Details of the Drug Combinations

General Information of This Drug (ID: DMRV7H0)

• Drug Name: Bumetanide (DMRV7H0)
• Synonyms: Aquazone; Bumedyl; Bumetanida; Bumetanidum; Bumethanide; Bumex; Burine; Burinex; Butinat; Cambiex; Diurama; Drenural; Fontego; Fordiuran; Lixil; Lunetoron; Miccil; Segurex; Yurinex; AstraZeneca Brand of Bumetanide; Atlantis Brand of Bumetanide; Bumetanide AstraZeneca Brand; Bumetanide Atlantis Brand; Bumetanide Farmacusi Brand; Bumetanide Grossmann Brand; Bumetanide Leo Brand; Bumetanide Roche Brand; Bumetanide Senosiain Brand; Farmacusi Brand of Bumetanide; Grossmann Brand of Bumetanide; Leo Brand of Bumetanide; Roche Brand of Bumetanide; Senosiain Brand of Bumetanide; B 3023; PF 1593; PF1593; Bumetanida [INN-Spanish]; Bumetanidum [INN-Latin]; Bumex (TN); Bumex, Bumetanide; Lixil-Leo; PF-1593; Ro 10-6338; Bumetanide (JP15/USP); Ro-10-6338; Bumetanide (JP15/USP/INN); Bumetanide [USAN:BAN:INN:JAN]; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid; 3-(aminosulfonyl)-5-(butylamino)-4-(phenyloxy)benzoic acid; 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid

Indication

Congestive heart failure; ICD 11: BD10; Status: Approved [1]; Edema; ICD 11: MG29; Status: Approved [2]

• Therapeutic Class: Diuretics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

43 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Bumetanide	DCEQJC9	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetohexamide + Bumetanide	DCZAMZJ	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Bumetanide	DC851GV	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Aprepitant	DCXD7AF	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Aliskiren	DCC3U9E	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Dantrolene	DC7QHMT	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Diethylcarbamazine	DCRNGX7	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Lumefantrine	DCY13FV	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Bumetanide + Lumefantrine	DCPGWYB	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Bumetanide + Epinephrine	DCWQKQ3	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + PMID28460551-Compound-2	DCZC5RM	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Fomepizole	DCXIB5P	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Guanfacine	DC3275Q	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Docetaxel	DCE4OQB	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + JZL195	DCA4285	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Daidzin	DCBT2U9	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Tolvaptan	DC5TSB3	Tolvaptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Tiagabine	DCP1FO3	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Oseltamivir	DCXTQDW	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Allopurinol	DCYFZOM	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Imatinib	DC40RTQ	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Artemisinin	DC6AAPQ	Artemisinin	DD2 (Cell Line: DD2)	[3]
Bumetanide + Leflunomide	DCMQKSG	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Chloroquine	DCQQHZX	Chloroquine	DD2 (Cell Line: DD2)	[3]
Bumetanide + Piperaquine	DC0Y3ZL	Piperaquine	DD2 (Cell Line: DD2)	[3]
Bumetanide + Mycophenolic acid	DC7V4C9	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Cisatracurium	DC4RCJ2	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Iloprost	DCT1PRG	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Nitisinone	DC3RS26	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Vorinostat	DCUSWCS	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Bumetanide	DC45E8S	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Bumetanide	DCIWPNO	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + Bumetanide	DCMBDD9	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imipramine + Bumetanide	DC912SV	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Isoproterenol + Bumetanide	DCFXKJO	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Bumetanide	DCXMW4F	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Bumetanide	DC2463B	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
NITD609 + Bumetanide	DCLZDIY	NITD609	Hepatoblastoma (Cell Line: HB3)	[4]
Norcisapride + Bumetanide	DCJO6PI	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Bumetanide	DCL3EY3	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Bumetanide	DCZZ2ES	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sumatriptan + Bumetanide	DCN5632	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Bumetanide	DCVN2HN	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dapagliflozin + Bumetanide	DC979BI	Dapagliflozin	Type 2 Diabetes Mellitus	[5]
Chlorthalidone + Bumetanide	DCF4P7S	Chlorthalidone	Renal Insufficiency, Chronic	[6]
Furosemide + Bumetanide	DCQ6FPL	Furosemide	Heart Failure, Congestive	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4837).
• [2] Bumetanide FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT00930865) Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects
• [6] ClinicalTrials.gov (NCT03923933) Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial
• [7] ClinicalTrials.gov (NCT06218199) Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts