein homolog 3 (PER3)	OTVKYVJA	PER3_HUMAN	Decreases Expression	[9]
Beta-secretase 1 (BACE1)	OTCA7B6A	BACE1_HUMAN	Decreases Expression	[11]
Junctional adhesion molecule B (JAM2)	OTHVJJRJ	JAM2_HUMAN	Decreases Expression	[7]
Gasdermin-D (GSDMD)	OTH39BKI	GSDMD_HUMAN	Decreases Expression	[34]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[29]
Uncharacterized protein C21orf58 (C21ORF58)	OTJR84YR	CU058_HUMAN	Decreases Expression	[9]
CD81 antigen (CD81)	OTQFXNAZ	CD81_HUMAN	Decreases Expression	[17]
Protein transport protein Sec61 subunit beta (SEC61B)	OTY1X6A2	SC61B_HUMAN	Increases Expression	[10]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Expression	[30]
Actin-related protein 3 (ACTR3)	OT05LJSH	ARP3_HUMAN	Decreases Expression	[10]
Large ribosomal subunit protein eL15 (RPL15)	OT7Y42LL	RL15_HUMAN	Increases Expression	[10]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Decreases Expression	[36]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Expression	[29]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Increases Expression	[6]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[53]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[9]
Large ribosomal subunit protein eL30 (RPL30)	OTLQVY1Z	RL30_HUMAN	Increases Expression	[10]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)	OTIIGGZ2	RS27A_HUMAN	Decreases Expression	[6]
Small ribosomal subunit protein RACK1 (RACK1)	OTZBCQ1U	RACK1_HUMAN	Decreases Expression	[6]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Decreases Expression	[9]
Melanoma antigen preferentially expressed in tumors (PRAME)	OTOG1JKJ	PRAME_HUMAN	Decreases Expression	[9]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Increases Expression	[9]
ETS-related transcription factor Elf-3 (ELF3)	OTUTLEQO	ELF3_HUMAN	Increases Expression	[9]
Interleukin-13 receptor subunit alpha-1 (IL13RA1)	OT59OYXP	I13R1_HUMAN	Decreases Expression	[17]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[9]
Neutrophil gelatinase-associated lipocalin (LCN2)	OTSB42BR	NGAL_HUMAN	Increases Expression	[9]
Metallothionein-1H (MT1H)	OT0MVBM6	MT1H_HUMAN	Increases Expression	[29]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Increases Expression	[29]
Small ribosomal subunit protein uS10m (MRPS10)	OTXF7D9J	RT10_HUMAN	Increases Expression	[15]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)	OTRWGNBF	LACTB_HUMAN	Increases Expression	[15]
Enhancer of rudimentary homolog (ERH)	OTJDWX99	ERH_HUMAN	Increases Expression	[10]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Decreases Expression	[17]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Decreases Expression	[14]
Cyclin-dependent kinase 5 (CDK5)	OT1YAK9F	CDK5_HUMAN	Decreases Expression	[7]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Decreases Expression	[8]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Decreases Expression	[17]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[17]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[9]
Transcription factor RelB (RELB)	OTU3QYEF	RELB_HUMAN	Increases Expression	[36]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Decreases Expression	[10]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[8]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Expression	[36]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)	OTPV1D60	FKBP4_HUMAN	Increases Expression	[15]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Decreases Activity	[41]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Increases Expression	[12]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[17]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[8]
Large ribosomal subunit protein eL18 (RPL18)	OTJCH62J	RL18_HUMAN	Increases Expression	[10]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Increases Expression	[15]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[28]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[9]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[30]
DNA polymerase epsilon catalytic subunit A (POLE)	OTFM3MMU	DPOE1_HUMAN	Decreases Expression	[8]
Quinone oxidoreductase (CRYZ)	OTD2F4C8	QOR_HUMAN	Increases Expression	[10]
Leukocyte surface antigen CD47 (CD47)	OTLDZ0KZ	CD47_HUMAN	Increases Expression	[17]
Histone-binding protein RBBP4 (RBBP4)	OTG3BT3M	RBBP4_HUMAN	Decreases Expression	[10]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Increases Expression	[10]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)	OT2LP7LJ	SNF5_HUMAN	Decreases Expression	[10]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[8]
Heat shock protein 75 kDa, mitochondrial (TRAP1)	OTNG0L8J	TRAP1_HUMAN	Increases Expression	[15]
Glutamate receptor ionotropic, kainate 2 (GRIK2)	OTQ41U3D	GRIK2_HUMAN	Increases Expression	[7]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Increases Expression	[9]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Decreases Expression	[9]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[8]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Decreases Expression	[10]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Increases Expression	[7]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Decreases Expression	[9]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Expression	[54]
Dentin matrix acidic phosphoprotein 1 (DMP1)	OTBWBWW7	DMP1_HUMAN	Increases Expression	[35]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[9]
Treacle protein (TCOF1)	OT4BOYTM	TCOF_HUMAN	Increases Expression	[10]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)	OT70Z4II	ADAM9_HUMAN	Increases Expression	[11]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[6]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[6]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)	OTS9YK3E	KCC2B_HUMAN	Decreases Expression	[11]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Increases Expression	[10]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)	OTPLXCDN	DYR1A_HUMAN	Decreases Expression	[11]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Decreases Expression	[17]
Laminin subunit gamma-2 (LAMC2)	OTJMTM72	LAMC2_HUMAN	Increases Expression	[8]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[29]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Increases Expression	[35]
Core-binding factor subunit beta (CBFB)	OTIAC6W4	PEBB_HUMAN	Decreases Expression	[7]
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Decreases Expression	[17]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Decreases Expression	[8]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[8]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[9]
Lymphocyte antigen 6D (LY6D)	OTXCR0SB	LY6D_HUMAN	Decreases Expression	[9]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[9]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Decreases Activity	[49]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[8]
Interleukin-11 receptor subunit alpha (IL11RA)	OTN6DBCJ	I11RA_HUMAN	Decreases Expression	[17]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Decreases Expression	[8]
Protein RRP5 homolog (PDCD11)	OTS1NJK2	RRP5_HUMAN	Increases Expression	[10]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Increases Expression	[7]
Major vault protein (MVP)	OTJGHJRB	MVP_HUMAN	Decreases Expression	[10]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[17]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Increases Expression	[12]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)	OT9EROL6	HERP1_HUMAN	Increases Expression	[29]
Metal cation symporter ZIP14 (SLC39A14)	OTGR686L	S39AE_HUMAN	Increases Expression	[12]
DNA polymerase delta subunit 3 (POLD3)	OTEQEFQ2	DPOD3_HUMAN	Decreases Expression	[8]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Decreases Expression	[11]
Plectin (PLEC)	OTU4XDEG	PLEC_HUMAN	Decreases Expression	[10]
Pericentriolar material 1 protein (PCM1)	OTFM133C	PCM1_HUMAN	Increases Expression	[7]
Inorganic pyrophosphatase (PPA1)	OTHZK1QB	IPYR_HUMAN	Increases Expression	[10]
Poly(rC)-binding protein 1 (PCBP1)	OTHN0TD7	PCBP1_HUMAN	Increases Expression	[10]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Secretion	[28]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)	OTDOTWU4	KS6A1_HUMAN	Increases Expression	[7]
Splicing factor 3A subunit 1 (SF3A1)	OTI733D7	SF3A1_HUMAN	Increases Expression	[10]
Surfeit locus protein 1 (SURF1)	OTAINRSS	SURF1_HUMAN	Decreases Expression	[15]
RISC-loading complex subunit TARBP2 (TARBP2)	OT1QQ8H3	TRBP2_HUMAN	Decreases Expression	[15]
Disks large homolog 2 (DLG2)	OTQ3BD8U	DLG2_HUMAN	Increases Expression	[10]
Mitochondrial import receptor subunit TOM34 (TOMM34)	OTH6MITE	TOM34_HUMAN	Decreases Expression	[10]
Sodium channel protein type 9 subunit alpha (SCN9A)	OTGSKLL8	SCN9A_HUMAN	Decreases Activity	[49]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[15]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Decreases Expression	[15]
Nuclear factor interleukin-3-regulated protein (NFIL3)	OTQH9HM3	NFIL3_HUMAN	Increases Expression	[29]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Increases Expression	[55]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[8]
Forkhead box protein D1 (FOXD1)	OT80PRHS	FOXD1_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 5 (DUSP5)	OTH96RA7	DUS5_HUMAN	Increases Expression	[9]
Histone H2A type 2-C (H2AC20)	OTEIVLM1	H2A2C_HUMAN	Increases Expression	[10]
NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)	OTMKQJJ8	NDUA9_HUMAN	Decreases Expression	[16]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[9]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (ST3GAL2)	OT8WM21E	SIA4B_HUMAN	Decreases Expression	[9]
Coiled-coil domain-containing protein 142 (CCDC142)	OTYTFB46	CC142_HUMAN	Decreases Expression	[9]
Pancreatic lipase-related protein 3 (PNLIPRP3)	OT7H4PSU	LIPR3_HUMAN	Increases Expression	[9]
Mucin-like protein 3 (MUCL3)	OTGAD3I0	MUCL3_HUMAN	Increases Expression	[7]
Protein MIX23 (MIX23)	OTZ5O14U	MIX23_HUMAN	Increases Expression	[7]
UMP-CMP kinase 2, mitochondrial (CMPK2)	OTOG90R0	CMPK2_HUMAN	Decreases Expression	[34]
Caspase recruitment domain-containing protein 16 (CARD16)	OT4NUHWB	CAR16_HUMAN	Decreases Expression	[17]
BCL-6 corepressor-like protein 1 (BCORL1)	OTPTFQN5	BCORL_HUMAN	Increases Expression	[7]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)	OTIH6283	FGD3_HUMAN	Decreases Expression	[9]
Centrosomal protein of 78 kDa (CEP78)	OTTAI5S2	CEP78_HUMAN	Increases Expression	[7]
PCI domain-containing protein 2 (PCID2)	OTF5LO98	PCID2_HUMAN	Decreases Expression	[7]
Long-chain fatty acid transport protein 3 (SLC27A3)	OTXB60L7	S27A3_HUMAN	Decreases Expression	[9]
Alpha-tubulin N-acetyltransferase 1 (ATAT1)	OTBE2LTI	ATAT_HUMAN	Decreases Expression	[17]
Uncharacterized protein C6orf141 (C6ORF141)	OTUS3SIQ	CF141_HUMAN	Increases Expression	[9]
Late cornified envelope protein 1F (LCE1F)	OTFSBZZF	LCE1F_HUMAN	Increases Expression	[9]
CD276 antigen (CD276)	OTKHTFVO	CD276_HUMAN	Increases Expression	[17]
Spermatogenesis-associated protein 31H1 (SPATA31H1)	OTN4HU1L	S31H1_HUMAN	Increases Expression	[7]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)	OTXIGC6I	LAIR1_HUMAN	Increases Expression	[56]
Proline-rich protein 5-like (PRR5L)	OTQ1Z0OU	PRR5L_HUMAN	Decreases Expression	[9]
Large ribosomal subunit protein mL54 (MRPL54)	OTWV3E31	RM54_HUMAN	Increases Expression	[15]
Glutathione hydrolase 6 (GGT6)	OTAQWSCC	GGT6_HUMAN	Decreases Expression	[9]
RNA polymerase-associated protein CTR9 homolog (CTR9)	OTP151PZ	CTR9_HUMAN	Increases Expression	[7]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Increases Expression	[7]
Protein cornichon homolog 2 (CNIH2)	OTT2ECCW	CNIH2_HUMAN	Decreases Expression	[9]
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2)	OTUR3E76	BL1S2_HUMAN	Increases Expression	[7]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[9]
Aftiphilin (AFTPH)	OTDUYPRS	AFTIN_HUMAN	Increases Expression	[7]
CD109 antigen (CD109)	OTDADBM4	CD109_HUMAN	Decreases Expression	[17]
Lysine-specific demethylase 7A (KDM7A)	OT1VGYCX	KDM7A_HUMAN	Increases Expression	[9]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Increases Expression	[7]
Protein LIAT1 (LIAT1)	OTOXIHJK	LIAT1_HUMAN	Increases Expression	[7]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)	OTMQXW7S	RAPH1_HUMAN	Increases Expression	[15]
Probable ATP-dependent RNA helicase DDX46 (DDX46)	OTB2X9TO	DDX46_HUMAN	Increases Expression	[10]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[8]
STE20-related kinase adapter protein alpha (STRADA)	OTG1Z6TY	STRAA_HUMAN	Decreases Expression	[15]
#NAME?	OTD229X7	MICA3_HUMAN	Decreases Expression	[15]
Probable helicase senataxin (SETX)	OTG3JNOQ	SETX_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Increases Expression	[7]
Notch-regulated ankyrin repeat-containing protein (NRARP)	OTMYHUV2	NRARP_HUMAN	Decreases Expression	[9]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Expression	[7]
Pleckstrin homology-like domain family B member 2 (PHLDB2)	OTDKMB2G	PHLB2_HUMAN	Increases Expression	[9]
NLR family member X1 (NLRX1)	OTEJ7ROA	NLRX1_HUMAN	Decreases Expression	[15]
Multidrug and toxin extrusion protein 2 (SLC47A2)	OTF2CNRD	S47A2_HUMAN	Decreases Expression	[9]
BLOC-2 complex member HPS6 (HPS6)	OTXL5KQW	HPS6_HUMAN	Decreases Expression	[9]
Leucine rich adaptor protein 1-like (LURAP1L)	OTSJ29M5	LUR1L_HUMAN	Increases Expression	[9]
Tripartite motif-containing protein 59 (TRIM59)	OT14I72L	TRI59_HUMAN	Decreases Expression	[9]
Cell division cycle and apoptosis regulator protein 1 (CCAR1)	OTUXLQZZ	CCAR1_HUMAN	Increases Expression	[10]
Mitochondrial Rho GTPase 2 (RHOT2)	OTV8WT2L	MIRO2_HUMAN	Increases Expression	[15]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)	OT5Q6SVK	SIR2_HUMAN	Decreases Expression	[30]
Ribonucleoprotein PTB-binding 1 (RAVER1)	OTMHBTLE	RAVR1_HUMAN	Decreases Expression	[10]
Fanconi anemia group M protein (FANCM)	OTNJG99Z	FANCM_HUMAN	Decreases Expression	[8]
Lung adenoma susceptibility protein 2 (C18ORF54)	OT4WJKTF	LAS2_HUMAN	Increases Expression	[7]
Ribonuclease SLFN12 (SLFN12)	OTTBXM25	SLN12_HUMAN	Decreases Expression	[9]
G-protein coupled receptor 135 (GPR135)	OTXOY5NW	GP135_HUMAN	Decreases Expression	[9]
Lysophosphatidylserine lipase ABHD12 (ABHD12)	OTDP4F02	ABD12_HUMAN	Increases Expression	[7]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[29]
Bardet-Biedl syndrome 5 protein (BBS5)	OTFWF9N1	BBS5_HUMAN	Increases Expression	[7]
Homologous recombination OB-fold protein (HROB)	OTMKZZU7	HROB_HUMAN	Increases Expression	[7]
EP300-interacting inhibitor of differentiation 2 (EID2)	OTK0KCN4	EID2_HUMAN	Decreases Expression	[9]
Acyl-coenzyme A diphosphatase FITM2 (FITM2)	OTED0W1S	FITM2_HUMAN	Decreases Expression	[9]
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2)	OT5QWTD2	TRIMM_HUMAN	Increases Expression	[9]
Fanconi anemia group B protein (FANCB)	OTMZTXB5	FANCB_HUMAN	Decreases Expression	[8]
Diacylglycerol lipase-beta (DAGLB)	OT1S9869	DGLB_HUMAN	Decreases Expression	[7]
Carbohydrate sulfotransferase 14 (CHST14)	OT3FLH7U	CHSTE_HUMAN	Decreases Expression	[9]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Increases Activity	[57]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG)	OTPSUBN2	LFNG_HUMAN	Decreases Expression	[9]
Transient receptor potential cation channel subfamily V member 3 (TRPV3)	OTC57YC6	TRPV3_HUMAN	Increases Expression	[9]
Delta and Notch-like epidermal growth factor-related receptor (DNER)	OT2GH2E5	DNER_HUMAN	Increases Expression	[7]
Semaphorin-6D (SEMA6D)	OTU0UAZS	SEM6D_HUMAN	Increases Expression	[7]
DNA helicase B (HELB)	OT769EC5	HELB_HUMAN	Increases Expression	[7]
Endonuclease 8-like 3 (NEIL3)	OTBCI2NS	NEIL3_HUMAN	Decreases Expression	[8]
Prostamide/prostaglandin F synthase (PRXL2B)	OTY5G543	PXL2B_HUMAN	Decreases Expression	[9]
Signal peptide peptidase-like 2A (SPPL2A)	OTCVF6MM	SPP2A_HUMAN	Increases Expression	[6]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)	OTBFIOVY	GTR14_HUMAN	Increases Expression	[12]
Transcription factor Sp7 (SP7)	OT07ETZT	SP7_HUMAN	Increases Expression	[28]
#NAME?	OTJEDVWA	MICA1_HUMAN	Decreases Expression	[15]
Partitioning defective 3 homolog B (PARD3B)	OTGZ43YI	PAR3L_HUMAN	Increases Expression	[15]
Phospholipase ABHD3 (ABHD3)	OTH8P977	ABHD3_HUMAN	Increases Expression	[7]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[9]
Fatty acyl-CoA reductase 1 (FAR1)	OTLHTYIE	FACR1_HUMAN	Increases Expression	[10]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Decreases Expression	[9]
ATR-interacting protein (ATRIP)	OT78O9LF	ATRIP_HUMAN	Decreases Expression	[8]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Decreases Expression	[9]
Zinc transporter SLC39A7 (SLC39A7)	OTYMA1VB	S39A7_HUMAN	Increases Expression	[12]
Histone H1.10 (H1-10)	OTBWDA4E	H1X_HUMAN	Decreases Expression	[17]
Nicastrin (NCSTN)	OT5QBTA4	NICA_HUMAN	Decreases Expression	[11]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)	OT3SQMLU	AN32B_HUMAN	Increases Expression	[7]
DNA repair and recombination protein RAD54-like (RAD54L)	OTEGMAKG	RAD54_HUMAN	Decreases Expression	[8]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Expression	[9]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Increases Expression	[9]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Decreases Expression	[17]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Increases Expression	[29]
Oxysterol-binding protein 2 (OSBP2)	OTDGLB4J	OSBP2_HUMAN	Increases Expression	[9]
Ribosome-releasing factor 2, mitochondrial (GFM2)	OT51TIMY	RRF2M_HUMAN	Increases Expression	[10]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Increases Expression	[8]
Crossover junction endonuclease EME1 (EME1)	OTD9RKD9	EME1_HUMAN	Decreases Expression	[8]
Arrestin domain-containing protein 3 (ARRDC3)	OTAKW7R9	ARRD3_HUMAN	Increases Expression	[9]
Gamma-secretase subunit APH-1A (APH1A)	OT97F1TU	APH1A_HUMAN	Decreases Expression	[11]
Leucine-rich repeat-containing protein 45 (LRRC45)	OTAAMYQO	LRC45_HUMAN	Decreases Expression	[9]
CAP-Gly domain-containing linker protein 3 (CLIP3)	OTGJEGIB	CLIP3_HUMAN	Decreases Expression	[6]
Microspherule protein 1 (MCRS1)	OT8K2X8P	MCRS1_HUMAN	Decreases Expression	[7]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[8]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase greatwall (MASTL)	OTQ7YKK5	GWL_HUMAN	Increases Expression	[7]
Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5)	OT6Q5M0C	PGAM5_HUMAN	Decreases Expression	[10]
Splicing factor 45 (RBM17)	OT9ROJCL	SPF45_HUMAN	Decreases Expression	[10]
Histone H2A type 1-H (H2AC12)	OTLXVB97	H2A1H_HUMAN	Decreases Expression	[9]
Rho-related GTP-binding protein RhoV (RHOV)	OTW4N3QN	RHOV_HUMAN	Increases Expression	[9]
Coiled-coil domain-containing protein 7 (CCDC7)	OTNCL9JR	CCDC7_HUMAN	Decreases Expression	[8]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Increases Expression	[7]
Uncharacterized protein C5orf34 (C5ORF34)	OTT2ESR4	CE034_HUMAN	Increases Expression	[7]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Decreases Expression	[17]
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)	OT7GE3BN	PP1RA_HUMAN	Decreases Expression	[9]
DEP domain-containing protein 7 (DEPDC7)	OT62C942	DEPD7_HUMAN	Increases Expression	[7]
ATPase family AAA domain-containing protein 5 (ATAD5)	OTI8ABKF	ATAD5_HUMAN	Decreases Expression	[9]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[29]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Increases Expression	[9]
LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1)	OTTLKELW	LYSM1_HUMAN	Decreases Expression	[9]
Protein IWS1 homolog (IWS1)	OTF96EYX	IWS1_HUMAN	Increases Expression	[7]
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1)	OTDEJXD0	CK5P1_HUMAN	Decreases Expression	[7]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[12]
Sodium channel protein type 2 subunit alpha (SCN2A)	OTUSYE4Z	SCN2A_HUMAN	Decreases Activity	[49]
Sortilin (SORT1)	OTFCQ4B1	SORT_HUMAN	Increases Expression	[10]
Transcription termination factor 1, mitochondrial (MTERF1)	OT3EIK39	MTEF1_HUMAN	Increases Expression	[15]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[9]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)	OTYRXD2T	PMYT1_HUMAN	Decreases Expression	[8]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC)	OTC8G2MX	C560_HUMAN	Increases Expression	[15]
Monoglyceride lipase (MGLL)	OT5ES4IE	MGLL_HUMAN	Decreases Expression	[7]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[8]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)	OT53LJGW	M3K3_HUMAN	Increases Expression	[6]
Transmembrane 9 superfamily member 2 (TM9SF2)	OTA0C202	TM9S2_HUMAN	Decreases Expression	[10]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[9]
Myeloid differentiation primary response protein MyD88 (MYD88)	OTB4D6FL	MYD88_HUMAN	Decreases Expression	[17]
Histone H2A type 1-J (H2AC14)	OT5Y4MMC	H2A1J_HUMAN	Decreases Expression	[9]
Forkhead box protein C2 (FOXC2)	OT83P1E0	FOXC2_HUMAN	Increases Expression	[7]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[29]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)	OTYKB9G3	SIN1_HUMAN	Increases Expression	[15]
B-cell CLL/lymphoma 7 protein family member B (BCL7B)	OT8DQQRD	BCL7B_HUMAN	Decreases Expression	[7]
Junctophilin-2 (JPH2)	OTL9YH7V	JPH2_HUMAN	Decreases Expression	[9]
Partner of Y14 and mago (PYM1)	OTEZ2WUO	PYM1_HUMAN	Increases Expression	[10]
Cilia- and flagella-associated protein 300 (CFAP300)	OTJWZZIO	CF300_HUMAN	Increases Expression	[7]
Migration and invasion enhancer 1 (MIEN1)	OTCQ8DAD	MIEN1_HUMAN	Decreases Expression	[17]
Polycomb group RING finger protein 1 (PCGF1)	OTHOU68T	PCGF1_HUMAN	Decreases Expression	[7]
Mitochondrial ribosome-associated GTPase 1 (MTG1)	OTC9U1LI	MTG1_HUMAN	Increases Expression	[15]
Death-inducer obliterator 1 (DIDO1)	OT9PB547	DIDO1_HUMAN	Decreases Expression	[9]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Increases Expression	[10]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[29]
Enoyl- reductase, mitochondrial (MECR)	OTJQ5XKQ	MECR_HUMAN	Increases Expression	[15]
Sister chromatid cohesion protein DCC1 (DSCC1)	OTPUVLZT	DCC1_HUMAN	Decreases Expression	[9]
Protein FAM174C (FAM174C)	OTK2U1QO	F174C_HUMAN	Increases Expression	[7]
Fanconi anemia group J protein (BRIP1)	OT38QBD4	FANCJ_HUMAN	Decreases Expression	[8]
Bcl-2-like protein 13 (BCL2L13)	OT2VRFTM	B2L13_HUMAN	Decreases Expression	[17]
AP-1 complex subunit mu-1 (AP1M1)	OT1IR6CD	AP1M1_HUMAN	Decreases Expression	[10]
EKC/KEOPS complex subunit GON7 (GON7)	OT36YA7Q	GON7_HUMAN	Increases Expression	[7]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[8]
Actin-related protein T3 (ACTRT3)	OT2U08K8	ACTT3_HUMAN	Decreases Expression	[9]
NF-kappa-B inhibitor zeta (NFKBIZ)	OTU728KS	IKBZ_HUMAN	Increases Expression	[9]
Hydroperoxide isomerase ALOXE3 (ALOXE3)	OT76J52A	LOXE3_HUMAN	Increases Expression	[9]
Sulfiredoxin-1 (SRXN1)	OTYDBO4L	SRXN1_HUMAN	Increases Expression	[12]
Kinetochore protein Nuf2 (NUF2)	OTOOQL35	NUF2_HUMAN	Increases Expression	[7]
STE20-related kinase adapter protein beta (STRADB)	OTUSF1A0	STRAB_HUMAN	Decreases Expression	[15]
Protein MIS12 homolog (MIS12)	OT90D4M0	MIS12_HUMAN	Increases Expression	[7]
Sharpin (SHARPIN)	OTU1J2KH	SHRPN_HUMAN	Decreases Expression	[6]
Coiled-coil domain-containing protein 8 (CCDC8)	OTO295IH	CCDC8_HUMAN	Decreases Expression	[9]
Epsin-3 (EPN3)	OTNNYDT6	EPN3_HUMAN	Decreases Expression	[9]
DNA replication factor Cdt1 (CDT1)	OTVY53VG	CDT1_HUMAN	Decreases Expression	[9]
Sphingosine 1-phosphate receptor 5 (S1PR5)	OTQF1R0U	S1PR5_HUMAN	Decreases Expression	[9]
Phosducin-like protein 3 (PDCL3)	OTD3WGV1	PDCL3_HUMAN	Decreases Expression	[17]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Increases Expression	[7]
5-azacytidine-induced protein 2 (AZI2)	OT61Q7Q8	AZI2_HUMAN	Increases Expression	[7]
5' exonuclease Apollo (DCLRE1B)	OT2LFW7A	DCR1B_HUMAN	Decreases Expression	[8]
5'-nucleotidase domain-containing protein 2 (NT5DC2)	OTPDRGGN	NT5D2_HUMAN	Decreases Expression	[9]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Increases Expression	[7]
Actin-related protein 5 (ACTR5)	OT7L2KS6	ARP5_HUMAN	Decreases Expression	[10]
Large ribosomal subunit protein mL44 (MRPL44)	OT27ZC26	RM44_HUMAN	Increases Expression	[15]
E3 ubiquitin-protein ligase SMURF2 (SMURF2)	OT3TRVL7	SMUF2_HUMAN	Increases Expression	[6]
Calcyclin-binding protein (CACYBP)	OTJMZD2T	CYBP_HUMAN	Increases Expression	[7]
Transient receptor potential cation channel subfamily V member 4 (TRPV4)	OTPZKQLX	TRPV4_HUMAN	Affects Activity	[58]
Plasminogen receptor (PLGRKT)	OT5ITHAW	PLRKT_HUMAN	Decreases Expression	[17]
Solute carrier family 38 member 10 (SLC38A10)	OTXPUL6S	S38AA_HUMAN	Decreases Expression	[9]
Chromobox protein homolog 8 (CBX8)	OT4U5V1T	CBX8_HUMAN	Increases Expression	[7]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Expression	[9]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Decreases Expression	[17]
Sodium- and chloride-dependent transporter XTRP3 (SLC6A20)	OTHRD4XO	S6A20_HUMAN	Increases Expression	[12]
Transcription and mRNA export factor ENY2 (ENY2)	OTTNU8RK	ENY2_HUMAN	Decreases Expression	[7]
Exosome complex component RRP41 (EXOSC4)	OTG4TICP	EXOS4_HUMAN	Increases Expression	[10]
Synembryn-A (RIC8A)	OT4YZOWE	RIC8A_HUMAN	Decreases Expression	[10]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)	OT37FKH0	CYLD_HUMAN	Increases Expression	[6]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Decreases Expression	[15]
Sphingosine kinase 2 (SPHK2)	OTNFG52M	SPHK2_HUMAN	Increases Expression	[7]
Platelet-derived growth factor C (PDGFC)	OT3ZJ0XU	PDGFC_HUMAN	Decreases Expression	[7]
DNA polymerase epsilon subunit 3 (POLE3)	OTOELRF6	DPOE3_HUMAN	Decreases Expression	[8]
Glutaredoxin-2, mitochondrial (GLRX2)	OT4LIRBC	GLRX2_HUMAN	Increases Expression	[15]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[17]
Protein FAM217B (FAM217B)	OTDB4M8G	F217B_HUMAN	Decreases Expression	[9]
SERTA domain-containing protein 4 (SERTAD4)	OTZ1GUD9	SRTD4_HUMAN	Decreases Expression	[9]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)	OT2H0MCE	TRM13_HUMAN	Decreases Expression	[10]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Decreases Expression	[8]
ATP-dependent RNA helicase DDX18 (DDX18)	OTKB9C3S	DDX18_HUMAN	Increases Expression	[7]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Increases Expression	[7]
Uncharacterized protein C14orf119 (C14ORF119)	OT0T836C	CN119_HUMAN	Increases Expression	[7]
Uncharacterized protein C2orf42 (C2ORF42)	OTN1MSWZ	CB042_HUMAN	Increases Expression	[7]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[29]
Nuclear distribution protein nudE homolog 1 (NDE1)	OT2N8Q17	NDE1_HUMAN	Increases Expression	[7]
Sodium channel protein type 3 subunit alpha (SCN3A)	OT4C2LCB	SCN3A_HUMAN	Decreases Activity	[49]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Decreases Expression	[8]
Endoplasmic reticulum aminopeptidase 1 (ERAP1)	OT72S99B	ERAP1_HUMAN	Decreases Expression	[10]
Gamma-secretase subunit PEN-2 (PSENEN)	OTJ7M7G9	PEN2_HUMAN	Decreases Expression	[11]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[16]
Opioid growth factor receptor (OGFR)	OTROS6RJ	OGFR_HUMAN	Decreases Expression	[7]
Dentin sialophosphoprotein (DSPP)	OT1TYNDN	DSPP_HUMAN	Increases Expression	[35]
Very-long-chain (HACD3)	OTISMCAF	HACD3_HUMAN	Increases Expression	[10]
Origin recognition complex subunit 3 (ORC3)	OTYQWB6B	ORC3_HUMAN	Increases Expression	[7]
DnaJ homolog subfamily B member 9 (DNAJB9)	OT38EQT6	DNJB9_HUMAN	Increases Expression	[29]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Decreases Expression	[8]
DnaJ homolog subfamily B member 4 (DNAJB4)	OTUD01BK	DNJB4_HUMAN	Increases Expression	[29]
Kelch-like protein 3 (KLHL3)	OTEJ6850	KLHL3_HUMAN	Decreases Expression	[9]
Prenylcysteine oxidase 1 (PCYOX1)	OT8FBKY0	PCYOX_HUMAN	Decreases Expression	[9]
DNA helicase MCM8 (MCM8)	OTC93H3S	MCM8_HUMAN	Decreases Expression	[8]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Increases Expression	[9]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)	OTTZVSK6	S2513_HUMAN	Decreases Expression	[10]
Peroxisomal carnitine O-octanoyltransferase (CROT)	OTWK68MM	OCTC_HUMAN	Decreases Expression	[9]
CASP8-associated protein 2 (CASP8AP2)	OTTWT68S	C8AP2_HUMAN	Decreases Expression	[9]
Nuclear pore complex protein Nup50 (NUP50)	OTOZ98K3	NUP50_HUMAN	Increases Expression	[10]
Protein CDV3 homolog (CDV3)	OTUA175T	CDV3_HUMAN	Increases Expression	[7]
Plexin-B3 (PLXNB3)	OTXRKPOO	PLXB3_HUMAN	Decreases Expression	[7]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Increases Expression	[12]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Decreases Expression	[17]
Inhibitor of growth protein 4 (ING4)	OT0VVG4V	ING4_HUMAN	Decreases Expression	[17]
AP-4 complex subunit epsilon-1 (AP4E1)	OT4DUNVU	AP4E1_HUMAN	Increases Expression	[7]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Increases Expression	[12]
Exonuclease 1 (EXO1)	OTI87RS5	EXO1_HUMAN	Decreases Expression	[8]
Sodium channel protein type 8 subunit alpha (SCN8A)	OT0JGIZN	SCN8A_HUMAN	Decreases Activity	[49]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1)	OTDAWAUZ	JIP1_HUMAN	Increases Expression	[7]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Increases Expression	[29]
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)	OTJGX19T	KCC2A_HUMAN	Decreases Expression	[11]
Chromodomain Y-like protein (CDYL)	OTCUK5KZ	CDYL_HUMAN	Increases Expression	[7]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)	OT403QC1	PIN4_HUMAN	Decreases Expression	[7]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[9]
Dexamethasone-induced Ras-related protein 1 (RASD1)	OT2BAJHK	RASD1_HUMAN	Increases Expression	[9]
Caspase recruitment domain-containing protein 8 (CARD8)	OTXXZYWU	CARD8_HUMAN	Decreases Expression	[17]
Small ribosomal subunit protein bS1m (MRPS28)	OT8CLJ6M	RT28_HUMAN	Increases Expression	[15]
MOB-like protein phocein (MOB4)	OTOQRMAS	PHOCN_HUMAN	Increases Expression	[10]
Small ribosomal subunit protein bS18m (MRPS18C)	OTL868QS	RT18C_HUMAN	Increases Expression	[15]
Mitochondrial fission 1 protein (FIS1)	OT2HL10J	FIS1_HUMAN	Decreases Expression	[15]
Serine-threonine kinase receptor-associated protein (STRAP)	OTT3T7QT	STRAP_HUMAN	Increases Expression	[6]
Talin-2 (TLN2)	OT10QQBC	TLN2_HUMAN	Decreases Expression	[10]
Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9)	OTK7PDNN	TIM9_HUMAN	Increases Expression	[15]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)	OTGZO1MT	TIM8B_HUMAN	Increases Expression	[15]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Decreases Expression	[8]
Cysteine sulfinic acid decarboxylase (CSAD)	OT3I2G0A	CSAD_HUMAN	Decreases Expression	[7]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[29]
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6)	OTZRVUH4	ALG6_HUMAN	Decreases Expression	[9]
Calcineurin-binding protein cabin-1 (CABIN1)	OT4G5CIK	CABIN_HUMAN	Decreases Expression	[15]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1)	OTY8J0S4	ZNT1_HUMAN	Increases Expression	[9]
Lymphocyte antigen 96 (LY96)	OTN4HXA2	LY96_HUMAN	Decreases Expression	[17]
Cytochrome P450 2J2 (CYP2J2)	OTJBTEH8	CP2J2_HUMAN	Increases Metabolism	[59]

Indication(s) of Morphine

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[4]
Chronic pain	MG30	Approved	[5]
Pain	MG30-MG3Z	Approved	[4]
Diarrhea	ME05.1	Investigative	[4]

Morphine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Modulator	[63]

Morphine Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[64]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[65]

Morphine Interacts with 6 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[66]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[67]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[68]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[69]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[70]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Metabolism	[71]

Morphine Interacts with 47 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Affects Chemical Synthesis	[72]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Response	[73]
Mu-type opioid receptor (OPRM1)	OT16AAT8	OPRM_HUMAN	Increases Response	[73]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Affects Binding	[74]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[75]
LIM homeobox transcription factor 1-beta (LMX1B)	OTM8145D	LMX1B_HUMAN	Increases Expression	[76]
Krueppel-like factor 7 (KLF7)	OTS3YVA0	KLF7_HUMAN	Increases Expression	[77]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[78]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases Expression	[79]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Increases Expression	[79]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[80]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[76]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Increases Expression	[81]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Secretion	[80]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Increases Expression	[79]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Decreases Secretion	[80]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[82]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Decreases Expression	[83]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[78]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[81]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[81]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[84]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Increases Activity	[85]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[82]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[75]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[81]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Increases Expression	[76]
C-C motif chemokine 8 (CCL8)	OTCTWYN8	CCL8_HUMAN	Increases Secretion	[80]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Increases Secretion	[75]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Phosphorylation	[78]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[82]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[86]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[84]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[87]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[76]
Ninjurin-1 (NINJ1)	OTLRZ1EU	NINJ1_HUMAN	Increases Expression	[76]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[76]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Increases Chemical Synthesis	[88]
Interleukin-1 receptor antagonist protein (IL1RN)	OT308CBE	IL1RA_HUMAN	Affects Response To Substance	[89]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases ADR	[90]
Beta-arrestin-2 (ARRB2)	OTAEJZCI	ARRB2_HUMAN	Affects Response To Substance	[91]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Chemical Synthesis	[92]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Affects Response To Substance	[91]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases ADR	[90]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases ADR	[90]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Decreases Response To Substance	[93]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Increases Chemical Synthesis	[88]

References

• [1] ClinicalTrials.gov (NCT06192589) Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
• [2] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Morphine FDA Label
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [6] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [7] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [8] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [9] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [10] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [11] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
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• [22] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
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• [24] TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
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